Abiraterone acetate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.123477
MYO6 myosin VI 0.100139
TSC22D2 TSC22 domain family, member 2 0.0991075
LOC112694756 uncharaterized LOC112694756 0.0763734
TRIO trio Rho guanine nucleotide exchange factor 0.0655438
IGFBP3 insulin-like growth factor binding protein 3 0.0643105
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0636539
ANXA2 annexin A2 0.062107
ARHGAP29 Rho GTPase activating protein 29 0.0573504
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0496103
FTH1 ferritin, heavy polypeptide 1 0.0488501
BCAR3 breast cancer anti-estrogen resistance 3 0.0483261
OGA O-GlcNAcase 0.0481391
HLA-B major histocompatibility complex, class I, B 0.0459434
NDRG1 N-myc downstream regulated 1 0.0455101
GOLGA4 golgin A4 0.0444618
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0434598
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0428846
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0425968
OSBPL3 oxysterol binding protein-like 3 0.042177
NRIP1 nuclear receptor interacting protein 1 0.0418194
LMO7 LIM domain 7 0.0402229
MACF1 microtubule-actin crosslinking factor 1 0.0398667
AFDN afadin, adherens junction formation factor 0.0390442
UGCG UDP-glucose ceramide glucosyltransferase 0.0383134
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.036868
MYO5B myosin VB 0.0364591
TM4SF1 transmembrane 4 L six family member 1 0.0364582
RASA2 RAS p21 protein activator 2 0.0355572
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0352135
PLEC plectin 0.0351502
PLAU plasminogen activator, urokinase 0.0348673
PICALM phosphatidylinositol binding clathrin assembly protein 0.0346968
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0344518
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0343446
VCL vinculin 0.0340771
ARRDC3 arrestin domain containing 3 0.0338367
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335054
RUNX1 runt-related transcription factor 1 0.0332746
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0329117
MEF2A myocyte enhancer factor 2A 0.0329115
HDLBP high density lipoprotein binding protein 0.032871
NAV2 neuron navigator 2 0.0321162
TFG TRK-fused gene 0.0312492
PDLIM5 PDZ and LIM domain 5 0.0312258
HLA-C major histocompatibility complex, class I, C 0.0309881
BIRC6 baculoviral IAP repeat containing 6 0.0308681
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0302005
RBM26 RNA binding motif protein 26 0.0299684
SEC23A Sec23 homolog A (S. cerevisiae) 0.0298283
EIF4H eukaryotic translation initiation factor 4H 0.029639
KDM6A lysine (K)-specific demethylase 6A 0.0295349
PRRC2A proline-rich coiled-coil 2A 0.0295332
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0292022
WSB1 WD repeat and SOCS box containing 1 0.0291437
ITCH itchy E3 ubiquitin protein ligase 0.0291178
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0285466
JMJD1C jumonji domain containing 1C 0.0277916
KRT18 keratin 18, type I 0.0273956
AKAP12 A kinase (PRKA) anchor protein 12 0.0271591
TMEM123 transmembrane protein 123 0.026842
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.026659
USP3 ubiquitin specific peptidase 3 0.0264545
FNBP1L formin binding protein 1-like 0.0262255
MYH9 myosin, heavy chain 9, non-muscle 0.0259617
PUM2 pumilio RNA-binding family member 2 0.0258594
HMGA1 high mobility group AT-hook 1 0.0257771
ATP13A3 ATPase type 13A3 0.0254872
IRF6 interferon regulatory factor 6 0.0254856
MYOF myoferlin 0.0253928
CUL3 cullin 3 0.0247907
CCNY cyclin Y 0.0246075
FAM3C family with sequence similarity 3, member C 0.024503
SAMD4A sterile alpha motif domain containing 4A 0.0244588
NIPBL Nipped-B homolog (Drosophila) 0.0243633
MAML2 mastermind-like 2 (Drosophila) 0.024244
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0241485
SPAG9 sperm associated antigen 9 0.0239342
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0237469
PPARD peroxisome proliferator-activated receptor delta 0.0236154
CDYL chromodomain protein, Y-like 0.0231886
ANXA3 annexin A3 0.0229777
CD59 CD59 molecule, complement regulatory protein 0.0229191
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0228701
EFHD2 EF-hand domain family, member D2 0.0227159
TRA2A transformer 2 alpha homolog (Drosophila) 0.0225814
NCEH1 neutral cholesterol ester hydrolase 1 0.0221568
NEK7 NIMA-related kinase 7 0.0221052
ZFAND3 zinc finger, AN1-type domain 3 0.0219562
FXR1 fragile X mental retardation, autosomal homolog 1 0.0217394
MARCHF6 membrane associated ring-CH-type finger 6 0.0217169
CD47 CD47 molecule 0.0216509
ATP11B ATPase, class VI, type 11B 0.0215149
NUP58 nucleoporin 58 0.0214611
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0213948
BCL2L1 BCL2-like 1 0.0211353
DDIT4 DNA-damage-inducible transcript 4 0.0211036
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0211031
AHNAK2 AHNAK nucleoprotein 2 0.0206531
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0203488

