Acetazolamide_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.207813
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.175829
APOB apolipoprotein B 0.123528
MT2A metallothionein 2A 0.0971877
FBF1 Fas (TNFRSF6) binding factor 1 0.0838721
RPS6 ribosomal protein S6 0.0802311
ERRFI1 ERBB receptor feedback inhibitor 1 0.0697789
RPL11 ribosomal protein L11 0.0640056
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.062542
APOA2 apolipoprotein A-II 0.0611693
RPS12 ribosomal protein S12 0.0602699
TPT1 tumor protein, translationally-controlled 1 0.0554576
ENO1 enolase 1, (alpha) 0.0502482
ELL2 elongation factor, RNA polymerase II, 2 0.0490404
FNDC3B fibronectin type III domain containing 3B 0.0477671
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0475357
TF transferrin 0.046967
GPC3 glypican 3 0.0465673
RPS8 ribosomal protein S8 0.0447693
RPS19 ribosomal protein S19 0.0444207
CPE carboxypeptidase E 0.0429825
FTL ferritin, light polypeptide 0.0424069
AFDN afadin, adherens junction formation factor 0.0423864
PRRC2C proline-rich coiled-coil 2C 0.0416496
RPS27A ribosomal protein S27a 0.041121
EIF3A eukaryotic translation initiation factor 3, subunit A 0.040618
CCL20 chemokine (C-C motif) ligand 20 0.0401913
RPLP1 ribosomal protein, large, P1 0.0389828
RPL37A ribosomal protein L37a 0.0388082
MATR3 matrin 3 0.0386866
SDC4 syndecan 4 0.0372053
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0371891
RPL26 ribosomal protein L26 0.0355571
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0348176
RPS13 ribosomal protein S13 0.0346162
MRTFA myocardin related transcription factor A 0.0344754
RPL12 ribosomal protein L12 0.0337057
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0334513
RPL5 ribosomal protein L5 0.0327123
RBM25 RNA binding motif protein 25 0.0317573
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0315081
RPS21 ribosomal protein S21 0.0312942
RPLP0 ribosomal protein, large, P0 0.0312267
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0312243
KIF5B kinesin family member 5B 0.0311595
PTPRM protein tyrosine phosphatase, receptor type, M 0.0305381
WDR45B WD repeat domain 45B 0.0293918
RPL23 ribosomal protein L23 0.0293726
RPL35A ribosomal protein L35a 0.0290241
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0289943
RPL34 ribosomal protein L34 0.0288273
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0286915
RPL9 ribosomal protein L9 0.0286402
KTN1 kinectin 1 (kinesin receptor) 0.0279408
KIF1B kinesin family member 1B 0.0278191
DLC1 DLC1 Rho GTPase activating protein 0.0273659
RPS25 ribosomal protein S25 0.0270447
CFB complement factor B 0.0268762
RPL31 ribosomal protein L31 0.0267679
EPS8 epidermal growth factor receptor pathway substrate 8 0.0266977
RPS3 ribosomal protein S3 0.0259381
TOP1 topoisomerase (DNA) I 0.0259119
RPS24 ribosomal protein S24 0.025891
RAB1A RAB1A, member RAS oncogene family 0.0258198
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0255047
NIPBL Nipped-B homolog (Drosophila) 0.0254053
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0250227
TIMP1 TIMP metallopeptidase inhibitor 1 0.0248065
RPL7A ribosomal protein L7a 0.0247332
MACF1 microtubule-actin crosslinking factor 1 0.0246502
DDIT4 DNA-damage-inducible transcript 4 0.02462
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0245025
TRIM26 tripartite motif containing 26 0.0244082
TM4SF1 transmembrane 4 L six family member 1 0.024108
RPLP2 ribosomal protein, large, P2 0.0240515
RPS23 ribosomal protein S23 0.024013
SOS1 son of sevenless homolog 1 (Drosophila) 0.023827
RPS17 ribosomal protein S17 0.0238232
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0237342
EIF1 eukaryotic translation initiation factor 1 0.0237278
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0236826
ZFAND3 zinc finger, AN1-type domain 3 0.0234983
RB1CC1 RB1-inducible coiled-coil 1 0.0230865
INSIG2 insulin induced gene 2 0.0230681
RPS14 ribosomal protein S14 0.0229777
MED13L mediator complex subunit 13-like 0.022763
RPS29 ribosomal protein S29 0.0223969
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0223663
CSDE1 cold shock domain containing E1, RNA-binding 0.0223334
LRRC1 leucine rich repeat containing 1 0.0221102
AMBP alpha-1-microglobulin/bikunin precursor 0.022045
RRBP1 ribosome binding protein 1 0.0220386
RPL19 ribosomal protein L19 0.0217396
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0216028
UBXN4 UBX domain protein 4 0.0215994
ARHGAP9 Rho GTPase activating protein 9 0.0213602
EML4 echinoderm microtubule associated protein like 4 0.0211239
JMJD1C jumonji domain containing 1C 0.0208236
KMT2C lysine (K)-specific methyltransferase 2C 0.020763
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0205551

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.463157
AKAP12 A kinase (PRKA) anchor protein 12 -0.118115
EHBP1 EH domain binding protein 1 -0.0938893
