Abiraterone acetate_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.185833
CD109 CD109 molecule 0.0672758
NDRG1 N-myc downstream regulated 1 0.0605558
EIF4H eukaryotic translation initiation factor 4H 0.0450828
VGF VGF nerve growth factor inducible 0.0399783
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0383369
LOC112694756 uncharaterized LOC112694756 0.0375998
IGFBP3 insulin-like growth factor binding protein 3 0.0333453
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0316603
ZMIZ1 zinc finger, MIZ-type containing 1 0.0304904
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0302244
TMEM178B transmembrane protein 178B 0.0297038
LEF1 lymphoid enhancer-binding factor 1 0.0292766
ARRDC3 arrestin domain containing 3 0.0283926
A2M alpha-2-macroglobulin 0.0283549
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0252266
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0243005
MIDEAS mitotic deacetylase associated SANT domain protein 0.0230936
SRRM2 serine/arginine repetitive matrix 2 0.0230512
CABIN1 calcineurin binding protein 1 0.0228922
FBXO7 F-box protein 7 0.0228585
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0223587
SETBP1 SET binding protein 1 0.0210221
SSBP3 single stranded DNA binding protein 3 0.0205848
RPL3 ribosomal protein L3 0.0204831
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0203572
EEF2 eukaryotic translation elongation factor 2 0.0203519
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0201484
FLNA filamin A, alpha 0.0198809
PRELID2 PRELI domain containing 2 0.0198573
NBAS neuroblastoma amplified sequence 0.0191658
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0185255
PLEC plectin 0.0182629
MCL1 myeloid cell leukemia 1 0.0178762
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0177223
TMEM255B transmembrane protein 255B 0.0161692
ZYX zyxin 0.0161163
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0158823
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0158357
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143606
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0142462
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0140569
NUP58 nucleoporin 58 0.01397
ACTN1 actinin, alpha 1 0.0138937
GLS2 glutaminase 2 (liver, mitochondrial) 0.0137468
STRIP2 striatin interacting protein 2 0.0137342
RNF150 ring finger protein 150 0.0135824
NUMA1 nuclear mitotic apparatus protein 1 0.0135504
NFE2L1 nuclear factor, erythroid 2-like 1 0.0133914
ETV3 ets variant 3 0.013212
RNF213 ring finger protein 213 0.0130873
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.013071
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0130178
KDM3A lysine (K)-specific demethylase 3A 0.0130095
MYH9 myosin, heavy chain 9, non-muscle 0.0127987
HLA-C major histocompatibility complex, class I, C 0.012753
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0122955
RELT RELT tumor necrosis factor receptor 0.0122467
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0121919
SND1 staphylococcal nuclease and tudor domain containing 1 0.0121774
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0120593
ERRFI1 ERBB receptor feedback inhibitor 1 0.0120276
IVNS1ABP influenza virus NS1A binding protein 0.0120127
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0119011
DDIT4 DNA-damage-inducible transcript 4 0.0117769
STOM stomatin 0.0117041
SOX13 SRY (sex determining region Y)-box 13 0.0114602
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0114447
HOOK2 hook microtubule-tethering protein 2 0.0113613
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0112654
PRRC2A proline-rich coiled-coil 2A 0.0111545
DCAF8 DDB1 and CUL4 associated factor 8 0.0111444
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0111058
SERGEF secretion regulating guanine nucleotide exchange factor 0.0110334
SCARB1 scavenger receptor class B, member 1 0.0110227
EXOC4 exocyst complex component 4 0.010991
VEGFA vascular endothelial growth factor A 0.010956
TMF1 TATA element modulatory factor 1 0.0109364
PPME1 protein phosphatase methylesterase 1 0.0108999
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.0108826
FRMD6 FERM domain containing 6 0.0108039
FOSL1 FOS-like antigen 1 0.0106801
CHSY1 chondroitin sulfate synthase 1 0.0103084
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0102598
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.010085
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0100233
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00977458
PLXNB2 plexin B2 0.00972825
TBC1D22A TBC1 domain family, member 22A 0.00972347
RIPK4 receptor-interacting serine-threonine kinase 4 0.00971834
CEMIP2 cell migration inducing hyaluronidase 2 0.00964623
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.00957715
GRAMD4 GRAM domain containing 4 0.00956486
SEC24D SEC24 family member D 0.00953383
BCL9L B-cell CLL/lymphoma 9-like 0.00942937
IQGAP3 IQ motif containing GTPase activating protein 3 0.00911951
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.00909467
