Abemaciclib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.164809
IGFBP3 insulin-like growth factor binding protein 3 0.134124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0982117
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0867911
HOOK2 hook microtubule-tethering protein 2 0.0831508
PBX3 pre-B-cell leukemia homeobox 3 0.0803575
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0789356
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0781747
DTNA dystrobrevin, alpha 0.0752248
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.072318
PRKCA protein kinase C, alpha 0.0696343
GLS2 glutaminase 2 (liver, mitochondrial) 0.0650644
ASPH aspartate beta-hydroxylase 0.0636635
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.058929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0544782
FMNL2 formin-like 2 0.0543021
ANXA1 annexin A1 0.0531472
FLNB filamin B, beta 0.0531194
ATP13A3 ATPase type 13A3 0.0520712
ZEB1 zinc finger E-box binding homeobox 1 0.0515316
INTS6 integrator complex subunit 6 0.047784
PRELID2 PRELI domain containing 2 0.0475506
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0470614
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0469847
NGLY1 N-glycanase 1 0.04696
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0462368
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0461205
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0456976
HSPA8 heat shock 70kDa protein 8 0.0445725
GPC6 glypican 6 0.0434352
PKM pyruvate kinase, muscle 0.0416145
HPCAL1 hippocalcin-like 1 0.0399285
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0395034
OXSR1 oxidative stress responsive 1 0.0394944
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0391767
MCL1 myeloid cell leukemia 1 0.0391011
RUNX1 runt-related transcription factor 1 0.0389955
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0385829
IRAK2 interleukin-1 receptor-associated kinase 2 0.0379663
SH3KBP1 SH3-domain kinase binding protein 1 0.0377231
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0375222
CD44 CD44 molecule (Indian blood group) 0.036509
MACF1 microtubule-actin crosslinking factor 1 0.0361687
MAP1B microtubule-associated protein 1B 0.035446
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0352524
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0351055
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0349409
CXCL8 chemokine (C-X-C motif) ligand 8 0.0333443
PTK2 protein tyrosine kinase 2 0.0328194
ZSWIM6 zinc finger, SWIM-type containing 6 0.0326947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0322001
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298644
CAPRIN2 caprin family member 2 0.0297517
SEC24D SEC24 family member D 0.0294051
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0291934
NIBAN2 niban apoptosis regulator 2 0.0287627
HSPH1 heat shock 105kDa/110kDa protein 1 0.0284661
MYO10 myosin X 0.0281766
SEPTIN10 septin 10 0.0278082
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0277321
ITGA6 integrin, alpha 6 0.0276647
IARS1 isoleucyl-tRNA synthetase 1 0.027524
TPST1 tyrosylprotein sulfotransferase 1 0.026766
MAP2K1 mitogen-activated protein kinase kinase 1 0.026657
GPC5 glypican 5 0.0265954
RAB1A RAB1A, member RAS oncogene family 0.0263623
PMM2 phosphomannomutase 2 0.0262248
ANO6 anoctamin 6 0.0261454
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0258662
E2F7 E2F transcription factor 7 0.0254575
SEPTIN9 septin 9 0.0251262
PDGFA platelet-derived growth factor alpha polypeptide 0.0250751
FNDC3A fibronectin type III domain containing 3A 0.0249369
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0247785
SCFD1 sec1 family domain containing 1 0.0245994
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0244136
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.024071
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0238748
PICALM phosphatidylinositol binding clathrin assembly protein 0.0237464
DENND5A DENN/MADD domain containing 5A 0.0236392
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0236064
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0235849
BIRC3 baculoviral IAP repeat containing 3 0.0233718
USP53 ubiquitin specific peptidase 53 0.0231595
AHNAK AHNAK nucleoprotein 0.023108
HMGA2 high mobility group AT-hook 2 0.022965
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0225717
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.022551
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0224105
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0219209
UBQLN1 ubiquilin 1 0.0218674
PGM3 phosphoglucomutase 3 0.021554
COL5A1 collagen, type V, alpha 1 0.0215329
BICD1 bicaudal D homolog 1 (Drosophila) 0.0215079
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0214023
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0213335
TRA2A transformer 2 alpha homolog (Drosophila) 0.0210268
GOLGA4 golgin A4 0.0209259
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0208427
