Abemaciclib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.124269
AKAP12 A kinase (PRKA) anchor protein 12 0.105659
SVIL supervillin 0.0889296
KIAA1217 KIAA1217 0.0685785
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0656729
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.059548
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0502476
ASPH aspartate beta-hydroxylase 0.0476735
DTNA dystrobrevin, alpha 0.0474613
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.04643
FAM107B family with sequence similarity 107, member B 0.043193
GMDS GDP-mannose 4,6-dehydratase 0.0395867
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0387791
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0387477
MACF1 microtubule-actin crosslinking factor 1 0.0386975
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0378571
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0369167
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0368997
KYNU kynureninase 0.0364109
GOLGA4 golgin A4 0.0338811
CPED1 cadherin-like and PC-esterase domain containing 1 0.0319867
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0313732
PDLIM5 PDZ and LIM domain 5 0.0305024
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0303212
ZEB1 zinc finger E-box binding homeobox 1 0.0301262
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0296171
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0294009
TRIO trio Rho guanine nucleotide exchange factor 0.0283885
FRMD5 FERM domain containing 5 0.027484
RTN4 reticulon 4 0.0264279
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0262947
SAMD4A sterile alpha motif domain containing 4A 0.0258558
ITCH itchy E3 ubiquitin protein ligase 0.0257879
CORO1C coronin, actin binding protein, 1C 0.0254495
CCNY cyclin Y 0.0254341
MAP1B microtubule-associated protein 1B 0.025306
KIF1B kinesin family member 1B 0.0252629
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0251375
RUNX1 runt-related transcription factor 1 0.0251024
SOX5 SRY (sex determining region Y)-box 5 0.0247803
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0243298
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0242307
PDGFB platelet-derived growth factor beta polypeptide 0.0241452
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0238451
RAI14 retinoic acid induced 14 0.0234019
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0229628
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0228588
PPARD peroxisome proliferator-activated receptor delta 0.0227456
GLS2 glutaminase 2 (liver, mitochondrial) 0.0226224
PMM2 phosphomannomutase 2 0.0225626
ABAT 4-aminobutyrate aminotransferase 0.0225395
HSPH1 heat shock 105kDa/110kDa protein 1 0.022118
BCL2L1 BCL2-like 1 0.022111
DIAPH1 diaphanous-related formin 1 0.0219002
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0217387
WDR43 WD repeat domain 43 0.0217323
RAB1A RAB1A, member RAS oncogene family 0.02171
CANX calnexin 0.0216541
NRIP1 nuclear receptor interacting protein 1 0.0216186
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0214934
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0209734
ANKRD11 ankyrin repeat domain 11 0.0208212
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0207952
MYO1B myosin IB 0.0207685
RBM19 RNA binding motif protein 19 0.0207463
CCDC88A coiled-coil domain containing 88A 0.0201125
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0200593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0200496
CLINT1 clathrin interactor 1 0.0199777
NGLY1 N-glycanase 1 0.0199757
FNIP1 folliculin interacting protein 1 0.0198336
SYNE1 spectrin repeat containing, nuclear envelope 1 0.019651
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0196116
TOP1 topoisomerase (DNA) I 0.0193775
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.019072
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0187178
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0183936
SEC24A SEC24 family member A 0.0183788
STRN3 striatin, calmodulin binding protein 3 0.0183682
RBM25 RNA binding motif protein 25 0.0183376
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0183223
DENND5A DENN/MADD domain containing 5A 0.0182991
AFF4 AF4/FMR2 family, member 4 0.0181306
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0180141
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0179913
USP34 ubiquitin specific peptidase 34 0.0179813
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0179554
ARL15 ADP-ribosylation factor-like 15 0.0179372
GPHN gephyrin 0.0177463
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0174775
RASA2 RAS p21 protein activator 2 0.0174647
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0173649
RAB10 RAB10, member RAS oncogene family 0.0172507
GRB10 growth factor receptor-bound protein 10 0.0171836
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0171053
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0171033
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0170531