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.361192
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.127526
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.094511
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0920295
TPT1 tumor protein, translationally-controlled 1 -0.0899268
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0830652
IFI27 interferon, alpha-inducible protein 27 -0.0629463
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0620482
PCLO piccolo presynaptic cytomatrix protein -0.0619323
EGR1 early growth response 1 -0.0587394
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0585311
KRT19 keratin 19, type I -0.0569868
LY6E lymphocyte antigen 6 complex, locus E -0.0531471
MX1 MX dynamin-like GTPase 1 -0.053098
RPS6 ribosomal protein S6 -0.0512002
C3 complement component 3 -0.0511942
EFNA5 ephrin-A5 -0.0506678
RPS15 ribosomal protein S15 -0.0504687
LAMA4 laminin, alpha 4 -0.0500245
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0491808
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0482919
MX2 MX dynamin-like GTPase 2 -0.048265
POTEF POTE ankyrin domain family, member F -0.0477805
LOC102724023 ES1 protein homolog, mitochondrial -0.0477184
FHIT fragile histidine triad -0.0473934
RNF213 ring finger protein 213 -0.0460847
VMP1 vacuole membrane protein 1 -0.045111
RPS24 ribosomal protein S24 -0.044734
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0441159
RPS23 ribosomal protein S23 -0.0440737
KRT8 keratin 8, type II -0.0435803
RPS29 ribosomal protein S29 -0.043218
CCNL1 cyclin L1 -0.0430535
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0426292
B2M beta-2-microglobulin -0.0422374
OSMR oncostatin M receptor -0.0421007
RIGI RNA sensor RIG-I -0.0410811
SAMD12 sterile alpha motif domain containing 12 -0.0407533
PLSCR1 phospholipid scramblase 1 -0.040297
BPTF bromodomain PHD finger transcription factor -0.0396161
EIF1 eukaryotic translation initiation factor 1 -0.0391411
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0388006
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0369385
EPSTI1 epithelial stromal interaction 1 (breast) -0.0364671
RPL28 ribosomal protein L28 -0.0361572
IFI16 interferon, gamma-inducible protein 16 -0.0359238
SP100 SP100 nuclear antigen -0.0359034
ZBTB20 zinc finger and BTB domain containing 20 -0.0357372
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0355745
PLAT plasminogen activator, tissue -0.0336904
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0334983
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0333445
EHF ets homologous factor -0.0332897
NAMPT nicotinamide phosphoribosyltransferase -0.0332112
DEK DEK proto-oncogene -0.0331047
HLA-A major histocompatibility complex, class I, A -0.0329127
RABGAP1L RAB GTPase activating protein 1-like -0.032675
RPS5 ribosomal protein S5 -0.0325077
IFIH1 interferon induced with helicase C domain 1 -0.0322078
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0316097
PLAUR plasminogen activator, urokinase receptor -0.0313431
IFI44L interferon-induced protein 44-like -0.0304518
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.030294
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0300953
FOXP1 forkhead box P1 -0.030089
DPYD dihydropyrimidine dehydrogenase -0.0300547
MT2A metallothionein 2A -0.0300546
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0295994
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0294585
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0294071
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0293045
RPLP2 ribosomal protein, large, P2 -0.0292538
RPLP1 ribosomal protein, large, P1 -0.029211
RPS13 ribosomal protein S13 -0.0291896
EZR ezrin -0.028566
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0282104
SKIL SKI-like proto-oncogene -0.0280875
ETV6 ets variant 6 -0.0279393
TGM2 transglutaminase 2 -0.027761
DUSP5 dual specificity phosphatase 5 -0.027729
RPS19 ribosomal protein S19 -0.0277165
RPL8 ribosomal protein L8 -0.0276472
TAPBP TAP binding protein (tapasin) -0.0276462
WARS1 tryptophanyl-tRNA synthetase 1 -0.0274019
RPS8 ribosomal protein S8 -0.0273926
PATJ PATJ crumbs cell polarity complex component -0.0273702
RPL31 ribosomal protein L31 -0.0273424
TXNIP thioredoxin interacting protein -0.0265319
ARHGAP26 Rho GTPase activating protein 26 -0.0262261
RAD51B RAD51 paralog B -0.0260337
IFITM1 interferon induced transmembrane protein 1 -0.0259341
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0258389
RPL23 ribosomal protein L23 -0.0257322
RPL7A ribosomal protein L7a -0.0253924
SMYD3 SET and MYND domain containing 3 -0.0253664
RPL19 ribosomal protein L19 -0.0252611
USP34 ubiquitin specific peptidase 34 -0.0248855
RPS25 ribosomal protein S25 -0.0247849
BCAS3 breast carcinoma amplified sequence 3 -0.0247294
MBD5 methyl-CpG binding domain protein 5 -0.0245801