Abiraterone acetate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.103071
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0912273
IGFBP3 insulin-like growth factor binding protein 3 0.0679577
NDRG1 N-myc downstream regulated 1 0.0653613
GRB10 growth factor receptor-bound protein 10 0.0605781
ACTG1 actin gamma 1 0.0558113
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0442897
RPL35A ribosomal protein L35a 0.0388525
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0385204
FTL ferritin, light polypeptide 0.0383347
FN1 fibronectin 1 0.0375194
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.037013
FOSL1 FOS-like antigen 1 0.0358041
PLEC plectin 0.035598
FAM13A family with sequence similarity 13, member A 0.0344885
LOC112694756 uncharaterized LOC112694756 0.0324196
VEGFA vascular endothelial growth factor A 0.0315869
HLA-C major histocompatibility complex, class I, C 0.0294012
FTH1 ferritin, heavy polypeptide 1 0.0292285
FXR1 fragile X mental retardation, autosomal homolog 1 0.0283793
SSBP2 single-stranded DNA binding protein 2 0.0277227
ISG15 ISG15 ubiquitin-like modifier 0.0269846
UBA6 ubiquitin-like modifier activating enzyme 6 0.0268462
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0227961
KMT2E lysine (K)-specific methyltransferase 2E 0.0222816
IRF6 interferon regulatory factor 6 0.0222446
USP3 ubiquitin specific peptidase 3 0.0206
HILPDA hypoxia inducible lipid droplet-associated 0.0205317
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0204604
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0203944
FAM162A family with sequence similarity 162, member A 0.0203001
HSPA8 heat shock 70kDa protein 8 0.0201223
EIF4H eukaryotic translation initiation factor 4H 0.0197609
ENO2 enolase 2 (gamma, neuronal) 0.0195545
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0192603
LAMB3 laminin, beta 3 0.0191297
RNF145 ring finger protein 145 0.0185694
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0180542
MSI2 musashi RNA-binding protein 2 0.0176396
AHDC1 AT hook, DNA binding motif, containing 1 0.0169152
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0168794
CSTB cystatin B (stefin B) 0.0162422
NUP58 nucleoporin 58 0.0161168
FAM168A family with sequence similarity 168, member A 0.0154729
TFG TRK-fused gene 0.0153324
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0151625
BHLHE40 basic helix-loop-helix family, member e40 0.0148205
ZMIZ1 zinc finger, MIZ-type containing 1 0.0147232
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0146011
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0141964
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0141636
FLNC filamin C, gamma 0.0140739
TRA2B transformer 2 beta homolog (Drosophila) 0.0138475
MXD1 MAX dimerization protein 1 0.013681
TPI1 triosephosphate isomerase 1 0.0136678
KDM5B lysine (K)-specific demethylase 5B 0.0136146
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.013222
FERMT2 fermitin family member 2 0.012517
CDC73 cell division cycle 73 0.0120967
FNBP1L formin binding protein 1-like 0.0119005
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0118398
F3 coagulation factor III (thromboplastin, tissue factor) 0.0118143
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 0.0117167
ATG3 autophagy related 3 0.0116181
RSRC2 arginine/serine-rich coiled-coil 2 0.0115758
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0115046
MXI1 MAX interactor 1, dimerization protein 0.0114327
CNN3 calponin 3, acidic 0.0112993
RPL29 ribosomal protein L29 0.0106983
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.0106482
COL6A1 collagen, type VI, alpha 1 0.0106151
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0106028
RNF213 ring finger protein 213 0.0105413
PER1 period circadian clock 1 0.0105325
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.010455
EGR1 early growth response 1 0.0103837
MRPS6 mitochondrial ribosomal protein S6 0.0102599
QKI QKI, KH domain containing, RNA binding 0.0100566
RIOK3 RIO kinase 3 0.0099539
SEC23A Sec23 homolog A (S. cerevisiae) 0.00976459
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00975152
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.00973076
MTMR3 myotubularin related protein 3 0.00967663
IFITM3 interferon induced transmembrane protein 3 0.00966977
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.00947993
RIPK4 receptor-interacting serine-threonine kinase 4 0.00944672
CIB1 calcium and integrin binding 1 (calmyrin) 0.00933178
PROSER2 proline and serine rich 2 0.00921031
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00913182
ELL elongation factor RNA polymerase II 0.00905263
OSBPL9 oxysterol binding protein-like 9 0.00891247
DSTN destrin (actin depolymerizing factor) 0.0088961
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.00888595
OAZ1 ornithine decarboxylase antizyme 1 0.00885407
CSRP2 cysteine and glycine-rich protein 2 0.00882489
ANXA5 annexin A5 0.00868996
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.00865532
