Abiraterone acetate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.146183
MT2A metallothionein 2A 0.107806
NDRG1 N-myc downstream regulated 1 0.0666909
RPS6 ribosomal protein S6 0.0573631
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0537836
PRRC2C proline-rich coiled-coil 2C 0.0491889
RPS12 ribosomal protein S12 0.0472759
RUNX2 runt-related transcription factor 2 0.0465737
CD109 CD109 molecule 0.0455653
VIM vimentin 0.045163
LOC112694756 uncharaterized LOC112694756 0.0448981
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0446563
RNF145 ring finger protein 145 0.0438371
GOLGA4 golgin A4 0.0417141
FTL ferritin, light polypeptide 0.0407511
RPL35A ribosomal protein L35a 0.0404138
OGA O-GlcNAcase 0.040071
RPS27 ribosomal protein S27 0.0387992
WDR45B WD repeat domain 45B 0.0381918
CENPF centromere protein F, 350/400kDa 0.0370496
RPS19 ribosomal protein S19 0.0366605
CAB39 calcium binding protein 39 0.0342796
RPS20 ribosomal protein S20 0.0336537
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0320988
WAC WW domain containing adaptor with coiled-coil 0.0316691
SRRM2 serine/arginine repetitive matrix 2 0.0314975
RPL37A ribosomal protein L37a 0.0312857
HLA-C major histocompatibility complex, class I, C 0.0311725
AKAP9 A kinase (PRKA) anchor protein 9 0.0308821
PNISR PNN-interacting serine/arginine-rich protein 0.0308505
MKI67 marker of proliferation Ki-67 0.030811
CLTC clathrin, heavy chain (Hc) 0.029984
RACK1 receptor for activated C kinase 1 0.0299388
RPL36 ribosomal protein L36 0.0298637
SEC23A Sec23 homolog A (S. cerevisiae) 0.029413
KTN1 kinectin 1 (kinesin receptor) 0.0292358
RPL34 ribosomal protein L34 0.028981
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0286762
SOS1 son of sevenless homolog 1 (Drosophila) 0.0278835
FAF2 Fas associated factor family member 2 0.0276248
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0273329
RPL12 ribosomal protein L12 0.0271532
RPL11 ribosomal protein L11 0.0271405
LGALS1 lectin, galactoside-binding, soluble, 1 0.0271228
NIPBL Nipped-B homolog (Drosophila) 0.0268175
TMEM165 transmembrane protein 165 0.0265847
CDC73 cell division cycle 73 0.0264991
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0264785
AKAP12 A kinase (PRKA) anchor protein 12 0.026403
MCTP2 multiple C2 domains, transmembrane 2 0.0263714
RPLP1 ribosomal protein, large, P1 0.0253876
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0249532
FBXL5 F-box and leucine-rich repeat protein 5 0.0248588
PTMA prothymosin, alpha 0.0247291
COG5 component of oligomeric golgi complex 5 0.0246594
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0241779
MIS18BP1 MIS18 binding protein 1 0.0238333
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0234734
RPL9 ribosomal protein L9 0.0230018
HILPDA hypoxia inducible lipid droplet-associated 0.0229742
UBA6 ubiquitin-like modifier activating enzyme 6 0.0226626
TM9SF3 transmembrane 9 superfamily member 3 0.0225064
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0222062
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0216661
RPS8 ribosomal protein S8 0.0208982
RPL37 ribosomal protein L37 0.0208493
UGCG UDP-glucose ceramide glucosyltransferase 0.0206529
TMSB10 thymosin beta 10 0.0199981
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0193654
ITGB5 integrin, beta 5 0.019151
ETNK1 ethanolamine kinase 1 0.0190412
RAB6A RAB6A, member RAS oncogene family 0.0188995
NUP58 nucleoporin 58 0.0188235
HELZ helicase with zinc finger 0.0187221
RPL30 ribosomal protein L30 0.0186961
SFXN1 sideroflexin 1 0.0184175
CABIN1 calcineurin binding protein 1 0.0184128
VDAC1 voltage-dependent anion channel 1 0.0183947
NACA nascent polypeptide-associated complex alpha subunit 0.0183755
S100A6 S100 calcium binding protein A6 0.0183258
SYNJ2 synaptojanin 2 0.0180731
TPR translocated promoter region, nuclear basket protein 0.0179852
HDGF hepatoma-derived growth factor 0.017931
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0177804
SEPTIN2 septin 2 0.0177678
ACBD3 acyl-CoA binding domain containing 3 0.0177275
RTN4 reticulon 4 0.0176395
WDFY1 WD repeat and FYVE domain containing 1 0.0175462
ATP11A ATPase, class VI, type 11A 0.017541
RPS3 ribosomal protein S3 0.0174108
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.017334
COPA coatomer protein complex, subunit alpha 0.0173167
RAB2A RAB2A, member RAS oncogene family 0.0172978
RPS29 ribosomal protein S29 0.0172974
RPS21 ribosomal protein S21 0.017266
FOXO3 forkhead box O3 0.0171686
SS18 synovial sarcoma translocation, chromosome 18 0.0169969
EEF2 eukaryotic translation elongation factor 2 0.0169906
PTBP3 polypyrimidine tract binding protein 3 0.0169101
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0168588

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.252758
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.238381
FN1 fibronectin 1 -0.155424
