| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | AZD2858 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the AZD2858_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.130761 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0949262 |
| LOC112694756 | uncharaterized LOC112694756 | 0.082111 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0747026 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0695793 |
| AHNAK | AHNAK nucleoprotein | 0.058799 |
| TXNRD1 | thioredoxin reductase 1 | 0.057309 |
| PLEC | plectin | 0.055374 |
| SMAD3 | SMAD family member 3 | 0.0523376 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.048654 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0464598 |
| LDHA | lactate dehydrogenase A | 0.0410561 |
| SQSTM1 | sequestosome 1 | 0.0402034 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0384256 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0381292 |
| CD44 | CD44 molecule (Indian blood group) | 0.0378687 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0373254 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0366003 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0363038 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0354187 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0353607 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0340073 |
| SVIL | supervillin | 0.0329466 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0315856 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0315017 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0314324 |
| SET | SET nuclear proto-oncogene | 0.0313606 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0312983 |
| RORA | RAR-related orphan receptor A | 0.0311213 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0310064 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0309883 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0308145 |
| CDK6 | cyclin-dependent kinase 6 | 0.029874 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0297877 |
| RTN4 | reticulon 4 | 0.0293916 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0291453 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0291217 |
| KIF5B | kinesin family member 5B | 0.0289021 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0287309 |
| EZR | ezrin | 0.0285492 |
| ZNF292 | zinc finger protein 292 | 0.0282049 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0280697 |
| RASAL2 | RAS protein activator like 2 | 0.0280185 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0279183 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0279027 |
| TXNIP | thioredoxin interacting protein | 0.027761 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0275932 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0269827 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0263249 |
| SEPTIN9 | septin 9 | 0.0261022 |
| ENO1 | enolase 1, (alpha) | 0.0257757 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0257378 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0256386 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255642 |
| FMNL2 | formin-like 2 | 0.0255624 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0255594 |
| CDCP1 | CUB domain containing protein 1 | 0.0255559 |
| NAV3 | neuron navigator 3 | 0.0255452 |
| PGK1 | phosphoglycerate kinase 1 | 0.0252683 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0252614 |
| FLNA | filamin A, alpha | 0.0243998 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0242173 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0241861 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.024131 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0236947 |
| ANXA2 | annexin A2 | 0.0236462 |
| TPI1 | triosephosphate isomerase 1 | 0.0236384 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0236068 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0235697 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0235356 |
| DTNA | dystrobrevin, alpha | 0.0234795 |
| GPC6 | glypican 6 | 0.0230241 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0227334 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0226648 |
| SLMAP | sarcolemma associated protein | 0.0224913 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0224767 |
| SEPTIN2 | septin 2 | 0.0224131 |
| ETV1 | ets variant 1 | 0.0222498 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0222107 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0221649 |
| JMJD1C | jumonji domain containing 1C | 0.0217673 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.021754 |
| ANO6 | anoctamin 6 | 0.0216971 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0216811 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0213624 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0211917 |
| IPO7 | importin 7 | 0.0211337 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0210798 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0210391 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0209246 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0208598 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0208046 |
| MYOF | myoferlin | 0.0207483 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0207206 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0206253 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0204613 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0204234 |
| CDK17 | cyclin-dependent kinase 17 | 0.0204008 |
| ITSN2 | intersectin 2 | 0.0203463 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0201072 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.138619 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.113487 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0761361 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0676619 |
| GNAS | GNAS complex locus | -0.0629814 |
| TMSB10 | thymosin beta 10 | -0.0592202 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0588269 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.057152 |
| VIM | vimentin | -0.0559341 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0552668 |
| IGF2 | insulin-like growth factor 2 | -0.0505809 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0478932 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0470552 |
| RPL35A | ribosomal protein L35a | -0.046511 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0455931 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0450512 |
| RPLP1 | ribosomal protein, large, P1 | -0.0418357 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0417453 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0410408 |
| SRPK2 | SRSF protein kinase 2 | -0.0399523 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0398144 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0390228 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0389588 |
| RPL15 | ribosomal protein L15 | -0.0380354 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0361409 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0359114 |
| RAI14 | retinoic acid induced 14 | -0.0347009 |
| AOPEP | aminopeptidase O (putative) | -0.034567 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0344837 |
| RCOR1 | REST corepressor 1 | -0.03446 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0342845 |
| RNF213 | ring finger protein 213 | -0.0339927 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0339422 |
| RPS15 | ribosomal protein S15 | -0.033888 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0331253 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0330601 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0329943 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0324258 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0323767 |
| POTEF | POTE ankyrin domain family, member F | -0.0323526 |
| RPL36 | ribosomal protein L36 | -0.0320606 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0317124 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0313609 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0312914 |
| RPS29 | ribosomal protein S29 | -0.0312497 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.031048 |
| SCFD1 | sec1 family domain containing 1 | -0.0309167 |
| FOXO3 | forkhead box O3 | -0.03089 |
| S100A9 | S100 calcium binding protein A9 | -0.0305546 |
| CDK12 | cyclin-dependent kinase 12 | -0.0304423 |
| RPL31 | ribosomal protein L31 | -0.0299253 |
| RPS13 | ribosomal protein S13 | -0.0297161 |
| DEK | DEK proto-oncogene | -0.0296012 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0295905 |
| TAOK3 | TAO kinase 3 | -0.0295368 |
| EGR1 | early growth response 1 | -0.0289604 |
| PTK2 | protein tyrosine kinase 2 | -0.0288022 |
| USP15 | ubiquitin specific peptidase 15 | -0.0287149 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0287106 |
| RPL37 | ribosomal protein L37 | -0.0286716 |
| HLA-B | major histocompatibility complex, class I, B | -0.028606 |
| RIGI | RNA sensor RIG-I | -0.0282306 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0278324 |
| RPL37A | ribosomal protein L37a | -0.0277694 |
| INTS6 | integrator complex subunit 6 | -0.0277499 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0276931 |
| RPS21 | ribosomal protein S21 | -0.0275638 |
| SETX | senataxin | -0.0275178 |
| IER3 | immediate early response 3 | -0.0272535 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | -0.0268526 |
| PRELID2 | PRELI domain containing 2 | -0.0266015 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0264111 |
| RPS8 | ribosomal protein S8 | -0.0261073 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0260174 |
| RBM27 | RNA binding motif protein 27 | -0.0258775 |
| MICU1 | mitochondrial calcium uptake 1 | -0.0254234 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0254142 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0253044 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0250119 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.0249815 |
| RBM39 | RNA binding motif protein 39 | -0.0249652 |
| SMYD3 | SET and MYND domain containing 3 | -0.0249025 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | -0.0244078 |
| VCL | vinculin | -0.0241337 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0240091 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0238128 |
| ZNF609 | zinc finger protein 609 | -0.0237663 |
| KLHL5 | kelch-like family member 5 | -0.0237468 |
| COG5 | component of oligomeric golgi complex 5 | -0.0236913 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0236424 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0236343 |
| NEMF | nuclear export mediator factor | -0.0235213 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0234494 |
| SNX14 | sorting nexin 14 | -0.0233548 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0233451 |
| NF1 | neurofibromin 1 | -0.0231906 |
| RPS24 | ribosomal protein S24 | -0.0231875 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0230634 |
| HLA-A | major histocompatibility complex, class I, A | -0.0230507 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0229387 |
