AZD2858_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the AZD2858_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.261447
RBMS3 RNA binding motif, single stranded interacting protein 3 0.193172
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.156185
CPED1 cadherin-like and PC-esterase domain containing 1 0.114801
FOXP1 forkhead box P1 0.110603
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0885705
EEF2 eukaryotic translation elongation factor 2 0.083473
EFNA5 ephrin-A5 0.0767578
SOX6 SRY (sex determining region Y)-box 6 0.0698267
HDAC9 histone deacetylase 9 0.0687346
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0629212
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0623179
NBEA neurobeachin 0.0590643
EGFR epidermal growth factor receptor 0.0587766
LPP LIM domain containing preferred translocation partner in lipoma 0.0574723
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0570353
ANXA1 annexin A1 0.0510374
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0501609
NFIA nuclear factor I/A 0.0499989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0445512
VCL vinculin 0.0430852
DLG1 discs, large homolog 1 (Drosophila) 0.0427998
ANKRD17 ankyrin repeat domain 17 0.0427584
SSBP2 single-stranded DNA binding protein 2 0.0422003
UBC ubiquitin C 0.0413865
DPYD dihydropyrimidine dehydrogenase 0.0398101
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.03917
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.038248
CUX1 cut-like homeobox 1 0.0380916
CAMKMT calmodulin-lysine N-methyltransferase 0.0376838
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0365296
TJP1 tight junction protein 1 0.0363692
ANKRD11 ankyrin repeat domain 11 0.0357168
MBNL2 muscleblind-like splicing regulator 2 0.0357019
HSPH1 heat shock 105kDa/110kDa protein 1 0.0353518
ZEB1 zinc finger E-box binding homeobox 1 0.0348864
ASCC3 activating signal cointegrator 1 complex subunit 3 0.034838
SRRM2 serine/arginine repetitive matrix 2 0.0347524
TCF12 transcription factor 12 0.0344415
NF1 neurofibromin 1 0.0342196
N4BP2L2 NEDD4 binding protein 2-like 2 0.0340973
BMP2K BMP2 inducible kinase 0.0339754
EVI5 ecotropic viral integration site 5 0.0337233
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0334875
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0326849
WNK1 WNK lysine deficient protein kinase 1 0.0321713
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0318284
PCBP2 poly(rC) binding protein 2 0.0316637
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.031507
RPL3 ribosomal protein L3 0.0314246
TRERF1 transcriptional regulating factor 1 0.0309812
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0305523
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0296885
MYOF myoferlin 0.0293354
TOP2A topoisomerase (DNA) II alpha 170kDa 0.029323
RAD18 RAD18 E3 ubiquitin protein ligase 0.0290264
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0288628
LARP1 La ribonucleoprotein domain family, member 1 0.0285675
EPS8 epidermal growth factor receptor pathway substrate 8 0.0279655
CENPF centromere protein F, 350/400kDa 0.0275722
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.027518
MACF1 microtubule-actin crosslinking factor 1 0.0272058
TMF1 TATA element modulatory factor 1 0.0262532
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0261737
TSC22D1 TSC22 domain family, member 1 0.0258525
NEBL nebulette 0.0257938
SBF2 SET binding factor 2 0.0257456
RABGAP1L RAB GTPase activating protein 1-like 0.025655
PLCE1 phospholipase C, epsilon 1 0.0255462
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0254304
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0253184
PICALM phosphatidylinositol binding clathrin assembly protein 0.0252766
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0251051
ENO2 enolase 2 (gamma, neuronal) 0.0249496
NAV2 neuron navigator 2 0.0248551
NPAS2 neuronal PAS domain protein 2 0.0248441
KTN1 kinectin 1 (kinesin receptor) 0.0244642
PDE7B phosphodiesterase 7B 0.0240354
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.02403
MSI2 musashi RNA-binding protein 2 0.023938
MYO5A myosin VA (heavy chain 12, myoxin) 0.0237661
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0236324
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0231809
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0231527
AEBP2 AE binding protein 2 0.0224236
DIAPH3 diaphanous-related formin 3 0.0224168
CSDE1 cold shock domain containing E1, RNA-binding 0.0222517
PTPRG protein tyrosine phosphatase, receptor type, G 0.0218312
LIMD1 LIM domains containing 1 0.0217135
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0216359
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0215664
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0214449
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0211989
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0211847
ZCCHC7 zinc finger, CCHC domain containing 7 0.0211711
