Abiraterone acetate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0546251
EIF4H eukaryotic translation initiation factor 4H 0.039476
SRRM2 serine/arginine repetitive matrix 2 0.0372354
VEGFA vascular endothelial growth factor A 0.036996
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0349257
FGFR1 fibroblast growth factor receptor 1 0.0309349
PRELID2 PRELI domain containing 2 0.0287943
RPL3 ribosomal protein L3 0.028728
ARHGAP21 Rho GTPase activating protein 21 0.0268086
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0261013
PRRC2C proline-rich coiled-coil 2C 0.024655
NCOR2 nuclear receptor corepressor 2 0.0243605
DDIT4 DNA-damage-inducible transcript 4 0.024054
UTRN utrophin 0.0240183
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0226577
SET SET nuclear proto-oncogene 0.0218051
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0210669
PDE4D phosphodiesterase 4D, cAMP-specific 0.0210156
DIPK2A divergent protein kinase domain 2A 0.0206165
PHF3 PHD finger protein 3 0.0203573
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.020139
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0200875
KMT2E lysine (K)-specific methyltransferase 2E 0.0195927
LOC112694756 uncharaterized LOC112694756 0.0191615
ZNF608 zinc finger protein 608 0.0190809
PCBP2 poly(rC) binding protein 2 0.0184733
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0184545
PRRC2A proline-rich coiled-coil 2A 0.0182245
CABIN1 calcineurin binding protein 1 0.0182221
GSE1 Gse1 coiled-coil protein 0.0181908
MATR3 matrin 3 0.0181555
FLNA filamin A, alpha 0.0176844
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0176494
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0175248
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0174544
MACF1 microtubule-actin crosslinking factor 1 0.017296
MYH9 myosin, heavy chain 9, non-muscle 0.0172431
KMT2C lysine (K)-specific methyltransferase 2C 0.0169346
SQSTM1 sequestosome 1 0.0168273
NFIB nuclear factor I/B 0.0165856
PBX3 pre-B-cell leukemia homeobox 3 0.016474
WDR45B WD repeat domain 45B 0.0162918
KAZN kazrin, periplakin interacting protein 0.0161572
SOX6 SRY (sex determining region Y)-box 6 0.0161537
PER1 period circadian clock 1 0.0158559
BRD2 bromodomain containing 2 0.0157741
PICALM phosphatidylinositol binding clathrin assembly protein 0.0156454
PLCG1 phospholipase C, gamma 1 0.0154677
ZEB1 zinc finger E-box binding homeobox 1 0.0152748
PRKG1 protein kinase, cGMP-dependent, type I 0.0152157
CEP250 centrosomal protein 250kDa 0.0151477
KIF11 kinesin family member 11 0.0151425
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0150259
TNIP1 TNFAIP3 interacting protein 1 0.0149084
HSPA8 heat shock 70kDa protein 8 0.0147907
MPRIP myosin phosphatase Rho interacting protein 0.0146997
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0146816
CTBP2 C-terminal binding protein 2 0.0144245
GPC6 glypican 6 0.0143603
SOBP sine oculis binding protein homolog (Drosophila) 0.014304
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.014059
EGFR epidermal growth factor receptor 0.013889
CALR calreticulin 0.0138257
ANKRD36 ankyrin repeat domain 36 0.0137113
BIRC6 baculoviral IAP repeat containing 6 0.0136994
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0136937
ZNF678 zinc finger protein 678 0.0136821
AHCYL2 adenosylhomocysteinase-like 2 0.0134099
SSBP2 single-stranded DNA binding protein 2 0.0133653
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0132798
TOP2B topoisomerase (DNA) II beta 180kDa 0.0131481
DROSHA drosha, ribonuclease type III 0.0129597
ELOVL5 ELOVL fatty acid elongase 5 0.0126968
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0126406
YTHDC1 YTH domain containing 1 0.0126131
ZNF516 zinc finger protein 516 0.0126023
USP9X ubiquitin specific peptidase 9, X-linked 0.0125942
PCNT pericentrin 0.0125933
RBM26 RNA binding motif protein 26 0.0125648
THSD4 thrombospondin, type I, domain containing 4 0.0124956
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0124475
FCHSD2 FCH and double SH3 domains 2 0.0123994
PRKCE protein kinase C, epsilon 0.0123958
UBA6 ubiquitin-like modifier activating enzyme 6 0.0123753
ZMIZ1 zinc finger, MIZ-type containing 1 0.012359
PNN pinin, desmosome associated protein 0.012354
MEST mesoderm specific transcript 0.0123197
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0123127
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0121753
GOLGA4 golgin A4 0.0120979
KDM1A lysine (K)-specific demethylase 1A 0.012091
MLEC malectin 0.0120891
EIF4B eukaryotic translation initiation factor 4B 0.0120783
RREB1 ras responsive element binding protein 1 0.0120586
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0120396
