| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.105821 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.105422 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0603757 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0550439 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.054747 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.052363 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0509543 |
| HDAC9 | histone deacetylase 9 | 0.0496582 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0484199 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.04812 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.047596 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0441815 |
| CDH13 | cadherin 13 | 0.0396357 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0370697 |
| MAP1B | microtubule-associated protein 1B | 0.0364927 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0363311 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0358223 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0328579 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0325326 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0301767 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0285413 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0284056 |
| CALR | calreticulin | 0.02807 |
| ASPH | aspartate beta-hydroxylase | 0.0267983 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0247278 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0241416 |
| MSI2 | musashi RNA-binding protein 2 | 0.0240214 |
| CCND1 | cyclin D1 | 0.0240078 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0235868 |
| RND3 | Rho family GTPase 3 | 0.0227019 |
| NAV2 | neuron navigator 2 | 0.0218609 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0217495 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0212275 |
| ANKRD30B | ankyrin repeat domain 30B | 0.0210661 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0208363 |
| GOLGA4 | golgin A4 | 0.0207108 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0189026 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0184907 |
| E2F7 | E2F transcription factor 7 | 0.0183289 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0173527 |
| TPM3 | tropomyosin 3 | 0.0168009 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0166525 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0165794 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0164948 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0163844 |
| DENND1A | DENN/MADD domain containing 1A | 0.0161276 |
| NAV3 | neuron navigator 3 | 0.0160473 |
| GPHN | gephyrin | 0.0157522 |
| MSN | moesin | 0.0156445 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.0155236 |
| INTS6 | integrator complex subunit 6 | 0.0153683 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0152738 |
| TSPAN5 | tetraspanin 5 | 0.0150912 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.014971 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0149634 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0148456 |
| CORO1C | coronin, actin binding protein, 1C | 0.0148006 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0147891 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.014444 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0143617 |
| FOSL1 | FOS-like antigen 1 | 0.014234 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0141444 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0139809 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0137856 |
| SEC24A | SEC24 family member A | 0.0136805 |
| SERTAD2 | SERTA domain containing 2 | 0.0136704 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0136519 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0135992 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0135874 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0135829 |
| FNIP2 | folliculin interacting protein 2 | 0.0135809 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0135553 |
| NUP58 | nucleoporin 58 | 0.013209 |
| MEIS2 | Meis homeobox 2 | 0.0131102 |
| RRM2 | ribonucleotide reductase M2 | 0.0130984 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0130393 |
| TLE4 | transducin-like enhancer of split 4 | 0.0130209 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0130057 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0129773 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.012936 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0129127 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0128927 |
| CLTC | clathrin, heavy chain (Hc) | 0.0125575 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0123513 |
| TNIK | TRAF2 and NCK interacting kinase | 0.01219 |
| HOMER1 | homer scaffolding protein 1 | 0.0121054 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0119534 |
| TCERG1 | transcription elongation regulator 1 | 0.0117807 |
| RGS7 | regulator of G-protein signaling 7 | 0.0117752 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0117632 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0115674 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0115381 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0115177 |
| ANXA1 | annexin A1 | 0.0114208 |
| EEA1 | early endosome antigen 1 | 0.0113494 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0112996 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0112941 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.011283 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.011205 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0111537 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.225024 |
| VIM | vimentin | -0.213654 |
| LOX | lysyl oxidase | -0.176353 |
| FBN1 | fibrillin 1 | -0.14761 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.134154 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.130723 |
| TMSB10 | thymosin beta 10 | -0.110366 |
| LOXL2 | lysyl oxidase-like 2 | -0.0980497 |
| MT2A | metallothionein 2A | -0.0912971 |
| COL1A2 | collagen, type I, alpha 2 | -0.0842013 |
| NDRG1 | N-myc downstream regulated 1 | -0.0837818 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0806687 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0788405 |
| COL5A2 | collagen, type V, alpha 2 | -0.0722229 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0705612 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0682702 |
| PLAT | plasminogen activator, tissue | -0.0673599 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0670792 |
| B2M | beta-2-microglobulin | -0.0648512 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0639583 |
| COL3A1 | collagen, type III, alpha 1 | -0.0574556 |
| ANXA2 | annexin A2 | -0.0533107 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0527728 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0512907 |
| CD99 | CD99 molecule | -0.0506683 |
| THBS2 | thrombospondin 2 | -0.0506641 |
| AHNAK | AHNAK nucleoprotein | -0.0506018 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0469768 |
| PODXL | podocalyxin-like | -0.0468891 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0464647 |
| HLA-B | major histocompatibility complex, class I, B | -0.04568 |
| MYADM | myeloid-associated differentiation marker | -0.0430481 |
| UBC | ubiquitin C | -0.0427263 |
| NAV1 | neuron navigator 1 | -0.0419977 |
| PRSS23 | protease, serine, 23 | -0.0418288 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0405104 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0405021 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0401566 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0399115 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0396207 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0386152 |
| FLNB | filamin B, beta | -0.0384358 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0380543 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0375038 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0368108 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0356792 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0349616 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0348133 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0336293 |
| MYOF | myoferlin | -0.0335822 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0333538 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0332803 |
| AUTS2 | autism susceptibility candidate 2 | -0.0325359 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0324152 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0320754 |
| OGA | O-GlcNAcase | -0.0318583 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.031616 |
| SBF2 | SET binding factor 2 | -0.0305102 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0300533 |
| STC1 | stanniocalcin 1 | -0.0298846 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0298316 |
| TAGLN2 | transgelin 2 | -0.0294659 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0289703 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0280378 |
| MX2 | MX dynamin-like GTPase 2 | -0.0277124 |
| S100A6 | S100 calcium binding protein A6 | -0.02734 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0271276 |
| SUCNR1 | succinate receptor 1 | -0.0269651 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0268525 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0267816 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0265438 |
| MAP4 | microtubule-associated protein 4 | -0.0259375 |
| KLHL24 | kelch-like family member 24 | -0.0255861 |
| TMOD1 | tropomodulin 1 | -0.0251081 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.024704 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0244421 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0244111 |
| SVIL | supervillin | -0.0238198 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.023713 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0236755 |
| HLA-E | major histocompatibility complex, class I, E | -0.0235397 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0233974 |
| AFAP1 | actin filament associated protein 1 | -0.023098 |
| COL5A1 | collagen, type V, alpha 1 | -0.0229697 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0226524 |
| PGK1 | phosphoglycerate kinase 1 | -0.0221359 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0219937 |
| MT1X | metallothionein 1X | -0.0217505 |
| HLA-C | major histocompatibility complex, class I, C | -0.0215323 |
| SDC4 | syndecan 4 | -0.0214138 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0209203 |
| SFTPA2 | surfactant protein A2 | -0.0208352 |
| FTL | ferritin, light polypeptide | -0.0207165 |
| LDHA | lactate dehydrogenase A | -0.0203959 |
| SP3 | Sp3 transcription factor | -0.0201487 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0200523 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0198515 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0197074 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0194232 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0194212 |
