| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.174274 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0734782 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.068599 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0655509 |
| GOLGA4 | golgin A4 | 0.0622588 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0593702 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0592939 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0569737 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0538353 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0490302 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0482542 |
| SEPTIN9 | septin 9 | 0.0476393 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0471855 |
| MTSS1 | metastasis suppressor 1 | 0.0458481 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0444577 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0442622 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.043891 |
| AADAC | arylacetamide deacetylase | 0.0404723 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0397125 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0388233 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0378504 |
| FNIP1 | folliculin interacting protein 1 | 0.0362986 |
| INTS6 | integrator complex subunit 6 | 0.0345363 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0337131 |
| RASAL2 | RAS protein activator like 2 | 0.0333397 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0333124 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0332357 |
| NAV2 | neuron navigator 2 | 0.0324068 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0322909 |
| COPA | coatomer protein complex, subunit alpha | 0.0321872 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.031505 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0313346 |
| DTNA | dystrobrevin, alpha | 0.0312772 |
| RCOR1 | REST corepressor 1 | 0.0298089 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0297888 |
| FBN1 | fibrillin 1 | 0.0297629 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0297307 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0296065 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0294094 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0293624 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0291676 |
| PRKCA | protein kinase C, alpha | 0.0289849 |
| MEF2A | myocyte enhancer factor 2A | 0.0284784 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0283303 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0279604 |
| NAV1 | neuron navigator 1 | 0.0276552 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0271489 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0269574 |
| CALU | calumenin | 0.0266792 |
| SEC24D | SEC24 family member D | 0.0262554 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0261601 |
| WLS | wntless Wnt ligand secretion mediator | 0.0261526 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0259047 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0253602 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0250441 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0247546 |
| PMM2 | phosphomannomutase 2 | 0.0247385 |
| SYT1 | synaptotagmin I | 0.0245101 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0241296 |
| RAI14 | retinoic acid induced 14 | 0.0240795 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0238709 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0231705 |
| MYO10 | myosin X | 0.0229637 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0229289 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0227837 |
| IFI44L | interferon-induced protein 44-like | 0.0227832 |
| ATF7 | activating transcription factor 7 | 0.0224969 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0224782 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.022282 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0216732 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0215992 |
| FHL2 | four and a half LIM domains 2 | 0.0214744 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0214564 |
| FBXO11 | F-box protein 11 | 0.0213508 |
| CCDC88A | coiled-coil domain containing 88A | 0.0212563 |
| PGM3 | phosphoglucomutase 3 | 0.0209932 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0209899 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0209764 |
| CDH13 | cadherin 13 | 0.0209433 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.020934 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.0209104 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0206524 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0206401 |
| HM13 | histocompatibility (minor) 13 | 0.0202942 |
| FNIP2 | folliculin interacting protein 2 | 0.020209 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0201476 |
| ZNF804A | zinc finger protein 804A | 0.0198766 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0197807 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0197796 |
| FAM219A | family with sequence similarity 219, member A | 0.0197479 |
| SRP54 | signal recognition particle 54kDa | 0.0196818 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0195977 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0195008 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0194525 |
| AUTS2 | autism susceptibility candidate 2 | 0.0193952 |
| CDK14 | cyclin-dependent kinase 14 | 0.0193745 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0193704 |
| GPHN | gephyrin | 0.0191781 |
| RAB10 | RAB10, member RAS oncogene family | 0.0189986 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0189256 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.216638 |
| FNDC3B | fibronectin type III domain containing 3B | -0.123028 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.118327 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0857129 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0792815 |
| CD44 | CD44 molecule (Indian blood group) | -0.0777948 |
| VIM | vimentin | -0.0739721 |
| SMAD3 | SMAD family member 3 | -0.0737954 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0699883 |
| FTL | ferritin, light polypeptide | -0.0659511 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0640358 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0596699 |
| OSMR | oncostatin M receptor | -0.0542836 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0527794 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0525383 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0523792 |
| RBM39 | RNA binding motif protein 39 | -0.0504964 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0483816 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0481435 |
| ETV6 | ets variant 6 | -0.0480691 |
| CDCP1 | CUB domain containing protein 1 | -0.046872 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0465298 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0463962 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0462156 |
| TMSB10 | thymosin beta 10 | -0.0455668 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0448328 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0423949 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0416209 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0384949 |
| OGA | O-GlcNAcase | -0.0382282 |
| KYNU | kynureninase | -0.0380542 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0361465 |
| RAD51B | RAD51 paralog B | -0.035734 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0357312 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0353396 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0343575 |
| ZNF292 | zinc finger protein 292 | -0.0340538 |
| EFNA5 | ephrin-A5 | -0.0331135 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0319865 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0314698 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0314344 |
| TXNRD1 | thioredoxin reductase 1 | -0.0305245 |
| LOX | lysyl oxidase | -0.0300246 |
| RPS19 | ribosomal protein S19 | -0.0298742 |
| NDRG1 | N-myc downstream regulated 1 | -0.0296598 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0294194 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0292063 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0286925 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.028225 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0280812 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0278713 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0274 |
| ATXN1 | ataxin 1 | -0.0265459 |
| RPS29 | ribosomal protein S29 | -0.0265384 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0260236 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0259616 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.025834 |
| ACTG1 | actin gamma 1 | -0.0256989 |
| RPS12 | ribosomal protein S12 | -0.0256196 |
| RPL35A | ribosomal protein L35a | -0.0254716 |
| RNF24 | ring finger protein 24 | -0.0254383 |
| YBX3 | Y box binding protein 3 | -0.0253241 |
| RPLP1 | ribosomal protein, large, P1 | -0.0252924 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0248607 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0248419 |
| RPS17 | ribosomal protein S17 | -0.0247238 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0245016 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0244087 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0243746 |
| RPLP2 | ribosomal protein, large, P2 | -0.0243603 |
| TBC1D15 | TBC1 domain family, member 15 | -0.0241944 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.024066 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0235479 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0233303 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0224575 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0222043 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0221098 |
| FBXO32 | F-box protein 32 | -0.0220454 |
| RPL23 | ribosomal protein L23 | -0.0218923 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0217625 |
| ADD3 | adducin 3 (gamma) | -0.0217496 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0217122 |
| SQSTM1 | sequestosome 1 | -0.0216875 |
| PCBP2 | poly(rC) binding protein 2 | -0.0213897 |
| GLCCI1 | glucocorticoid induced 1 | -0.021346 |
| RPS3 | ribosomal protein S3 | -0.0208163 |
| FOXO3 | forkhead box O3 | -0.0206782 |
| RPL12 | ribosomal protein L12 | -0.0206057 |
| RPS13 | ribosomal protein S13 | -0.0202614 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0202526 |
| EGR1 | early growth response 1 | -0.0202168 |
| RPL37A | ribosomal protein L37a | -0.0202034 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0201354 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0201327 |
| AHR | aryl hydrocarbon receptor | -0.0201191 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0200116 |
| RACK1 | receptor for activated C kinase 1 | -0.019896 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0196034 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0194443 |
| RPS21 | ribosomal protein S21 | -0.0192929 |