INO80 INO80 complex subunit 0.0210763
VMP1 vacuole membrane protein 1 0.0209829
BCL2 B-cell CLL/lymphoma 2 0.0209205
CLIP1 CAP-GLY domain containing linker protein 1 0.0206939
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0203741

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238588
PTMA prothymosin, alpha -0.209045
TPT1 tumor protein, translationally-controlled 1 -0.0993924
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0785709
RPL35A ribosomal protein L35a -0.073306
ACTG1 actin gamma 1 -0.0678881
RPLP2 ribosomal protein, large, P2 -0.0666049
RPS19 ribosomal protein S19 -0.0640735
PKM pyruvate kinase, muscle -0.0625086
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0622619
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0612752
RPL37A ribosomal protein L37a -0.0611013
ZNF292 zinc finger protein 292 -0.0599214
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0592915
NAMPT nicotinamide phosphoribosyltransferase -0.0576928
S100A6 S100 calcium binding protein A6 -0.053349
RPS6 ribosomal protein S6 -0.0523784
RPS27A ribosomal protein S27a -0.0517
RPL19 ribosomal protein L19 -0.0502727
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0488389
RPS3 ribosomal protein S3 -0.0482899
PYGB phosphorylase, glycogen; brain -0.047925
RTN4 reticulon 4 -0.0451193
FLNB filamin B, beta -0.0449057
PGK1 phosphoglycerate kinase 1 -0.0447081
RPL26 ribosomal protein L26 -0.0446669
RPLP1 ribosomal protein, large, P1 -0.0438792
GARS1 glycyl-tRNA synthetase 1 -0.0435093
AHNAK AHNAK nucleoprotein -0.042824
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0426204
RPL34 ribosomal protein L34 -0.0422631
PRELID2 PRELI domain containing 2 -0.0403506
S100A10 S100 calcium binding protein A10 -0.0374639
RPS8 ribosomal protein S8 -0.03732
S100A9 S100 calcium binding protein A9 -0.0371183
RBM39 RNA binding motif protein 39 -0.0362965
TMSB4X thymosin beta 4, X-linked -0.0361601
RPL13A ribosomal protein L13a -0.0357832
RPL12 ribosomal protein L12 -0.0357162
RPL9 ribosomal protein L9 -0.0356378
B2M beta-2-microglobulin -0.0345037
IFI6 interferon, alpha-inducible protein 6 -0.0343927
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0334908
RYBP RING1 and YY1 binding protein -0.0317851
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0313656
RPL28 ribosomal protein L28 -0.0313616
RBM25 RNA binding motif protein 25 -0.0312259
TMSB10 thymosin beta 10 -0.0308865
MT2A metallothionein 2A -0.0306121
EMP3 epithelial membrane protein 3 -0.0305489
ATP9B ATPase, class II, type 9B -0.0301917
RPL36A ribosomal protein L36a -0.030145
RPS12 ribosomal protein S12 -0.0295652
RPL36 ribosomal protein L36 -0.0294669
RPL38 ribosomal protein L38 -0.0292723
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0286282
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0281976
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0280525
PFN1 profilin 1 -0.0277434
RPL31 ribosomal protein L31 -0.0276601
RPS29 ribosomal protein S29 -0.0276429
CELF1 CUGBP, Elav-like family member 1 -0.0275746
IFI16 interferon, gamma-inducible protein 16 -0.0274448
GNAS GNAS complex locus -0.0272113
OGA O-GlcNAcase -0.026995
RAB1A RAB1A, member RAS oncogene family -0.0266878
FBXO11 F-box protein 11 -0.026575
PHIP pleckstrin homology domain interacting protein -0.0259194
EIF1 eukaryotic translation initiation factor 1 -0.0259032
RPL18 ribosomal protein L18 -0.0256153
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.02509
RPL23 ribosomal protein L23 -0.0249549
TM4SF1 transmembrane 4 L six family member 1 -0.0247542
RPS24 ribosomal protein S24 -0.0247198
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0242655
BRD2 bromodomain containing 2 -0.0239975
RPS13 ribosomal protein S13 -0.0236375
RPS25 ribosomal protein S25 -0.0236202
MEF2A myocyte enhancer factor 2A -0.0232637
SMAP1 small ArfGAP 1 -0.0231977
HMGB1 high mobility group box 1 -0.0231566
PTBP2 polypyrimidine tract binding protein 2 -0.0231099
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0230616
ARB2A ARB2 cotranscriptional regulator A -0.0229996
OSBPL9 oxysterol binding protein-like 9 -0.0227996
NCOR1 nuclear receptor corepressor 1 -0.022789
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0226211
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0226088
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0223764
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0222106
ANKRD10 ankyrin repeat domain 10 -0.0219379
ADAM10 ADAM metallopeptidase domain 10 -0.0218228
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0217981
ABI1 abl-interactor 1 -0.021685
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0215036
RPS2 ribosomal protein S2 -0.0214785
HEG1 heart development protein with EGF-like domains 1 -0.0214633
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0214475
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0208707
KDM3A lysine (K)-specific demethylase 3A -0.0207798