Abemaciclib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.116643
EGFR epidermal growth factor receptor 0.11647
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0920516
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0789599
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0778371
COL6A3 collagen, type VI, alpha 3 0.0733854
SAMD4A sterile alpha motif domain containing 4A 0.0720501
LIMCH1 LIM and calponin homology domains 1 0.0703985
RYBP RING1 and YY1 binding protein 0.0703537
BACE2 beta-site APP-cleaving enzyme 2 0.0703503
RUNX1 runt-related transcription factor 1 0.0700381
GLS2 glutaminase 2 (liver, mitochondrial) 0.0672533
MTUS1 microtubule associated tumor suppressor 1 0.0636396
TXNRD1 thioredoxin reductase 1 0.060467
ARRDC3 arrestin domain containing 3 0.0580367
TMEM165 transmembrane protein 165 0.0563918
NALF1 NALCN channel auxiliary factor 1 0.0559853
HDLBP high density lipoprotein binding protein 0.0533096
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0526815
SPNS2 spinster homolog 2 (Drosophila) 0.0501829
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0499627
FN1 fibronectin 1 0.0498577
SEC24A SEC24 family member A 0.0482416
PRKG1 protein kinase, cGMP-dependent, type I 0.0480871
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0480517
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0480399
MED13 mediator complex subunit 13 0.0467096
COL6A2 collagen, type VI, alpha 2 0.0462626
ARHGAP5 Rho GTPase activating protein 5 0.0452928
DPYD dihydropyrimidine dehydrogenase 0.0449249
MYO1B myosin IB 0.0438007
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0434615
TRA2A transformer 2 alpha homolog (Drosophila) 0.0423044
BRWD3 bromodomain and WD repeat domain containing 3 0.0422111
GPHN gephyrin 0.0410588
VEGFA vascular endothelial growth factor A 0.0409553
EWSR1 EWS RNA-binding protein 1 0.0403237
GCLC glutamate-cysteine ligase, catalytic subunit 0.0402915
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0401272
ANXA1 annexin A1 0.0401241
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0396671
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.039485
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0394244
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0390815
SPAG9 sperm associated antigen 9 0.0390383
PDE8A phosphodiesterase 8A 0.0389537
AGO3 argonaute RISC catalytic component 3 0.0381661
ATP11A ATPase, class VI, type 11A 0.0377583
ERRFI1 ERBB receptor feedback inhibitor 1 0.0376986
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0376067
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0369046
ZNF292 zinc finger protein 292 0.0368112
LAMB3 laminin, beta 3 0.0367265
HELZ helicase with zinc finger 0.0366469
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0365816
SKIC3 SKI3 subunit of superkiller complex 0.0365543
FNDC3A fibronectin type III domain containing 3A 0.0361235
RANBP2 RAN binding protein 2 0.0357013
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0356295
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0352613
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.0352583
CREB5 cAMP responsive element binding protein 5 0.035137
TTC3 tetratricopeptide repeat domain 3 0.0350984
CLTC clathrin, heavy chain (Hc) 0.0348925
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0344953
INTS6 integrator complex subunit 6 0.0342914
CD44 CD44 molecule (Indian blood group) 0.0339426
EPN2 epsin 2 0.0338345
HMGA2 high mobility group AT-hook 2 0.0337855
EIF5B eukaryotic translation initiation factor 5B 0.0337226
USP53 ubiquitin specific peptidase 53 0.0337147
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0332873
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0329813
LIMS1 LIM and senescent cell antigen-like domains 1 0.0327539
GSK3B glycogen synthase kinase 3 beta 0.0326263
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0323311
PDLIM5 PDZ and LIM domain 5 0.0322999
MBNL2 muscleblind-like splicing regulator 2 0.032237
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0321552
TPD52 tumor protein D52 0.0319246
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0313402
TPM3 tropomyosin 3 0.031136
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0311233
ANKRD17 ankyrin repeat domain 17 0.0311038
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0309694
COPA coatomer protein complex, subunit alpha 0.0308303
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.030767
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0306345
ADAM10 ADAM metallopeptidase domain 10 0.0305389
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0304206
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0303124
PIAS1 protein inhibitor of activated STAT, 1 0.0300758
UBL3 ubiquitin-like 3 0.0300281
FBXO11 F-box protein 11 0.029983
WASF2 WAS protein family, member 2 0.0299538
KIF5B kinesin family member 5B 0.0296716
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0295956
