Abiraterone acetate_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.0897368
NAV2 neuron navigator 2 0.0746941
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0633757
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.060812
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0606071
AKAP12 A kinase (PRKA) anchor protein 12 0.0585742
ANO1 anoctamin 1, calcium activated chloride channel 0.0559678
SDK1 sidekick cell adhesion molecule 1 0.0549397
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0481207
KRT18 keratin 18, type I 0.0436744
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0354779
RPL3 ribosomal protein L3 0.0346988
MRPS6 mitochondrial ribosomal protein S6 0.0346678
NDRG1 N-myc downstream regulated 1 0.034628
INTS6 integrator complex subunit 6 0.0337665
EIF4H eukaryotic translation initiation factor 4H 0.0333375
ITGB4 integrin, beta 4 0.0310851
ASPH aspartate beta-hydroxylase 0.0307537
MYH9 myosin, heavy chain 9, non-muscle 0.0301646
ACTN1 actinin, alpha 1 0.0297017
HSPA8 heat shock 70kDa protein 8 0.0293026
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0292219
FLNA filamin A, alpha 0.0291168
FLNB filamin B, beta 0.0289934
MSN moesin 0.0288114
LOC112694756 uncharaterized LOC112694756 0.0278658
SRRM2 serine/arginine repetitive matrix 2 0.0278071
NTSR1 neurotensin receptor 1 (high affinity) 0.0245106
IGFBP3 insulin-like growth factor binding protein 3 0.0240688
TNS4 tensin 4 0.0224094
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0214656
SET SET nuclear proto-oncogene 0.0212697
DDIT4 DNA-damage-inducible transcript 4 0.0210302
BACE2 beta-site APP-cleaving enzyme 2 0.0203355
MPRIP myosin phosphatase Rho interacting protein 0.0202652
FOSL1 FOS-like antigen 1 0.0199894
ZFP36L1 ZFP36 ring finger protein-like 1 0.0199484
CDH13 cadherin 13 0.0196819
ZMIZ1 zinc finger, MIZ-type containing 1 0.0191887
PRRC2A proline-rich coiled-coil 2A 0.0187369
TPM3 tropomyosin 3 0.0187342
NCOR2 nuclear receptor corepressor 2 0.0187245
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0180536
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0178665
RPL35A ribosomal protein L35a 0.017804
MCL1 myeloid cell leukemia 1 0.017648
HDGF hepatoma-derived growth factor 0.0175113
IGF2 insulin-like growth factor 2 0.0174389
FTH1 ferritin, heavy polypeptide 1 0.0173505
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0173395
HMGA1 high mobility group AT-hook 1 0.017008
RPS3 ribosomal protein S3 0.0169957
VEGFA vascular endothelial growth factor A 0.0168809
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0168639
LAMA5 laminin, alpha 5 0.0166004
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0158601
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.015538
STC2 stanniocalcin 2 0.015441
MYOF myoferlin 0.0154021
LMNA lamin A/C 0.0153589
POTEF POTE ankyrin domain family, member F 0.0150558
NUMA1 nuclear mitotic apparatus protein 1 0.0150015
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0149689
PFN1 profilin 1 0.0148836
TPM4 tropomyosin 4 0.0147391
CEMIP cell migration inducing protein, hyaluronan binding 0.0146332
CCND1 cyclin D1 0.0141545
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0141447
LRMDA leucine rich melanocyte differentiation associated 0.0140286
CLSTN2 calsyntenin 2 0.0140169
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0137511
PKM pyruvate kinase, muscle 0.0137196
CBX5 chromobox homolog 5 0.0136977
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0136368
SEPTIN9 septin 9 0.0136155
VCL vinculin 0.0134561
CD44 CD44 molecule (Indian blood group) 0.0133387
CADM1 cell adhesion molecule 1 0.0132797
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0132716
EEF2 eukaryotic translation elongation factor 2 0.013157
ANXA3 annexin A3 0.0130766
BCL9L B-cell CLL/lymphoma 9-like 0.0126418
KTN1 kinectin 1 (kinesin receptor) 0.0125572
ARRDC3 arrestin domain containing 3 0.0122823
FOSL2 FOS-like antigen 2 0.0121599
TNIK TRAF2 and NCK interacting kinase 0.0120196
RAD51B RAD51 paralog B 0.0119064
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0118687
RPL29 ribosomal protein L29 0.0117858
TNIP1 TNFAIP3 interacting protein 1 0.0117269
EPHA2 EPH receptor A2 0.0117244
UBAP2 ubiquitin associated protein 2 0.0117104
ZNF704 zinc finger protein 704 0.0116864
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0116571
JUP junction plakoglobin 0.0116401
EGFR epidermal growth factor receptor 0.0116138
MT2A metallothionein 2A 0.011169
CSMD3 CUB and Sushi multiple domains 3 0.0111481
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0111123
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0110541

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207723
NKD1 naked cuticle homolog 1 (Drosophila) -0.120331
SYT1 synaptotagmin I -0.0918885
LMO7 LIM domain 7 -0.0732272
