Abiraterone acetate_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.160004
NDRG1 N-myc downstream regulated 1 0.0920832
GRB10 growth factor receptor-bound protein 10 0.0880642
FN1 fibronectin 1 0.0831652
MEF2A myocyte enhancer factor 2A 0.0788701
PCBP2 poly(rC) binding protein 2 0.0774712
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0696276
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0638866
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0588569
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0568962
FAM13A family with sequence similarity 13, member A 0.0540023
AKAP12 A kinase (PRKA) anchor protein 12 0.0535268
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520565
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0505809
UBA6 ubiquitin-like modifier activating enzyme 6 0.0503814
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.045369
RUNX2 runt-related transcription factor 2 0.0447402
TRIO trio Rho guanine nucleotide exchange factor 0.0427581
PIAS2 protein inhibitor of activated STAT, 2 0.0425237
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0423832
HMGA2 high mobility group AT-hook 2 0.0386859
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0386176
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0385413
FTH1 ferritin, heavy polypeptide 1 0.0376458
PSD3 pleckstrin and Sec7 domain containing 3 0.0371152
JARID2 jumonji, AT rich interactive domain 2 0.0364379
VEGFA vascular endothelial growth factor A 0.0360679
SDK1 sidekick cell adhesion molecule 1 0.035334
PDIA3 protein disulfide isomerase family A, member 3 0.0347563
CD109 CD109 molecule 0.0333228
EIF4H eukaryotic translation initiation factor 4H 0.0330727
ATP13A3 ATPase type 13A3 0.0327795
ZEB2 zinc finger E-box binding homeobox 2 0.0325225
MRPS6 mitochondrial ribosomal protein S6 0.031774
MYO1B myosin IB 0.0317426
NUP58 nucleoporin 58 0.0313362
SIK3 SIK family kinase 3 0.0312605
FLNB filamin B, beta 0.0308698
MYH9 myosin, heavy chain 9, non-muscle 0.0307907
SRRM2 serine/arginine repetitive matrix 2 0.0305581
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0300956
SETD5 SET domain containing 5 0.0296695
COPA coatomer protein complex, subunit alpha 0.0296654
SRP54 signal recognition particle 54kDa 0.0293857
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0288098
HILPDA hypoxia inducible lipid droplet-associated 0.0283509
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0280004
MIDEAS mitotic deacetylase associated SANT domain protein 0.0274105
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0271446
ARRDC3 arrestin domain containing 3 0.0271018
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.026641
GOLGA4 golgin A4 0.0265978
RPL3 ribosomal protein L3 0.0265074
KMT2C lysine (K)-specific methyltransferase 2C 0.0263821
NCOR2 nuclear receptor corepressor 2 0.0262882
OPTN optineurin 0.0261815
RAB8B RAB8B, member RAS oncogene family 0.0255089
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0248495
NGLY1 N-glycanase 1 0.0241991
SNX9 sorting nexin 9 0.0241754
CABIN1 calcineurin binding protein 1 0.0241045
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0237599
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0235922
LOC112694756 uncharaterized LOC112694756 0.0228108
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0224599
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0224524
NPAS2 neuronal PAS domain protein 2 0.022148
WAC WW domain containing adaptor with coiled-coil 0.0221475
SEC23A Sec23 homolog A (S. cerevisiae) 0.0220458
ZMIZ1 zinc finger, MIZ-type containing 1 0.0219386
CDC73 cell division cycle 73 0.021855
HELZ helicase with zinc finger 0.0217969
EGFR epidermal growth factor receptor 0.0215264
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0213564
KTN1 kinectin 1 (kinesin receptor) 0.0213526
PGM3 phosphoglucomutase 3 0.0211629
ZNF292 zinc finger protein 292 0.0211474
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0210559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.020953
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0207368
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0207124
KCMF1 potassium channel modulatory factor 1 0.0207111
TFG TRK-fused gene 0.0205944
EEF2 eukaryotic translation elongation factor 2 0.0205639
FNDC3B fibronectin type III domain containing 3B 0.0204077
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0200807
APLP2 amyloid beta (A4) precursor-like protein 2 0.0198832
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0195005
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.019031
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0190299
JMJD1C jumonji domain containing 1C 0.0188016
HYOU1 hypoxia up-regulated 1 0.0187437
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.018733
RNF145 ring finger protein 145 0.0186526
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0186448
