Abemaciclib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.117481
NRIP1 nuclear receptor interacting protein 1 0.0819911
KIAA1217 KIAA1217 0.0776977
ALCAM activated leukocyte cell adhesion molecule 0.061809
PTK2 protein tyrosine kinase 2 0.0568232
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0533503
PODXL podocalyxin-like 0.051015
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0497706
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0496108
RAI14 retinoic acid induced 14 0.047223
ATF4 activating transcription factor 4 0.0437164
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0426995
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0420608
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0415464
TP63 tumor protein p63 0.0415379
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0413701
FNDC3B fibronectin type III domain containing 3B 0.0399306
HM13 histocompatibility (minor) 13 0.0393251
LUZP1 leucine zipper protein 1 0.0365947
F3 coagulation factor III (thromboplastin, tissue factor) 0.0364824
GARS1 glycyl-tRNA synthetase 1 0.0355987
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.032858
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0323586
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0322397
KMT2E lysine (K)-specific methyltransferase 2E 0.0321585
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0314081
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0313414
ATP13A3 ATPase type 13A3 0.0303411
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0302145
PMM2 phosphomannomutase 2 0.0300239
GOLGA4 golgin A4 0.0296406
RPL3 ribosomal protein L3 0.0296157
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0294542
MCL1 myeloid cell leukemia 1 0.0290345
PDZD8 PDZ domain containing 8 0.0286915
CEMIP2 cell migration inducing hyaluronidase 2 0.0276752
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 0.0273849
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0269276
PDLIM5 PDZ and LIM domain 5 0.0267262
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0264225
CDCP1 CUB domain containing protein 1 0.0262123
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0262008
COG6 component of oligomeric golgi complex 6 0.0253858
FRMD6 FERM domain containing 6 0.0253373
LOXL4 lysyl oxidase-like 4 0.0250913
EPS8 epidermal growth factor receptor pathway substrate 8 0.0247574
MTSS1 metastasis suppressor 1 0.0247364
ARF4 ADP-ribosylation factor 4 0.0243724
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0241746
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0239933
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0238757
RASAL2 RAS protein activator like 2 0.0237943
MON2 MON2 homolog (S. cerevisiae) 0.0234904
SLC35F3 solute carrier family 35, member F3 0.0231645
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0229794
PTGES2 prostaglandin E synthase 2 0.0229681
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.0223452
FNIP1 folliculin interacting protein 1 0.022254
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0218543
ANGPTL4 angiopoietin-like 4 0.0217498
RAB1A RAB1A, member RAS oncogene family 0.0217417
PDGFB platelet-derived growth factor beta polypeptide 0.0217136
EXT1 exostosin glycosyltransferase 1 0.0216565
LRRC8B leucine rich repeat containing 8 family, member B 0.0216244
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0215967
LAMC2 laminin, gamma 2 0.021572
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0215141
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0212026
SUCO SUN domain containing ossification factor 0.0211833
FRMD5 FERM domain containing 5 0.0211376
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0209482
SEC24A SEC24 family member A 0.0209076
SOD2 superoxide dismutase 2, mitochondrial 0.0208837
USP53 ubiquitin specific peptidase 53 0.0208672
SRP54 signal recognition particle 54kDa 0.0205614
AGO3 argonaute RISC catalytic component 3 0.0205473
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0203468
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0201611
PBX3 pre-B-cell leukemia homeobox 3 0.0200463
NSRP1 nuclear speckle splicing regulatory protein 1 0.020041
VMP1 vacuole membrane protein 1 0.0198445
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0198094
LAMA5 laminin, alpha 5 0.0196918
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0196753
SQLE squalene epoxidase 0.0196714
TBK1 TANK-binding kinase 1 0.0194934
CLIP1 CAP-GLY domain containing linker protein 1 0.0194065
PDS5A PDS5 cohesin associated factor A 0.0193226
MTDH metadherin 0.0192012
WDR36 WD repeat domain 36 0.0191782
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0190486
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0189391
UNC13B unc-13 homolog B (C. elegans) 0.0189182
COPB1 coatomer protein complex, subunit beta 1 0.0188395
