| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abemaciclib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Abemaciclib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.230831 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.141845 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.125705 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.119701 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.117306 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.109294 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0914603 |
| GOLGA4 | golgin A4 | 0.0839689 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0788357 |
| ATP13A3 | ATPase type 13A3 | 0.0761138 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.072418 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.067 |
| COG5 | component of oligomeric golgi complex 5 | 0.0656314 |
| SEC24A | SEC24 family member A | 0.0618899 |
| SEC24D | SEC24 family member D | 0.0597606 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0583976 |
| RAB1A | RAB1A, member RAS oncogene family | 0.058162 |
| FAM13A | family with sequence similarity 13, member A | 0.0580042 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0576221 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.055863 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0551832 |
| RBM39 | RNA binding motif protein 39 | 0.0541973 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0538749 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0495754 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0480487 |
| CLINT1 | clathrin interactor 1 | 0.0474748 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0468955 |
| RLF | rearranged L-myc fusion | 0.0464765 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0463094 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0461989 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0460421 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0458918 |
| RNF145 | ring finger protein 145 | 0.0457964 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.045483 |
| RYBP | RING1 and YY1 binding protein | 0.0450783 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.044219 |
| QKI | QKI, KH domain containing, RNA binding | 0.0438023 |
| GLG1 | golgi glycoprotein 1 | 0.0434716 |
| ADM | adrenomedullin | 0.0427941 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0424017 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0420716 |
| RND3 | Rho family GTPase 3 | 0.0416814 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0414677 |
| ANXA2 | annexin A2 | 0.0408625 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0408474 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0407808 |
| INSIG2 | insulin induced gene 2 | 0.0407762 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0405811 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0404997 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.040136 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0401245 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0393424 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0391381 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0388606 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0387346 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0386056 |
| TMEM39A | transmembrane protein 39A | 0.0385692 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0385074 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0384521 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0381494 |
| COL5A1 | collagen, type V, alpha 1 | 0.038076 |
| NRXN3 | neurexin 3 | 0.0376534 |
| TOP1 | topoisomerase (DNA) I | 0.0371629 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.037148 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0369927 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0362416 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0359571 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0359543 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0356804 |
| COPA | coatomer protein complex, subunit alpha | 0.0355418 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0355178 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0354067 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0353478 |
| RTN4 | reticulon 4 | 0.0348406 |
| CDK7 | cyclin-dependent kinase 7 | 0.0347187 |
| SUCO | SUN domain containing ossification factor | 0.0345765 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0341672 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.033934 |
| SETD5 | SET domain containing 5 | 0.0339283 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0337941 |
| COL6A3 | collagen, type VI, alpha 3 | 0.033276 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.033246 |
| PTGES2 | prostaglandin E synthase 2 | 0.0331906 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0330476 |
| VMP1 | vacuole membrane protein 1 | 0.0327082 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0327062 |
| ARRDC3 | arrestin domain containing 3 | 0.0326707 |
| FNDC3A | fibronectin type III domain containing 3A | 0.032405 |
| MATR3 | matrin 3 | 0.0322576 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0320195 |
| TFG | TRK-fused gene | 0.0319721 |
| XPO6 | exportin 6 | 0.0318612 |
| HLA-A | major histocompatibility complex, class I, A | 0.0317481 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0315955 |
| CLTC | clathrin, heavy chain (Hc) | 0.0311865 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0311056 |
| CALU | calumenin | 0.0308605 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0306502 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0305398 |
| WDR43 | WD repeat domain 43 | 0.0304042 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.141591 |
| VIM | vimentin | -0.10815 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.103193 |
| PRSS23 | protease, serine, 23 | -0.0759183 |
| MT2A | metallothionein 2A | -0.0742101 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0724891 |
| TMSB10 | thymosin beta 10 | -0.0712613 |
| COL1A2 | collagen, type I, alpha 2 | -0.0707378 |
| LOX | lysyl oxidase | -0.0692121 |
| B2M | beta-2-microglobulin | -0.0659393 |
| STC1 | stanniocalcin 1 | -0.0646529 |
| COL1A1 | collagen, type I, alpha 1 | -0.0644021 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0638409 |
| IL6 | interleukin 6 | -0.0590279 |
| CDH13 | cadherin 13 | -0.0539271 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0531229 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0517108 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0514859 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0514714 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0496339 |
| HMGA2 | high mobility group AT-hook 2 | -0.0474083 |
| SMAD3 | SMAD family member 3 | -0.0463705 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.044847 |
| RPLP1 | ribosomal protein, large, P1 | -0.0419568 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0413613 |
| POTEF | POTE ankyrin domain family, member F | -0.0395902 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0394106 |
| EFNA5 | ephrin-A5 | -0.0387038 |
| FLNB | filamin B, beta | -0.038283 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0379532 |
| EGR1 | early growth response 1 | -0.0372569 |
| RAD51B | RAD51 paralog B | -0.0369285 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0362335 |
| HDAC8 | histone deacetylase 8 | -0.03622 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0353616 |
| TNRC6B | trinucleotide repeat containing 6B | -0.034932 |
| UTRN | utrophin | -0.0338668 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0333056 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0332158 |
| CST3 | cystatin C | -0.0318197 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0308602 |
| TXNIP | thioredoxin interacting protein | -0.0307284 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0305467 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0304617 |
| TNS3 | tensin 3 | -0.0302448 |
| RIGI | RNA sensor RIG-I | -0.030198 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0299177 |
| ACTG1 | actin gamma 1 | -0.0295181 |
| TPM4 | tropomyosin 4 | -0.0292248 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0290373 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0289227 |
| KIZ | kizuna centrosomal protein | -0.028569 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0282392 |
| MMP2 | matrix metallopeptidase 2 | -0.0281436 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0281387 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0280748 |
| TMSB4X | thymosin beta 4, X-linked | -0.0280492 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0277129 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0267483 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0266539 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0260152 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0259421 |
| MAP1B | microtubule-associated protein 1B | -0.0257896 |
| RBL2 | retinoblastoma-like 2 | -0.0256718 |
| CDK6 | cyclin-dependent kinase 6 | -0.0255516 |
| UBAC2 | UBA domain containing 2 | -0.0254106 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0253277 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0251936 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0249429 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0248582 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0245699 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0241085 |
| SMYD3 | SET and MYND domain containing 3 | -0.0240748 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0240213 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0237671 |
| FRMD4A | FERM domain containing 4A | -0.0234712 |
| COL5A2 | collagen, type V, alpha 2 | -0.0232693 |
| BBX | bobby sox homolog (Drosophila) | -0.0232374 |
| LAMB3 | laminin, beta 3 | -0.0230479 |
| TANK | TRAF family member-associated NFKB activator | -0.0230472 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0229712 |
| CCSER2 | coiled-coil serine-rich protein 2 | -0.0229353 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.0227823 |
| ZNF721 | zinc finger protein 721 | -0.0225553 |
| HMGB1 | high mobility group box 1 | -0.02248 |
| AHNAK | AHNAK nucleoprotein | -0.022467 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0224064 |
| ATG7 | autophagy related 7 | -0.0221784 |
| CENPE | centromere protein E, 312kDa | -0.0219249 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0218615 |
| TENM2 | teneurin transmembrane protein 2 | -0.0218353 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0217512 |
| SEPTIN7 | septin 7 | -0.0217194 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0216808 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0216453 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0215764 |
| DEPP1 | DEPP autophagy regulator 1 | -0.0215243 |
| ITGA11 | integrin, alpha 11 | -0.0214399 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0214127 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.021339 |
