| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A thiadiazole that has formula C4H6N4O3S2. (Chemical Entities of Biological Interest Ontology, CHEBI_27690) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/1986 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Acetazolamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IL13RA1 | interleukin 13 receptor, alpha 1 | 2.16 |
| TTN | titin | 1.24 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 1.21 |
| RPL26 | ribosomal protein L26 | 1.13 |
| C17ORF80 | chromosome 17 open reading frame 80 | 1.04 |
| NCKAP1L | NCK-associated protein 1-like | 1.01 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.81 |
| FAM104A | family with sequence similarity 104, member A | 0.8 |
| FGB | fibrinogen beta chain | 0.69 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.69 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | 0.69 |
| JAK3 | Janus kinase 3 | 0.68 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.54 |
| TATDN2 | TatD DNase domain containing 2 | 0.53 |
| PACRGL | PARK2 co-regulated-like | 0.52 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.49 |
| IP6K2 | inositol hexakisphosphate kinase 2 | 0.48 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.48 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | 0.46 |
| RPL31 | ribosomal protein L31 | 0.45 |
| ECM1 | extracellular matrix protein 1 | 0.44 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.44 |
| YBX3 | Y box binding protein 3 | 0.44 |
| PRMT6 | protein arginine methyltransferase 6 | 0.43 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.43 |
| STK17B | serine/threonine kinase 17b | 0.41 |
| SUCO | SUN domain containing ossification factor | 0.41 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.41 |
| FGA | fibrinogen alpha chain | 0.39 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.39 |
| CMC4 | C-x(9)-C motif containing 4 | 0.37 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.36 |
| HECA | headcase homolog (Drosophila) | 0.36 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.35 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 0.35 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.35 |
| SORT1 | sortilin 1 | 0.35 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.35 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.35 |
| COMMD8 | COMM domain containing 8 | 0.34 |
| SNIP1 | Smad nuclear interacting protein 1 | 0.34 |
| RPL36AL | ribosomal protein L36a-like | 0.33 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.33 |
| ETV6 | ets variant 6 | 0.33 |
| N4BP3 | NEDD4 binding protein 3 | 0.33 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.33 |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | 0.32 |
| COMMD3 | COMM domain containing 3 | 0.32 |
| TBC1D12 | TBC1 domain family, member 12 | 0.32 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.31 |
| FN1 | fibronectin 1 | 0.31 |
| CEP63 | centrosomal protein 63kDa | 0.31 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.31 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.31 |
| LIX1L | Lix1 homolog (chicken) like | 0.3 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.3 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.3 |
| HDAC5 | histone deacetylase 5 | 0.3 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.3 |
| SET | SET nuclear proto-oncogene | 0.3 |
| S100A10 | S100 calcium binding protein A10 | 0.3 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.3 |
| ETAA1 | Ewing tumor-associated antigen 1 | 0.29 |
| TNNC2 | troponin C type 2 (fast) | 0.29 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | 0.29 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.29 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.29 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.29 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 0.28 |
| PLXNB1 | plexin B1 | 0.28 |
| GMFB | glia maturation factor, beta | 0.28 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.28 |
| FAM122A | family with sequence similarity 122A | 0.28 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.28 |
| HMGCL | 3-hydroxymethyl-3-methylglutaryl-CoA lyase | 0.28 |
| ELOB | elongin B | 0.27 |
| LAMTOR4 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 | 0.27 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.27 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | 0.27 |
| SPICE1 | spindle and centriole associated protein 1 | 0.27 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | 0.27 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.27 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.27 |
| SP100 | SP100 nuclear antigen | 0.27 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.27 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.27 |
| RYK | receptor-like tyrosine kinase | 0.26 |
| ZNF721 | zinc finger protein 721 | 0.26 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.26 |
| MATR3 | matrin 3 | 0.26 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.26 |
| C17ORF53 | chromosome 17 open reading frame 53 | 0.26 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.26 |
| KIAA1143 | KIAA1143 | 0.26 |
| RPS27A | ribosomal protein S27a | 0.26 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.25 |
