Abiraterone acetate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.129048
LPIN1 lipin 1 0.0825176
ZNF292 zinc finger protein 292 0.0389639
RNF213 ring finger protein 213 0.0363731
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0259027
VIM vimentin 0.0252756
ANXA2 annexin A2 0.0225574
CEMIP cell migration inducing protein, hyaluronan binding 0.0223089
PDE4D phosphodiesterase 4D, cAMP-specific 0.0213327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0198237
PTK2 protein tyrosine kinase 2 0.0197401
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.019344
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0189988
RPL35A ribosomal protein L35a 0.018818
PARP14 poly (ADP-ribose) polymerase family, member 14 0.018265
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0180429
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.017773
CHD4 chromodomain helicase DNA binding protein 4 0.0175131
CHD1 chromodomain helicase DNA binding protein 1 0.0173489
DIAPH3 diaphanous-related formin 3 0.0173014
OGA O-GlcNAcase 0.0172761
MTMR3 myotubularin related protein 3 0.0172276
FBXL17 F-box and leucine-rich repeat protein 17 0.0169526
MIS18BP1 MIS18 binding protein 1 0.016789
NCOR2 nuclear receptor corepressor 2 0.0167135
JMJD1C jumonji domain containing 1C 0.01662
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0164734
EIF1 eukaryotic translation initiation factor 1 0.0164083
ZEB1 zinc finger E-box binding homeobox 1 0.0163326
PHACTR2 phosphatase and actin regulator 2 0.0162696
FN1 fibronectin 1 0.0160513
XPO1 exportin 1 0.0158902
SOS1 son of sevenless homolog 1 (Drosophila) 0.0158188
MICU3 mitochondrial calcium uptake family, member 3 0.0156675
VGF VGF nerve growth factor inducible 0.0155863
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.015547
CCNG2 cyclin G2 0.0155406
RPL4 ribosomal protein L4 0.0153831
EZR ezrin 0.0153709
EIF4A2 eukaryotic translation initiation factor 4A2 0.0151137
SMAD3 SMAD family member 3 0.0149965
PDE8A phosphodiesterase 8A 0.0149294
COL3A1 collagen, type III, alpha 1 0.0148389
SLFN5 schlafen family member 5 0.014784
GOLIM4 golgi integral membrane protein 4 0.0146839
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0145042
CENPF centromere protein F, 350/400kDa 0.014488
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0144759
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0140357
MYH10 myosin, heavy chain 10, non-muscle 0.0140143
FCHSD2 FCH and double SH3 domains 2 0.0140073
DSTN destrin (actin depolymerizing factor) 0.0138835
WDPCP WD repeat containing planar cell polarity effector 0.0137159
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0137151
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0135761
TNRC6A trinucleotide repeat containing 6A 0.0135235
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0134918
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0134478
NAMPT nicotinamide phosphoribosyltransferase 0.0134172
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0134023
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0133738
SFTPA2 surfactant protein A2 0.0132662
UBC ubiquitin C 0.0132481
SRRM2 serine/arginine repetitive matrix 2 0.0132223
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0131701
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0130982
ZMIZ1 zinc finger, MIZ-type containing 1 0.0130062
AHNAK AHNAK nucleoprotein 0.0129325
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0128906
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.012767
AFDN afadin, adherens junction formation factor 0.0127282
PLEC plectin 0.0127156
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0126787
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0126464
PRKN parkin RBR E3 ubiquitin protein ligase 0.012494
TM9SF3 transmembrane 9 superfamily member 3 0.0124272
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0123886
RPS19 ribosomal protein S19 0.0123414
PPHLN1 periphilin 1 0.0123262
WRN Werner syndrome, RecQ helicase-like 0.0122745
NBAS neuroblastoma amplified sequence 0.0122599
ERBIN erbb2 interacting protein 0.012229
MX1 MX dynamin-like GTPase 1 0.0122211
CEP112 centrosomal protein 112kDa 0.0121749
TBCD tubulin folding cofactor D 0.0121483
CD164 CD164 molecule, sialomucin 0.0121186
DICER1 dicer 1, ribonuclease type III 0.0121029
CRYBG3 beta-gamma crystallin domain containing 3 0.0120712
THRAP3 thyroid hormone receptor associated protein 3 0.0119974
B2M beta-2-microglobulin 0.0118816
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0118532
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0118333
WBP11 WW domain binding protein 11 0.0118216
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0117481
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0116898
PREPL prolyl endopeptidase-like 0.0116536
VGLL4 vestigial-like family member 4 0.0116424
DENND4C DENN/MADD domain containing 4C 0.0116192
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0115881
TMEM181 transmembrane protein 181 0.0115545

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.183553
