| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0970073 |
| SLTM | SAFB-like, transcription modulator | 0.0862565 |
| DTNA | dystrobrevin, alpha | 0.0551405 |
| MYOF | myoferlin | 0.0423776 |
| RUNX1 | runt-related transcription factor 1 | 0.0423634 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0416169 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0414856 |
| FNIP1 | folliculin interacting protein 1 | 0.0407142 |
| TOP1 | topoisomerase (DNA) I | 0.0403165 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0396853 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0355309 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0314336 |
| SEPTIN10 | septin 10 | 0.0308039 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0307986 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0306222 |
| MCL1 | myeloid cell leukemia 1 | 0.0300595 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0293192 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0292853 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0291326 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0289062 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0287536 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0286656 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0283854 |
| NPTN | neuroplastin | 0.0283224 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0263032 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0259133 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0257505 |
| SRP54 | signal recognition particle 54kDa | 0.0253941 |
| GOLGA4 | golgin A4 | 0.0253657 |
| JMJD1C | jumonji domain containing 1C | 0.0253128 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0252163 |
| MSN | moesin | 0.0250791 |
| GPATCH2L | G patch domain containing 2-like | 0.0245108 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0240945 |
| ARRDC3 | arrestin domain containing 3 | 0.0240239 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0226392 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0224199 |
| NGLY1 | N-glycanase 1 | 0.0220996 |
| RTN4 | reticulon 4 | 0.0220793 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0220044 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0214401 |
| TMEM165 | transmembrane protein 165 | 0.0213457 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0210902 |
| ANXA5 | annexin A5 | 0.0207775 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0204852 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0203226 |
| SEC24A | SEC24 family member A | 0.0202355 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0202294 |
| GPHN | gephyrin | 0.0196691 |
| CD163L1 | CD163 molecule-like 1 | 0.0196117 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0191472 |
| COPA | coatomer protein complex, subunit alpha | 0.0190838 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0189597 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0188716 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0188261 |
| GPC5 | glypican 5 | 0.0187661 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0186815 |
| ATP13A3 | ATPase type 13A3 | 0.0186431 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0179986 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0179541 |
| PRELID2 | PRELI domain containing 2 | 0.0178725 |
| SEC24D | SEC24 family member D | 0.0178314 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0177992 |
| PMM2 | phosphomannomutase 2 | 0.0177154 |
| KIAA1217 | KIAA1217 | 0.0176619 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0176541 |
| GPC6 | glypican 6 | 0.0174358 |
| LYST | lysosomal trafficking regulator | 0.0173563 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0172978 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0170422 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0170164 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0169984 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0169908 |
| TMEM39A | transmembrane protein 39A | 0.0169752 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0168215 |
| YEATS2 | YEATS domain containing 2 | 0.0168 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0167803 |
| NUP58 | nucleoporin 58 | 0.01673 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0166576 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0166512 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0166174 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0164302 |
| XRRA1 | X-ray radiation resistance associated 1 | 0.0163743 |
| CSNK1E | casein kinase 1, epsilon | 0.0162915 |
| HELZ | helicase with zinc finger | 0.016282 |
| SUCO | SUN domain containing ossification factor | 0.0162256 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0162136 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0161677 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0161081 |
| NBAS | neuroblastoma amplified sequence | 0.0159328 |
| LINC02210-CRHR1 | LINC02210-CRHR1 readthrough | 0.0157086 |
| UVRAG | UV radiation resistance associated | 0.0155392 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0154789 |
| ENSA | endosulfine alpha | 0.015462 |
| CD109 | CD109 molecule | 0.0154582 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0154281 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0153511 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.014983 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0149699 |
| CANX | calnexin | 0.0148721 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.217355 |
| TXNRD1 | thioredoxin reductase 1 | -0.162054 |
| LMO7 | LIM domain 7 | -0.152678 |
| EGFR | epidermal growth factor receptor | -0.145811 |
| ASPH | aspartate beta-hydroxylase | -0.144518 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.133587 |
| TMSB10 | thymosin beta 10 | -0.132273 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131013 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.110049 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.109492 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.109468 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.107841 |
| EFNA5 | ephrin-A5 | -0.106039 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.105036 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0985875 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0938786 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0934756 |
| LAMC2 | laminin, gamma 2 | -0.0851631 |
| ACTG1 | actin gamma 1 | -0.075862 |
| OSMR | oncostatin M receptor | -0.0741922 |
| NDRG1 | N-myc downstream regulated 1 | -0.0740882 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0716718 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0712842 |
| AHNAK | AHNAK nucleoprotein | -0.0712554 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0710077 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0627009 |
| LDHA | lactate dehydrogenase A | -0.0621223 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0617072 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0608294 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0596747 |
| STC1 | stanniocalcin 1 | -0.0586784 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0542157 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0541721 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0540184 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0538121 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0533567 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0515139 |
| KRT18 | keratin 18, type I | -0.0493064 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0488581 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0486643 |
| CPE | carboxypeptidase E | -0.0455004 |
| KRT7 | keratin 7, type II | -0.0451508 |
| S100A10 | S100 calcium binding protein A10 | -0.04468 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0438323 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0434939 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0418178 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0412859 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.041209 |
| EGR1 | early growth response 1 | -0.0412062 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.040788 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.040519 |
| CST3 | cystatin C | -0.0402291 |
| DSPP | dentin sialophosphoprotein | -0.0398756 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0396473 |
| FOXP1 | forkhead box P1 | -0.0390732 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0390109 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0386585 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0381794 |
| RNF213 | ring finger protein 213 | -0.0375528 |
| GM2A | GM2 ganglioside activator | -0.0375509 |
| CUX1 | cut-like homeobox 1 | -0.0363451 |
| PKM | pyruvate kinase, muscle | -0.0362412 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0361305 |
| MYO1E | myosin IE | -0.0360972 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0356252 |
| LAMB3 | laminin, beta 3 | -0.0352477 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0352233 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0345147 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0339522 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0336447 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0332909 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0331929 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0329595 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.032377 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0320478 |
| HLA-B | major histocompatibility complex, class I, B | -0.0309088 |
| GRAMD1B | GRAM domain containing 1B | -0.0306511 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0306504 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0303283 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0301637 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0301618 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0296096 |
| CES1 | carboxylesterase 1 | -0.0292311 |
| VCL | vinculin | -0.0290276 |
| MGAT4C | MGAT4 family, member C | -0.0284018 |
| GNAS | GNAS complex locus | -0.0282301 |
| MYO1D | myosin ID | -0.0281662 |
| TNS3 | tensin 3 | -0.028164 |
| ANXA2 | annexin A2 | -0.0280189 |
| ENO1 | enolase 1, (alpha) | -0.0279093 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0273986 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0273755 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0273718 |
| S100A6 | S100 calcium binding protein A6 | -0.0269198 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0268883 |
| CCND1 | cyclin D1 | -0.0267045 |
| AGR2 | anterior gradient 2 | -0.0266555 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.026534 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0264536 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.02596 |