| CALU | calumenin | 0.25 |
| ANKRD26 | ankyrin repeat domain 26 | 0.25 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.95 |
| MLH3 | mutL homolog 3 | -1.29 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -1.12 |
| CFAP58 | cilia and flagella associated protein 58 | -1.11 |
| CCDC110 | coiled-coil domain containing 110 | -0.79 |
| ZNF623 | zinc finger protein 623 | -0.74 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.7 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.7 |
| MFAP3 | microfibrillar-associated protein 3 | -0.69 |
| TMC4 | transmembrane channel-like 4 | -0.64 |
| ZNF268 | zinc finger protein 268 | -0.6 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | -0.6 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.59 |
| MID2 | midline 2 | -0.59 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.59 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.54 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.48 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.47 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.47 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.46 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.46 |
| PUS10 | pseudouridylate synthase 10 | -0.46 |
| RNF130 | ring finger protein 130 | -0.46 |
| ATXN7L3B | ataxin 7-like 3B | -0.45 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.45 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -0.45 |
| TRIM37 | tripartite motif containing 37 | -0.44 |
| PLA2G12A | phospholipase A2, group XIIA | -0.43 |
| HOXA10 | homeobox A10 | -0.43 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.43 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.42 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.42 |
| ZNF362 | zinc finger protein 362 | -0.41 |
| RTL8C | retrotransposon Gag like 8C | -0.4 |
| SPIN4 | spindlin family, member 4 | -0.39 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.39 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.37 |
| ZBTB3 | zinc finger and BTB domain containing 3 | -0.37 |
| EPDR1 | ependymin related 1 | -0.37 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.37 |
| CEP57 | centrosomal protein 57kDa | -0.36 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.36 |
| HDAC4 | histone deacetylase 4 | -0.36 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.35 |
| TLL2 | tolloid-like 2 | -0.35 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -0.34 |
| SLC10A4 | solute carrier family 10, member 4 | -0.34 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.34 |
| RAD52 | RAD52 homolog (S. cerevisiae) | -0.34 |
| TMEM40 | transmembrane protein 40 | -0.34 |
| ADAP2 | ArfGAP with dual PH domains 2 | -0.34 |
| SMIM19 | small integral membrane protein 19 | -0.34 |
| ATF6B | activating transcription factor 6 beta | -0.34 |
| KIAA0825 | KIAA0825 | -0.34 |
| MT2A | metallothionein 2A | -0.34 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.34 |
| TTC8 | tetratricopeptide repeat domain 8 | -0.33 |
| ATL1 | atlastin GTPase 1 | -0.33 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.33 |
| SULF2 | sulfatase 2 | -0.33 |
| SERINC3 | serine incorporator 3 | -0.32 |
| FAM133A | family with sequence similarity 133, member A | -0.32 |
| MAF1 | MAF1 homolog (S. cerevisiae) | -0.32 |
| TSC22D2 | TSC22 domain family, member 2 | -0.32 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.31 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.31 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.31 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.31 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.31 |
| VIM | vimentin | -0.3 |
| FAT2 | FAT atypical cadherin 2 | -0.3 |
| OLFML3 | olfactomedin-like 3 | -0.3 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.3 |
| ZNF524 | zinc finger protein 524 | -0.3 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.3 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.29 |
| C7 | complement component 7 | -0.29 |
| B2M | beta-2-microglobulin | -0.29 |
| DOCK4 | dedicator of cytokinesis 4 | -0.29 |
| SLC35F6 | solute carrier family 35, member F6 | -0.28 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.28 |
| PRXL2A | peroxiredoxin like 2A | -0.28 |
| MEX3C | mex-3 RNA binding family member C | -0.28 |
| TUBAL3 | tubulin, alpha-like 3 | -0.27 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.27 |
| ANAPC11 | anaphase promoting complex subunit 11 | -0.27 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.27 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -0.27 |
| MSLN | mesothelin | -0.27 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.27 |
| LMBRD1 | LMBR1 domain containing 1 | -0.27 |
| LRP6 | low density lipoprotein receptor-related protein 6 | -0.26 |
| SCNM1 | sodium channel modifier 1 | -0.26 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | -0.26 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.26 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.26 |
| MTRF1 | mitochondrial translational release factor 1 | -0.26 |
| PHF1 | PHD finger protein 1 | -0.26 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.26 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.26 |
