Abiraterone acetate_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in BT-474 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Abiraterone acetate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.164096
ZMYND8 zinc finger, MYND-type containing 8 0.152626
SRCIN1 SRC kinase signaling inhibitor 1 0.12311
RPL23 ribosomal protein L23 0.107664
CATSPERB catsper channel auxiliary subunit beta 0.100165
ACACA acetyl-CoA carboxylase alpha 0.095243
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0902726
LASP1 LIM and SH3 protein 1 0.0721986
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0686924
THSD4 thrombospondin, type I, domain containing 4 0.0685875
KRT7 keratin 7, type II 0.0657608
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0654245
CDK12 cyclin-dependent kinase 12 0.064595
PLEC plectin 0.0639584
LOC112694756 uncharaterized LOC112694756 0.0579695
LPP LIM domain containing preferred translocation partner in lipoma 0.0578923
CCND1 cyclin D1 0.0555641
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0536224
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0520556
FASN fatty acid synthase 0.0509226
ACSS2 acyl-CoA synthetase short-chain family member 2 0.048493
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0461732
TRPS1 trichorhinophalangeal syndrome I 0.0458433
PRRC2B proline-rich coiled-coil 2B 0.0449847
RNF213 ring finger protein 213 0.0440589
RPS3 ribosomal protein S3 0.0412555
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.041221
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0407201
EEF2 eukaryotic translation elongation factor 2 0.0407118
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0403462
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0400447
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.0397559
LIMCH1 LIM and calponin homology domains 1 0.0378349
INTS6 integrator complex subunit 6 0.0366928
IFI6 interferon, alpha-inducible protein 6 0.0357739
RPL19 ribosomal protein L19 0.0353993
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0352343
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0348506
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.0335694
KRT18 keratin 18, type I 0.0323745
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0321437
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0316732
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0314426
PLSCR1 phospholipid scramblase 1 0.0313938
SP100 SP100 nuclear antigen 0.0312762
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.03039
RAD51B RAD51 paralog B 0.0303599
KIF1A kinesin family member 1A 0.0298213
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0293485
RIMS2 regulating synaptic membrane exocytosis 2 0.0292691
HLA-B major histocompatibility complex, class I, B 0.0291431
TNS3 tensin 3 0.0284633
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0282075
DENND1A DENN/MADD domain containing 1A 0.0280576
RBM47 RNA binding motif protein 47 0.0277294
EIF4H eukaryotic translation initiation factor 4H 0.0277157
ASPH aspartate beta-hydroxylase 0.0271443
NCOR2 nuclear receptor corepressor 2 0.0271401
TPM4 tropomyosin 4 0.0270282
TMSB10 thymosin beta 10 0.0270242
RPL35A ribosomal protein L35a 0.0266438
ACTG1 actin gamma 1 0.0264189
LMNA lamin A/C 0.0259002
FOXO3 forkhead box O3 0.0256986
VCP valosin containing protein 0.0254831
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0252847
SRRM2 serine/arginine repetitive matrix 2 0.0247317
PRRC2C proline-rich coiled-coil 2C 0.0246286
ZNF652 zinc finger protein 652 0.0245757
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245165
SAMD12 sterile alpha motif domain containing 12 0.0243492
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0242626
NCOA6 nuclear receptor coactivator 6 0.0241793
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240103
LDHA lactate dehydrogenase A 0.0238197
PRRC2A proline-rich coiled-coil 2A 0.0236533
HDLBP high density lipoprotein binding protein 0.0235207
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0235186
S100P S100 calcium binding protein P 0.0233042
ANKRD36C ankyrin repeat domain 36C 0.0232435
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0229066
MLPH melanophilin 0.0227117
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0226383
PTPRF protein tyrosine phosphatase, receptor type, F 0.0226012
FLNA filamin A, alpha 0.0225513
ZNFX1 zinc finger, NFX1-type containing 1 0.0225002
KRT19 keratin 19, type I 0.0224424
SLFN5 schlafen family member 5 0.0223869
ACTN4 actinin, alpha 4 0.0217951
ENO1 enolase 1, (alpha) 0.0217245
EEIG1 estrogen-induced osteoclastogenesis regulator 1 0.0216643
EGFR epidermal growth factor receptor 0.0216507
HLA-C major histocompatibility complex, class I, C 0.0215813
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.0214881
GRB10 growth factor receptor-bound protein 10 0.0213678
CLDN4 claudin 4 0.0213552
DUSP4 dual specificity phosphatase 4 0.0212819
FTH1 ferritin, heavy polypeptide 1 0.0211523
MMP24OS MMP24 opposite strand 0.0211129
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0211003

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.100692
