Abiraterone acetate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.265334
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.165415
FLNB filamin B, beta 0.153543
PLEC plectin 0.120446
LOC112694756 uncharaterized LOC112694756 0.114283
TRIO trio Rho guanine nucleotide exchange factor 0.105344
SLC35F3 solute carrier family 35, member F3 0.103157
PODXL podocalyxin-like 0.089298
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0690269
TMSB10 thymosin beta 10 0.0661707
PDLIM5 PDZ and LIM domain 5 0.0655367
KRT6A keratin 6A, type II 0.0653551
HSPG2 heparan sulfate proteoglycan 2 0.0608855
FTH1 ferritin, heavy polypeptide 1 0.0595399
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0582931
FLNA filamin A, alpha 0.0569666
LMO7 LIM domain 7 0.0566066
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0548333
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0519719
PSD3 pleckstrin and Sec7 domain containing 3 0.0514155
ANXA2 annexin A2 0.0514119
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.050435
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0502045
ANO1 anoctamin 1, calcium activated chloride channel 0.0494878
LAMA5 laminin, alpha 5 0.0480871
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0452097
NAV2 neuron navigator 2 0.0442492
MTSS1 metastasis suppressor 1 0.0440213
NDRG1 N-myc downstream regulated 1 0.0424995
LAMC2 laminin, gamma 2 0.0414826
RASAL2 RAS protein activator like 2 0.0413636
ZMIZ1 zinc finger, MIZ-type containing 1 0.0398135
RPL35A ribosomal protein L35a 0.0388063
GRB10 growth factor receptor-bound protein 10 0.0386759
MEGF6 multiple EGF-like-domains 6 0.0382784
ABI3BP ABI family, member 3 (NESH) binding protein 0.0380279
F3 coagulation factor III (thromboplastin, tissue factor) 0.0379962
IGF2 insulin-like growth factor 2 0.0376604
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0370888
NCOR2 nuclear receptor corepressor 2 0.0369638
MPRIP myosin phosphatase Rho interacting protein 0.0362907
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0359425
AHNAK AHNAK nucleoprotein 0.0358311
PRSS23 protease, serine, 23 0.0349919
SRRM2 serine/arginine repetitive matrix 2 0.0347724
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0343379
HLA-C major histocompatibility complex, class I, C 0.0338173
ALCAM activated leukocyte cell adhesion molecule 0.0328313
HDLBP high density lipoprotein binding protein 0.0321722
HLA-E major histocompatibility complex, class I, E 0.0320603
ANKRD11 ankyrin repeat domain 11 0.0315754
CAVIN1 caveolae associated protein 1 0.0314191
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0311127
CALR calreticulin 0.0305176
IGFBP6 insulin-like growth factor binding protein 6 0.0301265
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0293926
RPL34 ribosomal protein L34 0.0288317
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0282943
RACK1 receptor for activated C kinase 1 0.027786
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0274997
SQSTM1 sequestosome 1 0.026894
ITGB4 integrin, beta 4 0.0267893
EFHD2 EF-hand domain family, member D2 0.0266946
RPLP1 ribosomal protein, large, P1 0.0266021
KRT17 keratin 17, type I 0.0265645
CALB1 calbindin 1, 28kDa 0.0263736
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0263299
THBD thrombomodulin 0.0260339
PLS3 plastin 3 0.0259744
AKAP13 A kinase (PRKA) anchor protein 13 0.0253657
RPS3 ribosomal protein S3 0.025324
GUK1 guanylate kinase 1 0.0249098
LDHA lactate dehydrogenase A 0.0246861
RPS19 ribosomal protein S19 0.0246444
EIF4H eukaryotic translation initiation factor 4H 0.0243741
AHNAK2 AHNAK nucleoprotein 2 0.0243472
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.024072
SULF1 sulfatase 1 0.0239936
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0234104
FOSL1 FOS-like antigen 1 0.0234069
HMGA2 high mobility group AT-hook 2 0.0231834
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0227647
ACTG1 actin gamma 1 0.0225135
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0222953
KIAA1671 KIAA1671 0.0216818
RPL37 ribosomal protein L37 0.0216679
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0212331
TNS3 tensin 3 0.0210173
LGALS1 lectin, galactoside-binding, soluble, 1 0.021008
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0208575
EEF2 eukaryotic translation elongation factor 2 0.0207307
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0207175
S100A6 S100 calcium binding protein A6 0.0206175
CD9 CD9 molecule 0.0205818
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0205267
LMNA lamin A/C 0.0204449
PALLD palladin, cytoskeletal associated protein 0.020325
HM13 histocompatibility (minor) 13 0.0201714
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0200402
RCOR1 REST corepressor 1 0.0200195

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125446
CLU clusterin -0.122788
NAMPT nicotinamide phosphoribosyltransferase -0.102494