GARS1 glycyl-tRNA synthetase 1 0.00865279
ARRDC3 arrestin domain containing 3 0.0086516
RPS20 ribosomal protein S20 0.00862844

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.226352
UBC ubiquitin C -0.221031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195252
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.189166
ASPH aspartate beta-hydroxylase -0.123902
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0964426
SAMD4A sterile alpha motif domain containing 4A -0.0898697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0820745
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0741581
EFNA5 ephrin-A5 -0.0740961
AHNAK AHNAK nucleoprotein -0.0739286
PTMA prothymosin, alpha -0.0698261
ENO1 enolase 1, (alpha) -0.0686769
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0668547
EXT1 exostosin glycosyltransferase 1 -0.0647327
ERBIN erbb2 interacting protein -0.0647018
KRT7 keratin 7, type II -0.0614748
RPS27A ribosomal protein S27a -0.0602003
CANX calnexin -0.0551115
GOLGA4 golgin A4 -0.0548771
TMSB10 thymosin beta 10 -0.0533089
ALCAM activated leukocyte cell adhesion molecule -0.0532033
LMO7 LIM domain 7 -0.0529314
NAV2 neuron navigator 2 -0.0528739
LAMC2 laminin, gamma 2 -0.0526962
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0522353
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0490316
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0489456
CAPN2 calpain 2, (m/II) large subunit -0.0489119
S100A6 S100 calcium binding protein A6 -0.0485682
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0479698
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0473539
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.046458
TXNRD1 thioredoxin reductase 1 -0.0459145
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0456132
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0452108
POTEF POTE ankyrin domain family, member F -0.0448468
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0446225
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0442526
DSCAM Down syndrome cell adhesion molecule -0.0441195
LPP LIM domain containing preferred translocation partner in lipoma -0.0438396
ATXN1 ataxin 1 -0.0403934
FNDC3B fibronectin type III domain containing 3B -0.0401241
FBXO32 F-box protein 32 -0.0389561
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0385846
LIMCH1 LIM and calponin homology domains 1 -0.0380745
PRRC2C proline-rich coiled-coil 2C -0.0371429
MAP4 microtubule-associated protein 4 -0.036571
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0364961
TPT1 tumor protein, translationally-controlled 1 -0.0363927
MAP1B microtubule-associated protein 1B -0.036079
ARHGAP5 Rho GTPase activating protein 5 -0.0354921
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0352992
SLC38A1 solute carrier family 38, member 1 -0.0349589
CALU calumenin -0.0349217
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0347704
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0340115
SBF2 SET binding factor 2 -0.0339417
CDCP1 CUB domain containing protein 1 -0.0339333
CCNI cyclin I -0.033675
S100A10 S100 calcium binding protein A10 -0.0333842
EGFR epidermal growth factor receptor -0.0329996
GSK3B glycogen synthase kinase 3 beta -0.0328408
SVIL supervillin -0.0327652
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0324587
RPL23 ribosomal protein L23 -0.032283
PDIA4 protein disulfide isomerase family A, member 4 -0.0319155
RPS23 ribosomal protein S23 -0.0316328
VMP1 vacuole membrane protein 1 -0.0313846
ANTXR2 anthrax toxin receptor 2 -0.0307766
SMAD3 SMAD family member 3 -0.0307164
TXNIP thioredoxin interacting protein -0.0304133
SEC31A SEC31 homolog A (S. cerevisiae) -0.0303361
MBNL1 muscleblind-like splicing regulator 1 -0.0302951
PCBP2 poly(rC) binding protein 2 -0.0293181
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0292802
KRT8 keratin 8, type II -0.0292562
PLSCR1 phospholipid scramblase 1 -0.0291548
DLG1 discs, large homolog 1 (Drosophila) -0.0289864
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0289415
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.028619
JMJD1C jumonji domain containing 1C -0.0286138
DOCK5 dedicator of cytokinesis 5 -0.0284949
TNPO1 transportin 1 -0.0281943
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0276252
NIPBL Nipped-B homolog (Drosophila) -0.027573
PATJ PATJ crumbs cell polarity complex component -0.0275454
SDC4 syndecan 4 -0.027531
OSMR oncostatin M receptor -0.0275089
CCND1 cyclin D1 -0.0274843
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0273843
MYO1E myosin IE -0.0273736
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.027345
VIM vimentin -0.0271127
MYO6 myosin VI -0.0269269
RBM25 RNA binding motif protein 25 -0.026792
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -0.0266196
RPS24 ribosomal protein S24 -0.0264285
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0261185
ZBTB20 zinc finger and BTB domain containing 20 -0.0260757