Abemaciclib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0945846
DTNA dystrobrevin, alpha 0.0495796
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0404413
FHIT fragile histidine triad 0.0357383
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0352455
KIAA1217 KIAA1217 0.0326478
GLS2 glutaminase 2 (liver, mitochondrial) 0.0322596
EXT1 exostosin glycosyltransferase 1 0.0316222
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0312142
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0291915
PLEC plectin 0.0263219
ELL2 elongation factor, RNA polymerase II, 2 0.0256612
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0247448
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247339
RYBP RING1 and YY1 binding protein 0.022447
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.022246
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0221024
HSPA8 heat shock 70kDa protein 8 0.0213681
BIRC3 baculoviral IAP repeat containing 3 0.0210009
WWC1 WW and C2 domain containing 1 0.020805
UGDH UDP-glucose 6-dehydrogenase 0.0207542
TRAF3 TNF receptor-associated factor 3 0.0198977
PPARD peroxisome proliferator-activated receptor delta 0.0185606
SGMS2 sphingomyelin synthase 2 0.0179838
MSN moesin 0.0178585
USP53 ubiquitin specific peptidase 53 0.0177598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0175667
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0173817
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0170482
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0168731
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0167309
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0166357
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0164988
KIF21A kinesin family member 21A 0.0164435
GPHN gephyrin 0.016212
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0159918
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0158381
JARID2 jumonji, AT rich interactive domain 2 0.015806
MACC1 metastasis associated in colon cancer 1 0.0156353
TFRC transferrin receptor 0.0155538
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0155081
ANKRD17 ankyrin repeat domain 17 0.0154153
GPC6 glypican 6 0.015381
SEC24A SEC24 family member A 0.0153763
BRD2 bromodomain containing 2 0.0153585
PRRC2C proline-rich coiled-coil 2C 0.0152884
XPO1 exportin 1 0.0152044
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0151792
OTUD4 OTU deubiquitinase 4 0.0150388
PALLD palladin, cytoskeletal associated protein 0.01498
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0149191
FMNL2 formin-like 2 0.014856
MED13 mediator complex subunit 13 0.014752
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0146496
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0146344
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0145636
RAB10 RAB10, member RAS oncogene family 0.0142497
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0141285
CHD1 chromodomain helicase DNA binding protein 1 0.0141259
TRIO trio Rho guanine nucleotide exchange factor 0.0139557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0136363
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0134262
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0130808
MYO10 myosin X 0.0130676
NOCT nocturnin 0.0129869
RUNX1 runt-related transcription factor 1 0.0128907
NPTN neuroplastin 0.0128202
EPS8 epidermal growth factor receptor pathway substrate 8 0.0127866
PRKCA protein kinase C, alpha 0.0127328
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0127148
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0126409
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0125114
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0125005
MEMO1 mediator of cell motility 1 0.0124855
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.012455
SH3RF2 SH3 domain containing ring finger 2 0.0123802
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0123319
CRYBG3 beta-gamma crystallin domain containing 3 0.0123211
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0122917
IL6ST interleukin 6 signal transducer 0.0122243
OCLN occludin 0.0122218
C3ORF52 chromosome 3 open reading frame 52 0.0122116
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0121293
TJP1 tight junction protein 1 0.0121091
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0120702
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0120647
TUFT1 tuftelin 1 0.0118541
RCOR1 REST corepressor 1 0.0118092
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0117884
TRIM44 tripartite motif containing 44 0.0116378
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0114195
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0114023
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.011332
NUP98 nucleoporin 98kDa 0.0111039
ELOVL5 ELOVL fatty acid elongase 5 0.0111032
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0110819
