Abiraterone acetate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.07992
ERBB4 erb-b2 receptor tyrosine kinase 4 0.055312
ADGRG6 adhesion G protein-coupled receptor G6 0.0419846
DST dystonin 0.038861
ZNF608 zinc finger protein 608 0.0309082
NFIA nuclear factor I/A 0.028666
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0246173
TENM3 teneurin transmembrane protein 3 0.0246113
HHIP hedgehog interacting protein 0.0236808
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0233737
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0232702
GRID2 glutamate receptor, ionotropic, delta 2 0.0226734
FBXL7 F-box and leucine-rich repeat protein 7 0.0225246
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0224343
MAML3 mastermind-like 3 (Drosophila) 0.0216228
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0212375
ATP11A ATPase, class VI, type 11A 0.0210294
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0209341
CADM2 cell adhesion molecule 2 0.0203896
NALF1 NALCN channel auxiliary factor 1 0.0203847
ZNF292 zinc finger protein 292 0.0191648
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0190349
ZNF638 zinc finger protein 638 0.0187469
TPM3 tropomyosin 3 0.0177361
KMT2E lysine (K)-specific methyltransferase 2E 0.017486
AUTS2 autism susceptibility candidate 2 0.0174719
JMJD1C jumonji domain containing 1C 0.0174475
FAM13A family with sequence similarity 13, member A 0.0171794
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0168775
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0167567
SOX5 SRY (sex determining region Y)-box 5 0.0159285
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0156979
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0148307
ANKRD36 ankyrin repeat domain 36 0.0148144
FBXL17 F-box and leucine-rich repeat protein 17 0.0146693
ARL15 ADP-ribosylation factor-like 15 0.0144411
NPAS3 neuronal PAS domain protein 3 0.0139014
SLF1 SMC5-SMC6 complex localization factor 1 0.0138218
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0134881
ANK2 ankyrin 2, neuronal 0.0134741
KDM6A lysine (K)-specific demethylase 6A 0.0134208
EFNA5 ephrin-A5 0.0133956
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0133449
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0131099
XPO1 exportin 1 0.013082
CD164 CD164 molecule, sialomucin 0.0128013
KIAA1958 KIAA1958 0.0127426
NUP58 nucleoporin 58 0.0127204
YAP1 Yes-associated protein 1 0.0125859
USP9X ubiquitin specific peptidase 9, X-linked 0.0125638
PBX3 pre-B-cell leukemia homeobox 3 0.012155
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0120072
NGLY1 N-glycanase 1 0.0119748
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0119397
ZFAND3 zinc finger, AN1-type domain 3 0.0119002
MCL1 myeloid cell leukemia 1 0.0117358
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0116822
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0116789
CARD18 caspase recruitment domain family, member 18 0.011644
TPD52 tumor protein D52 0.0115778
PCDH11X protocadherin 11 X-linked 0.0115757
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0114721
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0114117
RPL3 ribosomal protein L3 0.0113938
PHF21A PHD finger protein 21A 0.0113575
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0113263
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0111902
GPHN gephyrin 0.011163
FOXO3 forkhead box O3 0.0111516
TNRC6A trinucleotide repeat containing 6A 0.0110774
RABGAP1L RAB GTPase activating protein 1-like 0.0110642
NCKAP1 NCK-associated protein 1 0.0110465
PNN pinin, desmosome associated protein 0.0109347
UBA6 ubiquitin-like modifier activating enzyme 6 0.0108222
ZBTB20 zinc finger and BTB domain containing 20 0.010821
HELZ helicase with zinc finger 0.010781
CABIN1 calcineurin binding protein 1 0.0107633
PLEC plectin 0.0106493
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0106285
UBE2H ubiquitin-conjugating enzyme E2H 0.0105982
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0105913
MED13L mediator complex subunit 13-like 0.0105321
KDM4C lysine (K)-specific demethylase 4C 0.010507
RNF150 ring finger protein 150 0.0103652
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0102703
AVL9 AVL9 homolog (S. cerevisiase) 0.0102301
EIF4H eukaryotic translation initiation factor 4H 0.010189
YEATS2 YEATS domain containing 2 0.0101754
SND1 staphylococcal nuclease and tudor domain containing 1 0.0101504
EXOC6B exocyst complex component 6B 0.0100991
TET2 tet methylcytosine dioxygenase 2 0.0100773
RNF145 ring finger protein 145 0.0100757
TRIP12 thyroid hormone receptor interactor 12 0.0100556
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.00999193
PTCH1 patched 1 0.00991401
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.00985059
