Abemaciclib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abemaciclib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abemaciclib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.140974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.12562
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111187
GOLGA4 golgin A4 0.0683358
EREG epiregulin 0.0672862
PRRC2C proline-rich coiled-coil 2C 0.0565765
COPA coatomer protein complex, subunit alpha 0.0530971
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0523806
FAT1 FAT atypical cadherin 1 0.0486977
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0475424
ELL2 elongation factor, RNA polymerase II, 2 0.0469461
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0463696
RAB1A RAB1A, member RAS oncogene family 0.045202
FRMD5 FERM domain containing 5 0.0434266
SUCO SUN domain containing ossification factor 0.0412556
RAB10 RAB10, member RAS oncogene family 0.0388125
GRB10 growth factor receptor-bound protein 10 0.0388043
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0374179
HELZ helicase with zinc finger 0.0373842
TRA2A transformer 2 alpha homolog (Drosophila) 0.0372275
CLINT1 clathrin interactor 1 0.0369634
NOP58 NOP58 ribonucleoprotein 0.0369111
TENT2 terminal nucleotidyltransferase 2 0.0366379
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0363277
TRIO trio Rho guanine nucleotide exchange factor 0.0358057
COG5 component of oligomeric golgi complex 5 0.0355264
KMT2C lysine (K)-specific methyltransferase 2C 0.0353355
MARCHF6 membrane associated ring-CH-type finger 6 0.0352085
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0335956
TTC3 tetratricopeptide repeat domain 3 0.0335472
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0334166
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0326685
VCAN versican 0.0326555
HILPDA hypoxia inducible lipid droplet-associated 0.0326218
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0325536
RNF145 ring finger protein 145 0.0323608
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0323305
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0322747
PSME4 proteasome (prosome, macropain) activator subunit 4 0.032071
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0317738
USP3 ubiquitin specific peptidase 3 0.0310575
CD109 CD109 molecule 0.0308923
SIK3 SIK family kinase 3 0.0307034
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0306267
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0305199
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0301658
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0299847
SRP54 signal recognition particle 54kDa 0.0295826
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0292922
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0287299
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0286594
ANKRD17 ankyrin repeat domain 17 0.0285015
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0283287
PCDH7 protocadherin 7 0.0283203
SYT1 synaptotagmin I 0.0280141
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0278153
UBA6 ubiquitin-like modifier activating enzyme 6 0.0276354
WAC WW domain containing adaptor with coiled-coil 0.0273193
SEC23A Sec23 homolog A (S. cerevisiae) 0.0272905
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259762
TFG TRK-fused gene 0.0256876
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.025663
NUP58 nucleoporin 58 0.0255779
FBXW11 F-box and WD repeat domain containing 11 0.0255379
PDLIM5 PDZ and LIM domain 5 0.0255325
SEC24A SEC24 family member A 0.0254825
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0253993
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0253574
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0253465
SEC24D SEC24 family member D 0.0253082
VEZT vezatin, adherens junctions transmembrane protein 0.0252572
ZFAND3 zinc finger, AN1-type domain 3 0.0251466
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0251464
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247917
BHLHE40 basic helix-loop-helix family, member e40 0.0247096
EPS8 epidermal growth factor receptor pathway substrate 8 0.0246149
SEC31A SEC31 homolog A (S. cerevisiae) 0.0243173
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0240548
ETNK1 ethanolamine kinase 1 0.0239437
DOCK4 dedicator of cytokinesis 4 0.0239212
PUM2 pumilio RNA-binding family member 2 0.0238807
LMNA lamin A/C 0.0237848
WDR43 WD repeat domain 43 0.0237597
YME1L1 YME1-like 1 ATPase 0.0237523
BIRC3 baculoviral IAP repeat containing 3 0.0236747
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0234914
WDR45B WD repeat domain 45B 0.0230607
OLA1 Obg-like ATPase 1 0.0229641
FNDC3A fibronectin type III domain containing 3A 0.0228544
FMNL2 formin-like 2 0.022838
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0227779
NPTN neuroplastin 0.0223584
RBM39 RNA binding motif protein 39 0.0223035
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0222173
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0221267
