Acetazolamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0693018
MATR3 matrin 3 0.0491318
DTNA dystrobrevin, alpha 0.0467381
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0440529
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0432955
OGA O-GlcNAcase 0.0424626
WDR45B WD repeat domain 45B 0.0404869
FOXO3 forkhead box O3 0.0386711
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0380409
KDM3A lysine (K)-specific demethylase 3A 0.0362985
SCAF11 SR-related CTD-associated factor 11 0.0347507
CANX calnexin 0.0347073
DSCAM Down syndrome cell adhesion molecule 0.0333079
NAP1L1 nucleosome assembly protein 1-like 1 0.0328657
RB1CC1 RB1-inducible coiled-coil 1 0.0314577
ZFAND3 zinc finger, AN1-type domain 3 0.0313344
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0309483
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0308855
TENT5A terminal nucleotidyltransferase 5A 0.0302513
FNDC3A fibronectin type III domain containing 3A 0.0302096
HELZ helicase with zinc finger 0.0295982
EIF4B eukaryotic translation initiation factor 4B 0.0290066
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0290029
CASC3 cancer susceptibility candidate 3 0.0278512
ETNK1 ethanolamine kinase 1 0.0271644
BCLAF1 BCL2-associated transcription factor 1 0.0271391
RSRC2 arginine/serine-rich coiled-coil 2 0.0269476
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0268008
ANKRD12 ankyrin repeat domain 12 0.0267272
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0265443
USP9X ubiquitin specific peptidase 9, X-linked 0.0265222
EEF2 eukaryotic translation elongation factor 2 0.0261242
PRRC2C proline-rich coiled-coil 2C 0.0258281
ZFC3H1 zinc finger, C3H1-type containing 0.0257596
SAMD4A sterile alpha motif domain containing 4A 0.025743
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.0257353
REST RE1-silencing transcription factor 0.0252117
CUL3 cullin 3 0.0249812
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0249677
XPO1 exportin 1 0.0248427
XRN2 5'-3' exoribonuclease 2 0.0247821
PNISR PNN-interacting serine/arginine-rich protein 0.0245145
TOP1 topoisomerase (DNA) I 0.0244211
MCU mitochondrial calcium uniporter 0.024259
CKAP5 cytoskeleton associated protein 5 0.0241226
KDM6A lysine (K)-specific demethylase 6A 0.0240362
RAB6A RAB6A, member RAS oncogene family 0.0237935
RIOK3 RIO kinase 3 0.0234914
ZBTB18 zinc finger and BTB domain containing 18 0.0233507
LCOR ligand dependent nuclear receptor corepressor 0.0231175
VGLL4 vestigial-like family member 4 0.0230241
PITPNB phosphatidylinositol transfer protein, beta 0.0229399
ITGAV integrin, alpha V 0.0229106
CADM1 cell adhesion molecule 1 0.0228028
SDK1 sidekick cell adhesion molecule 1 0.022774
NIPBL Nipped-B homolog (Drosophila) 0.0225683
WAC WW domain containing adaptor with coiled-coil 0.0225638
HILPDA hypoxia inducible lipid droplet-associated 0.0224398
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.022398
MYH9 myosin, heavy chain 9, non-muscle 0.0223711
CTNND1 catenin (cadherin-associated protein), delta 1 0.0222288
NCKAP1 NCK-associated protein 1 0.0220776
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0219477
ANKRD17 ankyrin repeat domain 17 0.0219286
METTL9 methyltransferase like 9 0.0216083
JARID2 jumonji, AT rich interactive domain 2 0.0214898
RPL37A ribosomal protein L37a 0.0214745
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.021312
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.021158
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0211327
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0210309
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0208852
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0207494
SET SET nuclear proto-oncogene 0.0206859
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0206613
AFDN afadin, adherens junction formation factor 0.0205954
TNRC6B trinucleotide repeat containing 6B 0.020514
VCL vinculin 0.0205122
DCAF6 DDB1 and CUL4 associated factor 6 0.0202942
PLAT plasminogen activator, tissue 0.0202791
EPS8 epidermal growth factor receptor pathway substrate 8 0.0202684
MXI1 MAX interactor 1, dimerization protein 0.0202485
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0202259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0201868
TNRC6C trinucleotide repeat containing 6C 0.0198905
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0198474
SREBF2 sterol regulatory element binding transcription factor 2 0.0198332
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0197841
RYBP RING1 and YY1 binding protein 0.0197549
CEP85L centrosomal protein 85kDa-like 0.0195968
CSDE1 cold shock domain containing E1, RNA-binding 0.0195532
FAM168A family with sequence similarity 168, member A 0.0194104
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0193995
EWSR1 EWS RNA-binding protein 1 0.0191412
MBNL1 muscleblind-like splicing regulator 1 0.0190752
UBAP2L ubiquitin associated protein 2-like 0.018929
CBFB core-binding factor, beta subunit 0.0188448
DDIT4 DNA-damage-inducible transcript 4 0.0186253
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0185646
