| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Abemaciclib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.139518 |
| PM20D1 | peptidase M20 domain containing 1 | 0.130285 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.118811 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.117962 |
| PDLIM5 | PDZ and LIM domain 5 | 0.10178 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0984164 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.097678 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0774158 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0701405 |
| RASAL2 | RAS protein activator like 2 | 0.0663586 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.065707 |
| KYNU | kynureninase | 0.0648633 |
| PRRC2C | proline-rich coiled-coil 2C | 0.063101 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0617362 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0605803 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0594857 |
| DST | dystonin | 0.0535844 |
| GPC6 | glypican 6 | 0.0532084 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0531563 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0531231 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0527417 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0521405 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0519266 |
| CLTC | clathrin, heavy chain (Hc) | 0.0514197 |
| CD44 | CD44 molecule (Indian blood group) | 0.0503519 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0503084 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0493911 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0489823 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0485058 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0464941 |
| FMNL2 | formin-like 2 | 0.0447905 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0440039 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0430998 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0423054 |
| INTS6 | integrator complex subunit 6 | 0.0422127 |
| VMP1 | vacuole membrane protein 1 | 0.0409007 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.040545 |
| FNIP1 | folliculin interacting protein 1 | 0.039574 |
| VCL | vinculin | 0.0394721 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0389449 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0388976 |
| ATP13A3 | ATPase type 13A3 | 0.038837 |
| PDE10A | phosphodiesterase 10A | 0.0383368 |
| AUTS2 | autism susceptibility candidate 2 | 0.0380619 |
| GPHN | gephyrin | 0.037821 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0377986 |
| MYO10 | myosin X | 0.0373852 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0369138 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0365018 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0363251 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0360438 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0355129 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0349052 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0346424 |
| MAP7 | microtubule-associated protein 7 | 0.0333392 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0331141 |
| CANX | calnexin | 0.0329393 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0321466 |
| PDE7B | phosphodiesterase 7B | 0.0320858 |
| APP | amyloid beta (A4) precursor protein | 0.0319441 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0318042 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0317986 |
| GOLGA4 | golgin A4 | 0.0316115 |
| NF1 | neurofibromin 1 | 0.0316025 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0315723 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0315269 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.031332 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0312991 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0311813 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0305795 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0304789 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.030334 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0299654 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0298774 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0297989 |
| MED13 | mediator complex subunit 13 | 0.0295786 |
| CORO1C | coronin, actin binding protein, 1C | 0.0293716 |
| PKM | pyruvate kinase, muscle | 0.0291848 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0291645 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0289822 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0289465 |
| TPM3 | tropomyosin 3 | 0.0287936 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0283373 |
| PAPOLA | poly(A) polymerase alpha | 0.0279375 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0279024 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0278951 |
| ENAH | enabled homolog (Drosophila) | 0.027797 |
| OLA1 | Obg-like ATPase 1 | 0.0277238 |
| COPA | coatomer protein complex, subunit alpha | 0.0276015 |
| TOP1 | topoisomerase (DNA) I | 0.0275232 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.027319 |
| ADIPOR2 | adiponectin receptor 2 | 0.0271645 |
| RAB10 | RAB10, member RAS oncogene family | 0.0271368 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.026774 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.026759 |
| HDLBP | high density lipoprotein binding protein | 0.026641 |
| RO60 | Ro60, Y RNA binding protein | 0.0264489 |
| KIF21A | kinesin family member 21A | 0.0264488 |
| PRELID2 | PRELI domain containing 2 | 0.0261274 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0261021 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.168709 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.125783 |
| GDA | guanine deaminase | -0.115191 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.109704 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.100878 |
| TMSB10 | thymosin beta 10 | -0.08835 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0861594 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0835303 |
| VIM | vimentin | -0.0676458 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.065706 |
| RPLP1 | ribosomal protein, large, P1 | -0.0636047 |
| RPL35A | ribosomal protein L35a | -0.0633128 |
| PYGL | phosphorylase, glycogen, liver | -0.0622797 |
| FTL | ferritin, light polypeptide | -0.058638 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0578826 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0570154 |
| PCBP3 | poly(rC) binding protein 3 | -0.0564955 |
| FN1 | fibronectin 1 | -0.0562929 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0540853 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0529764 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.051347 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0482961 |
| RPS27A | ribosomal protein S27a | -0.0481662 |
| STC1 | stanniocalcin 1 | -0.0463174 |
| PTMA | prothymosin, alpha | -0.0441524 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.043061 |
| RPL31 | ribosomal protein L31 | -0.0422835 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0419517 |
| OGA | O-GlcNAcase | -0.0410475 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0401778 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0398 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0397508 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0392801 |
| RTN1 | reticulon 1 | -0.0380764 |
| RPL38 | ribosomal protein L38 | -0.0372865 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0372275 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0361253 |
| NDRG1 | N-myc downstream regulated 1 | -0.0360923 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0357112 |
| RPS8 | ribosomal protein S8 | -0.0356481 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0353485 |
| RPL37A | ribosomal protein L37a | -0.0338579 |
| TBXT | T-box transcription factor T | -0.0337945 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0337687 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0328693 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.0327172 |
| TMSB4X | thymosin beta 4, X-linked | -0.0327096 |
| MFF | mitochondrial fission factor | -0.0319229 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0318245 |
| NTN4 | netrin 4 | -0.0316807 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0313253 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0310764 |
| RPS19 | ribosomal protein S19 | -0.0308552 |
| RPL9 | ribosomal protein L9 | -0.0306757 |
| PTGR1 | prostaglandin reductase 1 | -0.0302664 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0301219 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0295698 |
| GNAS | GNAS complex locus | -0.0294049 |
| RPL26 | ribosomal protein L26 | -0.0289757 |
| BMERB1 | bMERB domain containing 1 | -0.0284935 |
| CRLF2 | cytokine receptor-like factor 2 | -0.0283043 |
| PHF21A | PHD finger protein 21A | -0.0277965 |
| RPL36A | ribosomal protein L36a | -0.0277363 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.027623 |
| RPS24 | ribosomal protein S24 | -0.0271205 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0270737 |
| SRGN | serglycin | -0.0267295 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267202 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0266463 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0263441 |
| CTSL | cathepsin L | -0.0260686 |
| RPS6 | ribosomal protein S6 | -0.026018 |
| RPL37 | ribosomal protein L37 | -0.0258842 |
| RPL12 | ribosomal protein L12 | -0.0257304 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0256835 |
| RPS12 | ribosomal protein S12 | -0.025657 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0256011 |
| CCDC68 | coiled-coil domain containing 68 | -0.024845 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0247083 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0243403 |
| TPM4 | tropomyosin 4 | -0.024146 |
| HLA-A | major histocompatibility complex, class I, A | -0.0240714 |
| YBX3 | Y box binding protein 3 | -0.0237248 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0236934 |
| ZFHX3 | zinc finger homeobox 3 | -0.0236392 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0235701 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0234181 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0230647 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0229122 |
| RPS27 | ribosomal protein S27 | -0.022844 |
| IRS2 | insulin receptor substrate 2 | -0.0228159 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0225872 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0224867 |
| SBF2 | SET binding factor 2 | -0.0221982 |
| CALD1 | caldesmon 1 | -0.0220396 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0219913 |
| ABLIM1 | actin binding LIM protein 1 | -0.0219792 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0219483 |
| UBC | ubiquitin C | -0.0217321 |
| FRMD4B | FERM domain containing 4B | -0.0217069 |
