Abiraterone acetate_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HLA-C major histocompatibility complex, class I, C 0.0510822
FTH1 ferritin, heavy polypeptide 1 0.0402423
LOC112694756 uncharaterized LOC112694756 0.0204255
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0192379
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0148046
ATP13A3 ATPase type 13A3 0.0140226
TSC22D2 TSC22 domain family, member 2 0.0114271
PRRC2A proline-rich coiled-coil 2A 0.011205
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.00989015
MT2A metallothionein 2A 0.00947412
SCFD2 sec1 family domain containing 2 0.00881157
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00843246
IFI6 interferon, alpha-inducible protein 6 0.00811299
MON2 MON2 homolog (S. cerevisiae) 0.00777496
ANKRD10 ankyrin repeat domain 10 0.00768797
FTL ferritin, light polypeptide 0.00746663
COG6 component of oligomeric golgi complex 6 0.00736327
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.00703425
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.00685144
BTBD10 BTB (POZ) domain containing 10 0.00664247
ODF2 outer dense fiber of sperm tails 2 0.00644513
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.00629945
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00624961
SUCO SUN domain containing ossification factor 0.00616558
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.00603053
NDEL1 nudE neurodevelopment protein 1-like 1 0.00592989
TTC14 tetratricopeptide repeat domain 14 0.00590904
RAB18 RAB18, member RAS oncogene family 0.00582583
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.00567179
GOLGA2 golgin A2 0.00563173
TMEM39A transmembrane protein 39A 0.00561509
ZFC3H1 zinc finger, C3H1-type containing 0.00560944
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.00558804
MT1X metallothionein 1X 0.00534924
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00531335
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.00531334
WDR43 WD repeat domain 43 0.00514218
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.00511782
TMEM41B transmembrane protein 41B 0.00511657
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.005116
HLA-A major histocompatibility complex, class I, A 0.00510844
OSMR oncostatin M receptor 0.00509947
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.00508476
TMED3 transmembrane emp24 protein transport domain containing 3 0.00505958
CPAP centrosome assembly and centriole elongation protein 0.00505565
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00498899
CEP95 centrosomal protein 95kDa 0.00495585
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.00493596
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.00491401
GAK cyclin G associated kinase 0.00490046
C6ORF62 chromosome 6 open reading frame 62 0.0048554
GOLT1B golgi transport 1B 0.00485148
WRN Werner syndrome, RecQ helicase-like 0.00482051
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 0.00477299
GOSR2 golgi SNAP receptor complex member 2 0.00472015
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.00470087
GPR107 G protein-coupled receptor 107 0.00469052
EIF3M eukaryotic translation initiation factor 3, subunit M 0.0046875
GPX4 glutathione peroxidase 4 0.00467251
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00465829
PGM3 phosphoglucomutase 3 0.00462579
MARCHF6 membrane associated ring-CH-type finger 6 0.00461964
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.00460486
PNPLA8 patatin-like phospholipase domain containing 8 0.0045482
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.00453113
NAMPT nicotinamide phosphoribosyltransferase 0.00452189
KIAA0319L KIAA0319-like 0.00450718
B2M beta-2-microglobulin 0.00449977
NUP58 nucleoporin 58 0.00449342
LUZP1 leucine zipper protein 1 0.00445877
AGFG1 ArfGAP with FG repeats 1 0.00444973
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) 0.00442927
SENP5 SUMO1/sentrin specific peptidase 5 0.00441883
SURF4 surfeit 4 0.0044085
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.00438684
SKI SKI proto-oncogene 0.00437684
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.00437357
MAPK8 mitogen-activated protein kinase 8 0.00431829
GCN1 GCN1 activator of EIF2AK4 0.00430723
EIF4H eukaryotic translation initiation factor 4H 0.00430669
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.00426414
NLRP1 NLR family, pyrin domain containing 1 0.0042584
TM9SF2 transmembrane 9 superfamily member 2 0.00424933
BLCAP bladder cancer associated protein 0.00421961
KLHDC10 kelch domain containing 10 0.00421614
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00420216
SERP1 stress-associated endoplasmic reticulum protein 1 0.00419747
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.00419608
EVI5 ecotropic viral integration site 5 0.00417631
CREB1 cAMP responsive element binding protein 1 0.00417263
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00416104
SEC23A Sec23 homolog A (S. cerevisiae) 0.00416054
ZBTB43 zinc finger and BTB domain containing 43 0.00415604
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00413288
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.00407546
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00406566