GPC6 glypican 6 -0.089288
ASPH aspartate beta-hydroxylase -0.0766687
MAML2 mastermind-like 2 (Drosophila) -0.0699336
ATXN1 ataxin 1 -0.0641809
GMDS GDP-mannose 4,6-dehydratase -0.0556463
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.05209
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0515264
RERE arginine-glutamic acid dipeptide (RE) repeats -0.05018
NPAS2 neuronal PAS domain protein 2 -0.0448001
ZBTB20 zinc finger and BTB domain containing 20 -0.0423146
SAMD4A sterile alpha motif domain containing 4A -0.039492
RNF213 ring finger protein 213 -0.0390113
GK glycerol kinase -0.0386539
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0377183
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0357781
ATP10A ATPase, class V, type 10A -0.0345099
DTNA dystrobrevin, alpha -0.0343882
RIGI RNA sensor RIG-I -0.0330624
DST dystonin -0.0316302
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0314932
LRMDA leucine rich melanocyte differentiation associated -0.0305673
INTS6 integrator complex subunit 6 -0.030307
SOX5 SRY (sex determining region Y)-box 5 -0.0302925
TRIO trio Rho guanine nucleotide exchange factor -0.029756
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0276813
CP ceruloplasmin (ferroxidase) -0.027317
LPP LIM domain containing preferred translocation partner in lipoma -0.0271245
DNAH17 dynein, axonemal, heavy chain 17 -0.025457
EXT1 exostosin glycosyltransferase 1 -0.0254545
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0241381
FAM135A family with sequence similarity 135, member A -0.0231382
HDAC4 histone deacetylase 4 -0.0229119
PTCHD4 patched domain containing 4 -0.0222157
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0218832
TNS1 tensin 1 -0.0214761
PDLIM5 PDZ and LIM domain 5 -0.021355
GLS2 glutaminase 2 (liver, mitochondrial) -0.0211043
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0209741
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0206005
ZHX2 zinc fingers and homeoboxes 2 -0.0204504
RAD51B RAD51 paralog B -0.020398
FN1 fibronectin 1 -0.0198552
OSBPL10 oxysterol binding protein-like 10 -0.0193998
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0193929
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0191957
PRKCA protein kinase C, alpha -0.0191853
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0191742
NDRG1 N-myc downstream regulated 1 -0.0186217
PLXDC2 plexin domain containing 2 -0.0185359
HPCAL1 hippocalcin-like 1 -0.018359
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0183473
TNS3 tensin 3 -0.0182171
FRMD5 FERM domain containing 5 -0.0182156
RUNX1 runt-related transcription factor 1 -0.0177435
NABP1 nucleic acid binding protein 1 -0.0175241
FAM107B family with sequence similarity 107, member B -0.0172683
TTC28 tetratricopeptide repeat domain 28 -0.0171518
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.017079
MX2 MX dynamin-like GTPase 2 -0.0170136
IGFBP1 insulin-like growth factor binding protein 1 -0.0166874
KDM4C lysine (K)-specific demethylase 4C -0.0164881
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0161531
PTPRK protein tyrosine phosphatase, receptor type, K -0.0160845
NHSL1 NHS-like 1 -0.0160803
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0160046
GCLC glutamate-cysteine ligase, catalytic subunit -0.0158494
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0156782
MSI2 musashi RNA-binding protein 2 -0.0156107
SP100 SP100 nuclear antigen -0.0154194
VCAN versican -0.0153837
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0153615
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0153385
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0148855
EXOC4 exocyst complex component 4 -0.0147887
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0147289
FOXO3 forkhead box O3 -0.0145448
TBC1D22A TBC1 domain family, member 22A -0.0144996
GRB10 growth factor receptor-bound protein 10 -0.0144674
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0143928
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0141851
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0141773
UTRN utrophin -0.0140931
ZNF638 zinc finger protein 638 -0.0140477
AGO2 argonaute RISC catalytic component 2 -0.013917
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0138697
CMIP c-Maf inducing protein -0.0138629
CPQ carboxypeptidase Q -0.0137899
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0137076
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0135623
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0135164
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.013485
ARHGAP21 Rho GTPase activating protein 21 -0.0133478
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0132995
STC2 stanniocalcin 2 -0.0131758
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0131617
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0129938
STK39 serine threonine kinase 39 -0.0128409