JMJD1C jumonji domain containing 1C 0.0169632
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0169172
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0167643

decreased expression

Symbol Name Standardized Value
SLC38A2 solute carrier family 38, member 2 -0.140994
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.130992
C3 complement component 3 -0.113969
APOA2 apolipoprotein A-II -0.107028
FN1 fibronectin 1 -0.100039
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0924406
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0864268
APOB apolipoprotein B -0.0798822
MAML2 mastermind-like 2 (Drosophila) -0.0766571
RPL37A ribosomal protein L37a -0.0547236
MT2A metallothionein 2A -0.0536049
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0535328
AHSG alpha-2-HS-glycoprotein -0.0512512
RPL31 ribosomal protein L31 -0.047986
RERE arginine-glutamic acid dipeptide (RE) repeats -0.047037
NDRG1 N-myc downstream regulated 1 -0.0462215
RPL35A ribosomal protein L35a -0.0442983
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0442939
FTL ferritin, light polypeptide -0.0421527
TRIM26 tripartite motif containing 26 -0.0412386
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.04006
DLC1 DLC1 Rho GTPase activating protein -0.0382853
APOE apolipoprotein E -0.0381405
FBF1 Fas (TNFRSF6) binding factor 1 -0.0381157
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0357695
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0340488
RPS12 ribosomal protein S12 -0.0338503
TMSB10 thymosin beta 10 -0.0337397
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0335553
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.033516
RPL23 ribosomal protein L23 -0.0334142
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0333506
A2M alpha-2-macroglobulin -0.0332543
EML4 echinoderm microtubule associated protein like 4 -0.033129
FOXN3 forkhead box N3 -0.0327454
RPS24 ribosomal protein S24 -0.0321771
TNRC6B trinucleotide repeat containing 6B -0.032017
RPS19 ribosomal protein S19 -0.0319681
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0315283
RPS8 ribosomal protein S8 -0.0313746
PHF3 PHD finger protein 3 -0.0310765
PCBP2 poly(rC) binding protein 2 -0.030927
PEG3 paternally expressed 3 -0.0307207
DSPP dentin sialophosphoprotein -0.0304758
FNDC3B fibronectin type III domain containing 3B -0.0302112
RPL11 ribosomal protein L11 -0.0301794
TPT1 tumor protein, translationally-controlled 1 -0.0300999
MBNL2 muscleblind-like splicing regulator 2 -0.0294498
TMEM123 transmembrane protein 123 -0.0293544
EHBP1 EH domain binding protein 1 -0.0289638
APOA1 apolipoprotein A-I -0.0286109
RPS29 ribosomal protein S29 -0.0283655
CPE carboxypeptidase E -0.0276687
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0276362
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0271365
TF transferrin -0.0268117
GPC3 glypican 3 -0.0268083
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0257943
RPL5 ribosomal protein L5 -0.0257861
NKD1 naked cuticle homolog 1 (Drosophila) -0.0256762
ZMYND8 zinc finger, MYND-type containing 8 -0.0255112
AKAP9 A kinase (PRKA) anchor protein 9 -0.0253666
EIF1 eukaryotic translation initiation factor 1 -0.0250939
RPLP1 ribosomal protein, large, P1 -0.0250161
RPS27A ribosomal protein S27a -0.0246885
DOCK4 dedicator of cytokinesis 4 -0.0244906
GNAS GNAS complex locus -0.0242655
RPS6 ribosomal protein S6 -0.0240664
RB1CC1 RB1-inducible coiled-coil 1 -0.0239883
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0236889
RPS21 ribosomal protein S21 -0.0236724
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0236498
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0229525
RPL9 ribosomal protein L9 -0.0228393
MTUS1 microtubule associated tumor suppressor 1 -0.0228334
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0228219
IGF1R insulin-like growth factor 1 receptor -0.0225119
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0224783
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0224295
AHR aryl hydrocarbon receptor -0.0224029
RPS14 ribosomal protein S14 -0.0223272
LYZ lysozyme -0.0221804
ZFHX3 zinc finger homeobox 3 -0.02181
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0217775
RPL34 ribosomal protein L34 -0.0214271
ZBTB20 zinc finger and BTB domain containing 20 -0.0213205
ITGA1 integrin, alpha 1 -0.0212291
MBNL3 muscleblind-like splicing regulator 3 -0.0211887
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0209984
RPS23 ribosomal protein S23 -0.0208758
RPL7A ribosomal protein L7a -0.020847
FBXL20 F-box and leucine-rich repeat protein 20 -0.0206038
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0205564
CP ceruloplasmin (ferroxidase) -0.0205557
VEGFA vascular endothelial growth factor A -0.0205256
RBM39 RNA binding motif protein 39 -0.0204292
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0203302
RPS11 ribosomal protein S11 -0.0202557
LCOR ligand dependent nuclear receptor corepressor -0.0199694
PTBP3 polypyrimidine tract binding protein 3 -0.0199386