SRPRA SRP receptor subunit alpha 0.00406002
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.00403905
GPR173 G protein-coupled receptor 173 0.0040345
NUCB2 nucleobindin 2 0.00400437

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.171757
NALF1 NALCN channel auxiliary factor 1 -0.103312
IGFBP3 insulin-like growth factor binding protein 3 -0.0994899
NDRG1 N-myc downstream regulated 1 -0.0871178
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0820767
TRIO trio Rho guanine nucleotide exchange factor -0.0802035
ABI3BP ABI family, member 3 (NESH) binding protein -0.0712279
DLG1 discs, large homolog 1 (Drosophila) -0.0698832
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0695776
AKAP12 A kinase (PRKA) anchor protein 12 -0.0550589
PHACTR1 phosphatase and actin regulator 1 -0.0548405
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0532033
RAI14 retinoic acid induced 14 -0.0466514
ASPH aspartate beta-hydroxylase -0.0458569
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0448154
POTEF POTE ankyrin domain family, member F -0.0421615
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0401963
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0394627
ENO1 enolase 1, (alpha) -0.0387383
DTNA dystrobrevin, alpha -0.0366796
VIM vimentin -0.0357208
DEK DEK proto-oncogene -0.0350516
UGCG UDP-glucose ceramide glucosyltransferase -0.0338719
MARCKS myristoylated alanine-rich protein kinase C substrate -0.033373
NAV2 neuron navigator 2 -0.0313655
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0308846
DST dystonin -0.0306783
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.029848
LDHA lactate dehydrogenase A -0.029525
PKM pyruvate kinase, muscle -0.0294415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0282878
FNDC3B fibronectin type III domain containing 3B -0.0279561
FLNB filamin B, beta -0.027503
CANX calnexin -0.0270578
TPM4 tropomyosin 4 -0.0264819
EXT1 exostosin glycosyltransferase 1 -0.0261456
MAP4 microtubule-associated protein 4 -0.0259725
MAP1B microtubule-associated protein 1B -0.0254636
MMP12 matrix metallopeptidase 12 -0.0254416
ANXA2 annexin A2 -0.0253287
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0251336
F3 coagulation factor III (thromboplastin, tissue factor) -0.0246537
ADM adrenomedullin -0.0244314
SDK1 sidekick cell adhesion molecule 1 -0.0243766
PTMA prothymosin, alpha -0.0240206
TPM1 tropomyosin 1 (alpha) -0.0239632
PGK1 phosphoglycerate kinase 1 -0.0239146
LPP LIM domain containing preferred translocation partner in lipoma -0.0237539
PTK2 protein tyrosine kinase 2 -0.0232015
RPS6 ribosomal protein S6 -0.0226413
JUN jun proto-oncogene -0.0225843
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0224174
LIMCH1 LIM and calponin homology domains 1 -0.0223311
RAB7A RAB7A, member RAS oncogene family -0.0222396
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0219812
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0217617
PLCB4 phospholipase C, beta 4 -0.0217502
CCND1 cyclin D1 -0.0216644
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0214942
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0212954
WSB1 WD repeat and SOCS box containing 1 -0.0211962
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0210788
COL5A1 collagen, type V, alpha 1 -0.0204989
ACTG1 actin gamma 1 -0.0204514
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201647
SBF2 SET binding factor 2 -0.0197295
PODXL podocalyxin-like -0.0197003
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0193427
ERBIN erbb2 interacting protein -0.019047
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0190036
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0189403
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0188546
TPT1 tumor protein, translationally-controlled 1 -0.0188442
SMC4 structural maintenance of chromosomes 4 -0.0185248
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0184304
IGFBP5 insulin-like growth factor binding protein 5 -0.0181204
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0179688
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0179438
PLIN2 perilipin 2 -0.0178689
SLC12A8 solute carrier family 12, member 8 -0.0176735
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0175512
ZMYND8 zinc finger, MYND-type containing 8 -0.0174835
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0174511
TMSB4X thymosin beta 4, X-linked -0.0170991
KPNB1 karyopherin (importin) beta 1 -0.0170537
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0170159
EGFR epidermal growth factor receptor -0.0168767
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0168607
PTPRM protein tyrosine phosphatase, receptor type, M -0.0168594
CCDC80 coiled-coil domain containing 80 -0.0167175
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0165791
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0165311
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0165129
RIGI RNA sensor RIG-I -0.0164738
CCBE1 collagen and calcium binding EGF domains 1 -0.0162774
VEGFA vascular endothelial growth factor A -0.0162567
RND3 Rho family GTPase 3 -0.0162438
RAD51B RAD51 paralog B -0.0162336
NAV1 neuron navigator 1 -0.016132
CUX1 cut-like homeobox 1 -0.0160754