Abiraterone acetate_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Abiraterone acetate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Abiraterone acetate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.185488
TMSB10 thymosin beta 10 0.100127
NDRG1 N-myc downstream regulated 1 0.0901059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0726637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0718365
HLA-B major histocompatibility complex, class I, B 0.071637
RPL35A ribosomal protein L35a 0.0690075
RPS6 ribosomal protein S6 0.0649135
RPL34 ribosomal protein L34 0.0621787
FTL ferritin, light polypeptide 0.0608744
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0593914
MT2A metallothionein 2A 0.0592093
CALR calreticulin 0.0565777
RPS12 ribosomal protein S12 0.0562609
RPS8 ribosomal protein S8 0.0529216
TPT1 tumor protein, translationally-controlled 1 0.0519102
RPL37A ribosomal protein L37a 0.0507287
RPL23 ribosomal protein L23 0.0506194
B2M beta-2-microglobulin 0.0491821
RPLP1 ribosomal protein, large, P1 0.0475292
ADM adrenomedullin 0.0472341
AKAP12 A kinase (PRKA) anchor protein 12 0.0464891
ACTG1 actin gamma 1 0.0447304
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0435485
EIF1 eukaryotic translation initiation factor 1 0.0428413
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0400606
RPS3 ribosomal protein S3 0.0391682
FTH1 ferritin, heavy polypeptide 1 0.0380297
RPL26 ribosomal protein L26 0.037844
FMNL2 formin-like 2 0.0377562
FAM13A family with sequence similarity 13, member A 0.037054
RPL11 ribosomal protein L11 0.0367861
RPS19 ribosomal protein S19 0.0367775
SRRM2 serine/arginine repetitive matrix 2 0.0359334
LOC112694756 uncharaterized LOC112694756 0.0359274
EEF2 eukaryotic translation elongation factor 2 0.035606
PTMA prothymosin, alpha 0.0354102
GREM1 gremlin 1, DAN family BMP antagonist 0.0345746
RPL12 ribosomal protein L12 0.033837
HLA-C major histocompatibility complex, class I, C 0.0332973
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0332441
NAV2 neuron navigator 2 0.0330767
LGALS1 lectin, galactoside-binding, soluble, 1 0.0330719
COL6A2 collagen, type VI, alpha 2 0.032083
RPS27 ribosomal protein S27 0.0320601
GOLGA4 golgin A4 0.0313894
TM4SF1 transmembrane 4 L six family member 1 0.0311621
RPL37 ribosomal protein L37 0.0311121
TRIO trio Rho guanine nucleotide exchange factor 0.0307315
RPL9 ribosomal protein L9 0.0302176
HLA-A major histocompatibility complex, class I, A 0.0296823
RACK1 receptor for activated C kinase 1 0.0295631
RPL31 ribosomal protein L31 0.0295281
ENO1 enolase 1, (alpha) 0.0276678
YBX1 Y box binding protein 1 0.0272078
RPLP0 ribosomal protein, large, P0 0.0270247
RPL13A ribosomal protein L13a 0.0270147
UGCG UDP-glucose ceramide glucosyltransferase 0.026502
RPS14 ribosomal protein S14 0.0264792
MYH9 myosin, heavy chain 9, non-muscle 0.0264029
RPS17 ribosomal protein S17 0.0262675
TTC3 tetratricopeptide repeat domain 3 0.0261597
MMP12 matrix metallopeptidase 12 0.0257847
RPL27 ribosomal protein L27 0.0257698
RPLP2 ribosomal protein, large, P2 0.02432
PRRC2C proline-rich coiled-coil 2C 0.0240116
HILPDA hypoxia inducible lipid droplet-associated 0.0239364
S100A6 S100 calcium binding protein A6 0.0236797
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0230028
RAB6A RAB6A, member RAS oncogene family 0.0228284
RPS20 ribosomal protein S20 0.0224645
FGFR1 fibroblast growth factor receptor 1 0.0223025
SEPTIN9 septin 9 0.0222727
ENO2 enolase 2 (gamma, neuronal) 0.0220045
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0215149
IGF2 insulin-like growth factor 2 0.0212027
RPS16 ribosomal protein S16 0.0211417
RPS25 ribosomal protein S25 0.0210349
RPS27A ribosomal protein S27a 0.0208866
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0206107
NACA nascent polypeptide-associated complex alpha subunit 0.0203191
KTN1 kinectin 1 (kinesin receptor) 0.020281
RAI1 retinoic acid induced 1 0.0201375
RPL36 ribosomal protein L36 0.0201219
JARID2 jumonji, AT rich interactive domain 2 0.0197518
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0195869
RPS21 ribosomal protein S21 0.0194433
RPL5 ribosomal protein L5 0.0191037
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0190596
S100A9 S100 calcium binding protein A9 0.0189248
RPL32 ribosomal protein L32 0.0189189
SRSF11 serine/arginine-rich splicing factor 11 0.0183173
LMNA lamin A/C 0.0182613
MXI1 MAX interactor 1, dimerization protein 0.0181609
ANKRD11 ankyrin repeat domain 11 0.0180807
AFF3 AF4/FMR2 family, member 3 0.0178165
RPL19 ribosomal protein L19 0.01771
RPS13 ribosomal protein S13 0.0175278
GNAS GNAS complex locus 0.0172843
STC2 stanniocalcin 2 0.017246

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.173722
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169151
