Abemaciclib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0996605
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0855844
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0653275
EXT1 exostosin glycosyltransferase 1 0.0470317
GOLGA4 golgin A4 0.0423015
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0341375
TPT1 tumor protein, translationally-controlled 1 0.0317686
FTL ferritin, light polypeptide 0.0298282
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0289712
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0270388
CALR calreticulin 0.0244481
EIF1 eukaryotic translation initiation factor 1 0.0226964
RPS8 ribosomal protein S8 0.021358
RPS12 ribosomal protein S12 0.020935
RPL34 ribosomal protein L34 0.0189808
RPS13 ribosomal protein S13 0.0173449
RPL9 ribosomal protein L9 0.0162819
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0157274
RPL37A ribosomal protein L37a 0.0155339
PGM3 phosphoglucomutase 3 0.0153017
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0148481
RPS3 ribosomal protein S3 0.014714
RPL12 ribosomal protein L12 0.0144133
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0139619
HM13 histocompatibility (minor) 13 0.013878
SEC24D SEC24 family member D 0.0136739
RPS6 ribosomal protein S6 0.0135708
SEC31A SEC31 homolog A (S. cerevisiae) 0.013393
ERN1 endoplasmic reticulum to nucleus signaling 1 0.013271
ENO2 enolase 2 (gamma, neuronal) 0.0131334
RPL13A ribosomal protein L13a 0.0125617
LURAP1L leucine rich adaptor protein 1-like 0.0124959
RPS17 ribosomal protein S17 0.0124374
RPS25 ribosomal protein S25 0.0123653
PDZD8 PDZ domain containing 8 0.012328
RPS23 ribosomal protein S23 0.0122828
TMEM65 transmembrane protein 65 0.0122144
SQSTM1 sequestosome 1 0.011717
ISG15 ISG15 ubiquitin-like modifier 0.0112665
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0112589
USP53 ubiquitin specific peptidase 53 0.0111874
NUCB2 nucleobindin 2 0.0110915
RPS2 ribosomal protein S2 0.0110515
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0109558
FNIP1 folliculin interacting protein 1 0.0107502
HDLBP high density lipoprotein binding protein 0.0107413
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0106346
BRD2 bromodomain containing 2 0.0101324
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0100721
BTBD9 BTB (POZ) domain containing 9 0.00993413
HSPA8 heat shock 70kDa protein 8 0.00971866
RPL11 ribosomal protein L11 0.00965196
RPS29 ribosomal protein S29 0.00950325
GK glycerol kinase 0.00947371
RPS27 ribosomal protein S27 0.00915235
COPB1 coatomer protein complex, subunit beta 1 0.00910389
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00910003
PDIA3 protein disulfide isomerase family A, member 3 0.00903155
UNC13B unc-13 homolog B (C. elegans) 0.00893085
TMF1 TATA element modulatory factor 1 0.00889066
COPA coatomer protein complex, subunit alpha 0.00886566
DDIT3 DNA-damage-inducible transcript 3 0.00881524
ABHD3 abhydrolase domain containing 3 0.00881009
UBC ubiquitin C 0.0088016
GARS1 glycyl-tRNA synthetase 1 0.00876736
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00875802
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.00874993
RPS27A ribosomal protein S27a 0.00873797
COG6 component of oligomeric golgi complex 6 0.00862416
SEC63 SEC63 homolog (S. cerevisiae) 0.00857404
HYOU1 hypoxia up-regulated 1 0.008524
INTS6 integrator complex subunit 6 0.0084896
RPL7A ribosomal protein L7a 0.00847261
RPL21 ribosomal protein L21 0.00843328
RPS5 ribosomal protein S5 0.00837527
PNN pinin, desmosome associated protein 0.00836875
SEC24A SEC24 family member A 0.00833468
RND3 Rho family GTPase 3 0.00833455
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.00820558
PMM2 phosphomannomutase 2 0.00818033
SIK3 SIK family kinase 3 0.00811734
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00806716
TRPS1 trichorhinophalangeal syndrome I 0.00786557
MT1X metallothionein 1X 0.0078558
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.00785121
TMEM39A transmembrane protein 39A 0.00773202
HSPH1 heat shock 105kDa/110kDa protein 1 0.00771457
UFM1 ubiquitin-fold modifier 1 0.00766568
TFG TRK-fused gene 0.00760889
EPB41 erythrocyte membrane protein band 4.1 0.00760002
RPL23 ribosomal protein L23 0.00756546
CALU calumenin 0.0075477
TMEM263 transmembrane protein 263 0.0075431
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.00750564
RPS19 ribosomal protein S19 0.00748359
TTC3 tetratricopeptide repeat domain 3 0.00744002
RSAD2 radical S-adenosyl methionine domain containing 2 0.00743951
HOOK2 hook microtubule-tethering protein 2 0.00738606
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.00735668
MTDH metadherin 0.00734861

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.209871
PTMA prothymosin, alpha -0.183577
