Abiraterone acetate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 0.0349543
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0347565
RNF43 ring finger protein 43 0.0207739
SRRM2 serine/arginine repetitive matrix 2 0.0195727
NRIP1 nuclear receptor interacting protein 1 0.017111
COG6 component of oligomeric golgi complex 6 0.0166223
SAMD4A sterile alpha motif domain containing 4A 0.016421
PDIA3 protein disulfide isomerase family A, member 3 0.015363
SEC24D SEC24 family member D 0.0141863
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0139507
PTEN phosphatase and tensin homolog 0.0136675
NDRG1 N-myc downstream regulated 1 0.01301
HDLBP high density lipoprotein binding protein 0.0128927
SCARB1 scavenger receptor class B, member 1 0.0128685
ZNF451 zinc finger protein 451 0.0128443
AKAP9 A kinase (PRKA) anchor protein 9 0.0126895
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0126536
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0118613
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0112661
GOLGA2 golgin A2 0.0111803
NUCB2 nucleobindin 2 0.0109646
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0108414
USP3 ubiquitin specific peptidase 3 0.0106918
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0106774
SREBF2 sterol regulatory element binding transcription factor 2 0.0106706
HGD homogentisate 1,2-dioxygenase 0.0106392
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0104335
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0104013
TOP2A topoisomerase (DNA) II alpha 170kDa 0.01026
MON2 MON2 homolog (S. cerevisiae) 0.0102049
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.010096
PRRC1 proline-rich coiled-coil 1 0.0100726
USPL1 ubiquitin specific peptidase like 1 0.00995143
EIF4H eukaryotic translation initiation factor 4H 0.00994683
ARRDC3 arrestin domain containing 3 0.00987648
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.009773
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.00967806
FAM114A1 family with sequence similarity 114, member A1 0.00962118
TTC3 tetratricopeptide repeat domain 3 0.00959155
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.00952405
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00943646
MCTP2 multiple C2 domains, transmembrane 2 0.00937296
PGM3 phosphoglucomutase 3 0.00931778
HYOU1 hypoxia up-regulated 1 0.00926687
TMED2 transmembrane emp24 domain trafficking protein 2 0.00925429
TSC22D2 TSC22 domain family, member 2 0.00917231
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.00901782
SERP1 stress-associated endoplasmic reticulum protein 1 0.00896491
RNF149 ring finger protein 149 0.00885637
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.00882978
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.00868915
MINK1 misshapen-like kinase 1 0.00861901
SRP54 signal recognition particle 54kDa 0.00861406
AOPEP aminopeptidase O (putative) 0.0085982
TMEM39A transmembrane protein 39A 0.00855337
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 0.00854554
GOLGA4 golgin A4 0.00852068
CLCN3 chloride channel, voltage-sensitive 3 0.00846083
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00839449
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.00837866
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.00837324
PDIA5 protein disulfide isomerase family A, member 5 0.00825803
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0082331
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00822682
PDIA4 protein disulfide isomerase family A, member 4 0.0080643
SUCO SUN domain containing ossification factor 0.00805264
ERP44 endoplasmic reticulum protein 44 0.00803096
LMAN1 lectin, mannose-binding, 1 0.0080273
RBM26 RNA binding motif protein 26 0.00801397
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00798368
GRAMD2B GRAM domain containing 2B 0.00782453
KIZ kizuna centrosomal protein 0.007649
VEGFA vascular endothelial growth factor A 0.00757252
ELL2 elongation factor, RNA polymerase II, 2 0.00753382
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00748745
FOSL2 FOS-like antigen 2 0.00743958
SEC24C SEC24 family member C 0.00738591
PDZD8 PDZ domain containing 8 0.00732308
YEATS2 YEATS domain containing 2 0.00729524
PREPL prolyl endopeptidase-like 0.00728879
MKRN1 makorin ring finger protein 1 0.00727296
GALK2 galactokinase 2 0.00726486
ZNF841 zinc finger protein 841 0.00718265
EIF4B eukaryotic translation initiation factor 4B 0.00715374
AGR2 anterior gradient 2 0.00714651
LOC112694756 uncharaterized LOC112694756 0.00711075
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00707583
COPA coatomer protein complex, subunit alpha 0.00706265
SPICE1 spindle and centriole associated protein 1 0.00703574
SEC23A Sec23 homolog A (S. cerevisiae) 0.0070281
SEPTIN2 septin 2 0.00701937
DIAPH3 diaphanous-related formin 3 0.00688986
SZT2 seizure threshold 2 homolog (mouse) 0.00688923
CLTC clathrin, heavy chain (Hc) 0.00688632
TSPAN13 tetraspanin 13 0.00687131
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.00685704
