Aberrant Crypt Foci Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description a neoplastic lesion in which large, thick clusters of abnormal tube-like glands are found in the lining of the colon and rectum; aberrant crypt foci are precursors of colorectal polyps, adenoma and colon cancer (Mammalian Phenotype Ontology, MP_0012673)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D058739
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Genes

32 genes/proteins associated with the disease Aberrant Crypt Foci from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GCG glucagon 2.88009
APC adenomatous polyposis coli 2.88009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.88009
HRAS Harvey rat sarcoma viral oncogene homolog 1.49071
CCND1 cyclin D1 1.47966
IFNG interferon, gamma 1.45326
GSK3B glycogen synthase kinase 3 beta 1.41911
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.32696
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.32607
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.30421
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.28425
TP53 tumor protein p53 1.25619
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.22979
PCNA proliferating cell nuclear antigen 1.22501
IL2 interleukin 2 1.21206
EGFR epidermal growth factor receptor 1.18489
GSR glutathione reductase 1.17366
NFE2L2 nuclear factor, erythroid 2-like 2 1.12357
CAT catalase 1.11673
NOS2 nitric oxide synthase 2, inducible 1.10907
NQO1 NAD(P)H dehydrogenase, quinone 1 1.10282
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.08584
BCL2 B-cell CLL/lymphoma 2 1.06987
KRT5 keratin 5, type II 1.06588
PARP1 poly (ADP-ribose) polymerase 1 1.06297
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.0608
IL1B interleukin 1, beta 1.05274
MAPK3 mitogen-activated protein kinase 3 1.03567
MAPK1 mitogen-activated protein kinase 1 1.02821
MMP2 matrix metallopeptidase 2 1.02708
IL6 interleukin 6 1.02559
STAT1 signal transducer and activator of transcription 1, 91kDa 1.01739