| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Abiraterone acetate perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Abiraterone acetate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.11305 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.096097 |
| AFDN | afadin, adherens junction formation factor | 0.0856073 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0791124 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0729444 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.067844 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0638962 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0525333 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0505189 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0504329 |
| VEGFA | vascular endothelial growth factor A | 0.0484214 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0483317 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0479154 |
| RPS12 | ribosomal protein S12 | 0.0466305 |
| A2M | alpha-2-macroglobulin | 0.0464509 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0455627 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0428189 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0413661 |
| RPL3 | ribosomal protein L3 | 0.0400392 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0399398 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0392899 |
| TF | transferrin | 0.0392086 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0376707 |
| DTNA | dystrobrevin, alpha | 0.0375908 |
| WDR45B | WD repeat domain 45B | 0.0374735 |
| RPL37A | ribosomal protein L37a | 0.0349254 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0334021 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0333411 |
| TNS1 | tensin 1 | 0.0318477 |
| INSIG2 | insulin induced gene 2 | 0.0303893 |
| RPS3 | ribosomal protein S3 | 0.0296735 |
| MT2A | metallothionein 2A | 0.0293746 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0292722 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0291075 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0287334 |
| HELZ | helicase with zinc finger | 0.0276169 |
| GSE1 | Gse1 coiled-coil protein | 0.0272675 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0272599 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0271989 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0270566 |
| PLEC | plectin | 0.0269482 |
| PDE8A | phosphodiesterase 8A | 0.0265603 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0265045 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0258374 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0257564 |
| PTK2 | protein tyrosine kinase 2 | 0.025706 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0256183 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0254904 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0252852 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0252753 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0248528 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0246792 |
| CLTB | clathrin, light chain B | 0.0245004 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0243807 |
| NDRG1 | N-myc downstream regulated 1 | 0.0241452 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0237389 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0236561 |
| NUP58 | nucleoporin 58 | 0.0231913 |
| RPL13A | ribosomal protein L13a | 0.023001 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0224318 |
| ZNF292 | zinc finger protein 292 | 0.022244 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.022086 |
| NCKAP1 | NCK-associated protein 1 | 0.0215625 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0215121 |
| RPS6 | ribosomal protein S6 | 0.0214389 |
| FBXO42 | F-box protein 42 | 0.0213765 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0212438 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0211906 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0211514 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0211482 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0211436 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0210509 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0210233 |
| EFNA1 | ephrin-A1 | 0.0209058 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0208102 |
| USP3 | ubiquitin specific peptidase 3 | 0.0207309 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0207233 |
| RACK1 | receptor for activated C kinase 1 | 0.0206817 |
| FN1 | fibronectin 1 | 0.0206536 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0205645 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0205569 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.020548 |
| RPS17 | ribosomal protein S17 | 0.0205006 |
| PCBP2 | poly(rC) binding protein 2 | 0.020403 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0203428 |
| RPL11 | ribosomal protein L11 | 0.0202919 |
| MYO1B | myosin IB | 0.0202562 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0202097 |
| RPL23 | ribosomal protein L23 | 0.0198713 |
| RPL34 | ribosomal protein L34 | 0.0196139 |
| MED13L | mediator complex subunit 13-like | 0.0196125 |
| PCGF5 | polycomb group ring finger 5 | 0.0195176 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.019424 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0193443 |
| CPE | carboxypeptidase E | 0.0193385 |
| ZNF451 | zinc finger protein 451 | 0.0192479 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0192204 |
| APOA1 | apolipoprotein A-I | 0.0191588 |
| YAP1 | Yes-associated protein 1 | 0.019141 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0190013 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.262006 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.185464 |
| EHBP1 | EH domain binding protein 1 | -0.129834 |
| GPC6 | glypican 6 | -0.114813 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0910751 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.089602 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0860189 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0854004 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0849427 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0830004 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0776473 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0698344 |
| ASPH | aspartate beta-hydroxylase | -0.0684094 |
| CP | ceruloplasmin (ferroxidase) | -0.0661968 |
| APOA2 | apolipoprotein A-II | -0.0646908 |
| VCL | vinculin | -0.0640981 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0619122 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0594625 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0542667 |
| FRMD5 | FERM domain containing 5 | -0.05385 |
| RPS24 | ribosomal protein S24 | -0.0513297 |
| PTCHD4 | patched domain containing 4 | -0.046979 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.046142 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0453224 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0451442 |
| RIGI | RNA sensor RIG-I | -0.0443283 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0436581 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0433242 |
| TMSB10 | thymosin beta 10 | -0.0427916 |
| FOXP1 | forkhead box P1 | -0.0425011 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0379265 |
| ITGA1 | integrin, alpha 1 | -0.0378392 |
| ITGAV | integrin, alpha V | -0.0375698 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0375642 |
| MX2 | MX dynamin-like GTPase 2 | -0.0367707 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0365683 |
| EGR1 | early growth response 1 | -0.0363982 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0363488 |
| DST | dystonin | -0.0357807 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0356817 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0348677 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0342877 |
| GPC3 | glypican 3 | -0.0324845 |
| GK | glycerol kinase | -0.0320643 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0320376 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0318383 |
| RNF213 | ring finger protein 213 | -0.0309908 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0307426 |
| PEG3 | paternally expressed 3 | -0.0306476 |
| TPM4 | tropomyosin 4 | -0.0305137 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0286759 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0285525 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0285013 |
| SP100 | SP100 nuclear antigen | -0.0276252 |
| KLF6 | Kruppel-like factor 6 | -0.0273146 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0270981 |
| LAMA4 | laminin, alpha 4 | -0.0265531 |
| CNKSR3 | CNKSR family member 3 | -0.0265188 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0264437 |
| PERP | PERP, TP53 apoptosis effector | -0.0262481 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0257855 |
| BPTF | bromodomain PHD finger transcription factor | -0.0254098 |
| UBC | ubiquitin C | -0.025315 |
| TMEM123 | transmembrane protein 123 | -0.0252914 |
| ZFHX3 | zinc finger homeobox 3 | -0.0251702 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0251334 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0251183 |
| HMGA2 | high mobility group AT-hook 2 | -0.0251086 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0250451 |
| FAM107B | family with sequence similarity 107, member B | -0.0246273 |
| ATP10A | ATPase, class V, type 10A | -0.0246255 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0246159 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0244718 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0242588 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.024169 |
| JUN | jun proto-oncogene | -0.023744 |
| FERMT1 | fermitin family member 1 | -0.0236005 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0234293 |
| SVIL | supervillin | -0.023177 |
| PTMA | prothymosin, alpha | -0.0231593 |
| PLSCR1 | phospholipid scramblase 1 | -0.023097 |
| AHNAK | AHNAK nucleoprotein | -0.0225766 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0222211 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.022166 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0220578 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0219889 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0219041 |
| SYN3 | synapsin III | -0.0218679 |
| RNASET2 | ribonuclease T2 | -0.0218473 |
| NHSL1 | NHS-like 1 | -0.0217745 |
| PRKCA | protein kinase C, alpha | -0.0216449 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0215044 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0213364 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.021166 |
| ACTN4 | actinin, alpha 4 | -0.0208372 |
| KYNU | kynureninase | -0.020815 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0207747 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0204501 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0203128 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0199005 |
