AZD2858_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description AZD2858 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the AZD2858_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0401294
GLIS3 GLIS family zinc finger 3 0.0356272
SMAD3 SMAD family member 3 0.0350677
FNDC3B fibronectin type III domain containing 3B 0.034275
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0322189
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246222
SVIL supervillin 0.024264
EXT1 exostosin glycosyltransferase 1 0.0234284
GRB10 growth factor receptor-bound protein 10 0.0216363
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0212308
SEPTIN9 septin 9 0.02004
FAT1 FAT atypical cadherin 1 0.0185817
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0166152
ZSWIM6 zinc finger, SWIM-type containing 6 0.015892
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0158456
RUNX2 runt-related transcription factor 2 0.0157771
TPM3 tropomyosin 3 0.0154192
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0152891
HSPA1A heat shock 70kDa protein 1A 0.0150849
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0149686
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0147857
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0145049
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.014421
TMEM156 transmembrane protein 156 0.0141616
BICC1 BicC family RNA binding protein 1 0.0137862
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0137695
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0130787
PLEC plectin 0.013069
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0130527
ITGA1 integrin, alpha 1 0.0127464
CORO1C coronin, actin binding protein, 1C 0.0126797
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0123654
RAB31 RAB31, member RAS oncogene family 0.012044
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0120127
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0119472
HSPA8 heat shock 70kDa protein 8 0.0118544
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0115613
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0113386
FLNA filamin A, alpha 0.0111049
NPAS2 neuronal PAS domain protein 2 0.0109789
NAMPT nicotinamide phosphoribosyltransferase 0.0109496
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.010947
FXR1 fragile X mental retardation, autosomal homolog 1 0.0109397
AFF1 AF4/FMR2 family, member 1 0.0108958
ZFYVE16 zinc finger, FYVE domain containing 16 0.0107529
TNRC6A trinucleotide repeat containing 6A 0.0107256
WWTR1 WW domain containing transcription regulator 1 0.0107243
GHR growth hormone receptor 0.0106639
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.010436
GPC6 glypican 6 0.0103498
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0103261
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0102782
RSAD2 radical S-adenosyl methionine domain containing 2 0.0102634
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0102561
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0102369
EHBP1L1 EH domain binding protein 1-like 1 0.0102257
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0102076
PELI1 pellino E3 ubiquitin protein ligase 1 0.0100754
AHCYL2 adenosylhomocysteinase-like 2 0.0100274
PELO pelota homolog (Drosophila) 0.0100173
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.00994381
FAM219A family with sequence similarity 219, member A 0.00994178
ESYT2 extended synaptotagmin-like protein 2 0.00984273
EXOC5 exocyst complex component 5 0.00983775
IL1R1 interleukin 1 receptor, type I 0.00976222
RDH10 retinol dehydrogenase 10 (all-trans) 0.009751
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0097076
DOCK5 dedicator of cytokinesis 5 0.0097015
FLRT2 fibronectin leucine rich transmembrane protein 2 0.00962115
EWSR1 EWS RNA-binding protein 1 0.0096042
ANKRD28 ankyrin repeat domain 28 0.00959377
SGMS2 sphingomyelin synthase 2 0.00955442
CSDE1 cold shock domain containing E1, RNA-binding 0.00952909
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.00937444
SPTBN1 spectrin, beta, non-erythrocytic 1 0.009317
ATOSA atos homolog A 0.00929542
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00919837
CLIP2 CAP-GLY domain containing linker protein 2 0.00914821
SNX9 sorting nexin 9 0.00909146
LTBP1 latent transforming growth factor beta binding protein 1 0.00908473
NTN4 netrin 4 0.00907365
MYH9 myosin, heavy chain 9, non-muscle 0.00905633
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00894885
DUSP16 dual specificity phosphatase 16 0.00890483
RAD23B RAD23 homolog B (S. cerevisiae) 0.00884
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00883719
GPATCH2L G patch domain containing 2-like 0.00877823
SLIT2 slit homolog 2 (Drosophila) 0.00872824
ATP9A ATPase, class II, type 9A 0.0087174
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.00871002
CUX1 cut-like homeobox 1 0.0087076
NEK1 NIMA-related kinase 1 0.0086409
DNAH14 dynein, axonemal, heavy chain 14 0.00854364
HSPA1B heat shock 70kDa protein 1B 0.00849099