ASPH aspartate beta-hydroxylase -0.0746589
MBNL1 muscleblind-like splicing regulator 1 -0.0665963
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0656774
KMT2E lysine (K)-specific methyltransferase 2E -0.063847
FOXP1 forkhead box P1 -0.0597824
KIAA1217 KIAA1217 -0.0594719
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0581385
CUL4B cullin 4B -0.0577325
RPS2 ribosomal protein S2 -0.0552376
RBM39 RNA binding motif protein 39 -0.0548363
MSN moesin -0.0539277
MYOF myoferlin -0.0536621
RIN2 Ras and Rab interactor 2 -0.0515155
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.050197
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0483885
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0477057
FNDC3B fibronectin type III domain containing 3B -0.0463941
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0451795
ANLN anillin, actin binding protein -0.04472
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0434063
OSMR oncostatin M receptor -0.0427131
PLAT plasminogen activator, tissue -0.0424408
TXNIP thioredoxin interacting protein -0.0393124
ZNF292 zinc finger protein 292 -0.0371502
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0370855
ANO6 anoctamin 6 -0.0368354
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0365763
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0363157
STAU1 staufen double-stranded RNA binding protein 1 -0.0360751
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0360331
TGM2 transglutaminase 2 -0.0356032
SMAD3 SMAD family member 3 -0.0353204
FOXO1 forkhead box O1 -0.0351628
TPX2 TPX2, microtubule-associated -0.0349941
PRELID2 PRELI domain containing 2 -0.0346502
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0340564
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0338645
PDLIM1 PDZ and LIM domain 1 -0.033476
ARHGAP29 Rho GTPase activating protein 29 -0.032823
DSTN destrin (actin depolymerizing factor) -0.0327708
TOP1 topoisomerase (DNA) I -0.0324351
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0320831
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0319445
VMP1 vacuole membrane protein 1 -0.031941
BCL2L1 BCL2-like 1 -0.0315156
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0313582
YBX3 Y box binding protein 3 -0.031302
KTN1 kinectin 1 (kinesin receptor) -0.0312881
BZW2 basic leucine zipper and W2 domains 2 -0.0312102
YAP1 Yes-associated protein 1 -0.0306423
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0302731
ANKRD12 ankyrin repeat domain 12 -0.0302565
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0302258
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.029828
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0297617
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0296304
CEMIP cell migration inducing protein, hyaluronan binding -0.0291719
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.029103
NCOA3 nuclear receptor coactivator 3 -0.0279612
METTL15 methyltransferase like 15 -0.0274989
XPO1 exportin 1 -0.0274973
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0271742
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0271024
ADAR adenosine deaminase, RNA-specific -0.0268761
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0267818
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.026777
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0267099
KDM6A lysine (K)-specific demethylase 6A -0.0265818
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.026412
PTK2 protein tyrosine kinase 2 -0.0261407
CANX calnexin -0.0260014
COG5 component of oligomeric golgi complex 5 -0.0255686
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0252887
LIFR leukemia inhibitory factor receptor alpha -0.0252148
RB1CC1 RB1-inducible coiled-coil 1 -0.0252058
CKAP5 cytoskeleton associated protein 5 -0.0251781
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0249971
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0248815
JMJD1C jumonji domain containing 1C -0.0248276
DOK5 docking protein 5 -0.0248257
IL6ST interleukin 6 signal transducer -0.0248248
GOLGA4 golgin A4 -0.0241499
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238149
NKTR natural killer cell triggering receptor -0.0236676
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0235126
CENPF centromere protein F, 350/400kDa -0.0232628
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0231932
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0231719
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0231622
NEK7 NIMA-related kinase 7 -0.0230002
LDLR low density lipoprotein receptor -0.0228548
NDE1 nudE neurodevelopment protein 1 -0.0228289
UGCG UDP-glucose ceramide glucosyltransferase -0.0227605
WNK1 WNK lysine deficient protein kinase 1 -0.0227579
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0226905
ANKRD33B ankyrin repeat domain 33B -0.022611
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0225812