Acetazolamide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0864913
OGA O-GlcNAcase 0.0781669
CLU clusterin 0.0711737
MYH9 myosin, heavy chain 9, non-muscle 0.069211
KDM6A lysine (K)-specific demethylase 6A 0.0670083
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0663825
TMSB4X thymosin beta 4, X-linked 0.0661037
BZW1 basic leucine zipper and W2 domains 1 0.0574746
TPM3 tropomyosin 3 0.0558322
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0547846
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0540647
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0535812
ANXA1 annexin A1 0.048425
SUCO SUN domain containing ossification factor 0.0481707
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0477002
MATR3 matrin 3 0.046766
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0461185
SQSTM1 sequestosome 1 0.0458507
GRB10 growth factor receptor-bound protein 10 0.042716
RBM39 RNA binding motif protein 39 0.0409041
PODXL podocalyxin-like 0.0395422
ANLN anillin, actin binding protein 0.0393732
SLK STE20-like kinase 0.0393241
SPAG9 sperm associated antigen 9 0.0373094
NAMPT nicotinamide phosphoribosyltransferase 0.0362024
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0357884
EZR ezrin 0.0355326
APP amyloid beta (A4) precursor protein 0.0347586
THOC2 THO complex 2 0.0347268
MARCHF6 membrane associated ring-CH-type finger 6 0.0345746
DIAPH1 diaphanous-related formin 1 0.0339471
CDC73 cell division cycle 73 0.0332446
KDM3A lysine (K)-specific demethylase 3A 0.0329513
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0326927
PICALM phosphatidylinositol binding clathrin assembly protein 0.0322904
CANX calnexin 0.0318319
PGK1 phosphoglycerate kinase 1 0.0316458
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0314454
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0309955
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0307492
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0307167
USP9X ubiquitin specific peptidase 9, X-linked 0.03057
TM4SF1 transmembrane 4 L six family member 1 0.0301647
RLF rearranged L-myc fusion 0.0297177
SET SET nuclear proto-oncogene 0.0294732
SBF2 SET binding factor 2 0.0279911
LAMP2 lysosomal-associated membrane protein 2 0.0273251
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0272996
KRT17 keratin 17, type I 0.0271427
SMAD3 SMAD family member 3 0.0271105
EIF4A1 eukaryotic translation initiation factor 4A1 0.0268983
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0268234
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0267252
RSL1D1 ribosomal L1 domain containing 1 0.0263621
NAP1L1 nucleosome assembly protein 1-like 1 0.0261429
HLA-E major histocompatibility complex, class I, E 0.026072
CKAP5 cytoskeleton associated protein 5 0.0260645
RAB8B RAB8B, member RAS oncogene family 0.0258989
ATP13A3 ATPase type 13A3 0.0256947
GARS1 glycyl-tRNA synthetase 1 0.0256029
TNPO1 transportin 1 0.0253547
KMT2C lysine (K)-specific methyltransferase 2C 0.0251524
ARF4 ADP-ribosylation factor 4 0.0251444
RICTOR RPTOR independent companion of MTOR, complex 2 0.0251137
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0249034
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0246957
NUP58 nucleoporin 58 0.0246664
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0246378
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0245521
MSN moesin 0.0244822
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.024422
PLEC plectin 0.0244013
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238344
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0231889
ITCH itchy E3 ubiquitin protein ligase 0.0230034
TM9SF2 transmembrane 9 superfamily member 2 0.0229796
RNF145 ring finger protein 145 0.022881
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0227723
ANXA5 annexin A5 0.0226944
ECT2 epithelial cell transforming 2 0.022689
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0226808
TOP2B topoisomerase (DNA) II beta 180kDa 0.0225163
RAD21 RAD21 homolog (S. pombe) 0.0223561
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0220882
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0219921
SERINC1 serine incorporator 1 0.0219644
BCAR3 breast cancer anti-estrogen resistance 3 0.0219519
RNF19B ring finger protein 19B 0.021715
CDC42 cell division cycle 42 0.0216159
RHEB Ras homolog enriched in brain 0.021592
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0215419
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0214729
FLNA filamin A, alpha 0.021466
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0213972
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0213706
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0209228
TNIP1 TNFAIP3 interacting protein 1 0.0208632
