Abiraterone acetate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.0597086
LOC112694756 uncharaterized LOC112694756 0.0535571
SRRM2 serine/arginine repetitive matrix 2 0.0500348
RPL35A ribosomal protein L35a 0.0463802
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.041841
GOLGA4 golgin A4 0.0398942
RPL13A ribosomal protein L13a 0.0393056
EEF2 eukaryotic translation elongation factor 2 0.0376327
RPS6 ribosomal protein S6 0.0351646
ESYT2 extended synaptotagmin-like protein 2 0.0350623
HDLBP high density lipoprotein binding protein 0.0323372
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0315334
RPL3 ribosomal protein L3 0.0313607
EIF4H eukaryotic translation initiation factor 4H 0.0307745
RACK1 receptor for activated C kinase 1 0.029942
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0298852
DDIT4 DNA-damage-inducible transcript 4 0.0298727
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0291256
AKAP9 A kinase (PRKA) anchor protein 9 0.0283168
ASS1 argininosuccinate synthase 1 0.0265291
RAB6A RAB6A, member RAS oncogene family 0.0255358
RPL11 ribosomal protein L11 0.0244409
MLEC malectin 0.0234208
CALB1 calbindin 1, 28kDa 0.022576
SEC31A SEC31 homolog A (S. cerevisiae) 0.0225452
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0222438
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0217412
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0212088
NDRG1 N-myc downstream regulated 1 0.0211182
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0209782
HSPA8 heat shock 70kDa protein 8 0.0208534
GDF15 growth differentiation factor 15 0.0206534
TTC3 tetratricopeptide repeat domain 3 0.0195884
MT2A metallothionein 2A 0.0193541
RPL12 ribosomal protein L12 0.0192621
FTH1 ferritin, heavy polypeptide 1 0.0190882
RPS19 ribosomal protein S19 0.0189424
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0188255
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0187886
RPL34 ribosomal protein L34 0.018525
RPS14 ribosomal protein S14 0.0184268
MORF4L2 mortality factor 4 like 2 0.0183615
CLINT1 clathrin interactor 1 0.0176721
TMF1 TATA element modulatory factor 1 0.0173488
DNM2 dynamin 2 0.0172495
DGKD diacylglycerol kinase, delta 130kDa 0.0170376
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0170213
NCOR2 nuclear receptor corepressor 2 0.0169273
PABPC1 poly(A) binding protein, cytoplasmic 1 0.016874
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0168737
SRP54 signal recognition particle 54kDa 0.016865
HLA-C major histocompatibility complex, class I, C 0.0168393
S100A14 S100 calcium binding protein A14 0.0166701
RPS20 ribosomal protein S20 0.0165627
PLAC8 placenta-specific 8 0.0164915
TMED2 transmembrane emp24 domain trafficking protein 2 0.0162965
MON2 MON2 homolog (S. cerevisiae) 0.0162108
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0157875
RPLP1 ribosomal protein, large, P1 0.0157856
RPL37 ribosomal protein L37 0.0156658
ENO2 enolase 2 (gamma, neuronal) 0.0156065
RPL29 ribosomal protein L29 0.0154936
VEGFA vascular endothelial growth factor A 0.0153696
TRA2A transformer 2 alpha homolog (Drosophila) 0.0152172
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.015198
RPS2 ribosomal protein S2 0.0151793
TMSB10 thymosin beta 10 0.0150068
FTL ferritin, light polypeptide 0.0149682
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0149411
RPS3 ribosomal protein S3 0.0149349
FXR1 fragile X mental retardation, autosomal homolog 1 0.0147907
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0147138
LMNA lamin A/C 0.0146226
ARRDC3 arrestin domain containing 3 0.0145832
KIF5B kinesin family member 5B 0.0145218
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0144126
RPL27A ribosomal protein L27a 0.0142946
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.014278
RPL27 ribosomal protein L27 0.0142727
SEC24A SEC24 family member A 0.0142613
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0142491
DYNC2I1 dynein 2 intermediate chain 1 0.0141977
AFDN afadin, adherens junction formation factor 0.0138249
GOLGA2 golgin A2 0.0135591
PYGB phosphorylase, glycogen; brain 0.0135069
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0134229
JMY junction mediating and regulatory protein, p53 cofactor 0.0134196
RPL36 ribosomal protein L36 0.0134174
MXI1 MAX interactor 1, dimerization protein 0.0133476
TMEM165 transmembrane protein 165 0.0127881
BRD2 bromodomain containing 2 0.0127473
YBX1 Y box binding protein 1 0.012712
LRRC1 leucine rich repeat containing 1 0.0124545
SREBF2 sterol regulatory element binding transcription factor 2 0.0123436
SAFB2 scaffold attachment factor B2 0.0122296
MSI2 musashi RNA-binding protein 2 0.0121159
HMGA1 high mobility group AT-hook 1 0.011953
MPRIP myosin phosphatase Rho interacting protein 0.0119418
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0117889
SFXN1 sideroflexin 1 0.0116182

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.134082
