| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.271737 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.104811 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.103349 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.100946 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0866631 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0845914 |
| GOLGA4 | golgin A4 | 0.0743905 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0742982 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0691121 |
| IER3 | immediate early response 3 | 0.0679167 |
| COPA | coatomer protein complex, subunit alpha | 0.0677782 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0620238 |
| USP36 | ubiquitin specific peptidase 36 | 0.0585503 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0567165 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.056222 |
| WAC | WW domain containing adaptor with coiled-coil | 0.056165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0545037 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0542678 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0516533 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0508427 |
| RPLP1 | ribosomal protein, large, P1 | 0.0506516 |
| MT2A | metallothionein 2A | 0.0493177 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0473451 |
| TOP1 | topoisomerase (DNA) I | 0.0464437 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0458059 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0443777 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0428201 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0428114 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0423512 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0419445 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.04186 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0417198 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0416605 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0413792 |
| S100A6 | S100 calcium binding protein A6 | 0.0403813 |
| FMNL2 | formin-like 2 | 0.0398738 |
| OLA1 | Obg-like ATPase 1 | 0.03979 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0392996 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0391184 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0388728 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0376198 |
| NOP58 | NOP58 ribonucleoprotein | 0.037274 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0368905 |
| FAM107B | family with sequence similarity 107, member B | 0.0367051 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0348727 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0348499 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344474 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0344325 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0336279 |
| HLA-B | major histocompatibility complex, class I, B | 0.033609 |
| RBM6 | RNA binding motif protein 6 | 0.0335589 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0334469 |
| MCL1 | myeloid cell leukemia 1 | 0.0332194 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0332152 |
| PTK2 | protein tyrosine kinase 2 | 0.0327748 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0326595 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0326412 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0324066 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0322145 |
| MED13 | mediator complex subunit 13 | 0.0316806 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0315065 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0313087 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0312176 |
| NUP98 | nucleoporin 98kDa | 0.031172 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0309987 |
| RBM39 | RNA binding motif protein 39 | 0.030909 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.030786 |
| RBM25 | RNA binding motif protein 25 | 0.030183 |
| NCKAP1 | NCK-associated protein 1 | 0.0300826 |
| NHSL1 | NHS-like 1 | 0.0300824 |
| PTGES2 | prostaglandin E synthase 2 | 0.0300816 |
| CYTH1 | cytohesin 1 | 0.0299176 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0298627 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0297316 |
| LAMC2 | laminin, gamma 2 | 0.0296857 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0296817 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029464 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0294293 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 0.0292924 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0292712 |
| FTO | fat mass and obesity associated | 0.0290968 |
| SRP54 | signal recognition particle 54kDa | 0.0288843 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0283506 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0282408 |
| CTBP2 | C-terminal binding protein 2 | 0.0278336 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0277002 |
| HSPA8 | heat shock 70kDa protein 8 | 0.027482 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0272321 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0271848 |
| NUMB | numb homolog (Drosophila) | 0.0267804 |
| FUS | FUS RNA binding protein | 0.0266655 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0266465 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0266185 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0262791 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0262257 |
| ANKRD12 | ankyrin repeat domain 12 | 0.026017 |
| BRD2 | bromodomain containing 2 | 0.0259557 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0259512 |
| PUM1 | pumilio RNA-binding family member 1 | 0.025945 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0259096 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.200151 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.187922 |
| VIM | vimentin | -0.156269 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0953858 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0830481 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0786386 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0740238 |
| ERBIN | erbb2 interacting protein | -0.065932 |
| IGF2 | insulin-like growth factor 2 | -0.0628717 |
| TMSB10 | thymosin beta 10 | -0.0627052 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0597028 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0554353 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0536229 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0500885 |
| GRAMD1B | GRAM domain containing 1B | -0.0487086 |
| BICC1 | BicC family RNA binding protein 1 | -0.0485222 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0482255 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0474596 |
| NEGR1 | neuronal growth regulator 1 | -0.0461884 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0454096 |
| POTEF | POTE ankyrin domain family, member F | -0.0449682 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0449562 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0444612 |
| ZFHX3 | zinc finger homeobox 3 | -0.0434305 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0428381 |
| FGB | fibrinogen beta chain | -0.0427077 |
| HDAC9 | histone deacetylase 9 | -0.0416126 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.040809 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0408055 |
| NTN4 | netrin 4 | -0.0401521 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0396819 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0386999 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0382005 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0356352 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0340746 |
| TMEM123 | transmembrane protein 123 | -0.0338087 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0326761 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0322846 |
| CENPF | centromere protein F, 350/400kDa | -0.0319874 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0318492 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0310912 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0310386 |
| AHR | aryl hydrocarbon receptor | -0.0309128 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0306466 |
| UTRN | utrophin | -0.0305903 |
| ECT2 | epithelial cell transforming 2 | -0.0304271 |
| RAD51B | RAD51 paralog B | -0.0302795 |
| FOXP1 | forkhead box P1 | -0.0290251 |
| STC1 | stanniocalcin 1 | -0.0289279 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0287859 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0277406 |
| PRR16 | proline rich 16 | -0.0274738 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0273959 |
| THBS1 | thrombospondin 1 | -0.0273051 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0272874 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0272603 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0270006 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0259896 |
| NFIA | nuclear factor I/A | -0.0259406 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.025364 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0251648 |
| NRG1 | neuregulin 1 | -0.0249258 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0249105 |
| YY1 | YY1 transcription factor | -0.024796 |
| PTMA | prothymosin, alpha | -0.0242588 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0238635 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0236251 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0235361 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0235106 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233832 |
| FGG | fibrinogen gamma chain | -0.0230308 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0229431 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0228379 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.02237 |
| TPX2 | TPX2, microtubule-associated | -0.0223356 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0223074 |
| TPM4 | tropomyosin 4 | -0.0220028 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0218884 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0216505 |
| EGR1 | early growth response 1 | -0.0214388 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.021416 |
| YBX3 | Y box binding protein 3 | -0.0212923 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.021202 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0211133 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0207191 |
| KLF6 | Kruppel-like factor 6 | -0.020695 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0205096 |
| ATXN3 | ataxin 3 | -0.019803 |
| MYOF | myoferlin | -0.0197868 |
| MORF4L1 | mortality factor 4 like 1 | -0.0197645 |
| TAGLN2 | transgelin 2 | -0.0197301 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.01935 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0192976 |
| MKI67 | marker of proliferation Ki-67 | -0.019288 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0187897 |
| RNF213 | ring finger protein 213 | -0.018706 |
| EXOC4 | exocyst complex component 4 | -0.0186516 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0182866 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0180797 |
| CHN1 | chimerin 1 | -0.0180708 |