SEPTIN9 septin 9 0.0108968
PPME1 protein phosphatase methylesterase 1 0.0107013
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0106506
TPD52 tumor protein D52 0.0106408

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.181681
FN1 fibronectin 1 -0.141276
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1292
POTEF POTE ankyrin domain family, member F -0.112992
NDRG1 N-myc downstream regulated 1 -0.10855
ACTG1 actin gamma 1 -0.103478
PTMA prothymosin, alpha -0.093593
TMSB10 thymosin beta 10 -0.0921403
ASPH aspartate beta-hydroxylase -0.0775415
RPL35A ribosomal protein L35a -0.0678763
S100A6 S100 calcium binding protein A6 -0.0674145
LMO7 LIM domain 7 -0.067253
TPT1 tumor protein, translationally-controlled 1 -0.0596503
FBXO32 F-box protein 32 -0.0591702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0581548
TMSB4X thymosin beta 4, X-linked -0.0517323
LIMCH1 LIM and calponin homology domains 1 -0.051658
PGK1 phosphoglycerate kinase 1 -0.0514418
ENO1 enolase 1, (alpha) -0.050741
LPP LIM domain containing preferred translocation partner in lipoma -0.0496398
IGFBP3 insulin-like growth factor binding protein 3 -0.0496133
RPS23 ribosomal protein S23 -0.0496079
NPEPPS aminopeptidase puromycin sensitive -0.0471936
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0471349
EIF1 eukaryotic translation initiation factor 1 -0.0469593
TPM4 tropomyosin 4 -0.0464787
RPS8 ribosomal protein S8 -0.0445436
KRT7 keratin 7, type II -0.0415218
LDHA lactate dehydrogenase A -0.0409711
RPL8 ribosomal protein L8 -0.0398522
RPLP1 ribosomal protein, large, P1 -0.0398169
IFI27 interferon, alpha-inducible protein 27 -0.0395893
RPLP2 ribosomal protein, large, P2 -0.0394387
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0393036
IFITM3 interferon induced transmembrane protein 3 -0.039261
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0392349
CSTB cystatin B (stefin B) -0.0389154
UBC ubiquitin C -0.0384725
RPS29 ribosomal protein S29 -0.038219
RPS3 ribosomal protein S3 -0.0377887
MYO6 myosin VI -0.0374764
RACK1 receptor for activated C kinase 1 -0.0374697
RPL34 ribosomal protein L34 -0.0373606
GRB10 growth factor receptor-bound protein 10 -0.0372764
WSB1 WD repeat and SOCS box containing 1 -0.0365441
S100A10 S100 calcium binding protein A10 -0.0364285
RPL37 ribosomal protein L37 -0.0359125
ANXA2 annexin A2 -0.0358716
RPL23 ribosomal protein L23 -0.0357131
RPS13 ribosomal protein S13 -0.0349364
RPS19 ribosomal protein S19 -0.0342238
RPL12 ribosomal protein L12 -0.0333394
RPS27 ribosomal protein S27 -0.0331607
ITCH itchy E3 ubiquitin protein ligase -0.0329549
BASP1 brain abundant, membrane attached signal protein 1 -0.0321597
TM4SF1 transmembrane 4 L six family member 1 -0.032142
RAD21 RAD21 homolog (S. pombe) -0.0320265
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0320066
GNAS GNAS complex locus -0.0319936
KDM5B lysine (K)-specific demethylase 5B -0.031966
RPL11 ribosomal protein L11 -0.0319123
RPL31 ribosomal protein L31 -0.0314987
F3 coagulation factor III (thromboplastin, tissue factor) -0.0314894
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0314397
SOX4 SRY (sex determining region Y)-box 4 -0.0310182
RPS14 ribosomal protein S14 -0.0302973
LOC112694756 uncharaterized LOC112694756 -0.0302104
TPI1 triosephosphate isomerase 1 -0.0298762
BZW1 basic leucine zipper and W2 domains 1 -0.0298183
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.029574
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0295248
KLHL24 kelch-like family member 24 -0.0291187
IFI6 interferon, alpha-inducible protein 6 -0.0290137
VIM vimentin -0.028969
RPS27A ribosomal protein S27a -0.0285079
RPL32 ribosomal protein L32 -0.0282908
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0282584
TOP1 topoisomerase (DNA) I -0.0276421
RPL37A ribosomal protein L37a -0.0275784
CD2AP CD2-associated protein -0.0275016
LMAN1 lectin, mannose-binding, 1 -0.0274075
ISG15 ISG15 ubiquitin-like modifier -0.027346
HLA-A major histocompatibility complex, class I, A -0.0267875
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0266722
IFITM1 interferon induced transmembrane protein 1 -0.0263631
UPP1 uridine phosphorylase 1 -0.0262768
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0261457
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0255604
RPL19 ribosomal protein L19 -0.0255562
RPS17 ribosomal protein S17 -0.0254953
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0254223
HMGA1 high mobility group AT-hook 1 -0.0252815
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0251252
RPS16 ribosomal protein S16 -0.0250039
SACK1A scaffolding CK1 anchoring protein A -0.0247871
TMEM123 transmembrane protein 123 -0.0247095
FAM162A family with sequence similarity 162, member A -0.0245039
RPS6 ribosomal protein S6 -0.024434
RPS25 ribosomal protein S25 -0.0242604
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0242105