PDE4D phosphodiesterase 4D, cAMP-specific -0.126056
LMO7 LIM domain 7 -0.124734
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116309
UBC ubiquitin C -0.102575
RPS27A ribosomal protein S27a -0.0974244
MYO1E myosin IE -0.0943537
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0858964
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0675245
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0663278
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0651876
PTPRG protein tyrosine phosphatase, receptor type, G -0.0626635
TPT1 tumor protein, translationally-controlled 1 -0.0594402
RIMKLB ribosomal modification protein rimK-like family member B -0.056859
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0567785
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0563802
FOXO1 forkhead box O1 -0.0517468
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.050928
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0506971
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0504245
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0503011
AKAP13 A kinase (PRKA) anchor protein 13 -0.048167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0473671
PTMA prothymosin, alpha -0.046655
CCSER1 coiled-coil serine-rich protein 1 -0.0454816
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0445299
RIGI RNA sensor RIG-I -0.0443734
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0430654
PTPRK protein tyrosine phosphatase, receptor type, K -0.0430106
PRSS3 protease, serine, 3 -0.0430022
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0426889
ITPRID2 ITPR interacting domain containing 2 -0.0425241
PKP2 plakophilin 2 -0.0416955
KRT8 keratin 8, type II -0.04158
SERINC5 serine incorporator 5 -0.0412956
FOXP1 forkhead box P1 -0.0409646
MX1 MX dynamin-like GTPase 1 -0.0401858
PCBP2 poly(rC) binding protein 2 -0.0392816
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0391686
MUC13 mucin 13, cell surface associated -0.0387553
ITGA6 integrin, alpha 6 -0.0380005
SP100 SP100 nuclear antigen -0.0374257
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0368696
SMYD3 SET and MYND domain containing 3 -0.036354
PARD3B par-3 family cell polarity regulator beta -0.0353462
LPP LIM domain containing preferred translocation partner in lipoma -0.0347097
ASPH aspartate beta-hydroxylase -0.034616
SLC38A2 solute carrier family 38, member 2 -0.034557
SFPQ splicing factor proline/glutamine-rich -0.0339692
RAP1B RAP1B, member of RAS oncogene family -0.0338381
PKM pyruvate kinase, muscle -0.0333071
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.032979
RPS24 ribosomal protein S24 -0.0329261
RPLP2 ribosomal protein, large, P2 -0.0328569
TCF12 transcription factor 12 -0.0328309
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.032776
UBE2H ubiquitin-conjugating enzyme E2H -0.0326858
EREG epiregulin -0.0323357
SPON1 spondin 1, extracellular matrix protein -0.0321463
VCL vinculin -0.0321363
DSG3 desmoglein 3 -0.0319029
ETV6 ets variant 6 -0.0317548
RNF213 ring finger protein 213 -0.0312913
AHCYL2 adenosylhomocysteinase-like 2 -0.0312482
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0310928
HLA-B major histocompatibility complex, class I, B -0.0308538
DOCK5 dedicator of cytokinesis 5 -0.0306009
RPS23 ribosomal protein S23 -0.0304742
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0303184
RABGAP1L RAB GTPase activating protein 1-like -0.0302528
FRMD5 FERM domain containing 5 -0.0301721
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0298643
AREG amphiregulin -0.0295374
ATXN1 ataxin 1 -0.0295018
AHNAK AHNAK nucleoprotein -0.0294488
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0293085
MX2 MX dynamin-like GTPase 2 -0.0292204
NCOA7 nuclear receptor coactivator 7 -0.0290964
PTPRR protein tyrosine phosphatase, receptor type, R -0.0289118
FBXO11 F-box protein 11 -0.0286116
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0283984
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0283843
RPL4 ribosomal protein L4 -0.0279781
TSPAN8 tetraspanin 8 -0.0277522
WARS1 tryptophanyl-tRNA synthetase 1 -0.027673
EXT1 exostosin glycosyltransferase 1 -0.0275054
ARL15 ADP-ribosylation factor-like 15 -0.0273658
MYO1D myosin ID -0.0269995
WWC1 WW and C2 domain containing 1 -0.0268905
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0265883
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0265583
ABHD17C abhydrolase domain containing 17C -0.02631
TNRC18 trinucleotide repeat containing 18 -0.0262343
FER fer (fps/fes related) tyrosine kinase -0.0262114
VMP1 vacuole membrane protein 1 -0.0261277
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0260117
FAF1 Fas (TNFRSF6) associated factor 1 -0.0259028
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0257389
TRIM2 tripartite motif containing 2 -0.0255483
EGFR epidermal growth factor receptor -0.0250802