LCORL ligand dependent nuclear receptor corepressor-like 0.0221108
CUL3 cullin 3 0.0220971
RBM25 RNA binding motif protein 25 0.0219658
RAP1B RAP1B, member of RAS oncogene family 0.0216944
PICALM phosphatidylinositol binding clathrin assembly protein 0.021613

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.279785
FN1 fibronectin 1 -0.200053
HMGA2 high mobility group AT-hook 2 -0.169209
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.128562
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.115348
SQSTM1 sequestosome 1 -0.0922281
NDRG1 N-myc downstream regulated 1 -0.0802442
ASPH aspartate beta-hydroxylase -0.0701983
TMEM156 transmembrane protein 156 -0.0656522
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0612013
ZBTB20 zinc finger and BTB domain containing 20 -0.0565945
GLIS3 GLIS family zinc finger 3 -0.0538628
ACTG1 actin gamma 1 -0.0516668
AEBP2 AE binding protein 2 -0.0509823
EFNA5 ephrin-A5 -0.0496238
STC2 stanniocalcin 2 -0.0490188
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0474732
ITGA1 integrin, alpha 1 -0.0465186
FNDC3B fibronectin type III domain containing 3B -0.040775
KLHL5 kelch-like family member 5 -0.0396063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0374311
CENPF centromere protein F, 350/400kDa -0.0371874
TPT1 tumor protein, translationally-controlled 1 -0.0362069
TNS3 tensin 3 -0.0357251
LIMCH1 LIM and calponin homology domains 1 -0.0347179
CCDC91 coiled-coil domain containing 91 -0.0346463
RPL37A ribosomal protein L37a -0.0346209
ETV6 ets variant 6 -0.0342888
POTEF POTE ankyrin domain family, member F -0.0339055
ETV1 ets variant 1 -0.032263
DNAH5 dynein, axonemal, heavy chain 5 -0.0316284
PDE4D phosphodiesterase 4D, cAMP-specific -0.0313788
LOXL2 lysyl oxidase-like 2 -0.0312872
PLIN2 perilipin 2 -0.0304717
FTL ferritin, light polypeptide -0.0298544
FAM20C family with sequence similarity 20, member C -0.0297985
INTS6 integrator complex subunit 6 -0.0297505
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0294293
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0290718
AHR aryl hydrocarbon receptor -0.0287906
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0285878
RAI14 retinoic acid induced 14 -0.0282581
LOX lysyl oxidase -0.0281665
TENM4 teneurin transmembrane protein 4 -0.0274037
DST dystonin -0.0271323
EXOC4 exocyst complex component 4 -0.0269757
CDCP1 CUB domain containing protein 1 -0.0266665
SMOX spermine oxidase -0.0265179
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0263269
FRY furry homolog (Drosophila) -0.0260324
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259154
MAML2 mastermind-like 2 (Drosophila) -0.0257123
TFPI2 tissue factor pathway inhibitor 2 -0.0256456
AHNAK2 AHNAK nucleoprotein 2 -0.0256229
VIM vimentin -0.0254723
PHF3 PHD finger protein 3 -0.0254718
OSMR oncostatin M receptor -0.025383
RPS3 ribosomal protein S3 -0.0244116
LRMDA leucine rich melanocyte differentiation associated -0.0242641
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0242516
SLC35F3 solute carrier family 35, member F3 -0.0240586
SAMD4A sterile alpha motif domain containing 4A -0.0238543
TTC28 tetratricopeptide repeat domain 28 -0.0236626
RPS12 ribosomal protein S12 -0.0235964
RNF213 ring finger protein 213 -0.0235944
MBD5 methyl-CpG binding domain protein 5 -0.0231988
RPS16 ribosomal protein S16 -0.0231919
FBN1 fibrillin 1 -0.0231908
LRRC23 leucine rich repeat containing 23 -0.023008
IFI27 interferon, alpha-inducible protein 27 -0.0229247
HLA-B major histocompatibility complex, class I, B -0.02289
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0228701
TNRC6B trinucleotide repeat containing 6B -0.0227641
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0225721
VCL vinculin -0.0225452
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0221419
DPYD dihydropyrimidine dehydrogenase -0.0221361
ENO1 enolase 1, (alpha) -0.0219775
PRH1 proline-rich protein HaeIII subfamily 1 -0.0218657
NPC1 Niemann-Pick disease, type C1 -0.0215631
TSC22D1 TSC22 domain family, member 1 -0.021485
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0212105
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0211821
RPL31 ribosomal protein L31 -0.0210374
RB1CC1 RB1-inducible coiled-coil 1 -0.020955
RAD51B RAD51 paralog B -0.0208627
RPS27A ribosomal protein S27a -0.020852
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0208127
HIPK2 homeodomain interacting protein kinase 2 -0.0205557
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0204355
NTN4 netrin 4 -0.020434
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0204257
ATXN1 ataxin 1 -0.0203593
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0201206
AHNAK AHNAK nucleoprotein -0.0197232
EIF1 eukaryotic translation initiation factor 1 -0.0196119
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0195237
FBXO32 F-box protein 32 -0.0194715
RANBP17 RAN binding protein 17 -0.0193584
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0192342