Abemaciclib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.133773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.122033
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.103088
RPS16 ribosomal protein S16 0.0939001
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0891943
ANK2 ankyrin 2, neuronal 0.0884165
RPS8 ribosomal protein S8 0.0839623
PARD3B par-3 family cell polarity regulator beta 0.0729888
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0694462
PCLO piccolo presynaptic cytomatrix protein 0.0665171
CADM2 cell adhesion molecule 2 0.0633981
RPS3 ribosomal protein S3 0.0589788
RPL37A ribosomal protein L37a 0.0557483
TPT1 tumor protein, translationally-controlled 1 0.0555251
RPL11 ribosomal protein L11 0.0554362
MYO10 myosin X 0.0525374
RPL37 ribosomal protein L37 0.0520246
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0499135
RPS12 ribosomal protein S12 0.0493874
DST dystonin 0.0492165
CHD1 chromodomain helicase DNA binding protein 1 0.0492017
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0483036
RPS13 ribosomal protein S13 0.0482057
EEF2 eukaryotic translation elongation factor 2 0.0480049
RBM20 RNA binding motif protein 20 0.0457745
FOXP2 forkhead box P2 0.0442464
APP amyloid beta (A4) precursor protein 0.0433689
SLIT2 slit homolog 2 (Drosophila) 0.042005
GARS1 glycyl-tRNA synthetase 1 0.0419346
LDHA lactate dehydrogenase A 0.0413053
HMCN1 hemicentin 1 0.0412569
COL11A1 collagen, type XI, alpha 1 0.0403124
TENM3 teneurin transmembrane protein 3 0.0402818
CAMKMT calmodulin-lysine N-methyltransferase 0.0401833
OSBPL10 oxysterol binding protein-like 10 0.0389449
IARS1 isoleucyl-tRNA synthetase 1 0.0388437
LRRC4C leucine rich repeat containing 4C 0.0383854
RCOR1 REST corepressor 1 0.0376922
RPL5 ribosomal protein L5 0.0372097
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0371828
RPS27 ribosomal protein S27 0.0367359
RPL13A ribosomal protein L13a 0.0362697
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0359221
NCAM2 neural cell adhesion molecule 2 0.0357933
RPS2 ribosomal protein S2 0.0351926
RPL12 ribosomal protein L12 0.0348375
LHFPL6 LHFPL tetraspan subfamily member 6 0.0344501
SREBF2 sterol regulatory element binding transcription factor 2 0.0344392
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.034384
PRTG protogenin 0.0343008
RPL26 ribosomal protein L26 0.0341404
GLS2 glutaminase 2 (liver, mitochondrial) 0.0337067
RPL31 ribosomal protein L31 0.0327626
RPL7A ribosomal protein L7a 0.0325319
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0324778
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0324183
CDH19 cadherin 19, type 2 0.0321396
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0321175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0317318
WWC2 WW and C2 domain containing 2 0.0314082
WDR43 WD repeat domain 43 0.0307562
INTS6 integrator complex subunit 6 0.0304849
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0302083
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0301347
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0297332
SCFD1 sec1 family domain containing 1 0.0295365
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0295042
ZC3H12B zinc finger CCCH-type containing 12B 0.0293251
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0293077
SAMD4A sterile alpha motif domain containing 4A 0.0290448
RPL19 ribosomal protein L19 0.0288305
SRP72 signal recognition particle 72kDa 0.0287975
MDN1 MDN1, midasin homolog (yeast) 0.0283208
NCOR1 nuclear receptor corepressor 1 0.0282971
NPAS3 neuronal PAS domain protein 3 0.0281883
TTC3 tetratricopeptide repeat domain 3 0.0281792
CCDC88A coiled-coil domain containing 88A 0.0277382
RPL8 ribosomal protein L8 0.0277219
RPL36A ribosomal protein L36a 0.0276985
ANKRD12 ankyrin repeat domain 12 0.0276665
DNAH14 dynein, axonemal, heavy chain 14 0.0275486
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0274612
NEBL nebulette 0.0274474
DDIT4 DNA-damage-inducible transcript 4 0.027186
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0270565
GREB1L growth regulation by estrogen in breast cancer-like 0.0269959
FGFR1 fibroblast growth factor receptor 1 0.0269143
NACA nascent polypeptide-associated complex alpha subunit 0.0268861
CDK13 cyclin-dependent kinase 13 0.026857
JUN jun proto-oncogene 0.0268391
AGO3 argonaute RISC catalytic component 3 0.026801
RPS6 ribosomal protein S6 0.026706
RPS23 ribosomal protein S23 0.0265807
LOC112694756 uncharaterized LOC112694756 0.0264964
EIF1 eukaryotic translation initiation factor 1 0.02635
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0262895
ZNF146 zinc finger protein 146 0.0262165
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.026118
RPS25 ribosomal protein S25 0.025912
TTC17 tetratricopeptide repeat domain 17 0.0258475

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.16455