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.139686
HMGA2 high mobility group AT-hook 2 -0.116138
SQSTM1 sequestosome 1 -0.110886
NAMPT nicotinamide phosphoribosyltransferase -0.103376
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0922597
VCL vinculin -0.0905853
CANX calnexin -0.0826523
SYT1 synaptotagmin I -0.073804
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0667584
EXT1 exostosin glycosyltransferase 1 -0.0664451
INTS6 integrator complex subunit 6 -0.0655778
ASPH aspartate beta-hydroxylase -0.0642131
PDE4D phosphodiesterase 4D, cAMP-specific -0.0625926
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0580282
AEBP2 AE binding protein 2 -0.0579921
RAI14 retinoic acid induced 14 -0.0579595
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0563259
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0505533
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0494505
ITGA1 integrin, alpha 1 -0.0472962
LRMDA leucine rich melanocyte differentiation associated -0.045821
NCOA7 nuclear receptor coactivator 7 -0.0444213
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0443011
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0438549
PDLIM5 PDZ and LIM domain 5 -0.0435873
TTC28 tetratricopeptide repeat domain 28 -0.0430953
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0425832
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0414316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0402703
PALLD palladin, cytoskeletal associated protein -0.0395328
LIMCH1 LIM and calponin homology domains 1 -0.0392213
BICD1 bicaudal D homolog 1 (Drosophila) -0.0381554
GLIS3 GLIS family zinc finger 3 -0.0376939
LOXL2 lysyl oxidase-like 2 -0.0370392
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0359219
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0342232
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0341631
FBN1 fibrillin 1 -0.0331419
RNF213 ring finger protein 213 -0.0330375
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0322592
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0321108
EGR1 early growth response 1 -0.0315755
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0303534
SOX5 SRY (sex determining region Y)-box 5 -0.0302821
RIGI RNA sensor RIG-I -0.0302453
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.030148
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0298546
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0298362
MAP1B microtubule-associated protein 1B -0.0296807
SLC35F3 solute carrier family 35, member F3 -0.0296796
DST dystonin -0.0296159
NTN4 netrin 4 -0.0288619
GRB10 growth factor receptor-bound protein 10 -0.0285771
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0284451
UGDH UDP-glucose 6-dehydrogenase -0.0284113
BZW1 basic leucine zipper and W2 domains 1 -0.0281963
SAMD4A sterile alpha motif domain containing 4A -0.028124
MACF1 microtubule-actin crosslinking factor 1 -0.028101
CCSER1 coiled-coil serine-rich protein 1 -0.0275941
HLA-B major histocompatibility complex, class I, B -0.0274397
MCL1 myeloid cell leukemia 1 -0.0273446
USP34 ubiquitin specific peptidase 34 -0.027125
LOC102724023 ES1 protein homolog, mitochondrial -0.027025
SOX4 SRY (sex determining region Y)-box 4 -0.0267914
TENM4 teneurin transmembrane protein 4 -0.0265257
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0263553
EXOC4 exocyst complex component 4 -0.025976
MAML2 mastermind-like 2 (Drosophila) -0.0257432
SVIL supervillin -0.0256962
SFTPA2 surfactant protein A2 -0.0256345
DUSP6 dual specificity phosphatase 6 -0.0256315
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.025482
TFPI2 tissue factor pathway inhibitor 2 -0.0253515
TOP1 topoisomerase (DNA) I -0.0252945
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0251085
IER3 immediate early response 3 -0.0246725
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0245936
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0244462
WDR1 WD repeat domain 1 -0.0241245
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0240543
CLIP2 CAP-GLY domain containing linker protein 2 -0.0238809
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0237399
LRRC23 leucine rich repeat containing 23 -0.0235919
AHNAK AHNAK nucleoprotein -0.0235742
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0233482
ZC3H11A zinc finger CCCH-type containing 11A -0.0232224
MX2 MX dynamin-like GTPase 2 -0.0231938
TUFT1 tuftelin 1 -0.0230475
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0229718
OASL 2'-5'-oligoadenylate synthetase-like -0.0227613
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0227091
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0226953
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0223967
NXN nucleoredoxin -0.0221994
DNAH5 dynein, axonemal, heavy chain 5 -0.0216283
MMP13 matrix metallopeptidase 13 -0.0215787
JUN jun proto-oncogene -0.02136