| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abemaciclib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.164593 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.151136 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.114405 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.091021 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0746319 |
| FNIP1 | folliculin interacting protein 1 | 0.0730732 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0606933 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0556179 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0549859 |
| HDAC9 | histone deacetylase 9 | 0.052939 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.052714 |
| INTS6 | integrator complex subunit 6 | 0.0519417 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.048287 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0480204 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0431025 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0414183 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0412391 |
| NAV2 | neuron navigator 2 | 0.0411327 |
| APP | amyloid beta (A4) precursor protein | 0.0407112 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0398883 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0394621 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0391176 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0389265 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0388319 |
| TBC1D19 | TBC1 domain family, member 19 | 0.038558 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0377996 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0365577 |
| ARFGEF3 | ARFGEF family member 3 | 0.036544 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0364571 |
| PRELID2 | PRELI domain containing 2 | 0.0357683 |
| KIAA1217 | KIAA1217 | 0.0349667 |
| DUSP10 | dual specificity phosphatase 10 | 0.0348236 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0346514 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0334288 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0316535 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0311822 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0310132 |
| FMNL2 | formin-like 2 | 0.0304858 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0299144 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0298997 |
| FNIP2 | folliculin interacting protein 2 | 0.0293694 |
| IER3 | immediate early response 3 | 0.0288634 |
| FOXO3 | forkhead box O3 | 0.0288149 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0284304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0282893 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0281084 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0277437 |
| CEP250 | centrosomal protein 250kDa | 0.0275719 |
| JMJD1C | jumonji domain containing 1C | 0.0274973 |
| TLE4 | transducin-like enhancer of split 4 | 0.0273819 |
| USP53 | ubiquitin specific peptidase 53 | 0.027325 |
| RND3 | Rho family GTPase 3 | 0.0264266 |
| GPHN | gephyrin | 0.0263103 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0262684 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0259668 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.025523 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0253739 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0252624 |
| RYBP | RING1 and YY1 binding protein | 0.0249351 |
| GOLGA4 | golgin A4 | 0.024751 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0246333 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0241542 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0239614 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0239568 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0237885 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0236649 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.022996 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0228892 |
| TOP1 | topoisomerase (DNA) I | 0.0227833 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0227268 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0227029 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0227007 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.022577 |
| BRD2 | bromodomain containing 2 | 0.022399 |
| KLHL29 | kelch-like family member 29 | 0.0222726 |
| SPAG9 | sperm associated antigen 9 | 0.0218334 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0216338 |
| CDK17 | cyclin-dependent kinase 17 | 0.0216288 |
| FRMD5 | FERM domain containing 5 | 0.0215771 |
| VCAN | versican | 0.0215441 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0215322 |
| CANX | calnexin | 0.0213627 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0212931 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0209373 |
| SRP54 | signal recognition particle 54kDa | 0.0208957 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0208392 |
| FUS | FUS RNA binding protein | 0.0208381 |
| RCOR1 | REST corepressor 1 | 0.020622 |
| ZNF638 | zinc finger protein 638 | 0.0204878 |
| RASEF | RAS and EF-hand domain containing | 0.0204345 |
| PGM3 | phosphoglucomutase 3 | 0.0204224 |
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.0201689 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.020063 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0200528 |
| COPA | coatomer protein complex, subunit alpha | 0.0196006 |
| ATXN1 | ataxin 1 | 0.0192877 |
| CLTC | clathrin, heavy chain (Hc) | 0.0192343 |
| AEBP2 | AE binding protein 2 | 0.0191359 |
| NPC1 | Niemann-Pick disease, type C1 | 0.019043 |
| GDF15 | growth differentiation factor 15 | 0.0189622 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.298909 |
| FRMD4A | FERM domain containing 4A | -0.202897 |
| FN1 | fibronectin 1 | -0.193596 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.165253 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.12431 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0916659 |
| TMSB10 | thymosin beta 10 | -0.0884351 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0874795 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0864664 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0863893 |
| EGR1 | early growth response 1 | -0.0754889 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0745396 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0721162 |
| CD44 | CD44 molecule (Indian blood group) | -0.0698465 |
| FTL | ferritin, light polypeptide | -0.0632443 |
| VCL | vinculin | -0.0627583 |
| BICC1 | BicC family RNA binding protein 1 | -0.0583174 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0572663 |
| HLA-B | major histocompatibility complex, class I, B | -0.0567614 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0559878 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0556561 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0543675 |
| NDRG1 | N-myc downstream regulated 1 | -0.0541012 |
| ENO1 | enolase 1, (alpha) | -0.053236 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.052685 |
| CTSD | cathepsin D | -0.0525398 |
| GLIS3 | GLIS family zinc finger 3 | -0.0514521 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0504929 |
| DST | dystonin | -0.0498288 |
| TPM4 | tropomyosin 4 | -0.0496047 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0477918 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0473812 |
| LDHA | lactate dehydrogenase A | -0.0466468 |
| COL1A2 | collagen, type I, alpha 2 | -0.0461609 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0460602 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0456489 |
| C3 | complement component 3 | -0.0455724 |
| B2M | beta-2-microglobulin | -0.0446949 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0440506 |
| RTN4 | reticulon 4 | -0.0439374 |
| COL1A1 | collagen, type I, alpha 1 | -0.0436372 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.043412 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0423415 |
| ZNF292 | zinc finger protein 292 | -0.0418394 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.041331 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0399203 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0389225 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0380654 |
| THBS1 | thrombospondin 1 | -0.0372949 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0366614 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0365333 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0359291 |
| TPM1 | tropomyosin 1 (alpha) | -0.0353228 |
| PLIN2 | perilipin 2 | -0.0352214 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0350582 |
| KLHL24 | kelch-like family member 24 | -0.0347918 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0346435 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0343579 |
| RNF213 | ring finger protein 213 | -0.0340254 |
| HMGA1 | high mobility group AT-hook 1 | -0.0328287 |
| GNAS | GNAS complex locus | -0.0325772 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0323406 |
| PGK1 | phosphoglycerate kinase 1 | -0.0319947 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.031803 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0317849 |
| LOX | lysyl oxidase | -0.0317276 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0313897 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0309944 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0309583 |
| RPS6 | ribosomal protein S6 | -0.0305997 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0304535 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0303396 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0300153 |
| TMSB4X | thymosin beta 4, X-linked | -0.0295824 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0295749 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0295434 |
| CALD1 | caldesmon 1 | -0.0291946 |
| RAD51B | RAD51 paralog B | -0.0290093 |
| CENPF | centromere protein F, 350/400kDa | -0.0288406 |
| CCNL1 | cyclin L1 | -0.0286344 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0285736 |
| CLIC4 | chloride intracellular channel 4 | -0.0284954 |
| DIAPH2 | diaphanous-related formin 2 | -0.0280041 |
| POTEF | POTE ankyrin domain family, member F | -0.0279934 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0279879 |
| FBXO32 | F-box protein 32 | -0.0279295 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0279107 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0276961 |
| ACTG1 | actin gamma 1 | -0.0276457 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0276299 |
| PHF21A | PHD finger protein 21A | -0.0275304 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0273404 |
| RAI1 | retinoic acid induced 1 | -0.0273372 |
| TXNRD1 | thioredoxin reductase 1 | -0.0272855 |
| TAPBP | TAP binding protein (tapasin) | -0.0272049 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0270054 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0268295 |
| HLA-A | major histocompatibility complex, class I, A | -0.0266523 |
| NAV1 | neuron navigator 1 | -0.0264084 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0260334 |
