Abiraterone acetate_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0898995
FTH1 ferritin, heavy polypeptide 1 0.0611343
LAMB3 laminin, beta 3 0.056289
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.054329
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0531609
NFE2L2 nuclear factor, erythroid 2-like 2 0.0520945
DST dystonin 0.0505594
DICER1 dicer 1, ribonuclease type III 0.0492592
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0483262
TXNRD1 thioredoxin reductase 1 0.0470572
JMJD1C jumonji domain containing 1C 0.0454913
PDE4D phosphodiesterase 4D, cAMP-specific 0.0437479
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0436732
DIAPH1 diaphanous-related formin 1 0.0431246
FLNB filamin B, beta 0.0430926
SFTPA2 surfactant protein A2 0.0428478
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0424065
IGF1R insulin-like growth factor 1 receptor 0.0422946
GLS2 glutaminase 2 (liver, mitochondrial) 0.041817
USP15 ubiquitin specific peptidase 15 0.0410098
NAMPT nicotinamide phosphoribosyltransferase 0.0408419
LAMA4 laminin, alpha 4 0.0407188
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0406462
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0397983
STK24 serine/threonine kinase 24 0.0378103
UGCG UDP-glucose ceramide glucosyltransferase 0.0377098
PELI1 pellino E3 ubiquitin protein ligase 1 0.0371644
KRT17 keratin 17, type I 0.0371278
FN1 fibronectin 1 0.0370272
LAMC2 laminin, gamma 2 0.0369495
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0360183
KMT2C lysine (K)-specific methyltransferase 2C 0.035927
VEZT vezatin, adherens junctions transmembrane protein 0.0358402
ZFHX3 zinc finger homeobox 3 0.0358019
SMAD3 SMAD family member 3 0.0357306
MACF1 microtubule-actin crosslinking factor 1 0.0356064
KLF6 Kruppel-like factor 6 0.0353952
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0347703
OGA O-GlcNAcase 0.0347361
FMN1 formin 1 0.0344956
DSPP dentin sialophosphoprotein 0.0341865
IGFBP3 insulin-like growth factor binding protein 3 0.034159
LASP1 LIM and SH3 protein 1 0.0341292
ZNF644 zinc finger protein 644 0.0340605
PARD3 par-3 family cell polarity regulator 0.0338459
BACE2 beta-site APP-cleaving enzyme 2 0.0337312
CSDE1 cold shock domain containing E1, RNA-binding 0.0336249
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0333891
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0331661
ANKRD12 ankyrin repeat domain 12 0.0330659
CUL4B cullin 4B 0.0330173
STC2 stanniocalcin 2 0.0328447
FLNA filamin A, alpha 0.0325895
UBXN4 UBX domain protein 4 0.0323981
ATXN1 ataxin 1 0.0320614
RIOK3 RIO kinase 3 0.0320514
USP34 ubiquitin specific peptidase 34 0.0316849
GCC2 GRIP and coiled-coil domain containing 2 0.0316429
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0312375
NRIP1 nuclear receptor interacting protein 1 0.0312286
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0311796
DTNA dystrobrevin, alpha 0.0311266
PNISR PNN-interacting serine/arginine-rich protein 0.0309836
GLIS3 GLIS family zinc finger 3 0.0309728
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0307623
PABPC1 poly(A) binding protein, cytoplasmic 1 0.030607
CLTC clathrin, heavy chain (Hc) 0.0304235
HLA-C major histocompatibility complex, class I, C 0.030248
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0302408
EWSR1 EWS RNA-binding protein 1 0.0298941
NFIA nuclear factor I/A 0.0296104
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0293904
DOCK4 dedicator of cytokinesis 4 0.0293491
UBAP2L ubiquitin associated protein 2-like 0.0291622
IGF2 insulin-like growth factor 2 0.0291395
BTBD9 BTB (POZ) domain containing 9 0.0289256
SOS1 son of sevenless homolog 1 (Drosophila) 0.028871
RBM6 RNA binding motif protein 6 0.0287086
NEK7 NIMA-related kinase 7 0.0286294
MYH9 myosin, heavy chain 9, non-muscle 0.0283887
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0283573
RBM33 RNA binding motif protein 33 0.0283503
NT5C2 5'-nucleotidase, cytosolic II 0.0281973
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0280705
CARD16 caspase recruitment domain family, member 16 0.0276601
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0275993
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0274127
VEGFA vascular endothelial growth factor A 0.0273407
NDRG1 N-myc downstream regulated 1 0.0272654
ACTN4 actinin, alpha 4 0.0271304
HOOK2 hook microtubule-tethering protein 2 0.027106
NAP1L1 nucleosome assembly protein 1-like 1 0.0270281
EIF3H eukaryotic translation initiation factor 3, subunit H 0.026993
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0269066
LCOR ligand dependent nuclear receptor corepressor 0.0269035
EZR ezrin 0.0264528
ANKRD10 ankyrin repeat domain 10 0.026248
ADAM10 ADAM metallopeptidase domain 10 0.0260723
GSK3B glycogen synthase kinase 3 beta 0.0256317
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0254937

decreased expression

Symbol Name Standardized Value
SPAG9 sperm associated antigen 9 -0.0789403
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0692633
IFIH1 interferon induced with helicase C domain 1 -0.064695
