Abemaciclib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

191 genes differentially expressed following the Abemaciclib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.156461
EEF2 eukaryotic translation elongation factor 2 0.105455
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0921794
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0912571
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0855542
FMN1 formin 1 0.0826545
FLNB filamin B, beta 0.0816223
DTNA dystrobrevin, alpha 0.0793784
GRB10 growth factor receptor-bound protein 10 0.0782985
KMT2C lysine (K)-specific methyltransferase 2C 0.0765627
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0740627
NKD1 naked cuticle homolog 1 (Drosophila) 0.0735935
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0704463
RPS6 ribosomal protein S6 0.0702329
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0679894
FRMD5 FERM domain containing 5 0.067629
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.066912
PTGES2 prostaglandin E synthase 2 0.0668833
ANKRD17 ankyrin repeat domain 17 0.0659616
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0658983
BRD2 bromodomain containing 2 0.0630565
EZR ezrin 0.0616297
RPS27 ribosomal protein S27 0.0609753
ZBTB20 zinc finger and BTB domain containing 20 0.0609503
AK1 adenylate kinase 1 0.0585745
DDIT4 DNA-damage-inducible transcript 4 0.0557122
PCBP2 poly(rC) binding protein 2 0.0532578
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0503607
NCOR1 nuclear receptor corepressor 1 0.050097
CALR calreticulin 0.0496276
KTN1 kinectin 1 (kinesin receptor) 0.0491705
RPL36 ribosomal protein L36 0.0488645
PRRC2C proline-rich coiled-coil 2C 0.0485058
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0478047
RPL31 ribosomal protein L31 0.0473555
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0472863
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.04682
MAP2K1 mitogen-activated protein kinase kinase 1 0.0462756
ENO1 enolase 1, (alpha) 0.046158
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0459537
JMJD1C jumonji domain containing 1C 0.0459309
PTK2 protein tyrosine kinase 2 0.0452808
EIF5B eukaryotic translation initiation factor 5B 0.0442067
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.043482
ACTG1 actin gamma 1 0.0403733
ANKHD1 ankyrin repeat and KH domain containing 1 0.0403522
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0400213
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0397958
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0393576
VMP1 vacuole membrane protein 1 0.0392119
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0390674
APLP2 amyloid beta (A4) precursor-like protein 2 0.0389283
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0387473
RAB7A RAB7A, member RAS oncogene family 0.0382334
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0381736
BIRC6 baculoviral IAP repeat containing 6 0.0381425
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0380905
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0376338
RPS27A ribosomal protein S27a 0.03743
RPL11 ribosomal protein L11 0.0371285
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0370485
AFDN afadin, adherens junction formation factor 0.0359352
SQSTM1 sequestosome 1 0.0341511
RACK1 receptor for activated C kinase 1 0.0333807
PTPRG protein tyrosine phosphatase, receptor type, G 0.0318099
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0318098
LPP LIM domain containing preferred translocation partner in lipoma 0.0312299
HELZ helicase with zinc finger 0.0310826
ASPH aspartate beta-hydroxylase 0.0301653
RPL8 ribosomal protein L8 0.0300536
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296338
ANKRD11 ankyrin repeat domain 11 0.0293949
RUNX1 runt-related transcription factor 1 0.0291053
ZFAND3 zinc finger, AN1-type domain 3 0.0279709
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0266327
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0257878
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0240681
RPS23 ribosomal protein S23 0.0220917
RPL35A ribosomal protein L35a 0.0219291
FNDC3B fibronectin type III domain containing 3B 0.0218367
SLC38A2 solute carrier family 38, member 2 0.0212838
RPL37A ribosomal protein L37a 0.020858
MACF1 microtubule-actin crosslinking factor 1 0.0205084
RPS29 ribosomal protein S29 0.0203004
MYH9 myosin, heavy chain 9, non-muscle 0.019915
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0198595
RPL9 ribosomal protein L9 0.019852
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0195035
MED13 mediator complex subunit 13 0.018621
RPL13A ribosomal protein L13a 0.0185311
FTL ferritin, light polypeptide 0.0183637