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.071848
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0697283
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.060253
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0601846
RBM39 RNA binding motif protein 39 -0.0598184
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0597929
OXR1 oxidation resistance 1 -0.0574458
PGK1 phosphoglycerate kinase 1 -0.0550921
ETNK1 ethanolamine kinase 1 -0.0548155
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0546872
AOPEP aminopeptidase O (putative) -0.054434
JMJD1C jumonji domain containing 1C -0.0527234
RPS24 ribosomal protein S24 -0.0512747
THOC2 THO complex 2 -0.0500503
RUNX1 runt-related transcription factor 1 -0.0496792
GCC2 GRIP and coiled-coil domain containing 2 -0.0485033
PDE4D phosphodiesterase 4D, cAMP-specific -0.0479249
TNS3 tensin 3 -0.0474083
NF1 neurofibromin 1 -0.0463483
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0458323
VMP1 vacuole membrane protein 1 -0.0452355
IARS1 isoleucyl-tRNA synthetase 1 -0.0447165
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0445887
RPS27A ribosomal protein S27a -0.0436967
PTMA prothymosin, alpha -0.0426076
GLG1 golgi glycoprotein 1 -0.0423212
RAD21 RAD21 homolog (S. pombe) -0.0404334
DLG1 discs, large homolog 1 (Drosophila) -0.0402591
NAP1L1 nucleosome assembly protein 1-like 1 -0.0402378
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0400173
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0399384
FOXP1 forkhead box P1 -0.0398403
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0397907
AHNAK AHNAK nucleoprotein -0.0394869
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0387251
NIPBL Nipped-B homolog (Drosophila) -0.0384208
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0384123
NKTR natural killer cell triggering receptor -0.0381687
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0379315
SETD5 SET domain containing 5 -0.0379225
FNDC3A fibronectin type III domain containing 3A -0.0378833
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0378243
YAP1 Yes-associated protein 1 -0.0372881
UBC ubiquitin C -0.0372387
TMEM123 transmembrane protein 123 -0.0371805
SPATA13 spermatogenesis associated 13 -0.0371639
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0370024
TTC3 tetratricopeptide repeat domain 3 -0.0365656
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0365294
BPTF bromodomain PHD finger transcription factor -0.0359987
PERP PERP, TP53 apoptosis effector -0.0358558
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0358009
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0355193
RPL36A ribosomal protein L36a -0.0354765
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0354569
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0350915
DST dystonin -0.0346126
ZMYND8 zinc finger, MYND-type containing 8 -0.0345587
PROX1 prospero homeobox 1 -0.0345296
OGA O-GlcNAcase -0.0345113
MORF4L2 mortality factor 4 like 2 -0.0344275
GARS1 glycyl-tRNA synthetase 1 -0.0343969
USP34 ubiquitin specific peptidase 34 -0.0342844
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0342138
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0341145
TCF12 transcription factor 12 -0.0340403
CANX calnexin -0.0340191
ZFAND3 zinc finger, AN1-type domain 3 -0.0339915
ANKRD28 ankyrin repeat domain 28 -0.0339344
SMYD3 SET and MYND domain containing 3 -0.0338315
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0337698
ANKRD17 ankyrin repeat domain 17 -0.0337616
PUM2 pumilio RNA-binding family member 2 -0.0333678
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0330927
MARCHF6 membrane associated ring-CH-type finger 6 -0.0329375
CCDC82 coiled-coil domain containing 82 -0.0329076
BRWD3 bromodomain and WD repeat domain containing 3 -0.0325949
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0324491
CBFB core-binding factor, beta subunit -0.0323702
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0322874
SBF2 SET binding factor 2 -0.0321953
ZFR zinc finger RNA binding protein -0.0321456
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0319767
RPL4 ribosomal protein L4 -0.0319227
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0318853
BCAS3 breast carcinoma amplified sequence 3 -0.031383
TASP1 taspase, threonine aspartase, 1 -0.031351
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0310701
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0310659
CEMIP2 cell migration inducing hyaluronidase 2 -0.0309305
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0308558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0306449
TMSB10 thymosin beta 10 -0.0306214
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0304748
CD46 CD46 molecule, complement regulatory protein -0.0304687
SENP5 SUMO1/sentrin specific peptidase 5 -0.0302514