AZD2858_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.126976
SOD2 superoxide dismutase 2, mitochondrial 0.124917
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0699593
EEF2 eukaryotic translation elongation factor 2 0.0619649
MYH9 myosin, heavy chain 9, non-muscle 0.0592566
RPS12 ribosomal protein S12 0.0472232
COL6A3 collagen, type VI, alpha 3 0.0442076
SMAD3 SMAD family member 3 0.0424967
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0348121
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347363
EEF1G eukaryotic translation elongation factor 1 gamma 0.0344221
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0337102
PLEC plectin 0.0327257
ARRDC3 arrestin domain containing 3 0.0319711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0309116
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0292948
RPL37A ribosomal protein L37a 0.0285263
RPL3 ribosomal protein L3 0.0280767
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278204
CEP250 centrosomal protein 250kDa 0.0267822
TPM3 tropomyosin 3 0.0267288
AHNAK AHNAK nucleoprotein 0.0261688
FLNA filamin A, alpha 0.0246754
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0242512
TRIO trio Rho guanine nucleotide exchange factor 0.0234324
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0233753
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0233269
ANKRD11 ankyrin repeat domain 11 0.0231937
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230945
APLP2 amyloid beta (A4) precursor-like protein 2 0.0230146
NFE2L1 nuclear factor, erythroid 2-like 1 0.022487
PDIA3 protein disulfide isomerase family A, member 3 0.022362
RPS20 ribosomal protein S20 0.0221458
LDHA lactate dehydrogenase A 0.0213437
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0205707
PRELID2 PRELI domain containing 2 0.0203867
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0203853
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.02
PKM pyruvate kinase, muscle 0.0197099
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0196014
LOC112694756 uncharaterized LOC112694756 0.0190817
SET SET nuclear proto-oncogene 0.0188592
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0187346
RPS3 ribosomal protein S3 0.0180903
RPL13A ribosomal protein L13a 0.0180877
CTBP2 C-terminal binding protein 2 0.0180732
MT2A metallothionein 2A 0.0180601
RPL7 ribosomal protein L7 0.0174933
DSPP dentin sialophosphoprotein 0.0174626
SHB Src homology 2 domain containing adaptor protein B 0.0173648
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171979
RPS27 ribosomal protein S27 0.0168654
EZR ezrin 0.0167127
NONO non-POU domain containing, octamer-binding 0.0167015
YEATS2 YEATS domain containing 2 0.0165885
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0164112
PHF3 PHD finger protein 3 0.0162697
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0158709
SMYD3 SET and MYND domain containing 3 0.0158364
AHR aryl hydrocarbon receptor 0.0157451
MLPH melanophilin 0.0155327
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0154707
EIF4B eukaryotic translation initiation factor 4B 0.015412
EIF5 eukaryotic translation initiation factor 5 0.0153155
SKAP2 src kinase associated phosphoprotein 2 0.0151895
LMO7 LIM domain 7 0.0151861
USP37 ubiquitin specific peptidase 37 0.015151
COL4A1 collagen, type IV, alpha 1 0.0150958
LOXL2 lysyl oxidase-like 2 0.0149787
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0147832
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0145755
VEGFA vascular endothelial growth factor A 0.0145583
MBNL2 muscleblind-like splicing regulator 2 0.0143199
RPS18 ribosomal protein S18 0.0142433
MBNL1 muscleblind-like splicing regulator 1 0.0141238
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0140842
PCBP2 poly(rC) binding protein 2 0.0140771
ASCC3 activating signal cointegrator 1 complex subunit 3 0.014018
RPS17 ribosomal protein S17 0.0138739
FXR1 fragile X mental retardation, autosomal homolog 1 0.0137936
FNDC3A fibronectin type III domain containing 3A 0.0136963
BRD2 bromodomain containing 2 0.0136216
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0136026
RYBP RING1 and YY1 binding protein 0.0136016
YBX1 Y box binding protein 1 0.0135483
HYOU1 hypoxia up-regulated 1 0.013526
ZMIZ1 zinc finger, MIZ-type containing 1 0.0132067
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0131205
NRDC nardilysin convertase 0.0131133
LNPEP leucyl/cystinyl aminopeptidase 0.0130156
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0129915
ZC3H11A zinc finger CCCH-type containing 11A 0.0129841
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0129259
ANO6 anoctamin 6 0.0129002
TPI1 triosephosphate isomerase 1 0.0127873
DSTN destrin (actin depolymerizing factor) 0.0126465
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0125953
CANX calnexin 0.0123377