SPAG9 sperm associated antigen 9 0.0182392
CSNK1A1 casein kinase 1, alpha 1 0.0179859
RPL15 ribosomal protein L15 0.0179359
TPR translocated promoter region, nuclear basket protein 0.0165264
NAP1L1 nucleosome assembly protein 1-like 1 0.0150687
CCNI cyclin I 0.0141369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.014123
MYOF myoferlin 0.0139223
ANXA2 annexin A2 0.0128983

decreased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 -0.266823
HMGA2 high mobility group AT-hook 2 -0.150673
VIM vimentin -0.144722
MT2A metallothionein 2A -0.134245
STC1 stanniocalcin 1 -0.129814
TRIO trio Rho guanine nucleotide exchange factor -0.121012
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111538
TPT1 tumor protein, translationally-controlled 1 -0.104968
CDH13 cadherin 13 -0.0972438
PSD3 pleckstrin and Sec7 domain containing 3 -0.0873503
NDRG1 N-myc downstream regulated 1 -0.0845908
VCL vinculin -0.0832717
NALF1 NALCN channel auxiliary factor 1 -0.0821296
B2M beta-2-microglobulin -0.0820692
TMSB10 thymosin beta 10 -0.0805627
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0726438
DIAPH2 diaphanous-related formin 2 -0.0708401
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.065845
EFNA5 ephrin-A5 -0.0629233
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0618787
MCL1 myeloid cell leukemia 1 -0.0566487
RPL34 ribosomal protein L34 -0.0557123
RAB2A RAB2A, member RAS oncogene family -0.0502928
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0482486
EGFR epidermal growth factor receptor -0.0449899
RPS19 ribosomal protein S19 -0.0445389
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0435309
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0418395
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0412588
RIGI RNA sensor RIG-I -0.0404236
BTG1 B-cell translocation gene 1, anti-proliferative -0.0384175
MORF4L2 mortality factor 4 like 2 -0.0380629
LAMB3 laminin, beta 3 -0.0362368
RPS25 ribosomal protein S25 -0.0354908
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0337183
RPS24 ribosomal protein S24 -0.0334836
INHBA inhibin, beta A -0.0332447
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0327319
PARD3 par-3 family cell polarity regulator -0.0321727
KMT2E lysine (K)-specific methyltransferase 2E -0.0320466
EPS8 epidermal growth factor receptor pathway substrate 8 -0.031424
WSB1 WD repeat and SOCS box containing 1 -0.0308992
IGFBP3 insulin-like growth factor binding protein 3 -0.0297312
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0295187
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0294909
PDE10A phosphodiesterase 10A -0.0261729
RPLP1 ribosomal protein, large, P1 -0.0259306
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0249363
RPLP2 ribosomal protein, large, P2 -0.0247614
PRKCA protein kinase C, alpha -0.0246297
HDLBP high density lipoprotein binding protein -0.0244123
SP100 SP100 nuclear antigen -0.023326
PGK1 phosphoglycerate kinase 1 -0.0217881
N4BP2L2 NEDD4 binding protein 2-like 2 -0.02158
FN1 fibronectin 1 -0.0213732
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0209899
IGF2 insulin-like growth factor 2 -0.0206682
TXNIP thioredoxin interacting protein -0.0201618
HIPK2 homeodomain interacting protein kinase 2 -0.0201214
PTMA prothymosin, alpha -0.0187084
USP34 ubiquitin specific peptidase 34 -0.0184993
RPL26 ribosomal protein L26 -0.0183948
SMYD3 SET and MYND domain containing 3 -0.0178761
RPL23 ribosomal protein L23 -0.0171842
NAMPT nicotinamide phosphoribosyltransferase -0.016966
MBD5 methyl-CpG binding domain protein 5 -0.0160744
ZNF292 zinc finger protein 292 -0.0141481
PRELID2 PRELI domain containing 2 -0.0139073
RPS5 ribosomal protein S5 -0.0129554
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0125257
SBF2 SET binding factor 2 -0.0123725
ELL2 elongation factor, RNA polymerase II, 2 -0.0122909
RPL38 ribosomal protein L38 -0.0114786
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0108864
KIF5B kinesin family member 5B -0.0102423
DSCAM Down syndrome cell adhesion molecule -0.00962248
NAV2 neuron navigator 2 -0.00900412
RAD51B RAD51 paralog B -0.00898761
PKM pyruvate kinase, muscle -0.00882733
RBM39 RNA binding motif protein 39 -0.00874169
GSK3B glycogen synthase kinase 3 beta -0.00607146
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.00596046
MYO1E myosin IE -0.00589694
CANX calnexin -0.00544381
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00496522
RTN4 reticulon 4 -0.00494396
FMNL2 formin-like 2 -0.00277736
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00277344
SAMD4A sterile alpha motif domain containing 4A -0.00245029
RPS8 ribosomal protein S8 -7.31095E-4
TXNRD1 thioredoxin reductase 1 -1.95617E-4