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.111834
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0880692
POTEF POTE ankyrin domain family, member F -0.0757078
TMSB4X thymosin beta 4, X-linked -0.074202
PFN1 profilin 1 -0.073811
TSC22D2 TSC22 domain family, member 2 -0.0728751
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0710263
ITGAV integrin, alpha V -0.0679756
SLC38A2 solute carrier family 38, member 2 -0.0638213
PEG10 paternally expressed 10 -0.063377
RAD21 RAD21 homolog (S. pombe) -0.0628854
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0616233
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0579831
MED13L mediator complex subunit 13-like -0.0577081
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0566978
PCBP2 poly(rC) binding protein 2 -0.055091
IGF1R insulin-like growth factor 1 receptor -0.0498049
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0486191
ADAM9 ADAM metallopeptidase domain 9 -0.0472973
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0467192
STAG2 stromal antigen 2 -0.0454443
EMP1 epithelial membrane protein 1 -0.0454147
COL5A2 collagen, type V, alpha 2 -0.0449585
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0448276
ZNF217 zinc finger protein 217 -0.0446975
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0445693
PCDH9 protocadherin 9 -0.04317
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0430063
OGA O-GlcNAcase -0.0417107
YBX1 Y box binding protein 1 -0.0411139
HMGA1 high mobility group AT-hook 1 -0.0398738
SOX2 SRY (sex determining region Y)-box 2 -0.0389745
CENPF centromere protein F, 350/400kDa -0.0388067
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0383217
AHNAK AHNAK nucleoprotein -0.0382993
NEK7 NIMA-related kinase 7 -0.035836
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0357066
TMEM123 transmembrane protein 123 -0.0356517
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0353345
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0347332
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0346909
PDE4D phosphodiesterase 4D, cAMP-specific -0.034446
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0339148
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0333407
DSTN destrin (actin depolymerizing factor) -0.032701
MRPS30 mitochondrial ribosomal protein S30 -0.0326626
TPX2 TPX2, microtubule-associated -0.0325708
CBX3 chromobox homolog 3 -0.0324105
TOX thymocyte selection-associated high mobility group box -0.032394
DEK DEK proto-oncogene -0.0320085
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0318075
ECT2 epithelial cell transforming 2 -0.0306393
PHIP pleckstrin homology domain interacting protein -0.0305738
ANXA1 annexin A1 -0.0303174
EAPP E2F-associated phosphoprotein -0.0302321
OSBPL9 oxysterol binding protein-like 9 -0.0299483
RHEB Ras homolog enriched in brain -0.0299246
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0295694
RNF13 ring finger protein 13 -0.0294432
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0291293
PNISR PNN-interacting serine/arginine-rich protein -0.0291155
SMC4 structural maintenance of chromosomes 4 -0.02895
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0285007
PARD3 par-3 family cell polarity regulator -0.028418
ANXA2 annexin A2 -0.0283037
SEPTIN7 septin 7 -0.0282365
ANXA5 annexin A5 -0.0282128
RAI1 retinoic acid induced 1 -0.0281863
RBM39 RNA binding motif protein 39 -0.0281442
ZFAND3 zinc finger, AN1-type domain 3 -0.0280359
COTL1 coactosin-like F-actin binding protein 1 -0.027772
B2M beta-2-microglobulin -0.0274692
SERINC1 serine incorporator 1 -0.0274424
ZNF292 zinc finger protein 292 -0.0274423
FN1 fibronectin 1 -0.0269441
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0269242
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0267292
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0266905
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0265492
NAP1L1 nucleosome assembly protein 1-like 1 -0.0264552
CAMTA1 calmodulin binding transcription activator 1 -0.0264176
RBM33 RNA binding motif protein 33 -0.0262318
CDC73 cell division cycle 73 -0.0261959
TXNRD1 thioredoxin reductase 1 -0.0260453
SOX5 SRY (sex determining region Y)-box 5 -0.0260221
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0257438
ATP5F1B ATP synthase F1 subunit beta -0.0254839
RIOK3 RIO kinase 3 -0.0254797
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0253703
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0248973
SYT1 synaptotagmin I -0.0248646
RTN4 reticulon 4 -0.0247239
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0246105
SETD5 SET domain containing 5 -0.0244619
ZNF608 zinc finger protein 608 -0.0242223
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0241551
RSF1 remodeling and spacing factor 1 -0.0240911
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0240277
U2SURP U2 snRNP-associated SURP domain containing -0.0240256