| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.220532 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.183901 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.135594 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.129108 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.116151 |
| ENO1 | enolase 1, (alpha) | 0.11312 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.111812 |
| B2M | beta-2-microglobulin | 0.107451 |
| COL6A3 | collagen, type VI, alpha 3 | 0.101393 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10082 |
| CANX | calnexin | 0.0958673 |
| VIM | vimentin | 0.0958309 |
| KYNU | kynureninase | 0.0934675 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0856869 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0815006 |
| LDHA | lactate dehydrogenase A | 0.0716257 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0634714 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.062506 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0614698 |
| PRELID2 | PRELI domain containing 2 | 0.0611081 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0596428 |
| CALR | calreticulin | 0.0594581 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0582869 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0582838 |
| AHNAK | AHNAK nucleoprotein | 0.0575558 |
| PLEC | plectin | 0.0529817 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0499842 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0497024 |
| UBC | ubiquitin C | 0.0495914 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0490255 |
| GSE1 | Gse1 coiled-coil protein | 0.0482448 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0476061 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0473226 |
| CALU | calumenin | 0.0459581 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0456258 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0452617 |
| ARRDC3 | arrestin domain containing 3 | 0.0451657 |
| SFTPA2 | surfactant protein A2 | 0.0437401 |
| FAM13A | family with sequence similarity 13, member A | 0.0425918 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0417847 |
| RND3 | Rho family GTPase 3 | 0.0410985 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.041028 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0404872 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0402545 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 0.0388515 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0386013 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0381679 |
| VCL | vinculin | 0.0380375 |
| MYOF | myoferlin | 0.0377683 |
| NRXN3 | neurexin 3 | 0.037082 |
| RIGI | RNA sensor RIG-I | 0.0366729 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0361957 |
| CLINT1 | clathrin interactor 1 | 0.0361152 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0360162 |
| ANXA2 | annexin A2 | 0.035766 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0356078 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0347533 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0344798 |
| MCL1 | myeloid cell leukemia 1 | 0.0344737 |
| ITGAV | integrin, alpha V | 0.0343064 |
| RACK1 | receptor for activated C kinase 1 | 0.0337546 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0331374 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0322281 |
| TPM3 | tropomyosin 3 | 0.0321135 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0316861 |
| NAV1 | neuron navigator 1 | 0.0316612 |
| PTN | pleiotrophin | 0.0311728 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0310892 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.031046 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0306723 |
| TMSB10 | thymosin beta 10 | 0.0305725 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.0302112 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0298402 |
| HIP1 | huntingtin interacting protein 1 | 0.029489 |
| RNF24 | ring finger protein 24 | 0.029343 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.029255 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0288087 |
| RPL3 | ribosomal protein L3 | 0.0287467 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | 0.0281156 |
| INHBA | inhibin, beta A | 0.0277518 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0277422 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0273787 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0273619 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0271638 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0271035 |
| JPH2 | junctophilin 2 | 0.0268667 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | 0.0266344 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0265342 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0264796 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0264744 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0264358 |
| ATXN1 | ataxin 1 | 0.0262401 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0261149 |
| PRMT2 | protein arginine methyltransferase 2 | 0.0260879 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0259416 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0257841 |
| HLA-B | major histocompatibility complex, class I, B | 0.0256874 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0256655 |
| RCOR1 | REST corepressor 1 | 0.0256114 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0255218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.138101 |
| COL1A1 | collagen, type I, alpha 1 | -0.0956541 |
| NDRG1 | N-myc downstream regulated 1 | -0.0779582 |
| ACTG1 | actin gamma 1 | -0.068774 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0684562 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0499908 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0465329 |
| SMYD3 | SET and MYND domain containing 3 | -0.0463218 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0436828 |
| EGR1 | early growth response 1 | -0.0419754 |
| CD109 | CD109 molecule | -0.0394709 |
| CADM1 | cell adhesion molecule 1 | -0.0389574 |
| PTMA | prothymosin, alpha | -0.0389036 |
| NOP58 | NOP58 ribonucleoprotein | -0.0387234 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0384478 |
| SETD5 | SET domain containing 5 | -0.0381545 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0378351 |
| RPL35A | ribosomal protein L35a | -0.0355096 |
| STC1 | stanniocalcin 1 | -0.0344659 |
| FOSL1 | FOS-like antigen 1 | -0.0342279 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0338904 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0334406 |
| ERBIN | erbb2 interacting protein | -0.0333341 |
| NKTR | natural killer cell triggering receptor | -0.0332992 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0330857 |
| COL1A2 | collagen, type I, alpha 2 | -0.0329978 |
| RDX | radixin | -0.0325716 |
| ECE1 | endothelin converting enzyme 1 | -0.0322711 |
| HMGA2 | high mobility group AT-hook 2 | -0.0319236 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0316605 |
| RPS3 | ribosomal protein S3 | -0.0316078 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0315709 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0314788 |
| RAD51B | RAD51 paralog B | -0.0313529 |
| RTN4 | reticulon 4 | -0.0308322 |
| EFNA5 | ephrin-A5 | -0.030614 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0303174 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0299864 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0296621 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0295999 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0295495 |
| FNBP4 | formin binding protein 4 | -0.0294631 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0292537 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0291992 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0290203 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0287646 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0286248 |
| PARD3 | par-3 family cell polarity regulator | -0.0285268 |
| ZFHX3 | zinc finger homeobox 3 | -0.0282604 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0281999 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0280971 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0278667 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0278334 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0274882 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0273948 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0270868 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0269388 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0267715 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0267492 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0264702 |
| TANK | TRAF family member-associated NFKB activator | -0.0264672 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0261729 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0261167 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.026063 |
| HPCAL1 | hippocalcin-like 1 | -0.0258997 |
| FTL | ferritin, light polypeptide | -0.0258833 |
| RPS16 | ribosomal protein S16 | -0.0258562 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0253065 |
| YTHDC1 | YTH domain containing 1 | -0.0252969 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0252729 |
| RPS11 | ribosomal protein S11 | -0.0252189 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0252042 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.025124 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0247085 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.0243948 |
| COL3A1 | collagen, type III, alpha 1 | -0.0242697 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0240181 |
| KLHDC10 | kelch domain containing 10 | -0.0238139 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0235689 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0234483 |
| FUS | FUS RNA binding protein | -0.0233897 |
| RBM25 | RNA binding motif protein 25 | -0.0233831 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0233337 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0233202 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0231859 |
| FAT1 | FAT atypical cadherin 1 | -0.0230648 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0230092 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0229289 |
| HLA-E | major histocompatibility complex, class I, E | -0.0228886 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0226297 |
| BBX | bobby sox homolog (Drosophila) | -0.0226273 |
| AK1 | adenylate kinase 1 | -0.0224741 |
| RPL9 | ribosomal protein L9 | -0.0224146 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0223876 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.022367 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0223655 |
| RREB1 | ras responsive element binding protein 1 | -0.0222679 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0220675 |
| PDE8A | phosphodiesterase 8A | -0.0218214 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0217374 |