TMEM263 transmembrane protein 263 0.0208414
FAR1 fatty acyl CoA reductase 1 0.0206556
SERINC3 serine incorporator 3 0.0206246

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.207596
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182689
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.16788
TMSB10 thymosin beta 10 -0.090349
LOC112694756 uncharaterized LOC112694756 -0.0878895
SULF1 sulfatase 1 -0.0840576
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0783329
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0727476
DPYD dihydropyrimidine dehydrogenase -0.0710939
HSPG2 heparan sulfate proteoglycan 2 -0.0710027
MT2A metallothionein 2A -0.067232
S100A10 S100 calcium binding protein A10 -0.0640909
FTH1 ferritin, heavy polypeptide 1 -0.0571254
RPLP1 ribosomal protein, large, P1 -0.0527859
PDE4D phosphodiesterase 4D, cAMP-specific -0.0517849
RPS8 ribosomal protein S8 -0.051304
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0501018
LMO7 LIM domain 7 -0.0490501
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0487399
IFITM3 interferon induced transmembrane protein 3 -0.0477379
RPL35A ribosomal protein L35a -0.0477193
PALLD palladin, cytoskeletal associated protein -0.047166
CYB5R3 cytochrome b5 reductase 3 -0.0466444
S100A9 S100 calcium binding protein A9 -0.0463683
DOCK5 dedicator of cytokinesis 5 -0.0444673
OSMR oncostatin M receptor -0.0429303
FOXP1 forkhead box P1 -0.0427875
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0426385
S100A6 S100 calcium binding protein A6 -0.0425409
PDLIM5 PDZ and LIM domain 5 -0.0413023
RPS21 ribosomal protein S21 -0.0401842
AKAP9 A kinase (PRKA) anchor protein 9 -0.0398918
RPS19 ribosomal protein S19 -0.0397575
RPLP2 ribosomal protein, large, P2 -0.0393101
RPL8 ribosomal protein L8 -0.0385566
TGM2 transglutaminase 2 -0.0385513
N4BP2L2 NEDD4 binding protein 2-like 2 -0.038456
MRPS6 mitochondrial ribosomal protein S6 -0.0383219
RPL27A ribosomal protein L27a -0.0373119
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0363952
RABGAP1L RAB GTPase activating protein 1-like -0.0362819
ITGB4 integrin, beta 4 -0.0360692
EFNA5 ephrin-A5 -0.03553
ANKRD12 ankyrin repeat domain 12 -0.0347826
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0338661
HM13 histocompatibility (minor) 13 -0.0332172
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0331787
RPS14 ribosomal protein S14 -0.0329422
GNAS GNAS complex locus -0.0329355
RPL19 ribosomal protein L19 -0.0323684
BLCAP bladder cancer associated protein -0.0323235
RPL39 ribosomal protein L39 -0.0322398
DGKH diacylglycerol kinase, eta -0.0322111
FTL ferritin, light polypeptide -0.0317691
RPL9 ribosomal protein L9 -0.0309309
NRG1 neuregulin 1 -0.030913
MYADM myeloid-associated differentiation marker -0.0308723
EXT1 exostosin glycosyltransferase 1 -0.0307461
LDHA lactate dehydrogenase A -0.0307028
P4HB prolyl 4-hydroxylase, beta polypeptide -0.030474
EGFR epidermal growth factor receptor -0.0301952
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0301536
CNRIP1 cannabinoid receptor interacting protein 1 -0.0300192
RPL23 ribosomal protein L23 -0.0298895
RPS27 ribosomal protein S27 -0.0296278
PRSS23 protease, serine, 23 -0.0291723
FOXO1 forkhead box O1 -0.0282172
MT1X metallothionein 1X -0.0280629
CALR calreticulin -0.0279873
RPLP0 ribosomal protein, large, P0 -0.0278317
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0277214
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0275989
EGR1 early growth response 1 -0.0275912
GUK1 guanylate kinase 1 -0.0275304
RPL30 ribosomal protein L30 -0.0273964
TAGLN2 transgelin 2 -0.0273519
ZMYND8 zinc finger, MYND-type containing 8 -0.0273285
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0267539
COG6 component of oligomeric golgi complex 6 -0.0266238
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0265425
MBNL2 muscleblind-like splicing regulator 2 -0.0265033
SMYD3 SET and MYND domain containing 3 -0.0263325
IGF2 insulin-like growth factor 2 -0.0262088
RPL28 ribosomal protein L28 -0.0261924
IFI27 interferon, alpha-inducible protein 27 -0.0260955
PFN1 profilin 1 -0.0260927
CEMIP cell migration inducing protein, hyaluronan binding -0.026044
GOLGB1 golgin B1 -0.025722
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0254854
RPL37 ribosomal protein L37 -0.0253978
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0253312
LAMA5 laminin, alpha 5 -0.0251635
CMIP c-Maf inducing protein -0.0251305
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0250496
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0249945
CNTNAP3 contactin associated protein-like 3 -0.0246689
LMNA lamin A/C -0.0244417
NLRP1 NLR family, pyrin domain containing 1 -0.0241784
BSG basigin (Ok blood group) -0.0240601
ZNF395 zinc finger protein 395 -0.0240155