CEMIP cell migration inducing protein, hyaluronan binding -0.158623
FAT1 FAT atypical cadherin 1 -0.127865
NALF1 NALCN channel auxiliary factor 1 -0.10978
ITGA6 integrin, alpha 6 -0.109306
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.105395
ANXA2 annexin A2 -0.0847722
FLNB filamin B, beta -0.0767961
EZR ezrin -0.0731179
TMSB10 thymosin beta 10 -0.0728031
GREB1L growth regulation by estrogen in breast cancer-like -0.0688201
TNS4 tensin 4 -0.0684282
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0655284
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0653587
AHNAK AHNAK nucleoprotein -0.0642425
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0627789
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0610917
KRT18 keratin 18, type I -0.0566807
GPHN gephyrin -0.0559896
ACTN4 actinin, alpha 4 -0.0553568
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.054354
KRT8 keratin 8, type II -0.0533522
DSPP dentin sialophosphoprotein -0.0527799
ALCAM activated leukocyte cell adhesion molecule -0.0526142
CADPS Ca++-dependent secretion activator -0.0520646
ONECUT3 one cut homeobox 3 -0.0461042
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0459404
RNF217 ring finger protein 217 -0.044816
PPARG peroxisome proliferator-activated receptor gamma -0.0442524
EHBP1 EH domain binding protein 1 -0.0441977
ANTXR2 anthrax toxin receptor 2 -0.0436614
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0424941
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0415415
PRSS3 protease, serine, 3 -0.0406052
FERMT1 fermitin family member 1 -0.039749
MAML2 mastermind-like 2 (Drosophila) -0.039535
S100A6 S100 calcium binding protein A6 -0.0392391
CALB1 calbindin 1, 28kDa -0.0391345
RNF43 ring finger protein 43 -0.0389915
PTPRR protein tyrosine phosphatase, receptor type, R -0.0380595
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0375391
LDHA lactate dehydrogenase A -0.037504
TPM4 tropomyosin 4 -0.0373654
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0369898
ITGB4 integrin, beta 4 -0.0365427
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0364049
FOXP1 forkhead box P1 -0.0362199
LMO7 LIM domain 7 -0.0354909
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354902
ASPH aspartate beta-hydroxylase -0.0352291
SH3D19 SH3 domain containing 19 -0.0347553
ARHGAP32 Rho GTPase activating protein 32 -0.0344082
ABHD2 abhydrolase domain containing 2 -0.0342918
ZBTB20 zinc finger and BTB domain containing 20 -0.0342302
MAML3 mastermind-like 3 (Drosophila) -0.0341967
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0341256
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0340129
TBC1D5 TBC1 domain family, member 5 -0.0337898
PRELID2 PRELI domain containing 2 -0.0337369
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0336968
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.033681
PIGR polymeric immunoglobulin receptor -0.0336192
PKM pyruvate kinase, muscle -0.03346
MLEC malectin -0.0328604
MED13L mediator complex subunit 13-like -0.0325941
PGK1 phosphoglycerate kinase 1 -0.0324656
GCC2 GRIP and coiled-coil domain containing 2 -0.0324378
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0321228
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0320065
NFIA nuclear factor I/A -0.0320024
PSD3 pleckstrin and Sec7 domain containing 3 -0.031201
GMDS GDP-mannose 4,6-dehydratase -0.0310768
RAD51B RAD51 paralog B -0.0310503
PATJ PATJ crumbs cell polarity complex component -0.0309553
PTPRK protein tyrosine phosphatase, receptor type, K -0.0309087
DIAPH2 diaphanous-related formin 2 -0.0307331
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.030495
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304075
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0303848
SLC35F3 solute carrier family 35, member F3 -0.0303061
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.02989
RIN2 Ras and Rab interactor 2 -0.0295809
CD46 CD46 molecule, complement regulatory protein -0.0295806
KLF3 Kruppel-like factor 3 (basic) -0.0293792
NDRG1 N-myc downstream regulated 1 -0.0286843
EHF ets homologous factor -0.0286698
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0284493
SMYD3 SET and MYND domain containing 3 -0.0282374
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0272594
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0271425
SERINC5 serine incorporator 5 -0.026621
DENND1A DENN/MADD domain containing 1A -0.0265727
MSI2 musashi RNA-binding protein 2 -0.0265309
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0264592
TRIO trio Rho guanine nucleotide exchange factor -0.0264482
DLG1 discs, large homolog 1 (Drosophila) -0.0261927
KIF5B kinesin family member 5B -0.0261693
CDK6 cyclin-dependent kinase 6 -0.025874
NCOR1 nuclear receptor corepressor 1 -0.0257391