OXSR1 oxidative stress responsive 1 0.0184476
DTNA dystrobrevin, alpha 0.0184299
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0182495
NFE2L1 nuclear factor, erythroid 2-like 1 0.0180773
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0180235

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.344761
VIM vimentin -0.184317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.138291
TMSB10 thymosin beta 10 -0.109802
FTL ferritin, light polypeptide -0.0973167
MT2A metallothionein 2A -0.0958045
RPLP1 ribosomal protein, large, P1 -0.0886021
NAMPT nicotinamide phosphoribosyltransferase -0.0855651
IER3 immediate early response 3 -0.0825175
TPT1 tumor protein, translationally-controlled 1 -0.0709966
PDE4D phosphodiesterase 4D, cAMP-specific -0.0644271
RPS24 ribosomal protein S24 -0.0639461
RPL32 ribosomal protein L32 -0.0612375
RPS19 ribosomal protein S19 -0.0598454
PTMA prothymosin, alpha -0.0579789
SLC38A1 solute carrier family 38, member 1 -0.0576298
EIF1 eukaryotic translation initiation factor 1 -0.0570483
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0537516
RPLP2 ribosomal protein, large, P2 -0.050848
NCOA7 nuclear receptor coactivator 7 -0.0507754
RPS29 ribosomal protein S29 -0.0501948
RPL23 ribosomal protein L23 -0.048853
CD44 CD44 molecule (Indian blood group) -0.0486823
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0485516
RPS21 ribosomal protein S21 -0.047848
RPLP0 ribosomal protein, large, P0 -0.0478433
C15ORF48 chromosome 15 open reading frame 48 -0.0478055
RPL34 ribosomal protein L34 -0.0476683
RPS8 ribosomal protein S8 -0.0476549
SOD2 superoxide dismutase 2, mitochondrial -0.0455326
RPL35A ribosomal protein L35a -0.044923
RPL19 ribosomal protein L19 -0.0433015
KDM3A lysine (K)-specific demethylase 3A -0.040898
RPL11 ribosomal protein L11 -0.0405289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.040325
RPS16 ribosomal protein S16 -0.0398541
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0395107
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0393271
ZBTB20 zinc finger and BTB domain containing 20 -0.0392475
RPL12 ribosomal protein L12 -0.0392445
RPS6 ribosomal protein S6 -0.0384787
NAP1L1 nucleosome assembly protein 1-like 1 -0.0380984
CCNI cyclin I -0.0376254
S100A10 S100 calcium binding protein A10 -0.0369843
RPS5 ribosomal protein S5 -0.0365853
TMSB4X thymosin beta 4, X-linked -0.0363474
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0363144
RPS23 ribosomal protein S23 -0.0357384
RPL37A ribosomal protein L37a -0.0351687
RPS13 ribosomal protein S13 -0.0349769
OSMR oncostatin M receptor -0.0345059
RPS25 ribosomal protein S25 -0.0343312
RPL7A ribosomal protein L7a -0.0335577
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0335413
TFPI2 tissue factor pathway inhibitor 2 -0.0333236
USP34 ubiquitin specific peptidase 34 -0.032878
SRGN serglycin -0.0325066
RPS11 ribosomal protein S11 -0.0323534
VDAC1 voltage-dependent anion channel 1 -0.0319854
RPL31 ribosomal protein L31 -0.031917
RPL36 ribosomal protein L36 -0.0311363
RPL38 ribosomal protein L38 -0.0305666
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0304799
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0299788
YBX3 Y box binding protein 3 -0.0295775
EFNA5 ephrin-A5 -0.0295004
BPTF bromodomain PHD finger transcription factor -0.0293029
RPL28 ribosomal protein L28 -0.0292916
BASP1 brain abundant, membrane attached signal protein 1 -0.0289266
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0289001
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0274437
RPL4 ribosomal protein L4 -0.0270443
TBC1D5 TBC1 domain family, member 5 -0.026886
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0264899
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0262721
RPL27A ribosomal protein L27a -0.0260071
TM4SF1 transmembrane 4 L six family member 1 -0.025868
RPL30 ribosomal protein L30 -0.0258237
RPS12 ribosomal protein S12 -0.0256149
RHOBTB3 Rho-related BTB domain containing 3 -0.0254444
MYO9A myosin IXA -0.0254077
ARHGAP5 Rho GTPase activating protein 5 -0.0253978
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0253832
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.025346
GPHN gephyrin -0.0251232
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0246247
RPL5 ribosomal protein L5 -0.0245406
UBC ubiquitin C -0.0245232
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241158
RPL37 ribosomal protein L37 -0.0239165
MBD5 methyl-CpG binding domain protein 5 -0.023902
RPS15 ribosomal protein S15 -0.0238274
GNAS GNAS complex locus -0.0236595
GCC2 GRIP and coiled-coil domain containing 2 -0.0235444
SMAD3 SMAD family member 3 -0.023439
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0233939
KYNU kynureninase -0.0231575
ANKRD28 ankyrin repeat domain 28 -0.0229379
SP100 SP100 nuclear antigen -0.0228668
FNBP1 formin binding protein 1 -0.0228334