CD44 CD44 molecule (Indian blood group) -0.1338
INHBA inhibin, beta A -0.109529
ADGRB3 adhesion G protein-coupled receptor B3 -0.0998845
NALF1 NALCN channel auxiliary factor 1 -0.0874051
FNDC3B fibronectin type III domain containing 3B -0.0849026
PRKG1 protein kinase, cGMP-dependent, type I -0.0838579
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0804148
EMP1 epithelial membrane protein 1 -0.0772521
EXT1 exostosin glycosyltransferase 1 -0.074399
MYO10 myosin X -0.0645302
SMAD3 SMAD family member 3 -0.0601258
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0576851
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0544327
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0523103
MMP1 matrix metallopeptidase 1 -0.0513071
ASPH aspartate beta-hydroxylase -0.048407
RAI14 retinoic acid induced 14 -0.0475122
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0453345
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0440231
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0440084
HMGA2 high mobility group AT-hook 2 -0.0439093
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0436797
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0429682
ARHGAP24 Rho GTPase activating protein 24 -0.0429571
CALD1 caldesmon 1 -0.0409039
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.039408
OXR1 oxidation resistance 1 -0.0385281
AKAP13 A kinase (PRKA) anchor protein 13 -0.0381159
PDE4D phosphodiesterase 4D, cAMP-specific -0.0379341
SOD2 superoxide dismutase 2, mitochondrial -0.0352051
GLIS3 GLIS family zinc finger 3 -0.0352044
ANKRD28 ankyrin repeat domain 28 -0.0351996
VCL vinculin -0.0331327
ZEB1 zinc finger E-box binding homeobox 1 -0.0328254
MAML2 mastermind-like 2 (Drosophila) -0.0326381
SLIT2 slit homolog 2 (Drosophila) -0.0325255
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0323804
VMP1 vacuole membrane protein 1 -0.0322164
COL4A1 collagen, type IV, alpha 1 -0.0322011
NAV1 neuron navigator 1 -0.0319879
PDE8A phosphodiesterase 8A -0.0316024
ANO6 anoctamin 6 -0.030796
MAP1B microtubule-associated protein 1B -0.0306399
EGFR epidermal growth factor receptor -0.0305546
FRMD4A FERM domain containing 4A -0.030036
SASH1 SAM and SH3 domain containing 1 -0.0299616
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0299086
COL5A3 collagen, type V, alpha 3 -0.0298826
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0293766
OSMR oncostatin M receptor -0.0293365
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.0289316
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0286908
SEPTIN11 septin 11 -0.0285689
CAV1 caveolin 1, caveolae protein, 22kDa -0.0282807
AHNAK AHNAK nucleoprotein -0.0281062
ELL2 elongation factor, RNA polymerase II, 2 -0.027919
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0277524
RUNX1 runt-related transcription factor 1 -0.0272777
NOTCH2 notch 2 -0.0272717
ATP13A3 ATPase type 13A3 -0.0268536
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0263189
KLF12 Kruppel-like factor 12 -0.0262077
FN1 fibronectin 1 -0.0256347
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0248669
PDE4B phosphodiesterase 4B, cAMP-specific -0.0248168
CCDC102B coiled-coil domain containing 102B -0.0247015
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0245974
FBN1 fibrillin 1 -0.024586
LOX lysyl oxidase -0.0234611
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0233762
NRP1 neuropilin 1 -0.0231506
COL1A2 collagen, type I, alpha 2 -0.023121
EBF1 early B-cell factor 1 -0.0230037
WNT5A wingless-type MMTV integration site family, member 5A -0.0227556
FOXP1 forkhead box P1 -0.022717
STC1 stanniocalcin 1 -0.02121
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0211119
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0210731
PLPP3 phospholipid phosphatase 3 -0.020754
CPA6 carboxypeptidase A6 -0.0207527
CLTC clathrin, heavy chain (Hc) -0.0205428
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0204459
CHSY3 chondroitin sulfate synthase 3 -0.0203252
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0201815
PRRX1 paired related homeobox 1 -0.0201236
LTBP1 latent transforming growth factor beta binding protein 1 -0.019935
DIAPH2 diaphanous-related formin 2 -0.0198744
DLG1 discs, large homolog 1 (Drosophila) -0.0191348
TXNIP thioredoxin interacting protein -0.0189746
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0186695
ETV6 ets variant 6 -0.0186608
CCND1 cyclin D1 -0.0186607
NABP1 nucleic acid binding protein 1 -0.018519
MBD5 methyl-CpG binding domain protein 5 -0.0184693
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0183902
BCAS3 breast carcinoma amplified sequence 3 -0.018377
ARHGAP31 Rho GTPase activating protein 31 -0.0183617
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0182168