MED13 mediator complex subunit 13 0.0187828
CEMIP cell migration inducing protein, hyaluronan binding 0.0187786
CTBP2 C-terminal binding protein 2 0.0187697
RPL36 ribosomal protein L36 0.0187631
ANKHD1 ankyrin repeat and KH domain containing 1 0.0187573
CTNNBL1 catenin, beta like 1 0.0186883

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.255524
FLNB filamin B, beta -0.151742
TIMP3 TIMP metallopeptidase inhibitor 3 -0.148459
NDRG1 N-myc downstream regulated 1 -0.117047
DPYD dihydropyrimidine dehydrogenase -0.105441
SULF1 sulfatase 1 -0.0945577
ITGA6 integrin, alpha 6 -0.0827013
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0803616
MYOF myoferlin -0.0706633
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0705369
LMO7 LIM domain 7 -0.0700905
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0693035
CAV1 caveolin 1, caveolae protein, 22kDa -0.0689178
FOXO1 forkhead box O1 -0.0688234
EMP1 epithelial membrane protein 1 -0.0665618
STC1 stanniocalcin 1 -0.061984
POTEF POTE ankyrin domain family, member F -0.0571703
FN1 fibronectin 1 -0.0541942
PSD3 pleckstrin and Sec7 domain containing 3 -0.0496934
RIN2 Ras and Rab interactor 2 -0.0477686
PDE4D phosphodiesterase 4D, cAMP-specific -0.0471655
CD44 CD44 molecule (Indian blood group) -0.0462755
LDHA lactate dehydrogenase A -0.0459072
MEF2A myocyte enhancer factor 2A -0.0457717
EZR ezrin -0.0455802
OGA O-GlcNAcase -0.0452202
ASPH aspartate beta-hydroxylase -0.0451576
FOXP1 forkhead box P1 -0.0445106
NEK7 NIMA-related kinase 7 -0.0417802
HSPG2 heparan sulfate proteoglycan 2 -0.0412034
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0404052
CUL4B cullin 4B -0.0403565
KRT6A keratin 6A, type II -0.0398162
ANLN anillin, actin binding protein -0.0389137
PRSS23 protease, serine, 23 -0.0379519
ANXA2 annexin A2 -0.0377008
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0376327
MAML2 mastermind-like 2 (Drosophila) -0.0373727
ZMYND8 zinc finger, MYND-type containing 8 -0.0373391
MECOM MDS1 and EVI1 complex locus -0.0372383
KRT17 keratin 17, type I -0.0368512
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0365513
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.035789
TMSB4X thymosin beta 4, X-linked -0.0354928
SAMD9 sterile alpha motif domain containing 9 -0.0353151
DOCK5 dedicator of cytokinesis 5 -0.034886
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0332914
ANXA1 annexin A1 -0.0330472
ACTN4 actinin, alpha 4 -0.0329668
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0326145
C4BPB complement component 4 binding protein, beta -0.031956
YBX3 Y box binding protein 3 -0.0318462
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0317595
SERINC3 serine incorporator 3 -0.0315223
AHNAK AHNAK nucleoprotein -0.0312424
SLC38A2 solute carrier family 38, member 2 -0.0308167
UTRN utrophin -0.0307503
BCL2L1 BCL2-like 1 -0.0305425
RBM39 RNA binding motif protein 39 -0.0298781
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0296411
CLU clusterin -0.0296301
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0292791
AKAP13 A kinase (PRKA) anchor protein 13 -0.0292465
PKM pyruvate kinase, muscle -0.0292288
PALLD palladin, cytoskeletal associated protein -0.0291082
CD99 CD99 molecule -0.0290659
AKAP9 A kinase (PRKA) anchor protein 9 -0.0289804
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.028656
PLAT plasminogen activator, tissue -0.0286552
RIGI RNA sensor RIG-I -0.0283952
WASF2 WAS protein family, member 2 -0.0282601
BLCAP bladder cancer associated protein -0.027838
RB1CC1 RB1-inducible coiled-coil 1 -0.0278145
B2M beta-2-microglobulin -0.0277454
S100A10 S100 calcium binding protein A10 -0.0274466
NRG1 neuregulin 1 -0.0270616
TNRC6B trinucleotide repeat containing 6B -0.0265341
EXOC4 exocyst complex component 4 -0.0264203
DIAPH3 diaphanous-related formin 3 -0.0263697
IGF2 insulin-like growth factor 2 -0.0263498
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0260858
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260092
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0255703
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0255575
CD59 CD59 molecule, complement regulatory protein -0.0253681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0251926
CENPF centromere protein F, 350/400kDa -0.0249743
CRACDL CRACD like -0.0249205
LMNA lamin A/C -0.0246177
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0245687
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0244571
TGM2 transglutaminase 2 -0.0243109
RAD51B RAD51 paralog B -0.0242373
TNS3 tensin 3 -0.0241983
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0241277
RSF1 remodeling and spacing factor 1 -0.0240952
DPYSL2 dihydropyrimidinase-like 2 -0.0237327
TMSB10 thymosin beta 10 -0.0235214
SPAG9 sperm associated antigen 9 -0.0235185
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0234587