Abemaciclib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRPPRC leucine-rich pentatricopeptide repeat containing 0.147094
GPHN gephyrin 0.119261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112073
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0851003
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0794842
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0706064
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0700451
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0698348
AKAP12 A kinase (PRKA) anchor protein 12 0.0669286
MACF1 microtubule-actin crosslinking factor 1 0.066499
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0656932
RAB7A RAB7A, member RAS oncogene family 0.0624639
CAMKMT calmodulin-lysine N-methyltransferase 0.0592064
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0591466
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0589956
WDR43 WD repeat domain 43 0.0582097
TAS2R14 taste receptor, type 2, member 14 0.0577373
ANK2 ankyrin 2, neuronal 0.057026
FAF1 Fas (TNFRSF6) associated factor 1 0.0556893
SCFD2 sec1 family domain containing 2 0.055193
EML4 echinoderm microtubule associated protein like 4 0.0545188
SND1 staphylococcal nuclease and tudor domain containing 1 0.0539995
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.052988
CTTN cortactin 0.050812
ZCCHC7 zinc finger, CCHC domain containing 7 0.0499729
INTS6 integrator complex subunit 6 0.0494073
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.048774
CCND2 cyclin D2 0.0480307
SAMD4A sterile alpha motif domain containing 4A 0.0460693
DST dystonin 0.0447922
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0443574
TASOR2 transcription activation suppressor family member 2 0.0442876
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0441381
OSMR oncostatin M receptor 0.0439244
AFF3 AF4/FMR2 family, member 3 0.0426632
PRKCE protein kinase C, epsilon 0.0423573
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0406464
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0406285
CLTC clathrin, heavy chain (Hc) 0.0400568
EIF5B eukaryotic translation initiation factor 5B 0.0397659
PDLIM5 PDZ and LIM domain 5 0.0393345
ANKRD17 ankyrin repeat domain 17 0.0392397
COPA coatomer protein complex, subunit alpha 0.0391842
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.039019
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0389746
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0387955
ZFAND3 zinc finger, AN1-type domain 3 0.038769
ANKRD11 ankyrin repeat domain 11 0.0387377
TPM3 tropomyosin 3 0.0386607
PNN pinin, desmosome associated protein 0.0385297
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0384553
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0370522
GTPBP4 GTP binding protein 4 0.0369116
CDK17 cyclin-dependent kinase 17 0.0366257
MCL1 myeloid cell leukemia 1 0.0365608
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0364657
GOLGA4 golgin A4 0.0356353
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0356164
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0356056
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0355505
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0354635
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0340765
GMDS GDP-mannose 4,6-dehydratase 0.0338352
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0334993
FKBP4 FK506 binding protein 4, 59kDa 0.0334054
FNDC3B fibronectin type III domain containing 3B 0.033302
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.033223
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.032947
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0327627
TOP1 topoisomerase (DNA) I 0.0327564
PMM2 phosphomannomutase 2 0.032548
GLS2 glutaminase 2 (liver, mitochondrial) 0.0325401
GDI2 GDP dissociation inhibitor 2 0.0324699
RBM25 RNA binding motif protein 25 0.0322289
MCTP1 multiple C2 domains, transmembrane 1 0.032002
XPOT exportin, tRNA 0.0317634
MYH9 myosin, heavy chain 9, non-muscle 0.0317004
PA2G4 proliferation-associated 2G4, 38kDa 0.0315875
VCL vinculin 0.0315659
STK4 serine/threonine kinase 4 0.0315464
PRRC2C proline-rich coiled-coil 2C 0.031513
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.031437
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0309504
HSPA8 heat shock 70kDa protein 8 0.03039
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0301283
RBM19 RNA binding motif protein 19 0.0296817
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0290533
IARS1 isoleucyl-tRNA synthetase 1 0.0289669
RAB1A RAB1A, member RAS oncogene family 0.0289215
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.028567
E2F3 E2F transcription factor 3 0.0281883
YARS1 tyrosyl-tRNA synthetase 1 0.0279072
ACTN1 actinin, alpha 1 0.027889
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0278492
IPO7 importin 7 0.027359
ATP13A3 ATPase type 13A3 0.027261
ADIPOR2 adiponectin receptor 2 0.027215