APLP2 amyloid beta (A4) precursor-like protein 2 0.00982864
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00982231
SKIL SKI-like proto-oncogene 0.00972878
QKI QKI, KH domain containing, RNA binding 0.00970486

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215064
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.106284
PTMA prothymosin, alpha -0.101343
RPL11 ribosomal protein L11 -0.0837595
ACTG1 actin gamma 1 -0.0783978
TMSB10 thymosin beta 10 -0.077553
RPS6 ribosomal protein S6 -0.0760709
SLIT2 slit homolog 2 (Drosophila) -0.06866
RPLP1 ribosomal protein, large, P1 -0.0649874
RPS8 ribosomal protein S8 -0.0648454
RPS21 ribosomal protein S21 -0.0637634
RPL12 ribosomal protein L12 -0.0571565
RPS24 ribosomal protein S24 -0.0530802
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0522134
RPLP2 ribosomal protein, large, P2 -0.0505043
RPL34 ribosomal protein L34 -0.0490504
RPL9 ribosomal protein L9 -0.0482804
RPL37A ribosomal protein L37a -0.0471373
RPL35A ribosomal protein L35a -0.0449295
RPL26 ribosomal protein L26 -0.0446667
HMGB1 high mobility group box 1 -0.0437747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0423351
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0422145
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0416697
RPS13 ribosomal protein S13 -0.0402929
RPL19 ribosomal protein L19 -0.0397166
ENO1 enolase 1, (alpha) -0.0395737
TPT1 tumor protein, translationally-controlled 1 -0.0393906
RPL23 ribosomal protein L23 -0.0388686
CENPF centromere protein F, 350/400kDa -0.038394
RPS11 ribosomal protein S11 -0.0375595
MYL12B myosin, light chain 12B, regulatory -0.0374463
RPS29 ribosomal protein S29 -0.0373986
RPL13A ribosomal protein L13a -0.0357528
NEBL nebulette -0.0353358
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0351038
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0346661
RPS3 ribosomal protein S3 -0.0344691
RPS19 ribosomal protein S19 -0.0341789
RPLP0 ribosomal protein, large, P0 -0.0341055
RPS12 ribosomal protein S12 -0.0338931
RPL28 ribosomal protein L28 -0.0337101
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0334632
RPL31 ribosomal protein L31 -0.0330796
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0330208
LDHA lactate dehydrogenase A -0.0328725
RPS25 ribosomal protein S25 -0.0328169
NAP1L1 nucleosome assembly protein 1-like 1 -0.0327958
KPNB1 karyopherin (importin) beta 1 -0.0322381
SHROOM3 shroom family member 3 -0.0318986
RPL32 ribosomal protein L32 -0.0317324
RPL7A ribosomal protein L7a -0.0316424
RPS27A ribosomal protein S27a -0.0313427
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0299501
RPL18 ribosomal protein L18 -0.0296251
RPS15 ribosomal protein S15 -0.0296168
RPS14 ribosomal protein S14 -0.0294995
RPS5 ribosomal protein S5 -0.0294229
RSL1D1 ribosomal L1 domain containing 1 -0.029226
HMGA1 high mobility group AT-hook 1 -0.0286278
RPL5 ribosomal protein L5 -0.0285483
RPL8 ribosomal protein L8 -0.0271492
MKI67 marker of proliferation Ki-67 -0.0270654
RPL36 ribosomal protein L36 -0.0268357
RPL38 ribosomal protein L38 -0.0266611
RPL27A ribosomal protein L27a -0.0264646
RPL35 ribosomal protein L35 -0.0264341
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0261227
RPS17 ribosomal protein S17 -0.0256164
IFI6 interferon, alpha-inducible protein 6 -0.0255349
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0248882
RPL37 ribosomal protein L37 -0.0247949
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.024153
RPS16 ribosomal protein S16 -0.0238686
RPS28 ribosomal protein S28 -0.0235976
RAN RAN, member RAS oncogene family -0.0234268
TAS2R14 taste receptor, type 2, member 14 -0.0232324
EIF5B eukaryotic translation initiation factor 5B -0.0229593
RPS10 ribosomal protein S10 -0.0228084
DEK DEK proto-oncogene -0.0226119
SERBP1 SERPINE1 mRNA binding protein 1 -0.0224389
RPL30 ribosomal protein L30 -0.0223634
PFN1 profilin 1 -0.0223254
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0222889
S100A9 S100 calcium binding protein A9 -0.0221686
RACK1 receptor for activated C kinase 1 -0.021989
RPL36A ribosomal protein L36a -0.0219707
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0219506
RBM25 RNA binding motif protein 25 -0.0214632
RPL7 ribosomal protein L7 -0.0214048
ARHGAP32 Rho GTPase activating protein 32 -0.0210577
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0203435
RPL22L1 ribosomal protein L22-like 1 -0.0202443
ISG15 ISG15 ubiquitin-like modifier -0.0201093
CCDC138 coiled-coil domain containing 138 -0.0200285
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0198614
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0197537
VCL vinculin -0.0196933
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0196404
HMGB2 high mobility group box 2 -0.0195531