VCL vinculin -0.127037
EXT1 exostosin glycosyltransferase 1 -0.100016
NRG1 neuregulin 1 -0.0902838
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0878798
AKAP12 A kinase (PRKA) anchor protein 12 -0.0715461
PLAT plasminogen activator, tissue -0.0638337
FMN1 formin 1 -0.0621615
VMP1 vacuole membrane protein 1 -0.0583409
MAP1B microtubule-associated protein 1B -0.0580488
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0566682
TLE4 transducin-like enhancer of split 4 -0.0534
FAM13A family with sequence similarity 13, member A -0.0531008
FNDC3B fibronectin type III domain containing 3B -0.0530052
FNDC3A fibronectin type III domain containing 3A -0.0527764
SYT1 synaptotagmin I -0.0525376
KLHL13 kelch-like family member 13 -0.0513224
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0504721
HELZ helicase with zinc finger -0.0485418
LSAMP limbic system-associated membrane protein -0.0482093
PTPRD protein tyrosine phosphatase, receptor type, D -0.0465207
NREP neuronal regeneration related protein -0.0453161
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0434329
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.041686
COL4A5 collagen, type IV, alpha 5 -0.0413319
GLCCI1 glucocorticoid induced 1 -0.0406237
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0405327
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0401171
RPTOR regulatory associated protein of MTOR, complex 1 -0.0393966
GREM2 gremlin 2, DAN family BMP antagonist -0.0391559
MBNL2 muscleblind-like splicing regulator 2 -0.0390802
ZBTB20 zinc finger and BTB domain containing 20 -0.0388703
MEIS2 Meis homeobox 2 -0.0388607
BCAS3 breast carcinoma amplified sequence 3 -0.0384178
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0379367
AHR aryl hydrocarbon receptor -0.0371555
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0353931
SIK2 salt-inducible kinase 2 -0.0352776
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0348527
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0338714
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0334618
PTPRM protein tyrosine phosphatase, receptor type, M -0.0334559
MAPK10 mitogen-activated protein kinase 10 -0.0333654
CALD1 caldesmon 1 -0.033279
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0325689
KDM3A lysine (K)-specific demethylase 3A -0.0321494
WDR45B WD repeat domain 45B -0.0316266
NBEA neurobeachin -0.0313651
RAP1B RAP1B, member of RAS oncogene family -0.0311188
EGR1 early growth response 1 -0.0307777
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.030465
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0299198
DPH6 diphthamine biosynthesis 6 -0.0296748
LPP LIM domain containing preferred translocation partner in lipoma -0.0296716
MSI2 musashi RNA-binding protein 2 -0.0296164
ATRNL1 attractin-like 1 -0.0294011
BPTF bromodomain PHD finger transcription factor -0.0292759
TENT5A terminal nucleotidyltransferase 5A -0.0290417
CRH corticotropin releasing hormone -0.0286329
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0286166
FERMT2 fermitin family member 2 -0.0280607
TPST1 tyrosylprotein sulfotransferase 1 -0.0280184
BICD1 bicaudal D homolog 1 (Drosophila) -0.0280111
NALF1 NALCN channel auxiliary factor 1 -0.0279386
NDRG1 N-myc downstream regulated 1 -0.0278575
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0277531
NPAS2 neuronal PAS domain protein 2 -0.0276289
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0273647
MEF2A myocyte enhancer factor 2A -0.0269861
SLIT2 slit homolog 2 (Drosophila) -0.0268635
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.026726
FNBP4 formin binding protein 4 -0.0266037
MORF4L2 mortality factor 4 like 2 -0.0265703
CUX1 cut-like homeobox 1 -0.0263849
SLC38A2 solute carrier family 38, member 2 -0.0262997
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0262204
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0260615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0260575
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0258663
HMBOX1 homeobox containing 1 -0.0256691
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0254858
TAOK1 TAO kinase 1 -0.025453
IER3 immediate early response 3 -0.0253687
RBM26 RNA binding motif protein 26 -0.0252053
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0251939
TPM4 tropomyosin 4 -0.0250972
ARHGAP32 Rho GTPase activating protein 32 -0.0249533
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0249267
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0247706
SEC31A SEC31 homolog A (S. cerevisiae) -0.0246059
KCNIP4 Kv channel interacting protein 4 -0.0244109
ITPRID2 ITPR interacting domain containing 2 -0.024182
SSH2 slingshot protein phosphatase 2 -0.0241372
PRKCA protein kinase C, alpha -0.0240296
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.023908
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0238464
MBNL1 muscleblind-like splicing regulator 1 -0.023738
TRPS1 trichorhinophalangeal syndrome I -0.0237038
STXBP5 syntaxin binding protein 5 (tomosyn) -0.02347
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0234324