| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.119691 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0959979 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0707841 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0616405 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0415919 |
| INTS6 | integrator complex subunit 6 | 0.040894 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0366914 |
| JMJD1C | jumonji domain containing 1C | 0.036252 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0346751 |
| ADIPOR2 | adiponectin receptor 2 | 0.0334241 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0322449 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0289736 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0276182 |
| PEG10 | paternally expressed 10 | 0.0266809 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0256419 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0255646 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0252195 |
| BRD2 | bromodomain containing 2 | 0.0244651 |
| RAB10 | RAB10, member RAS oncogene family | 0.0239576 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0227395 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0225859 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0220572 |
| RCOR1 | REST corepressor 1 | 0.021196 |
| SERTAD2 | SERTA domain containing 2 | 0.0205542 |
| ANK2 | ankyrin 2, neuronal | 0.0202624 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0199285 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0198083 |
| USP15 | ubiquitin specific peptidase 15 | 0.0197655 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0193574 |
| VMP1 | vacuole membrane protein 1 | 0.0191519 |
| EPHA6 | EPH receptor A6 | 0.0190625 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0186018 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0183606 |
| INTS4 | integrator complex subunit 4 | 0.0183264 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0183137 |
| GPHN | gephyrin | 0.0182123 |
| KIF21A | kinesin family member 21A | 0.0181868 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0176023 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0173556 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0170536 |
| RPS6 | ribosomal protein S6 | 0.0169665 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0168377 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0168166 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0167694 |
| RTN4 | reticulon 4 | 0.0163727 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0162965 |
| LRRC23 | leucine rich repeat containing 23 | 0.0161055 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0160888 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | 0.016058 |
| MSR1 | macrophage scavenger receptor 1 | 0.0159532 |
| PCNX4 | pecanex 4 | 0.0159121 |
| HMGA2 | high mobility group AT-hook 2 | 0.0157913 |
| GOLGA4 | golgin A4 | 0.0157024 |
| PCDH9 | protocadherin 9 | 0.0156778 |
| SSH2 | slingshot protein phosphatase 2 | 0.0155364 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 0.0149961 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0146705 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0146406 |
| CLTC | clathrin, heavy chain (Hc) | 0.0146014 |
| STXBP4 | syntaxin binding protein 4 | 0.0145445 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0144656 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.014413 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.014377 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0142195 |
| FNIP1 | folliculin interacting protein 1 | 0.0141668 |
| GPATCH8 | G patch domain containing 8 | 0.0141546 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0138994 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0137811 |
| USP47 | ubiquitin specific peptidase 47 | 0.0136141 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.0134749 |
| MEMO1 | mediator of cell motility 1 | 0.0133706 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0133667 |
| LEMD3 | LEM domain containing 3 | 0.0133428 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0132025 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0131726 |
| CCDC88A | coiled-coil domain containing 88A | 0.0131063 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0130416 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0129834 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0128682 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0127725 |
| ZNF146 | zinc finger protein 146 | 0.0127107 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.012633 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0125557 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0125444 |
| SCFD1 | sec1 family domain containing 1 | 0.0124826 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.0124444 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0124166 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.012035 |
| UBAP2 | ubiquitin associated protein 2 | 0.0120246 |
| CCNT2 | cyclin T2 | 0.0118613 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0118201 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.0118007 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.011692 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0114921 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0114625 |
| ABHD3 | abhydrolase domain containing 3 | 0.0114108 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0114094 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0113578 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0112786 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0112585 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.151541 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.127115 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.12078 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.119484 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.117906 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0956618 |
| VIM | vimentin | -0.0869707 |
| MMP12 | matrix metallopeptidase 12 | -0.0858314 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.083072 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0786841 |
| DST | dystonin | -0.0740259 |
| ANXA1 | annexin A1 | -0.073175 |
| TENM3 | teneurin transmembrane protein 3 | -0.0612981 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0604081 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0590187 |
| AHNAK | AHNAK nucleoprotein | -0.058346 |
| TMSB10 | thymosin beta 10 | -0.0571036 |
| LMO7 | LIM domain 7 | -0.0559261 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0556994 |
| NEK7 | NIMA-related kinase 7 | -0.055565 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0552711 |
| MYL12B | myosin, light chain 12B, regulatory | -0.054541 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0541748 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0529051 |
| NEBL | nebulette | -0.0516447 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0511296 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0502706 |
| PCDH7 | protocadherin 7 | -0.0500265 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0498035 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0484775 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0482553 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.048063 |
| MED13L | mediator complex subunit 13-like | -0.0473239 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0473121 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0468909 |
| MGAT4C | MGAT4 family, member C | -0.0453121 |
| KLHL24 | kelch-like family member 24 | -0.0442672 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0426703 |
| USP34 | ubiquitin specific peptidase 34 | -0.0411767 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0408946 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0408792 |
| TMEM123 | transmembrane protein 123 | -0.0402913 |
| ZNF217 | zinc finger protein 217 | -0.04023 |
| XPO1 | exportin 1 | -0.0395981 |
| EXOC4 | exocyst complex component 4 | -0.0394411 |
| RAD51B | RAD51 paralog B | -0.0389791 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0388608 |
| YBX3 | Y box binding protein 3 | -0.0387902 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0380994 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0372514 |
| PCBP2 | poly(rC) binding protein 2 | -0.036797 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0366624 |
| EHBP1 | EH domain binding protein 1 | -0.0361115 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.035862 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0355496 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0345826 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0339341 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0338204 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0337502 |
| SBF2 | SET binding factor 2 | -0.0333687 |
| PGK1 | phosphoglycerate kinase 1 | -0.0327325 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0326427 |
| ZNF292 | zinc finger protein 292 | -0.0326423 |
| TXNRD1 | thioredoxin reductase 1 | -0.0324415 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.032383 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.032342 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.031924 |
| SMYD3 | SET and MYND domain containing 3 | -0.0317147 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0314894 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0314373 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0312036 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0311675 |
| CLDN1 | claudin 1 | -0.0309128 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.030573 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0305003 |
| ECT2 | epithelial cell transforming 2 | -0.0304184 |
| CMIP | c-Maf inducing protein | -0.0302916 |
| EXOC6B | exocyst complex component 6B | -0.0301042 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0298422 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0298259 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.029426 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293642 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0292137 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0291937 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0290602 |
| FOXP1 | forkhead box P1 | -0.0289798 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.02853 |
| CCN2 | cellular communication network factor 2 | -0.0279417 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0278093 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.027654 |
| PDGFC | platelet derived growth factor C | -0.027605 |
| CDK19 | cyclin-dependent kinase 19 | -0.0267922 |
| MTAP | methylthioadenosine phosphorylase | -0.0264191 |
| PHF3 | PHD finger protein 3 | -0.0264089 |
| SYT1 | synaptotagmin I | -0.0261239 |
| CANX | calnexin | -0.0261116 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0261095 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0256834 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0256703 |
| AHR | aryl hydrocarbon receptor | -0.0256437 |