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0741461
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0705602
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0705315
MT2A metallothionein 2A -0.0647256
EXT1 exostosin glycosyltransferase 1 -0.0635792
TSC22D2 TSC22 domain family, member 2 -0.0632728
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0599248
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0566209
NAMPT nicotinamide phosphoribosyltransferase -0.0497487
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0444301
PTMA prothymosin, alpha -0.0435288
ELL2 elongation factor, RNA polymerase II, 2 -0.0402355
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0377543
VMP1 vacuole membrane protein 1 -0.0371531
FBXL20 F-box and leucine-rich repeat protein 20 -0.0357848
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0333039
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0322902
ZNF217 zinc finger protein 217 -0.0319564
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0314099
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0307898
CLTC clathrin, heavy chain (Hc) -0.0306473
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0305917
STK17A serine/threonine kinase 17a -0.0304362
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300028
USP53 ubiquitin specific peptidase 53 -0.0297916
WSB1 WD repeat and SOCS box containing 1 -0.0297764
MYO1B myosin IB -0.0296653
JMJD1C jumonji domain containing 1C -0.0295247
ELOVL5 ELOVL fatty acid elongase 5 -0.0295044
RBM39 RNA binding motif protein 39 -0.0289
ITCH itchy E3 ubiquitin protein ligase -0.0288559
CAB39 calcium binding protein 39 -0.0277419
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0276018
CREB5 cAMP responsive element binding protein 5 -0.02756
IGFBP5 insulin-like growth factor binding protein 5 -0.0275073
WWC1 WW and C2 domain containing 1 -0.0274062
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0271389
ALCAM activated leukocyte cell adhesion molecule -0.0270586
RPS2 ribosomal protein S2 -0.0261436
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0250806
NDRG1 N-myc downstream regulated 1 -0.0247461
ANKRD12 ankyrin repeat domain 12 -0.0244817
ARHGAP29 Rho GTPase activating protein 29 -0.024247
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0231492
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0230888
SDC4 syndecan 4 -0.0230486
USP47 ubiquitin specific peptidase 47 -0.0228469
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0227855
CCNL1 cyclin L1 -0.0218292
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0213485
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0212848
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0211743
FNDC3A fibronectin type III domain containing 3A -0.0211408
TENM2 teneurin transmembrane protein 2 -0.0210362
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0208952
PNPLA8 patatin-like phospholipase domain containing 8 -0.0200258
SLMAP sarcolemma associated protein -0.0193855
SUCO SUN domain containing ossification factor -0.0192001
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0191847
TXNRD1 thioredoxin reductase 1 -0.0189549
MYO6 myosin VI -0.0187833
TMEM41B transmembrane protein 41B -0.0187518
AGFG1 ArfGAP with FG repeats 1 -0.0186404
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.018492
KTN1 kinectin 1 (kinesin receptor) -0.0184147
PRR11 proline rich 11 -0.0183713
ZFAND3 zinc finger, AN1-type domain 3 -0.0181201
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0181075
YAP1 Yes-associated protein 1 -0.0180415
ANLN anillin, actin binding protein -0.0179273
ESYT2 extended synaptotagmin-like protein 2 -0.0177083
SETD5 SET domain containing 5 -0.0175835
ARHGAP42 Rho GTPase activating protein 42 -0.017283
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0172772
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0171273
KDM7A lysine (K)-specific demethylase 7A -0.0170387
ARL5B ADP-ribosylation factor-like 5B -0.016991
DUSP16 dual specificity phosphatase 16 -0.016845
GOLGA4 golgin A4 -0.0168284
KAZN kazrin, periplakin interacting protein -0.0166428
IFNGR1 interferon gamma receptor 1 -0.0165699
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0164441
ICAM1 intercellular adhesion molecule 1 -0.01644
PARD6B par-6 family cell polarity regulator beta -0.0162163
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0160768
PNN pinin, desmosome associated protein -0.0157429
KDM3A lysine (K)-specific demethylase 3A -0.0157165
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0156214
MSMO1 methylsterol monooxygenase 1 -0.0156123
ZFAND6 zinc finger, AN1-type domain 6 -0.0155727
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0155283
MAPK8 mitogen-activated protein kinase 8 -0.0154777
GSK3B glycogen synthase kinase 3 beta -0.0153893
HMGB2 high mobility group box 2 -0.0153498
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0151838
ZFR zinc finger RNA binding protein -0.0151561
MARCHF6 membrane associated ring-CH-type finger 6 -0.015135
YBX3 Y box binding protein 3 -0.0151257
RNF24 ring finger protein 24 -0.0151202