| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Abemaciclib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.282343 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.238185 |
| CADM1 | cell adhesion molecule 1 | 0.183964 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.172898 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.100914 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0987093 |
| NDRG1 | N-myc downstream regulated 1 | 0.0949999 |
| IER3 | immediate early response 3 | 0.0927253 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0794597 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0776432 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.074733 |
| CDH13 | cadherin 13 | 0.0698073 |
| MRTFA | myocardin related transcription factor A | 0.0688974 |
| MT2A | metallothionein 2A | 0.0680534 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0674503 |
| CALR | calreticulin | 0.0659171 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0655742 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0639026 |
| MTDH | metadherin | 0.0630302 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.062597 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0555389 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0542094 |
| ADM | adrenomedullin | 0.0520263 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0516432 |
| IL6 | interleukin 6 | 0.0500168 |
| TFG | TRK-fused gene | 0.0442429 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0427104 |
| GOLGA4 | golgin A4 | 0.0424812 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0424463 |
| VIM | vimentin | 0.0422225 |
| PTK2 | protein tyrosine kinase 2 | 0.0420586 |
| TRAM1 | translocation associated membrane protein 1 | 0.0419002 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0407339 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0404353 |
| HIP1 | huntingtin interacting protein 1 | 0.0402439 |
| RLF | rearranged L-myc fusion | 0.0399703 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0397043 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0394713 |
| COL1A2 | collagen, type I, alpha 2 | 0.038877 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0378627 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.03729 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0367612 |
| USP3 | ubiquitin specific peptidase 3 | 0.0366624 |
| RND3 | Rho family GTPase 3 | 0.0366485 |
| ZNF292 | zinc finger protein 292 | 0.0364643 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.036345 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0355829 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0351603 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0343463 |
| TMSB10 | thymosin beta 10 | 0.0340538 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0339911 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0339444 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0336442 |
| PTMA | prothymosin, alpha | 0.0333417 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0332678 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0332105 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0331678 |
| SP100 | SP100 nuclear antigen | 0.0328548 |
| RASA2 | RAS p21 protein activator 2 | 0.0320657 |
| RYBP | RING1 and YY1 binding protein | 0.0320585 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0318864 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0314735 |
| ATP13A3 | ATPase type 13A3 | 0.0312026 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0311418 |
| QKI | QKI, KH domain containing, RNA binding | 0.0311025 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0307605 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0307486 |
| ARRDC3 | arrestin domain containing 3 | 0.0306674 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0304703 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0302511 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0302162 |
| CCNY | cyclin Y | 0.0301986 |
| SPAG9 | sperm associated antigen 9 | 0.0296039 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0293802 |
| COPA | coatomer protein complex, subunit alpha | 0.0292676 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0291725 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0290142 |
| IRF1 | interferon regulatory factor 1 | 0.0289012 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0288333 |
| MED13L | mediator complex subunit 13-like | 0.0287081 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.028218 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0280854 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0279916 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0273782 |
| MAP4 | microtubule-associated protein 4 | 0.027377 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0271616 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0271196 |
| TMEM39A | transmembrane protein 39A | 0.0268785 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0268476 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0267341 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.02664 |
| TPM4 | tropomyosin 4 | 0.0265178 |
| CANX | calnexin | 0.0264965 |
| COL3A1 | collagen, type III, alpha 1 | 0.0263943 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0263563 |
| GNAS | GNAS complex locus | 0.0262276 |
| FMNL2 | formin-like 2 | 0.0261825 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0261346 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.025926 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0257561 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.270039 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0776533 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0756451 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0642323 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0641608 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0607827 |
| PRELID2 | PRELI domain containing 2 | -0.0469015 |
| COL5A1 | collagen, type V, alpha 1 | -0.0459052 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0456192 |
| DST | dystonin | -0.0441777 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0427664 |
| HMGA2 | high mobility group AT-hook 2 | -0.0411037 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0395389 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0394265 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0387587 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0355046 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0326647 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0290902 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0273871 |
| EPHB1 | EPH receptor B1 | -0.0262462 |
| CNTN5 | contactin 5 | -0.0258326 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.025549 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0252542 |
| LOX | lysyl oxidase | -0.0249784 |
| POTEF | POTE ankyrin domain family, member F | -0.0239196 |
| MAP1B | microtubule-associated protein 1B | -0.0238425 |
| ASPH | aspartate beta-hydroxylase | -0.0235978 |
| EGFR | epidermal growth factor receptor | -0.0232044 |
| SMYD3 | SET and MYND domain containing 3 | -0.022865 |
| TNS3 | tensin 3 | -0.0225691 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0218326 |
| ATXN1 | ataxin 1 | -0.0218048 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0216938 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.021332 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0211164 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0206613 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0205539 |
| FBN1 | fibrillin 1 | -0.0205261 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0201594 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0200728 |
| CENPF | centromere protein F, 350/400kDa | -0.0200218 |
| EXOC4 | exocyst complex component 4 | -0.0199661 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0198255 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0196282 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0193532 |
| GLIS3 | GLIS family zinc finger 3 | -0.0190671 |
| NREP | neuronal regeneration related protein | -0.0189182 |
| VEGFA | vascular endothelial growth factor A | -0.018717 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0185176 |
| VCL | vinculin | -0.018493 |
| PRR16 | proline rich 16 | -0.0183482 |
| PFN1 | profilin 1 | -0.0182213 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.017341 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0172575 |
| HMGA1 | high mobility group AT-hook 1 | -0.0172241 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0171405 |
| SBF2 | SET binding factor 2 | -0.0167567 |
| KLF12 | Kruppel-like factor 12 | -0.0166809 |
| EBF1 | early B-cell factor 1 | -0.0166327 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0165656 |
| NAV1 | neuron navigator 1 | -0.0164273 |
| ITGA11 | integrin, alpha 11 | -0.0163655 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0163497 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0161582 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.01601 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0157974 |
| NRG3 | neuregulin 3 | -0.0157783 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0156938 |
| TENM3 | teneurin transmembrane protein 3 | -0.0153799 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0152982 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0152901 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0152019 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0148676 |
| CPQ | carboxypeptidase Q | -0.0148485 |
| JAK2 | Janus kinase 2 | -0.0147298 |
| MYLK | myosin light chain kinase | -0.0147027 |
| NRP1 | neuropilin 1 | -0.0146972 |
| RAD51B | RAD51 paralog B | -0.0145835 |
| SMAD3 | SMAD family member 3 | -0.014381 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0143743 |
| PRSS23 | protease, serine, 23 | -0.0142965 |
| WDR27 | WD repeat domain 27 | -0.0142872 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.014286 |
| TPM1 | tropomyosin 1 (alpha) | -0.0142659 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0142518 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0142372 |
| METTL15 | methyltransferase like 15 | -0.0141543 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0141424 |
| RANBP17 | RAN binding protein 17 | -0.0141219 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0140978 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0140634 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0139103 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0136178 |
| ACACA | acetyl-CoA carboxylase alpha | -0.013608 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0135955 |
| BNC2 | basonuclin 2 | -0.0135248 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0132423 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0132239 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0131743 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0131472 |
