Abiraterone acetate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.104561
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0929332
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0722758
LOC112694756 uncharaterized LOC112694756 0.0683881
EEF2 eukaryotic translation elongation factor 2 0.0661238
EIF4H eukaryotic translation initiation factor 4H 0.0626064
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0535351
DDIT4 DNA-damage-inducible transcript 4 0.0517831
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0476237
MYH9 myosin, heavy chain 9, non-muscle 0.0448269
WDR45B WD repeat domain 45B 0.0444535
FAM117B family with sequence similarity 117, member B 0.0402562
NUP58 nucleoporin 58 0.0402064
VEGFA vascular endothelial growth factor A 0.0395352
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0386018
SRP54 signal recognition particle 54kDa 0.0380993
PRELID2 PRELI domain containing 2 0.0360301
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0351759
RNMT RNA (guanine-7-) methyltransferase 0.0339952
HDLBP high density lipoprotein binding protein 0.0330707
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0325104
GARS1 glycyl-tRNA synthetase 1 0.0315711
UBA6 ubiquitin-like modifier activating enzyme 6 0.0314324
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0314284
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0310524
FDPS farnesyl diphosphate synthase 0.0310124
RPL3 ribosomal protein L3 0.0309811
BRD2 bromodomain containing 2 0.030731
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0305319
SFXN1 sideroflexin 1 0.0303771
GOLGA2 golgin A2 0.0299664
NCOR1 nuclear receptor corepressor 1 0.0298445
TMF1 TATA element modulatory factor 1 0.0297315
SRRM2 serine/arginine repetitive matrix 2 0.0295222
DSPP dentin sialophosphoprotein 0.0293357
FTL ferritin, light polypeptide 0.0287597
YEATS2 YEATS domain containing 2 0.0285764
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0279946
PER1 period circadian clock 1 0.0278852
HILPDA hypoxia inducible lipid droplet-associated 0.0277242
KDM2A lysine (K)-specific demethylase 2A 0.0273587
AKAP9 A kinase (PRKA) anchor protein 9 0.0272345
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0270671
KMT2E lysine (K)-specific methyltransferase 2E 0.0267938
TRA2A transformer 2 alpha homolog (Drosophila) 0.0265926
PHF3 PHD finger protein 3 0.0262221
ARRDC3 arrestin domain containing 3 0.0261204
FOXO3 forkhead box O3 0.0260252
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0258572
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0255265
INSIG2 insulin induced gene 2 0.02548
YBX1 Y box binding protein 1 0.025393
PRRC2A proline-rich coiled-coil 2A 0.0251078
TNRC6A trinucleotide repeat containing 6A 0.025079
SCARB1 scavenger receptor class B, member 1 0.0249867
RAB6A RAB6A, member RAS oncogene family 0.0248297
TTC3 tetratricopeptide repeat domain 3 0.0247857
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0247023
PCM1 pericentriolar material 1 0.0245005
THRAP3 thyroid hormone receptor associated protein 3 0.0243015
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0239496
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0239041
ZNF292 zinc finger protein 292 0.0238631
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0237466
MSMO1 methylsterol monooxygenase 1 0.0235324
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0232359
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0231759
TMEM41B transmembrane protein 41B 0.0229183
PLEC plectin 0.0227945
OLA1 Obg-like ATPase 1 0.0227026
TXNIP thioredoxin interacting protein 0.0226016
TPM3 tropomyosin 3 0.0224129
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0222919
RNF213 ring finger protein 213 0.0220746
HOXB3 homeobox B3 0.0220151
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0219624
HOXB9 homeobox B9 0.0219232
SEC24A SEC24 family member A 0.0218572
SND1 staphylococcal nuclease and tudor domain containing 1 0.021453
MATR3 matrin 3 0.0214261
USP37 ubiquitin specific peptidase 37 0.0211942
MIDEAS mitotic deacetylase associated SANT domain protein 0.0210958
MIMS1 mitochondrial inner membrane scaffold 1 0.021012
BIRC6 baculoviral IAP repeat containing 6 0.0208494
RIOK3 RIO kinase 3 0.0208363
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0206469
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0205439
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0203773
GYS1 glycogen synthase 1 (muscle) 0.0202511
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0201941
SEC24C SEC24 family member C 0.0200807
ARF1 ADP-ribosylation factor 1 0.0200561
TFRC transferrin receptor 0.0200265
MSI2 musashi RNA-binding protein 2 0.0200176
MARK3 MAP/microtubule affinity-regulating kinase 3 0.019476
CCDC186 coiled-coil domain containing 186 0.019228
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.019187
