Abiraterone acetate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 0.0488594
MACF1 microtubule-actin crosslinking factor 1 0.0404664
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0386364
SMAD3 SMAD family member 3 0.0377681
PBX3 pre-B-cell leukemia homeobox 3 0.0376123
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0366689
ATXN1 ataxin 1 0.0354113
DST dystonin 0.0348147
PALM2AKAP2 PALM2 and AKAP2 fusion 0.033449
NDRG1 N-myc downstream regulated 1 0.0332648
BCAR3 breast cancer anti-estrogen resistance 3 0.0327777
FNDC3B fibronectin type III domain containing 3B 0.0323995
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.032045
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0316991
CEP250 centrosomal protein 250kDa 0.0303168
PICALM phosphatidylinositol binding clathrin assembly protein 0.0275111
FMN1 formin 1 0.0274429
SVIL supervillin 0.0273807
NUP58 nucleoporin 58 0.0271304
AHNAK AHNAK nucleoprotein 0.0266821
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0260159
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0253728
SAMD4A sterile alpha motif domain containing 4A 0.0251239
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0245899
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0242719
RUNX1 runt-related transcription factor 1 0.0239851
MPRIP myosin phosphatase Rho interacting protein 0.0236815
YEATS2 YEATS domain containing 2 0.0235153
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0234332
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0232745
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0231122
NT5E 5'-nucleotidase, ecto (CD73) 0.0228413
ASXL1 additional sex combs like transcriptional regulator 1 0.0224964
PRRC2B proline-rich coiled-coil 2B 0.022394
MYH9 myosin, heavy chain 9, non-muscle 0.0222824
FLNA filamin A, alpha 0.0221209
PANX1 pannexin 1 0.022008
NIBAN2 niban apoptosis regulator 2 0.0215081
AHNAK2 AHNAK nucleoprotein 2 0.0207983
ATM ATM serine/threonine kinase 0.0206843
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0206808
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0204257
SCAF8 SR-related CTD-associated factor 8 0.0202456
RAD23B RAD23 homolog B (S. cerevisiae) 0.0202077
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0201489
ANKRD36 ankyrin repeat domain 36 0.0197255
DERA deoxyribose-phosphate aldolase (putative) 0.0195685
ITCH itchy E3 ubiquitin protein ligase 0.0192972
BIRC3 baculoviral IAP repeat containing 3 0.0188979
MBNL1 muscleblind-like splicing regulator 1 0.0187923
NPTN neuroplastin 0.0185299
FMNL2 formin-like 2 0.0182765
ZNF292 zinc finger protein 292 0.0181447
PLEC plectin 0.0180144
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0179557
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0178514
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0178187
PRELID2 PRELI domain containing 2 0.0177693
PRPF8 pre-mRNA processing factor 8 0.0177084
SLC39A9 solute carrier family 39, member 9 0.0174199
DNAAF9 dynein axonemal assembly factor 9 0.017269
NONO non-POU domain containing, octamer-binding 0.0172035
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0171095
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0169584
EXOC6B exocyst complex component 6B 0.0169064
TRIO trio Rho guanine nucleotide exchange factor 0.0168992
STEAP3 STEAP family member 3, metalloreductase 0.0168807
NALCN sodium leak channel, non selective 0.0167047
PRRC2A proline-rich coiled-coil 2A 0.0166897
SRRM2 serine/arginine repetitive matrix 2 0.0164428
HMGA2 high mobility group AT-hook 2 0.0163968
HELZ helicase with zinc finger 0.0163216
CD59 CD59 molecule, complement regulatory protein 0.0162667
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0160677
NPAS2 neuronal PAS domain protein 2 0.0160534
FBXL5 F-box and leucine-rich repeat protein 5 0.0160519
AKAP12 A kinase (PRKA) anchor protein 12 0.0160248
TRRAP transformation/transcription domain-associated protein 0.0159655
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0159555
CRY1 cryptochrome circadian clock 1 0.0158909
EIF4H eukaryotic translation initiation factor 4H 0.0155761
ARCN1 archain 1 0.0155723
ANO6 anoctamin 6 0.0155611
WWOX WW domain containing oxidoreductase 0.015482
PER1 period circadian clock 1 0.0154429
USP9X ubiquitin specific peptidase 9, X-linked 0.0153999
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0153898
CAPRIN1 cell cycle associated protein 1 0.0153798
GLS2 glutaminase 2 (liver, mitochondrial) 0.0153721
KIAA1549L KIAA1549-like 0.015294
CLTA clathrin, light chain A 0.0152302
EP300 E1A binding protein p300 0.0151546
RBM15 RNA binding motif protein 15 0.0151485
HIPK3 homeodomain interacting protein kinase 3 0.0151412
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0151033
KIAA1671 KIAA1671 0.0150054
EEF2 eukaryotic translation elongation factor 2 0.0150052
PTPRK protein tyrosine phosphatase, receptor type, K 0.0148003