SPOPL speckle-type POZ protein-like 0.00844607
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.00843744
MEF2D myocyte enhancer factor 2D 0.00841597
SIK3 SIK family kinase 3 0.00841311
CCPG1 cell cycle progression 1 0.00831404
ATP11A ATPase, class VI, type 11A 0.00830212

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.194269
MT2A metallothionein 2A -0.165575
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159053
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.15206
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132284
VIM vimentin -0.124799
TMSB10 thymosin beta 10 -0.117067
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0997503
NDRG1 N-myc downstream regulated 1 -0.0939619
TPT1 tumor protein, translationally-controlled 1 -0.091672
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0853481
FTL ferritin, light polypeptide -0.0845563
HLA-B major histocompatibility complex, class I, B -0.0750445
RPL37A ribosomal protein L37a -0.0718222
IFI27 interferon, alpha-inducible protein 27 -0.0699971
FN1 fibronectin 1 -0.0671039
RPS6 ribosomal protein S6 -0.0651142
NRG1 neuregulin 1 -0.064029
RPL31 ribosomal protein L31 -0.0593305
RPL26 ribosomal protein L26 -0.0586059
IER3 immediate early response 3 -0.0551504
CANX calnexin -0.0544943
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0544812
RPS12 ribosomal protein S12 -0.0540033
RPS19 ribosomal protein S19 -0.0476827
RPS27A ribosomal protein S27a -0.0476455
CALR calreticulin -0.0468995
RPL35A ribosomal protein L35a -0.0463854
RACK1 receptor for activated C kinase 1 -0.0460811
S100A6 S100 calcium binding protein A6 -0.0452246
RPS8 ribosomal protein S8 -0.044487
B2M beta-2-microglobulin -0.0443961
ACTG1 actin gamma 1 -0.043677
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0436202
RPL9 ribosomal protein L9 -0.0433838
ENO2 enolase 2 (gamma, neuronal) -0.0415362
RPL38 ribosomal protein L38 -0.0411519
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0410728
RPS3 ribosomal protein S3 -0.0395407
RPS25 ribosomal protein S25 -0.0383431
TMSB4X thymosin beta 4, X-linked -0.0374405
WSB1 WD repeat and SOCS box containing 1 -0.0373142
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367449
RPS29 ribosomal protein S29 -0.0361053
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0356851
RPL23 ribosomal protein L23 -0.0351693
RPL19 ribosomal protein L19 -0.034362
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0342106
RPS24 ribosomal protein S24 -0.0338488
RPLP2 ribosomal protein, large, P2 -0.0333645
RPLP1 ribosomal protein, large, P1 -0.0333484
GNAS GNAS complex locus -0.0331134
RPS21 ribosomal protein S21 -0.0326145
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0324952
RPS16 ribosomal protein S16 -0.0318753
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0318625
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0316644
RPL28 ribosomal protein L28 -0.0312484
HMGA1 high mobility group AT-hook 1 -0.0311005
GOLGA4 golgin A4 -0.0308225
SRRM2 serine/arginine repetitive matrix 2 -0.0303849
STC2 stanniocalcin 2 -0.0303162
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0302891
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0301473
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.029744
RPL34 ribosomal protein L34 -0.0297363
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0297039
FBXO11 F-box protein 11 -0.0294891
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0292938
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0292661
VCL vinculin -0.029238
RPS27 ribosomal protein S27 -0.0291203
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0288244
ACBD3 acyl-CoA binding domain containing 3 -0.0287072
RPL12 ribosomal protein L12 -0.0280576
PGK1 phosphoglycerate kinase 1 -0.028054
PLIN2 perilipin 2 -0.0278724
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0277427
RPL37 ribosomal protein L37 -0.0277417
RPL11 ribosomal protein L11 -0.0276639
SYT1 synaptotagmin I -0.027626
ENO1 enolase 1, (alpha) -0.0274005
HILPDA hypoxia inducible lipid droplet-associated -0.0273075
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0267879
S100A9 S100 calcium binding protein A9 -0.0267226
EIF1 eukaryotic translation initiation factor 1 -0.0264677
TM4SF1 transmembrane 4 L six family member 1 -0.0263815
BPTF bromodomain PHD finger transcription factor -0.0262772
SLC38A2 solute carrier family 38, member 2 -0.0262462
OGA O-GlcNAcase -0.0261416
RPS23 ribosomal protein S23 -0.0260764
TMEM263 transmembrane protein 263 -0.0259545
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0255672
HLA-A major histocompatibility complex, class I, A -0.0254686
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0251194
TMEM165 transmembrane protein 165 -0.0248809
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0246218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0244448
CENPF centromere protein F, 350/400kDa -0.0237669
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0235212