RAB10 RAB10, member RAS oncogene family 0.02083

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.163533
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144169
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.112451
TMSB10 thymosin beta 10 -0.0918292
YBX3 Y box binding protein 3 -0.0786235
ZBTB20 zinc finger and BTB domain containing 20 -0.0743062
ANKRD28 ankyrin repeat domain 28 -0.0733173
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0710075
TPT1 tumor protein, translationally-controlled 1 -0.0651524
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0649469
DIAPH3 diaphanous-related formin 3 -0.0555121
SMYD3 SET and MYND domain containing 3 -0.0537659
TNRC6B trinucleotide repeat containing 6B -0.0525011
LMO7 LIM domain 7 -0.0503812
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0501789
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0483444
CENPF centromere protein F, 350/400kDa -0.0480523
ERBIN erbb2 interacting protein -0.0468592
DST dystonin -0.0468004
PTMA prothymosin, alpha -0.046751
EFNA5 ephrin-A5 -0.0451581
OSMR oncostatin M receptor -0.0442651
RBM39 RNA binding motif protein 39 -0.0438786
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0438303
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0435211
FMN1 formin 1 -0.0427888
NCEH1 neutral cholesterol ester hydrolase 1 -0.0414954
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0413012
ACTG1 actin gamma 1 -0.0410222
RPL35A ribosomal protein L35a -0.0407522
NALCN sodium leak channel, non selective -0.0399471
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0394045
RSF1 remodeling and spacing factor 1 -0.0393482
POTEF POTE ankyrin domain family, member F -0.0389829
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0384794
BBX bobby sox homolog (Drosophila) -0.0384757
TPX2 TPX2, microtubule-associated -0.0381296
ATF7IP activating transcription factor 7 interacting protein -0.0377428
MT2A metallothionein 2A -0.0372606
RB1CC1 RB1-inducible coiled-coil 1 -0.0370891
VCL vinculin -0.0370194
SMC4 structural maintenance of chromosomes 4 -0.0366558
MBD5 methyl-CpG binding domain protein 5 -0.0363862
NCOR1 nuclear receptor corepressor 1 -0.0363001
GCC2 GRIP and coiled-coil domain containing 2 -0.0359996
ZMYND8 zinc finger, MYND-type containing 8 -0.0356881
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0354984
RPL23 ribosomal protein L23 -0.0350738
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0349991
EXOC6B exocyst complex component 6B -0.0349702
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0347783
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0345122
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0340744
TMEM123 transmembrane protein 123 -0.0338889
PHF3 PHD finger protein 3 -0.0337879
FTH1 ferritin, heavy polypeptide 1 -0.0331358
RPS6 ribosomal protein S6 -0.0325957
SLC38A2 solute carrier family 38, member 2 -0.0318633
MBNL1 muscleblind-like splicing regulator 1 -0.0317619
DPYD dihydropyrimidine dehydrogenase -0.0317117
BCAS3 breast carcinoma amplified sequence 3 -0.0316622
PHIP pleckstrin homology domain interacting protein -0.0313926
PHF14 PHD finger protein 14 -0.0312351
RPS21 ribosomal protein S21 -0.0312058
RPS25 ribosomal protein S25 -0.0310032
PARD3 par-3 family cell polarity regulator -0.0309091
MKI67 marker of proliferation Ki-67 -0.0308792
PDE8A phosphodiesterase 8A -0.0306554
AKAP10 A kinase (PRKA) anchor protein 10 -0.0304331
NBR1 neighbor of BRCA1 gene 1 -0.0302785
RPL9 ribosomal protein L9 -0.0302199
RORA RAR-related orphan receptor A -0.030006
DEK DEK proto-oncogene -0.0298242
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0292369
BPTF bromodomain PHD finger transcription factor -0.0291893
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0288446
SGO2 shugoshin 2 -0.0283256
UBB ubiquitin B -0.0279148
ZFAND6 zinc finger, AN1-type domain 6 -0.0278599
SAMD4A sterile alpha motif domain containing 4A -0.0275649
RPL32 ribosomal protein L32 -0.0275008
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0273707
FBXL17 F-box and leucine-rich repeat protein 17 -0.0272411
OGA O-GlcNAcase -0.0271316
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0270123
ZNF292 zinc finger protein 292 -0.0268196
CCDC91 coiled-coil domain containing 91 -0.0268046
ATM ATM serine/threonine kinase -0.0267458
RPLP2 ribosomal protein, large, P2 -0.0265155
TBC1D15 TBC1 domain family, member 15 -0.0264722
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0263307
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.0263265
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.026306
DERA deoxyribose-phosphate aldolase (putative) -0.0263013
TXNRD1 thioredoxin reductase 1 -0.0263009
HDAC9 histone deacetylase 9 -0.0261624
TBC1D5 TBC1 domain family, member 5 -0.0261098
PHF20 PHD finger protein 20 -0.0256922
RBM33 RNA binding motif protein 33 -0.025507
UBAC2 UBA domain containing 2 -0.0252898