FBN1 fibrillin 1 0.011998
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0119713
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0119163
PUM3 pumilio RNA binding family member 3 0.0118877
NFIA nuclear factor I/A 0.0118705

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148475
VIM vimentin -0.147331
PTMA prothymosin, alpha -0.0691379
RPS6 ribosomal protein S6 -0.0641215
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0606805
MGP matrix Gla protein -0.0593793
RPS23 ribosomal protein S23 -0.0521587
RPS24 ribosomal protein S24 -0.0485716
CADM2 cell adhesion molecule 2 -0.0447477
TMSB10 thymosin beta 10 -0.0446146
RPLP1 ribosomal protein, large, P1 -0.0434814
RPS8 ribosomal protein S8 -0.0415239
RPLP2 ribosomal protein, large, P2 -0.0405561
FTL ferritin, light polypeptide -0.0379433
RPL12 ribosomal protein L12 -0.037786
RPL35A ribosomal protein L35a -0.0372312
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0349304
TPT1 tumor protein, translationally-controlled 1 -0.034473
RPS11 ribosomal protein S11 -0.0330853
HMGB1 high mobility group box 1 -0.0323842
RPL31 ribosomal protein L31 -0.0311577
RPS19 ribosomal protein S19 -0.02966
RPS25 ribosomal protein S25 -0.0289061
MT2A metallothionein 2A -0.0280047
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.027964
SOX4 SRY (sex determining region Y)-box 4 -0.0274901
RPS12 ribosomal protein S12 -0.0271733
RPL26 ribosomal protein L26 -0.0266743
RPL32 ribosomal protein L32 -0.0264723
HMGA1 high mobility group AT-hook 1 -0.0258919
RPS27A ribosomal protein S27a -0.0258753
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0245207
RPL37 ribosomal protein L37 -0.0244652
RPL8 ribosomal protein L8 -0.024211
RPS15 ribosomal protein S15 -0.0239361
RPS5 ribosomal protein S5 -0.0237337
RAD21 RAD21 homolog (S. pombe) -0.0231392
RPS29 ribosomal protein S29 -0.0231215
RPL28 ribosomal protein L28 -0.0229324
FNDC3B fibronectin type III domain containing 3B -0.0222848
RPL23 ribosomal protein L23 -0.0220875
RPL34 ribosomal protein L34 -0.0218576
S100A9 S100 calcium binding protein A9 -0.0217896
RPL5 ribosomal protein L5 -0.0217212
CSDE1 cold shock domain containing E1, RNA-binding -0.020805
TNPO1 transportin 1 -0.0205569
ACTG1 actin gamma 1 -0.0204546
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0196323
FOXC1 forkhead box C1 -0.0195759
RPS17 ribosomal protein S17 -0.0194093
CENPF centromere protein F, 350/400kDa -0.0188244
RPS13 ribosomal protein S13 -0.0186011
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0180825
RPLP0 ribosomal protein, large, P0 -0.0179778
SEPTIN11 septin 11 -0.0179005
RPS21 ribosomal protein S21 -0.0177886
DLG1 discs, large homolog 1 (Drosophila) -0.0175168
RPL11 ribosomal protein L11 -0.0174178
PEG10 paternally expressed 10 -0.0172805
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0172153
RPS14 ribosomal protein S14 -0.0171659
RPL7A ribosomal protein L7a -0.0168817
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0168544
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0167621
MEIS2 Meis homeobox 2 -0.0166788
IER3 immediate early response 3 -0.0166492
PFN1 profilin 1 -0.0163781
RPL30 ribosomal protein L30 -0.0161034
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0160999
TPI1 triosephosphate isomerase 1 -0.0159496
COG5 component of oligomeric golgi complex 5 -0.0158329
RPS10 ribosomal protein S10 -0.0157486
TUBA1B tubulin, alpha 1b -0.0155351
ATP5F1B ATP synthase F1 subunit beta -0.0154666
RTN4 reticulon 4 -0.0151454
IFT88 intraflagellar transport 88 -0.0151336
RPL39 ribosomal protein L39 -0.0150469
UQCRB ubiquinol-cytochrome c reductase binding protein -0.014751
POTEF POTE ankyrin domain family, member F -0.0147434
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0147173
FUS FUS RNA binding protein -0.0145875
RPS3 ribosomal protein S3 -0.0143795
HSPB1 heat shock 27kDa protein 1 -0.0143316
WASF2 WAS protein family, member 2 -0.0142089
HLA-B major histocompatibility complex, class I, B -0.0140569
FAM162A family with sequence similarity 162, member A -0.0140272
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0140059
RAB1A RAB1A, member RAS oncogene family -0.0139417
S100A6 S100 calcium binding protein A6 -0.0137475
SBF2 SET binding factor 2 -0.0136746
RPL38 ribosomal protein L38 -0.013638
ZNF770 zinc finger protein 770 -0.013439
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0134041
RPL36A ribosomal protein L36a -0.013363
RPL4 ribosomal protein L4 -0.0133538
COX20 COX20 cytochrome c oxidase assembly factor -0.0133078
RPL19 ribosomal protein L19 -0.013284
GPATCH8 G patch domain containing 8 -0.0132598
EIF3D eukaryotic translation initiation factor 3, subunit D -0.0130912
GNAS GNAS complex locus -0.0130838