Abiraterone acetate_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.142546
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0802185
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0560363
MT2A metallothionein 2A 0.0539876
DTNA dystrobrevin, alpha 0.0529057
NAV2 neuron navigator 2 0.0454583
LOC112694756 uncharaterized LOC112694756 0.0451296
ANKRD11 ankyrin repeat domain 11 0.0415178
NDRG1 N-myc downstream regulated 1 0.0394895
RPLP1 ribosomal protein, large, P1 0.0389342
RPL35A ribosomal protein L35a 0.0364155
RPS6 ribosomal protein S6 0.0343778
TMSB10 thymosin beta 10 0.0315943
RPS19 ribosomal protein S19 0.0312808
FTH1 ferritin, heavy polypeptide 1 0.0308907
RASA3 RAS p21 protein activator 3 0.0298639
SDK1 sidekick cell adhesion molecule 1 0.0293271
RPL23 ribosomal protein L23 0.029085
RPL34 ribosomal protein L34 0.0286325
PLEC plectin 0.0285974
RPL12 ribosomal protein L12 0.0279513
RPL37A ribosomal protein L37a 0.0271753
TNS1 tensin 1 0.0268117
GRB10 growth factor receptor-bound protein 10 0.0259788
PRELID2 PRELI domain containing 2 0.025367
CAMTA1 calmodulin binding transcription activator 1 0.0252546
SMTN smoothelin 0.024882
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0244564
HJURP Holliday junction recognition protein 0.0242189
RPL9 ribosomal protein L9 0.0231596
PPARD peroxisome proliferator-activated receptor delta 0.0229082
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224936
COL6A2 collagen, type VI, alpha 2 0.022179
AFF3 AF4/FMR2 family, member 3 0.0215435
DOT1L DOT1-like histone H3K79 methyltransferase 0.0208189
RPS12 ribosomal protein S12 0.0206837
JARID2 jumonji, AT rich interactive domain 2 0.0205787
ARHGAP22 Rho GTPase activating protein 22 0.0202498
IRS2 insulin receptor substrate 2 0.0200276
WDR45B WD repeat domain 45B 0.0199946
RPS8 ribosomal protein S8 0.0199712
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0197371
UBE2O ubiquitin-conjugating enzyme E2O 0.0196133
HSPA8 heat shock 70kDa protein 8 0.0195827
RRM2 ribonucleotide reductase M2 0.0195436
FGFR1 fibroblast growth factor receptor 1 0.0195211
MYO1B myosin IB 0.0194694
RACK1 receptor for activated C kinase 1 0.0190023
UBA6 ubiquitin-like modifier activating enzyme 6 0.018869
YBX1 Y box binding protein 1 0.0187423
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0187298
FLNA filamin A, alpha 0.0186193
HELZ helicase with zinc finger 0.0176309
HLA-C major histocompatibility complex, class I, C 0.0175968
DIAPH2 diaphanous-related formin 2 0.0171343
UGCG UDP-glucose ceramide glucosyltransferase 0.017053
LGALS1 lectin, galactoside-binding, soluble, 1 0.0169813
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0165859
SEPTIN9 septin 9 0.0165258
MIS18BP1 MIS18 binding protein 1 0.0163868
RPL36 ribosomal protein L36 0.0162191
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0160972
WAC WW domain containing adaptor with coiled-coil 0.0160654
RPS17 ribosomal protein S17 0.0160536
RPS20 ribosomal protein S20 0.0160472
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0158804
EFNA5 ephrin-A5 0.015867
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0157309
RPL30 ribosomal protein L30 0.0156366
BACE2 beta-site APP-cleaving enzyme 2 0.0156148
MIDEAS mitotic deacetylase associated SANT domain protein 0.0151727
RPS27 ribosomal protein S27 0.0151714
ZMIZ1 zinc finger, MIZ-type containing 1 0.0151119
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0150579
AMPD3 adenosine monophosphate deaminase 3 0.0149998
RPL3 ribosomal protein L3 0.0149207
RPS3 ribosomal protein S3 0.0147931
RPS4X ribosomal protein S4, X-linked 0.0145965
RPL11 ribosomal protein L11 0.0141609
VEGFA vascular endothelial growth factor A 0.0141585
SRRM2 serine/arginine repetitive matrix 2 0.0139656
RPL27 ribosomal protein L27 0.013955
NUP58 nucleoporin 58 0.0138638
RUNX1 runt-related transcription factor 1 0.0137994
DIAPH3 diaphanous-related formin 3 0.0136647
EEF2 eukaryotic translation elongation factor 2 0.0131419
FOSL1 FOS-like antigen 1 0.0131106
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.013041
FAM13A family with sequence similarity 13, member A 0.0130145
ANGPTL4 angiopoietin-like 4 0.0129655
SHB Src homology 2 domain containing adaptor protein B 0.0129515
FMNL2 formin-like 2 0.0128806
UBA2 ubiquitin-like modifier activating enzyme 2 0.0127824
ESYT2 extended synaptotagmin-like protein 2 0.0126796
CHD1L chromodomain helicase DNA binding protein 1-like 0.012507
FLNB filamin B, beta 0.0125004
G0S2 G0/G1 switch 2 0.0123828
RPL7 ribosomal protein L7 0.0123072
GPATCH2L G patch domain containing 2-like 0.0122031
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0121989

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.293775
FN1 fibronectin 1 -0.289366
CD44 CD44 molecule (Indian blood group) -0.166606
