Abemaciclib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.125567
DST dystonin 0.113403
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.061931
CMIP c-Maf inducing protein 0.0592242
P4HB prolyl 4-hydroxylase, beta polypeptide 0.056468
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.054401
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0517135
RUNX1 runt-related transcription factor 1 0.0514989
TSC22D2 TSC22 domain family, member 2 0.0495342
FNIP1 folliculin interacting protein 1 0.0494494
GMDS GDP-mannose 4,6-dehydratase 0.049405
ZFAND3 zinc finger, AN1-type domain 3 0.0487997
MACF1 microtubule-actin crosslinking factor 1 0.0482528
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0477098
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0461974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0444876
TTC3 tetratricopeptide repeat domain 3 0.0442474
COL5A2 collagen, type V, alpha 2 0.0436412
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0436135
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0434872
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0430808
GPHN gephyrin 0.0424593
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0414855
PRELID2 PRELI domain containing 2 0.0403076
FAF1 Fas (TNFRSF6) associated factor 1 0.0401399
GLS2 glutaminase 2 (liver, mitochondrial) 0.0385255
GOLGA4 golgin A4 0.0384956
CADM2 cell adhesion molecule 2 0.0378653
ANK2 ankyrin 2, neuronal 0.0365025
HOOK2 hook microtubule-tethering protein 2 0.0361723
CLTC clathrin, heavy chain (Hc) 0.0361702
EHBP1 EH domain binding protein 1 0.0359887
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0353716
SND1 staphylococcal nuclease and tudor domain containing 1 0.034739
SEC24A SEC24 family member A 0.0345314
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0343614
SDCCAG8 serologically defined colon cancer antigen 8 0.0331101
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0310924
DPH6 diphthamine biosynthesis 6 0.0307975
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0305172
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0298125
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0296754
BIRC6 baculoviral IAP repeat containing 6 0.0292636
CSMD3 CUB and Sushi multiple domains 3 0.0282026
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0281077
DPYD dihydropyrimidine dehydrogenase 0.0279413
IARS1 isoleucyl-tRNA synthetase 1 0.0271503
HSPA8 heat shock 70kDa protein 8 0.0269895
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0269085
TP63 tumor protein p63 0.0268523
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265803
INTS6 integrator complex subunit 6 0.0263149
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0258115
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0256358
CLIP1 CAP-GLY domain containing linker protein 1 0.0251212
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0251032
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0250891
ZBTB38 zinc finger and BTB domain containing 38 0.0250854
IPO9 importin 9 0.0250705
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0250429
AHI1 Abelson helper integration site 1 0.0250221
NBAS neuroblastoma amplified sequence 0.0248155
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.0247824
FNDC3B fibronectin type III domain containing 3B 0.0247804
DENND1A DENN/MADD domain containing 1A 0.0247409
PRKCE protein kinase C, epsilon 0.024737
HDAC9 histone deacetylase 9 0.0241729
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0241645
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0241629
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0238764
KMT2C lysine (K)-specific methyltransferase 2C 0.0237153
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0236863
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0235117
ANKRD50 ankyrin repeat domain 50 0.0233401
H1-0 H1.0 linker histone 0.0232276
PSD3 pleckstrin and Sec7 domain containing 3 0.0232113
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0232107
ADAR adenosine deaminase, RNA-specific 0.0231562
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.023083
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0228538
PDIA4 protein disulfide isomerase family A, member 4 0.0225707
SRSF1 serine/arginine-rich splicing factor 1 0.0224039
MB21D2 Mab-21 domain containing 2 0.0223073
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0222749
ZDHHC14 zinc finger, DHHC-type containing 14 0.0222727
HELLS helicase, lymphoid-specific 0.0222522
NAV1 neuron navigator 1 0.0222379
ZSWIM6 zinc finger, SWIM-type containing 6 0.0221916
EIF4A2 eukaryotic translation initiation factor 4A2 0.0221757
GSK3B glycogen synthase kinase 3 beta 0.0219108
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0219042
WARS1 tryptophanyl-tRNA synthetase 1 0.0217811
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0217667
SIK3 SIK family kinase 3 0.0217601
SPIDR scaffolding protein involved in DNA repair 0.0217522
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0216035
RAB27B RAB27B, member RAS oncogene family 0.0214183