RNMT RNA (guanine-7-) methyltransferase 0.0184436

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.316808
NRG1 neuregulin 1 -0.245334
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.174829
NALF1 NALCN channel auxiliary factor 1 -0.124749
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0949234
LINGO2 leucine rich repeat and Ig domain containing 2 -0.084248
LSAMP limbic system-associated membrane protein -0.0697224
ZBTB20 zinc finger and BTB domain containing 20 -0.0662371
SYT1 synaptotagmin I -0.0637848
LIMCH1 LIM and calponin homology domains 1 -0.0588821
SOS1 son of sevenless homolog 1 (Drosophila) -0.058264
THSD4 thrombospondin, type I, domain containing 4 -0.0582005
NCAM2 neural cell adhesion molecule 2 -0.0574134
NAMPT nicotinamide phosphoribosyltransferase -0.0544358
TRIO trio Rho guanine nucleotide exchange factor -0.0495237
PTPRD protein tyrosine phosphatase, receptor type, D -0.0486097
EXOC4 exocyst complex component 4 -0.0483264
MAML2 mastermind-like 2 (Drosophila) -0.0476819
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0474192
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0465818
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0455499
CENPF centromere protein F, 350/400kDa -0.0454079
PTMA prothymosin, alpha -0.0450687
ANTXR1 anthrax toxin receptor 1 -0.0448972
UNC5C unc-5 homolog C (C. elegans) -0.0443756
MBNL2 muscleblind-like splicing regulator 2 -0.0440873
IFI16 interferon, gamma-inducible protein 16 -0.0439347
GDF15 growth differentiation factor 15 -0.0422923
NDRG1 N-myc downstream regulated 1 -0.0410676
MAP1B microtubule-associated protein 1B -0.0396992
ATRNL1 attractin-like 1 -0.0394985
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0388222
ZNF292 zinc finger protein 292 -0.038201
FRMD4A FERM domain containing 4A -0.0366827
AHR aryl hydrocarbon receptor -0.0365396
DLG1 discs, large homolog 1 (Drosophila) -0.0363306
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0357289
VMP1 vacuole membrane protein 1 -0.0356917
LPP LIM domain containing preferred translocation partner in lipoma -0.0355908
KDM5B lysine (K)-specific demethylase 5B -0.035384
ITPRID2 ITPR interacting domain containing 2 -0.0348185
NPAS3 neuronal PAS domain protein 3 -0.0345204
LMNA lamin A/C -0.0341079
COL4A5 collagen, type IV, alpha 5 -0.0340064
CADM2 cell adhesion molecule 2 -0.0337438
CRH corticotropin releasing hormone -0.033068
DLC1 DLC1 Rho GTPase activating protein -0.0329855
ENAH enabled homolog (Drosophila) -0.0329481
MBTD1 mbt domain containing 1 -0.0326626
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0325353
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0324046
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0320362
CCND1 cyclin D1 -0.0317221
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0317112
RAB7A RAB7A, member RAS oncogene family -0.0316157
FHIT fragile histidine triad -0.0316105
BICD1 bicaudal D homolog 1 (Drosophila) -0.0314618
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0312968
MACF1 microtubule-actin crosslinking factor 1 -0.030384
RPL35A ribosomal protein L35a -0.030102
DNM3 dynamin 3 -0.029937
CD36 CD36 molecule (thrombospondin receptor) -0.0295835
CHD9 chromodomain helicase DNA binding protein 9 -0.0292441
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0289345
BSG basigin (Ok blood group) -0.0288982
SEPTIN9 septin 9 -0.0285849
JMY junction mediating and regulatory protein, p53 cofactor -0.0284037
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0282458
NBEA neurobeachin -0.0282348
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0281691
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0278453
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274133
BCAS3 breast carcinoma amplified sequence 3 -0.0271451
BPTF bromodomain PHD finger transcription factor -0.0269899
DIAPH2 diaphanous-related formin 2 -0.026876
STC1 stanniocalcin 1 -0.0268156
EXOC2 exocyst complex component 2 -0.0266408
MCPH1 microcephalin 1 -0.0265735
HMGA2 high mobility group AT-hook 2 -0.0263369
ANGPT1 angiopoietin 1 -0.0261258
RPL19 ribosomal protein L19 -0.0259675
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0258478
IGFBP3 insulin-like growth factor binding protein 3 -0.0258049
RABGAP1L RAB GTPase activating protein 1-like -0.0256261
PRKCA protein kinase C, alpha -0.0256204
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0252785
RPS24 ribosomal protein S24 -0.0252527
B2M beta-2-microglobulin -0.0248114
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0247031
CDK6 cyclin-dependent kinase 6 -0.0246956
MYO9A myosin IXA -0.0245909
MMP2 matrix metallopeptidase 2 -0.0244849
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0244767
MEF2D myocyte enhancer factor 2D -0.0244617
GLS2 glutaminase 2 (liver, mitochondrial) -0.0243585
PCDH15 protocadherin-related 15 -0.0242672
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.02419
MEIS2 Meis homeobox 2 -0.0241667
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0240576
COL1A1 collagen, type I, alpha 1 -0.0240495