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0122558
NRIP1 nuclear receptor interacting protein 1 0.012228

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253113
VIM vimentin -0.238778
HLA-B major histocompatibility complex, class I, B -0.168608
MARCKS myristoylated alanine-rich protein kinase C substrate -0.146524
TPT1 tumor protein, translationally-controlled 1 -0.134533
AKAP12 A kinase (PRKA) anchor protein 12 -0.133734
TMSB10 thymosin beta 10 -0.111202
FRMD4A FERM domain containing 4A -0.109662
IER3 immediate early response 3 -0.107537
CD44 CD44 molecule (Indian blood group) -0.106338
ADM adrenomedullin -0.0971623
VCL vinculin -0.0917256
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0891994
GLIS3 GLIS family zinc finger 3 -0.077114
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.076621
FTL ferritin, light polypeptide -0.0746048
EGR1 early growth response 1 -0.0742599
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0719804
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0706776
COL1A1 collagen, type I, alpha 1 -0.06986
FTH1 ferritin, heavy polypeptide 1 -0.0682097
ZMYND8 zinc finger, MYND-type containing 8 -0.0673207
BASP1 brain abundant, membrane attached signal protein 1 -0.0638881
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0596255
RAB7A RAB7A, member RAS oncogene family -0.0594285
UBC ubiquitin C -0.0578817
CDH13 cadherin 13 -0.0575268
ACTG1 actin gamma 1 -0.0547313
SLC38A1 solute carrier family 38, member 1 -0.0506887
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.049379
CTSD cathepsin D -0.049081
PTMA prothymosin, alpha -0.0485277
PDE10A phosphodiesterase 10A -0.045507
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.044816
ERBIN erbb2 interacting protein -0.0438202
TMSB4X thymosin beta 4, X-linked -0.0433441
RPS21 ribosomal protein S21 -0.0421604
MT1X metallothionein 1X -0.0420681
INHBA inhibin, beta A -0.0408367
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0405368
RPS24 ribosomal protein S24 -0.0400327
STC1 stanniocalcin 1 -0.0388155
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0384809
GNAS GNAS complex locus -0.0380283
SFRP1 secreted frizzled-related protein 1 -0.0379572
DIAPH2 diaphanous-related formin 2 -0.0377228
BTG1 B-cell translocation gene 1, anti-proliferative -0.0367052
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0364358
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.036299
RPL32 ribosomal protein L32 -0.0360761
KPNB1 karyopherin (importin) beta 1 -0.0360568
LOC102724023 ES1 protein homolog, mitochondrial -0.0354731
TMEM263 transmembrane protein 263 -0.0350833
EXT1 exostosin glycosyltransferase 1 -0.0339556
PLIN2 perilipin 2 -0.0334652
CADM1 cell adhesion molecule 1 -0.0332139
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0329084
NRN1 neuritin 1 -0.0323961
RTN4 reticulon 4 -0.0323038
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0322182
HLA-A major histocompatibility complex, class I, A -0.0319588
WSB1 WD repeat and SOCS box containing 1 -0.031885
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0318498
HMGA1 high mobility group AT-hook 1 -0.0318093
NABP1 nucleic acid binding protein 1 -0.0315056
NDRG1 N-myc downstream regulated 1 -0.031186
CALD1 caldesmon 1 -0.0309348
SDK1 sidekick cell adhesion molecule 1 -0.0309255
TMEM132D transmembrane protein 132D -0.0308202
IFI16 interferon, gamma-inducible protein 16 -0.0305278
RPL34 ribosomal protein L34 -0.0299535
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.029872
ARL4C ADP-ribosylation factor-like 4C -0.0296722
C3 complement component 3 -0.0295089
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0292226
ZBTB38 zinc finger and BTB domain containing 38 -0.0292138
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0289605
CTSB cathepsin B -0.0289349
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0287133
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0283529
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.02835
SRGN serglycin -0.0281591
LOX lysyl oxidase -0.0279645
FN1 fibronectin 1 -0.0277883
ZFAND3 zinc finger, AN1-type domain 3 -0.0274602
GPC6 glypican 6 -0.0273877
MIDN midnolin -0.0273059
ABI3BP ABI family, member 3 (NESH) binding protein -0.0272422
ANKRD12 ankyrin repeat domain 12 -0.0270772
NAV1 neuron navigator 1 -0.0257939
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0254647
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0253035
CLMP CXADR-like membrane protein -0.0252567
SLC38A2 solute carrier family 38, member 2 -0.0251235
KLF6 Kruppel-like factor 6 -0.0250977
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0248297
CXCL8 chemokine (C-X-C motif) ligand 8 -0.024714
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0246471
RPS23 ribosomal protein S23 -0.0243112
RPL35A ribosomal protein L35a -0.0242235