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0213651
TRIM55 tripartite motif containing 55 0.0213361
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0212872

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.454511
MT2A metallothionein 2A -0.157579
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.143602
PTMA prothymosin, alpha -0.123221
TMSB10 thymosin beta 10 -0.114648
TMSB4X thymosin beta 4, X-linked -0.0907658
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0740015
ZMYND8 zinc finger, MYND-type containing 8 -0.0676667
SLC38A2 solute carrier family 38, member 2 -0.064371
FTL ferritin, light polypeptide -0.0589537
RAI1 retinoic acid induced 1 -0.0571652
ACTG1 actin gamma 1 -0.0479253
FTH1 ferritin, heavy polypeptide 1 -0.0466373
SRGN serglycin -0.0462483
RPL35A ribosomal protein L35a -0.0458322
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0450191
HMGA1 high mobility group AT-hook 1 -0.044381
RB1CC1 RB1-inducible coiled-coil 1 -0.044356
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0441134
MT1E metallothionein 1E -0.042457
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0416452
CENPF centromere protein F, 350/400kDa -0.0404184
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0390562
WSB1 WD repeat and SOCS box containing 1 -0.0384193
POTEF POTE ankyrin domain family, member F -0.0376219
KLHL24 kelch-like family member 24 -0.0366889
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0362438
OGA O-GlcNAcase -0.0362268
IFITM1 interferon induced transmembrane protein 1 -0.0346339
NDRG1 N-myc downstream regulated 1 -0.0346217
RPS8 ribosomal protein S8 -0.0337404
SQSTM1 sequestosome 1 -0.0333804
AHNAK AHNAK nucleoprotein -0.0327453
EIF1 eukaryotic translation initiation factor 1 -0.0320747
CLIP2 CAP-GLY domain containing linker protein 2 -0.0320272
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0313293
TNRC6B trinucleotide repeat containing 6B -0.030399
EZR ezrin -0.0296108
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0291705
AKAP9 A kinase (PRKA) anchor protein 9 -0.0288908
TPT1 tumor protein, translationally-controlled 1 -0.0287585
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0287079
RPS6 ribosomal protein S6 -0.028268
EMP1 epithelial membrane protein 1 -0.0279063
YBX1 Y box binding protein 1 -0.0278384
YBX3 Y box binding protein 3 -0.0273497
TMEM123 transmembrane protein 123 -0.0271569
ANKRD12 ankyrin repeat domain 12 -0.0269918
SEPTIN7 septin 7 -0.0267988
PAIP2 poly(A) binding protein interacting protein 2 -0.0260515
KDM5B lysine (K)-specific demethylase 5B -0.0259887
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0256816
BRWD1 bromodomain and WD repeat domain containing 1 -0.0254863
S100A6 S100 calcium binding protein A6 -0.0252285
CDK19 cyclin-dependent kinase 19 -0.0247128
SLK STE20-like kinase -0.0240308
PHF3 PHD finger protein 3 -0.0240264
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0238632
KLF6 Kruppel-like factor 6 -0.0237026
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.023634
NEK7 NIMA-related kinase 7 -0.0232906
ITGB4 integrin, beta 4 -0.0229809
CCDC91 coiled-coil domain containing 91 -0.0226321
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0222173
GCLM glutamate-cysteine ligase, modifier subunit -0.0221184
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.021976
ZNF217 zinc finger protein 217 -0.0216316
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0215896
MT1X metallothionein 1X -0.0213598
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0212169
UBE2B ubiquitin-conjugating enzyme E2B -0.0211612
EXOC4 exocyst complex component 4 -0.0207367
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0206802
AHNAK2 AHNAK nucleoprotein 2 -0.0205555
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0205459
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0205068
PGK1 phosphoglycerate kinase 1 -0.0204844
RACK1 receptor for activated C kinase 1 -0.0203648
PHF21A PHD finger protein 21A -0.0202139
HBP1 HMG-box transcription factor 1 -0.0199
EPS15 epidermal growth factor receptor pathway substrate 15 -0.019796
S100A10 S100 calcium binding protein A10 -0.0197715
CREBRF CREB3 regulatory factor -0.0196844
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0196251
WASF2 WAS protein family, member 2 -0.0195438
RPLP1 ribosomal protein, large, P1 -0.0194985
LOC112694756 uncharaterized LOC112694756 -0.0194423
KDM3A lysine (K)-specific demethylase 3A -0.0192247
PCBP2 poly(rC) binding protein 2 -0.0192103
GCC2 GRIP and coiled-coil domain containing 2 -0.0191951
UBXN7 UBX domain protein 7 -0.0191654
ADAM17 ADAM metallopeptidase domain 17 -0.0189864
ESYT2 extended synaptotagmin-like protein 2 -0.01892
VDAC1 voltage-dependent anion channel 1 -0.0189101
RPS19 ribosomal protein S19 -0.0186996
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0184308
SBF2 SET binding factor 2 -0.0184003
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0183939
NAV2 neuron navigator 2 -0.018374
MXI1 MAX interactor 1, dimerization protein -0.018245