EFCAB13 EF-hand calcium binding domain 13 0.00906849
NEK6 NIMA-related kinase 6 0.00903305
SYNM synemin, intermediate filament protein 0.00900893

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.522012
VIM vimentin -0.2889
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.173938
FMN1 formin 1 -0.0953736
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0913666
TMSB10 thymosin beta 10 -0.0883911
HLA-B major histocompatibility complex, class I, B -0.0882972
GPC6 glypican 6 -0.0880112
MT2A metallothionein 2A -0.0806701
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0805457
S100A6 S100 calcium binding protein A6 -0.0762363
IFI16 interferon, gamma-inducible protein 16 -0.0725292
NLGN1 neuroligin 1 -0.0702446
IGFBP5 insulin-like growth factor binding protein 5 -0.0641037
RPLP1 ribosomal protein, large, P1 -0.0599875
PTMA prothymosin, alpha -0.0576219
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0540461
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0530222
ACTG1 actin gamma 1 -0.0527034
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0470102
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0447672
IER3 immediate early response 3 -0.0439814
DCT dopachrome tautomerase -0.0436395
PGK1 phosphoglycerate kinase 1 -0.0432195
FTL ferritin, light polypeptide -0.0412395
GDF15 growth differentiation factor 15 -0.0409979
S100A9 S100 calcium binding protein A9 -0.0409718
RHEB Ras homolog enriched in brain -0.0407023
SRPK2 SRSF protein kinase 2 -0.0406928
TPT1 tumor protein, translationally-controlled 1 -0.0403335
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0403225
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0391031
RPS8 ribosomal protein S8 -0.037738
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0376984
RPLP2 ribosomal protein, large, P2 -0.0365122
ENO1 enolase 1, (alpha) -0.0364457
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0363433
WSB1 WD repeat and SOCS box containing 1 -0.0359777
CALD1 caldesmon 1 -0.0358395
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0354152
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0352322
RAB7A RAB7A, member RAS oncogene family -0.0347744
S100A10 S100 calcium binding protein A10 -0.0340862
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0337175
TAGLN2 transgelin 2 -0.0334773
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0329544
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0327624
MTPN myotrophin -0.0327517
LAMB1 laminin, beta 1 -0.0318107
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0316913
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0316133
IFI6 interferon, alpha-inducible protein 6 -0.0315715
LOC102724023 ES1 protein homolog, mitochondrial -0.0315054
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0312
RPL37A ribosomal protein L37a -0.0307979
NPAS2 neuronal PAS domain protein 2 -0.0303347
RPS19 ribosomal protein S19 -0.030319
CUX1 cut-like homeobox 1 -0.0302703
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.030069
GNAS GNAS complex locus -0.0299677
RPS6 ribosomal protein S6 -0.0297855
CD63 CD63 molecule -0.0292457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0287608
EHBP1 EH domain binding protein 1 -0.0287195
POTEF POTE ankyrin domain family, member F -0.028671
CALU calumenin -0.0286055
FUS FUS RNA binding protein -0.0283028
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0282944
RPL35A ribosomal protein L35a -0.0278803
PTPRD protein tyrosine phosphatase, receptor type, D -0.027413
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0270969
COL19A1 collagen, type XIX, alpha 1 -0.026612
FNDC3B fibronectin type III domain containing 3B -0.0265795
AKAP9 A kinase (PRKA) anchor protein 9 -0.0265584
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0265583
RPL34 ribosomal protein L34 -0.0263915
ESYT2 extended synaptotagmin-like protein 2 -0.0259691
FRMD4A FERM domain containing 4A -0.0258882
RAD21 RAD21 homolog (S. pombe) -0.0257449
RPL19 ribosomal protein L19 -0.0257062
ZMYND8 zinc finger, MYND-type containing 8 -0.0256608
KMT2E lysine (K)-specific methyltransferase 2E -0.0256587
KDM2A lysine (K)-specific demethylase 2A -0.0256179
RPLP0 ribosomal protein, large, P0 -0.0254939
EGR1 early growth response 1 -0.0253245
RLF rearranged L-myc fusion -0.0252576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0250104
PKM pyruvate kinase, muscle -0.0243541
B2M beta-2-microglobulin -0.0242938
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0241314
IFITM3 interferon induced transmembrane protein 3 -0.024083
FBXO11 F-box protein 11 -0.0239521
RPL12 ribosomal protein L12 -0.0237672
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0235159
COG5 component of oligomeric golgi complex 5 -0.0231634
ARHGAP5 Rho GTPase activating protein 5 -0.022896
UBE2H ubiquitin-conjugating enzyme E2H -0.022781
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0227003
SEPTIN7 septin 7 -0.0226759
OSMR oncostatin M receptor -0.0225838