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0147814
HJURP Holliday junction recognition protein 0.0147686

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.296443
MT2A metallothionein 2A -0.149014
TMSB10 thymosin beta 10 -0.0944328
VIM vimentin -0.0826885
FTL ferritin, light polypeptide -0.0757175
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0707112
PTMA prothymosin, alpha -0.0702041
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0626514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0610217
RPL19 ribosomal protein L19 -0.0549725
RPS29 ribosomal protein S29 -0.0524518
RPS13 ribosomal protein S13 -0.0523745
RPL31 ribosomal protein L31 -0.0521206
RPL37A ribosomal protein L37a -0.0505583
HILPDA hypoxia inducible lipid droplet-associated -0.0505051
B2M beta-2-microglobulin -0.0477584
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0474729
TAOK3 TAO kinase 3 -0.0464728
RPS8 ribosomal protein S8 -0.0463793
TPT1 tumor protein, translationally-controlled 1 -0.0453681
MAP1B microtubule-associated protein 1B -0.0439823
PKM pyruvate kinase, muscle -0.0438627
AKAP9 A kinase (PRKA) anchor protein 9 -0.0438374
RAB1A RAB1A, member RAS oncogene family -0.0426764
HLA-B major histocompatibility complex, class I, B -0.0419613
CD44 CD44 molecule (Indian blood group) -0.0417752
RPLP1 ribosomal protein, large, P1 -0.0409919
RPS6 ribosomal protein S6 -0.0409088
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0400862
GOLGB1 golgin B1 -0.0394274
POTEF POTE ankyrin domain family, member F -0.0393414
RPL7A ribosomal protein L7a -0.039293
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0391
WSB1 WD repeat and SOCS box containing 1 -0.0387303
RPL35A ribosomal protein L35a -0.0383446
CCDC88A coiled-coil domain containing 88A -0.0378126
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0376854
BRD4 bromodomain containing 4 -0.0374941
RPS12 ribosomal protein S12 -0.0373528
RPS27A ribosomal protein S27a -0.0362699
RPS11 ribosomal protein S11 -0.0359478
EIF1 eukaryotic translation initiation factor 1 -0.0355944
MTDH metadherin -0.035183
SETD5 SET domain containing 5 -0.0343056
RPL12 ribosomal protein L12 -0.0332062
CCNH cyclin H -0.0331337
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0331042
RPL11 ribosomal protein L11 -0.0329327
S100A9 S100 calcium binding protein A9 -0.0329045
MIS18BP1 MIS18 binding protein 1 -0.0326795
NKTR natural killer cell triggering receptor -0.0325863
RPL26 ribosomal protein L26 -0.0324459
RPS23 ribosomal protein S23 -0.0319517
RPS15 ribosomal protein S15 -0.0315539
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0310831
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0310013
HM13 histocompatibility (minor) 13 -0.0302941
RPLP0 ribosomal protein, large, P0 -0.0297361
RPS25 ribosomal protein S25 -0.0292659
VDAC1 voltage-dependent anion channel 1 -0.0288828
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0288599
S100A10 S100 calcium binding protein A10 -0.0287883
EGR1 early growth response 1 -0.0286123
RPS17 ribosomal protein S17 -0.0280758
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0279323
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0278591
NCOR1 nuclear receptor corepressor 1 -0.0276032
FBXO11 F-box protein 11 -0.0273407
S100A6 S100 calcium binding protein A6 -0.0272165
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.0271666
GOLGA4 golgin A4 -0.0265921
RPL5 ribosomal protein L5 -0.0263198
RPS10 ribosomal protein S10 -0.0261284
USP36 ubiquitin specific peptidase 36 -0.025855
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0255913
RPL15 ribosomal protein L15 -0.0252112
IGF2 insulin-like growth factor 2 -0.0251618
SMC4 structural maintenance of chromosomes 4 -0.0251606
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0251413
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0251389
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0250954
RPL8 ribosomal protein L8 -0.0250784
RPL9 ribosomal protein L9 -0.0247923
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0247494
HLA-A major histocompatibility complex, class I, A -0.0246543
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0246184
IARS1 isoleucyl-tRNA synthetase 1 -0.0246115
MYO9B myosin IXB -0.0244799
RPL38 ribosomal protein L38 -0.0242533
PIBF1 progesterone immunomodulatory binding factor 1 -0.0240927
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0240279
RAB7A RAB7A, member RAS oncogene family -0.023911
TRA2A transformer 2 alpha homolog (Drosophila) -0.02335
H3-3B H3.3 histone B -0.0233414
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0232232
ZNF609 zinc finger protein 609 -0.0231343
RPS24 ribosomal protein S24 -0.0230858
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0228343
SSH2 slingshot protein phosphatase 2 -0.0219775
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0219278