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0295157
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0293566
CMIP c-Maf inducing protein 0.0292711

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159091
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.157921
TMSB10 thymosin beta 10 -0.0980419
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0911354
AKAP12 A kinase (PRKA) anchor protein 12 -0.0855883
EFNA5 ephrin-A5 -0.0799568
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0758698
PTMA prothymosin, alpha -0.0710945
ZMYND8 zinc finger, MYND-type containing 8 -0.0705685
NKD1 naked cuticle homolog 1 (Drosophila) -0.0699768
TPT1 tumor protein, translationally-controlled 1 -0.0695778
SEC31A SEC31 homolog A (S. cerevisiae) -0.0643831
KYNU kynureninase -0.0627265
JMJD1C jumonji domain containing 1C -0.0599048
PARD3 par-3 family cell polarity regulator -0.0571599
FNDC3B fibronectin type III domain containing 3B -0.0566536
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0552583
ANKRD11 ankyrin repeat domain 11 -0.0549748
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0547333
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0540889
FLNB filamin B, beta -0.0540436
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0537538
EZR ezrin -0.0533838
IGFBP3 insulin-like growth factor binding protein 3 -0.0533039
DLG1 discs, large homolog 1 (Drosophila) -0.0529788
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0528705
RPL35A ribosomal protein L35a -0.0524363
FTL ferritin, light polypeptide -0.0519467
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.050831
RPS19 ribosomal protein S19 -0.0504099
NT5C2 5'-nucleotidase, cytosolic II -0.0496276
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.049096
S100A6 S100 calcium binding protein A6 -0.0490755
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0481336
WSB1 WD repeat and SOCS box containing 1 -0.0452058
KMT2C lysine (K)-specific methyltransferase 2C -0.0444604
TPM4 tropomyosin 4 -0.0441887
RPL26 ribosomal protein L26 -0.0440868
MBD5 methyl-CpG binding domain protein 5 -0.0440769
ZNF638 zinc finger protein 638 -0.0439609
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.043598
PRKCSH protein kinase C substrate 80K-H -0.0427605
RICTOR RPTOR independent companion of MTOR, complex 2 -0.042144
GRB10 growth factor receptor-bound protein 10 -0.0418835
ZEB1 zinc finger E-box binding homeobox 1 -0.0417639
VIM vimentin -0.0417028
RAB10 RAB10, member RAS oncogene family -0.0415351
SLC38A1 solute carrier family 38, member 1 -0.0406039
USP34 ubiquitin specific peptidase 34 -0.0402653
KATNBL1 katanin p80 subunit B-like 1 -0.0401726
NEK7 NIMA-related kinase 7 -0.0399045
AKAP9 A kinase (PRKA) anchor protein 9 -0.0395116
KDM6A lysine (K)-specific demethylase 6A -0.0394019
RPS6 ribosomal protein S6 -0.0392884
RPLP1 ribosomal protein, large, P1 -0.0389043
CLIP1 CAP-GLY domain containing linker protein 1 -0.0383933
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0381037
SQSTM1 sequestosome 1 -0.0380504
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0376213
RPL37A ribosomal protein L37a -0.0376141
EXT1 exostosin glycosyltransferase 1 -0.0371515
S100A9 S100 calcium binding protein A9 -0.0370838
ZBTB20 zinc finger and BTB domain containing 20 -0.0369265
CAPN2 calpain 2, (m/II) large subunit -0.0364354
TSHZ2 teashirt zinc finger homeobox 2 -0.0362921
MAML3 mastermind-like 3 (Drosophila) -0.035964
RAB7A RAB7A, member RAS oncogene family -0.0357789
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0351623
RPS12 ribosomal protein S12 -0.0351417
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0349197
SIK3 SIK family kinase 3 -0.0346208
ASPH aspartate beta-hydroxylase -0.0345772
MYOF myoferlin -0.0345139
RBM39 RNA binding motif protein 39 -0.0344481
RPS8 ribosomal protein S8 -0.0344255
ENO1 enolase 1, (alpha) -0.034343
THBS1 thrombospondin 1 -0.0342967
CDH13 cadherin 13 -0.0342907
S100A10 S100 calcium binding protein A10 -0.0338679
RPL37 ribosomal protein L37 -0.0333677
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0332177
RBM47 RNA binding motif protein 47 -0.0325326
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0323844
UGCG UDP-glucose ceramide glucosyltransferase -0.0319294
RPS14 ribosomal protein S14 -0.03185
RPL12 ribosomal protein L12 -0.0317147
RPS25 ribosomal protein S25 -0.0316494
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.031264
DOCK4 dedicator of cytokinesis 4 -0.0312506
KRT17 keratin 17, type I -0.0306417
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0305015
EGR1 early growth response 1 -0.0304613
RIGI RNA sensor RIG-I -0.0294358
PGK1 phosphoglycerate kinase 1 -0.029306
FTH1 ferritin, heavy polypeptide 1 -0.0291847
KDM1A lysine (K)-specific demethylase 1A -0.029108
ANTXR2 anthrax toxin receptor 2 -0.0291015
EXOC4 exocyst complex component 4 -0.029048
RPLP0 ribosomal protein, large, P0 -0.0283934
DIDO1 death inducer-obliterator 1 -0.0278108