TMED2 transmembrane emp24 domain trafficking protein 2 0.0189823
SREBF1 sterol regulatory element binding transcription factor 1 0.0188644
MED15 mediator complex subunit 15 0.0188071

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.302595
AHNAK AHNAK nucleoprotein -0.175058
PTMA prothymosin, alpha -0.101539
TMSB10 thymosin beta 10 -0.0997107
TPT1 tumor protein, translationally-controlled 1 -0.0888953
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0672082
UBC ubiquitin C -0.0664385
RPS27A ribosomal protein S27a -0.0643489
RPS8 ribosomal protein S8 -0.0594207
RPS6 ribosomal protein S6 -0.0572279
SLC38A2 solute carrier family 38, member 2 -0.0539486
KRT8 keratin 8, type II -0.0538586
MT2A metallothionein 2A -0.0531198
ENO1 enolase 1, (alpha) -0.0521399
S100A10 S100 calcium binding protein A10 -0.0475107
PKM pyruvate kinase, muscle -0.0455597
ASPH aspartate beta-hydroxylase -0.0421116
RPS24 ribosomal protein S24 -0.0415126
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.041024
RPL26 ribosomal protein L26 -0.0365339
SERINC5 serine incorporator 5 -0.0336703
RPL23 ribosomal protein L23 -0.0322432
PATJ PATJ crumbs cell polarity complex component -0.032204
SDC4 syndecan 4 -0.0315503
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0304496
RPL9 ribosomal protein L9 -0.0301425
RPL19 ribosomal protein L19 -0.0300006
RPL31 ribosomal protein L31 -0.0296371
VMP1 vacuole membrane protein 1 -0.0296126
RPLP2 ribosomal protein, large, P2 -0.029248
SPDYA speedy/RINGO cell cycle regulator family member A -0.0288172
RPL12 ribosomal protein L12 -0.0287988
EGFR epidermal growth factor receptor -0.027234
PERP PERP, TP53 apoptosis effector -0.0272262
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0271054
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0268818
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0257634
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0256143
CD2AP CD2-associated protein -0.0253811
RPLP0 ribosomal protein, large, P0 -0.0251789
RPS29 ribosomal protein S29 -0.0248805
RAD21 RAD21 homolog (S. pombe) -0.0248367
RPL5 ribosomal protein L5 -0.0243968
RPS15 ribosomal protein S15 -0.0242653
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0241643
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0236078
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.023039
RPL37A ribosomal protein L37a -0.0229379
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0228934
RPS12 ribosomal protein S12 -0.0228186
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0226293
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0224668
MYO9A myosin IXA -0.0224002
SLC38A1 solute carrier family 38, member 1 -0.0221647
KLF5 Kruppel-like factor 5 (intestinal) -0.0220315
RPL32 ribosomal protein L32 -0.0220016
RPLP1 ribosomal protein, large, P1 -0.0218304
SAMD4A sterile alpha motif domain containing 4A -0.0217234
POTEF POTE ankyrin domain family, member F -0.0217093
RPS21 ribosomal protein S21 -0.0215256
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0214993
EPCAM epithelial cell adhesion molecule -0.0213953
KLF6 Kruppel-like factor 6 -0.0213319
ITPRID2 ITPR interacting domain containing 2 -0.0212556
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.021223
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0211294
ANKRD12 ankyrin repeat domain 12 -0.0211243
RPL28 ribosomal protein L28 -0.0209815
RPL8 ribosomal protein L8 -0.0209155
RPS10 ribosomal protein S10 -0.0206526
RPS25 ribosomal protein S25 -0.0206299
CDCP1 CUB domain containing protein 1 -0.0206162
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0203778
ZFAND3 zinc finger, AN1-type domain 3 -0.0202366
RPL7A ribosomal protein L7a -0.0200028
NUP50 nucleoporin 50kDa -0.0197917
ACTG1 actin gamma 1 -0.0197693
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0195603
RPS11 ribosomal protein S11 -0.0195393
EXOC4 exocyst complex component 4 -0.0195381
RPS23 ribosomal protein S23 -0.0195151
FUS FUS RNA binding protein -0.0194174
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.019332
RPL38 ribosomal protein L38 -0.01909
RBBP6 retinoblastoma binding protein 6 -0.0188978
RPL4 ribosomal protein L4 -0.0187797
JUN jun proto-oncogene -0.0187345
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0187142
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0187002
RPS19 ribosomal protein S19 -0.0186575
TUBA1B tubulin, alpha 1b -0.0186501
RPS27 ribosomal protein S27 -0.0185438
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0185425
MIDN midnolin -0.0184285
RPL37 ribosomal protein L37 -0.0184065
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0183402
WSB1 WD repeat and SOCS box containing 1 -0.0182882
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0180636
RAB10 RAB10, member RAS oncogene family -0.0179398
TOP1 topoisomerase (DNA) I -0.0178458