ASPH aspartate beta-hydroxylase -0.13285
EXT1 exostosin glycosyltransferase 1 -0.113644
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.107882
RAI14 retinoic acid induced 14 -0.0972863
DST dystonin -0.0890439
GLIS3 GLIS family zinc finger 3 -0.0863006
HMGA2 high mobility group AT-hook 2 -0.0826173
CANX calnexin -0.0805361
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0802261
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0754453
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0731857
TENM2 teneurin transmembrane protein 2 -0.0710725
ENO1 enolase 1, (alpha) -0.0631653
CCND1 cyclin D1 -0.0610899
TNNC1 troponin C type 1 (slow) -0.0587308
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0575158
CALU calumenin -0.0570718
EGR1 early growth response 1 -0.0565354
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0551273
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0548111
ANKRD28 ankyrin repeat domain 28 -0.0542385
IL1B interleukin 1, beta -0.0540892
PGK1 phosphoglycerate kinase 1 -0.0532204
PDE10A phosphodiesterase 10A -0.0519172
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0513359
TXNIP thioredoxin interacting protein -0.0512672
AHNAK AHNAK nucleoprotein -0.0505788
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0502382
THBS1 thrombospondin 1 -0.0493967
LOX lysyl oxidase -0.0476732
SYAP1 synapse associated protein 1 -0.0459305
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0456061
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0442605
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0433366
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0432553
ZBTB20 zinc finger and BTB domain containing 20 -0.0429349
CDCP1 CUB domain containing protein 1 -0.0429258
VCL vinculin -0.0423608
COL1A1 collagen, type I, alpha 1 -0.0420159
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0412503
INHBA inhibin, beta A -0.040858
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0400572
BPTF bromodomain PHD finger transcription factor -0.0398618
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0388606
IGF2 insulin-like growth factor 2 -0.0385438
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0381798
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0376095
GLG1 golgi glycoprotein 1 -0.0373564
TPM4 tropomyosin 4 -0.0370956
BICD1 bicaudal D homolog 1 (Drosophila) -0.0370213
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0369087
PDIA3 protein disulfide isomerase family A, member 3 -0.0368695
ELL2 elongation factor, RNA polymerase II, 2 -0.0368343
RIN2 Ras and Rab interactor 2 -0.0361906
ZBTB38 zinc finger and BTB domain containing 38 -0.0332503
CALR calreticulin -0.0330106
NAMPT nicotinamide phosphoribosyltransferase -0.0329368
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0328027
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0327998
LDHA lactate dehydrogenase A -0.0323792
VMP1 vacuole membrane protein 1 -0.0323702
PKM pyruvate kinase, muscle -0.0318914
NF1 neurofibromin 1 -0.0316641
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0308275
PTMA prothymosin, alpha -0.0305451
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0304001
MACF1 microtubule-actin crosslinking factor 1 -0.029214
CLIC4 chloride intracellular channel 4 -0.0287031
PTPRG protein tyrosine phosphatase, receptor type, G -0.0286586
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0286375
PDE4D phosphodiesterase 4D, cAMP-specific -0.0284782
ETV6 ets variant 6 -0.0282539
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0272513
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0270118
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0269318
MBD5 methyl-CpG binding domain protein 5 -0.0266517
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0266169
ZMYND8 zinc finger, MYND-type containing 8 -0.025971
USP34 ubiquitin specific peptidase 34 -0.0256926
PTPRK protein tyrosine phosphatase, receptor type, K -0.0255912
TNS3 tensin 3 -0.0253234
CDH13 cadherin 13 -0.0252206
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0251834
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0251574
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0250069
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0249098
MAP1B microtubule-associated protein 1B -0.0249018
TGFBI transforming growth factor, beta-induced, 68kDa -0.0248467
SFTPA2 surfactant protein A2 -0.0246101
OSMR oncostatin M receptor -0.0245925
PCBP3 poly(rC) binding protein 3 -0.0245179
MBNL1 muscleblind-like splicing regulator 1 -0.0245059
TXNRD1 thioredoxin reductase 1 -0.0244882
SLIT2 slit homolog 2 (Drosophila) -0.0244828
TTC3 tetratricopeptide repeat domain 3 -0.0244328
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0243914
KLF12 Kruppel-like factor 12 -0.0242415