NEK6 NIMA-related kinase 6 0.00684257
SEC23B Sec23 homolog B (S. cerevisiae) 0.00683237
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.006832
HELZ helicase with zinc finger 0.00681073

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.159844
TPT1 tumor protein, translationally-controlled 1 -0.159294
B2M beta-2-microglobulin -0.122716
STAT1 signal transducer and activator of transcription 1, 91kDa -0.116605
LCN2 lipocalin 2 -0.110076
RNF213 ring finger protein 213 -0.109667
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.10691
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.090702
PTMA prothymosin, alpha -0.0906906
SP100 SP100 nuclear antigen -0.0874413
XAF1 XIAP associated factor 1 -0.0844034
MX2 MX dynamin-like GTPase 2 -0.0830633
AREG amphiregulin -0.0812798
RIGI RNA sensor RIG-I -0.0811976
IFI6 interferon, alpha-inducible protein 6 -0.0788987
C6ORF132 chromosome 6 open reading frame 132 -0.0777128
STS steroid sulfatase (microsomal), isozyme S -0.0759848
HLA-B major histocompatibility complex, class I, B -0.0736399
RAB7A RAB7A, member RAS oncogene family -0.0730796
EGR1 early growth response 1 -0.0709614
MX1 MX dynamin-like GTPase 1 -0.0692543
LMO7 LIM domain 7 -0.0685531
ERBIN erbb2 interacting protein -0.0683352
GMDS GDP-mannose 4,6-dehydratase -0.0671156
LYZ lysozyme -0.066059
MACC1 metastasis associated in colon cancer 1 -0.0653177
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0644543
ANXA2 annexin A2 -0.0641719
ARHGAP26 Rho GTPase activating protein 26 -0.062142
RABGAP1L RAB GTPase activating protein 1-like -0.0595963
LOC102724023 ES1 protein homolog, mitochondrial -0.0590495
PERP PERP, TP53 apoptosis effector -0.0587298
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0583838
GCLC glutamate-cysteine ligase, catalytic subunit -0.0583114
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0566356
ZMYND8 zinc finger, MYND-type containing 8 -0.0564113
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0544539
EZR ezrin -0.0527584
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.052735
EXT1 exostosin glycosyltransferase 1 -0.0526803
TJP1 tight junction protein 1 -0.0526769
JUN jun proto-oncogene -0.0522578
TM4SF1 transmembrane 4 L six family member 1 -0.0485328
PLSCR1 phospholipid scramblase 1 -0.0474109
AKAP13 A kinase (PRKA) anchor protein 13 -0.0468877
ITGA6 integrin, alpha 6 -0.0467391
TMSB10 thymosin beta 10 -0.0463406
VCL vinculin -0.0459716
SLC38A1 solute carrier family 38, member 1 -0.0455115
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0442014
IFI27 interferon, alpha-inducible protein 27 -0.0441066
TSHZ2 teashirt zinc finger homeobox 2 -0.0437545
PRKCA protein kinase C, alpha -0.0433328
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0422407
RPL7L1 ribosomal protein L7-like 1 -0.0419214
MYO1E myosin IE -0.0416918
FNDC3B fibronectin type III domain containing 3B -0.0414075
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0412955
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0410996
PMP22 peripheral myelin protein 22 -0.0410692
ASPH aspartate beta-hydroxylase -0.0406613
ACTG1 actin gamma 1 -0.0406041
LPP LIM domain containing preferred translocation partner in lipoma -0.0400247
PKM pyruvate kinase, muscle -0.0392603
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0386783
MSI2 musashi RNA-binding protein 2 -0.038492
IFIH1 interferon induced with helicase C domain 1 -0.0382488
TMC5 transmembrane channel-like 5 -0.0381962
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0367355
UBC ubiquitin C -0.0356545
ZNF292 zinc finger protein 292 -0.0356486
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355464
NPSR1 neuropeptide S receptor 1 -0.0354038
MUC20 mucin 20, cell surface associated -0.0351332
KLF6 Kruppel-like factor 6 -0.0347325
SAMD9 sterile alpha motif domain containing 9 -0.0345065
ETV6 ets variant 6 -0.0341921
LAMA4 laminin, alpha 4 -0.0341118
MAP7 microtubule-associated protein 7 -0.0340735
SPATA13 spermatogenesis associated 13 -0.0339355
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0331422
ZNFX1 zinc finger, NFX1-type containing 1 -0.033127
GCC2 GRIP and coiled-coil domain containing 2 -0.033063
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0330067
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0328885
APOL1 apolipoprotein L, 1 -0.0317141
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0315874
EPCAM epithelial cell adhesion molecule -0.0310214
ENO1 enolase 1, (alpha) -0.0308569
NCOA7 nuclear receptor coactivator 7 -0.0307888
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0307221
BCL2L1 BCL2-like 1 -0.0304683
SQSTM1 sequestosome 1 -0.0304198
H1-0 H1.0 linker histone -0.0301935
ABLIM1 actin binding LIM protein 1 -0.0301703
FTL ferritin, light polypeptide -0.0301355
KLF5 Kruppel-like factor 5 (intestinal) -0.0301287
CATSPERB catsper channel auxiliary subunit beta -0.0300691
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0300307
ANKRD10 ankyrin repeat domain 10 -0.0299044