MYO1E myosin IE -0.0598512
FNDC3A fibronectin type III domain containing 3A -0.0580163
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0570894
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0539488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0526632
STK17A serine/threonine kinase 17a -0.052633
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0506914
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0504999
OASL 2'-5'-oligoadenylate synthetase-like -0.0500612
WSB1 WD repeat and SOCS box containing 1 -0.049873
SLTM SAFB-like, transcription modulator -0.0488371
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.046428
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0434555
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0427992
PAPOLA poly(A) polymerase alpha -0.0422236
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0402888
GOLGA4 golgin A4 -0.0393014
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0392932
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0390591
FUBP1 far upstream element (FUSE) binding protein 1 -0.0389424
RAD51B RAD51 paralog B -0.0382018
SYT1 synaptotagmin I -0.0377088
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0371509
FAT1 FAT atypical cadherin 1 -0.0365557
RIGI RNA sensor RIG-I -0.036393
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0361985
PCBP3 poly(rC) binding protein 3 -0.0359304
SLC38A1 solute carrier family 38, member 1 -0.0357259
RBM25 RNA binding motif protein 25 -0.0353801
TRIO trio Rho guanine nucleotide exchange factor -0.0352749
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0351821
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.0349156
SMYD3 SET and MYND domain containing 3 -0.0346428
PTK2 protein tyrosine kinase 2 -0.0342536
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0341053
RFX7 regulatory factor X, 7 -0.0337288
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0334726
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0334127
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0329423
AFF1 AF4/FMR2 family, member 1 -0.0328826
RPL26 ribosomal protein L26 -0.0325914
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0318453
THSD4 thrombospondin, type I, domain containing 4 -0.0318216
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.0316174
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.0315648
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0313645
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0309013
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0307629
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303982
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0300729
FAM13A family with sequence similarity 13, member A -0.0300691
DSCAM Down syndrome cell adhesion molecule -0.029875
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0293606
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0292629
KDM5C lysine (K)-specific demethylase 5C -0.0292361
JAK1 Janus kinase 1 -0.0290013
ARHGAP5 Rho GTPase activating protein 5 -0.0289196
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0286311
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0284158
NBAS neuroblastoma amplified sequence -0.0283825
ASPH aspartate beta-hydroxylase -0.0282159
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0281727
SMG7 SMG7 nonsense mediated mRNA decay factor -0.028169
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0279111
NF1 neurofibromin 1 -0.0277314
LMO7 LIM domain 7 -0.0276613
SUB1 SUB1 homolog (S. cerevisiae) -0.0274275
RHOA ras homolog family member A -0.0273114
ZC3H13 zinc finger CCCH-type containing 13 -0.0272795
RORA RAR-related orphan receptor A -0.0272364
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0271916
DENND4A DENN/MADD domain containing 4A -0.0271881
EEF2 eukaryotic translation elongation factor 2 -0.027128
HMBOX1 homeobox containing 1 -0.0268932
PTPRD protein tyrosine phosphatase, receptor type, D -0.0268589
KDM2A lysine (K)-specific demethylase 2A -0.0267955
SOX4 SRY (sex determining region Y)-box 4 -0.0267815
PDE10A phosphodiesterase 10A -0.0265678
NKD1 naked cuticle homolog 1 (Drosophila) -0.02642
ACVR1 activin A receptor, type I -0.0263683
EGFR epidermal growth factor receptor -0.0263362
CNKSR3 CNKSR family member 3 -0.0263097
KMT2E lysine (K)-specific methyltransferase 2E -0.0263001
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.025976
MEF2A myocyte enhancer factor 2A -0.0259318
NRG1 neuregulin 1 -0.0258566
COPA coatomer protein complex, subunit alpha -0.025293
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0252622
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0252369
MAML3 mastermind-like 3 (Drosophila) -0.0251966
WWOX WW domain containing oxidoreductase -0.0249787
LMNA lamin A/C -0.0247219
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0246675
FTO fat mass and obesity associated -0.0246482
BASP1 brain abundant, membrane attached signal protein 1 -0.024577
AHR aryl hydrocarbon receptor -0.0244369
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0243977