SRSF1 serine/arginine-rich splicing factor 1 0.02719
CORO1C coronin, actin binding protein, 1C 0.0271726
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0271345

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.132031
YBX3 Y box binding protein 3 -0.123526
TFPI2 tissue factor pathway inhibitor 2 -0.0902324
VIM vimentin -0.0878653
TXNRD1 thioredoxin reductase 1 -0.0821106
ZBTB20 zinc finger and BTB domain containing 20 -0.0783966
MYL12B myosin, light chain 12B, regulatory -0.0721611
RPL35A ribosomal protein L35a -0.0671629
RB1CC1 RB1-inducible coiled-coil 1 -0.0590057
EGR1 early growth response 1 -0.0570348
BBX bobby sox homolog (Drosophila) -0.0553734
RICTOR RPTOR independent companion of MTOR, complex 2 -0.050966
WSB1 WD repeat and SOCS box containing 1 -0.0493833
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0493573
PHIP pleckstrin homology domain interacting protein -0.0474218
CCDC91 coiled-coil domain containing 91 -0.0456172
RPLP1 ribosomal protein, large, P1 -0.0446498
BCAS3 breast carcinoma amplified sequence 3 -0.0442703
IGF1R insulin-like growth factor 1 receptor -0.0437758
RPL23 ribosomal protein L23 -0.0429748
TNRC6B trinucleotide repeat containing 6B -0.0427292
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.04214
MT2A metallothionein 2A -0.0403646
FTL ferritin, light polypeptide -0.0389692
PFN1 profilin 1 -0.0369996
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.036387
SLC38A2 solute carrier family 38, member 2 -0.0360733
KDM3A lysine (K)-specific demethylase 3A -0.0351065
MED13L mediator complex subunit 13-like -0.0349852
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0345967
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0344826
GATAD2B GATA zinc finger domain containing 2B -0.0335011
PHF21A PHD finger protein 21A -0.0327406
RPL12 ribosomal protein L12 -0.0321781
RSF1 remodeling and spacing factor 1 -0.0317934
DENND5B DENN/MADD domain containing 5B -0.0317742
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0314009
KRT18 keratin 18, type I -0.0313003
OGA O-GlcNAcase -0.0309635
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0307056
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0306701
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.03005
RPS19 ribosomal protein S19 -0.0295911
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.029483
RPS8 ribosomal protein S8 -0.0294787
POTEF POTE ankyrin domain family, member F -0.0294331
ZMYND8 zinc finger, MYND-type containing 8 -0.0292753
S100A6 S100 calcium binding protein A6 -0.0291464
PGK1 phosphoglycerate kinase 1 -0.0289447
RPL26 ribosomal protein L26 -0.0283888
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283367
FOXP1 forkhead box P1 -0.0282521
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0280454
RPL32 ribosomal protein L32 -0.0279064
SERINC3 serine incorporator 3 -0.0279009
UBB ubiquitin B -0.027728
FBXL20 F-box and leucine-rich repeat protein 20 -0.0271445
IGF2 insulin-like growth factor 2 -0.0271173
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0270677
TPI1 triosephosphate isomerase 1 -0.0269838
RPL5 ribosomal protein L5 -0.0255167
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0254497
WASF2 WAS protein family, member 2 -0.0252704
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0251938
RPS21 ribosomal protein S21 -0.0248549
EXOC4 exocyst complex component 4 -0.0245828
CDK19 cyclin-dependent kinase 19 -0.0245591
SEPTIN7 septin 7 -0.0245553
SINHCAF SIN3-HDAC complex associated factor -0.0241048
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0239606
RPL19 ribosomal protein L19 -0.0239401
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0238986
AKAP9 A kinase (PRKA) anchor protein 9 -0.0237987
RPS15 ribosomal protein S15 -0.0234918
GSTP1 glutathione S-transferase pi 1 -0.0232933
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0230762
RPS4X ribosomal protein S4, X-linked -0.0228748
NEK7 NIMA-related kinase 7 -0.022806
RPS29 ribosomal protein S29 -0.022784
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0226351
JAK1 Janus kinase 1 -0.0226194
ZNF292 zinc finger protein 292 -0.0224576
S100A11 S100 calcium binding protein A11 -0.0224529
MIS18BP1 MIS18 binding protein 1 -0.0223705
RPS27 ribosomal protein S27 -0.0222304
NBR1 neighbor of BRCA1 gene 1 -0.0220794
CBX3 chromobox homolog 3 -0.0220655
AHNAK AHNAK nucleoprotein -0.022012
RPLP0 ribosomal protein, large, P0 -0.0218505
LOC112694756 uncharaterized LOC112694756 -0.0215588
YBX1 Y box binding protein 1 -0.0215203
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0213222
RPS14 ribosomal protein S14 -0.021193
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0210511
HBP1 HMG-box transcription factor 1 -0.0210232
ATP5F1E ATP synthase F1 subunit epsilon -0.0210107
ANKRD12 ankyrin repeat domain 12 -0.0206598
RAD21 RAD21 homolog (S. pombe) -0.0206505
RPL37A ribosomal protein L37a -0.0205958
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0205379